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674289-55-5,MFCD04113775
Catalog No.:AA003287

674289-55-5 | (±)-Blebbistatin

Pack Size
Purity
Availability
Price(USD)
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1mg
≥99%
in stock  
$93.00   $65.00
- +
5mg
≥98%
in stock  
$123.00   $86.00
- +
25mg
≥98%
in stock  
$480.00   $336.00
- +
50mg
≥99%
in stock  
$691.00   $484.00
- +
100mg
97%
in stock  
$727.00   $509.00
- +
250mg
97%
in stock  
$1,317.00   $922.00
- +
1g
97%
in stock  
$2,584.00   $1,809.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003287
Chemical Name:
(±)-Blebbistatin
CAS Number:
674289-55-5
Molecular Formula:
C18H16N2O2
Molecular Weight:
292.3318
MDL Number:
MFCD04113775
SMILES:
Cc1ccc2c(c1)C(=O)C1(C(=N2)N(CC1)c1ccccc1)O
Properties
Properties
 
Form:
Solid  
MP:
>180°C (dec.)  
Storage:
Room Temperature;  

Computed Properties
 
Complexity:
497  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
1  
Undefined Atom Stereocenter Count:
1  
XLogP3:
2.4  

Literature

Title: A highly soluble, non-phototoxic, non-fluorescent blebbistatin derivative.

Journal: Scientific reports 20160101

Title: Temporal analysis of vascular smooth muscle cell elasticity and adhesion reveals oscillation waveforms that differ with aging.

Journal: Aging cell 20121001

Title: Modifications of mechanoelectric feedback induced by 2,3-butanedione monoxime and Blebbistatin in Langendorff-perfused rabbit hearts.

Journal: Acta physiologica (Oxford, England) 20120901

Title: Contractility in type III cochlear fibrocytes is dependent on non-muscle myosin II and intercellular gap junctional coupling.

Journal: Journal of the Association for Research in Otolaryngology : JARO 20120801

Title: Interventricular heterogeneity as a substrate for arrhythmogenesis of decoupled mitochondria during ischemia in the whole heart.

Journal: American journal of physiology. Heart and circulatory physiology 20120715

Title: Cytoskeletal modulation of lipid interactions regulates Lck kinase activity.

Journal: The Journal of biological chemistry 20120713

Title: Blebbistatin, a myosin inhibitor, is phototoxic to human cancer cells under exposure to blue light.

Journal: Biochimica et biophysica acta 20120701

Title: LTP induction translocates cortactin at distant synapses in wild-type but not Fmr1 knock-out mice.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20120523

Title: Enrichment of cell populations in metaphase, anaphase, and telophase by synchronization using nocodazole and blebbistatin: a novel method suitable for examining dynamic changes in proteins during mitotic progression.

Journal: European journal of cell biology 20120501

Title: Hyaluronic acid matrices show matrix stiffness in 2D and 3D dictates cytoskeletal order and myosin-II phosphorylation within stem cells.

Journal: Integrative biology : quantitative biosciences from nano to macro 20120401

Title: Inhibition of actin dynamics during epithelial-to-mesenchymal transition.

Journal: Biochemical and biophysical research communications 20120309

Title: Myosin II activity regulates neurite outgrowth and guidance in response to chondroitin sulfate proteoglycans.

Journal: Journal of neurochemistry 20120301

Title: Enucleation of human erythroblasts involves non-muscle myosin IIB.

Journal: Blood 20120126

Title: Smooth muscle myosin expression, isoform composition, and functional activities in rat corpus cavernosum altered by the streptozotocin-induced type 1 diabetes.

Journal: American journal of physiology. Endocrinology and metabolism 20120101

Title: The role of dynamic instability and wavelength in arrhythmia maintenance as revealed by panoramic imaging with blebbistatin vs. 2,3-butanedione monoxime.

Journal: American journal of physiology. Heart and circulatory physiology 20120101

Title: Pre-power-stroke cross-bridges contribute to force transients during imposed shortening in isolated muscle fibers.

Journal: PloS one 20120101

Title: Mechanics regulates fate decisions of human embryonic stem cells.

Journal: PloS one 20120101

Title: Involvement of actin filament in the generation of Ca2+ mobilizing messengers in glucose-induced Ca2+ signaling in pancreatic β-cells.

Journal: Islets 20120101

Title: [A single E726Q mutation in the membrane proximal α-helix of integrin β3 subunit induces membrane blebbing by disrupting the membrane-actin cortex interaction].

Journal: Zhongguo shi yan xue ye xue za zhi 20111201

Title: LPA(1) -induced migration requires nonmuscle myosin II light chain phosphorylation in breast cancer cells.

Journal: Journal of cellular physiology 20111101

Title: Non-muscle myosin IIA is required for the development of the zebrafish glomerulus.

Journal: Kidney international 20111101

Title: Dynamic changes of acoustic load and complex impedance as reporters for the cytotoxicity of small molecule inhibitors.

Journal: Chemical research in toxicology 20110919

Title: Titin based viscosity in ventricular physiology: an integrative investigation of PEVK-actin interactions.

Journal: Journal of molecular and cellular cardiology 20110901

Title: Dynamic maintenance of asymmetric meiotic spindle position through Arp2/3-complex-driven cytoplasmic streaming in mouse oocytes.

Journal: Nature cell biology 20110828

Title: Drifting motions of the adenovirus receptor CAR and immobile integrins initiate virus uncoating and membrane lytic protein exposure.

Journal: Cell host & microbe 20110818

Title: Inhibition of suicidal erythrocyte death by blebbistatin.

Journal: American journal of physiology. Cell physiology 20110801

Title: Inhibiting myosin-ATPase reveals a dynamic range of mitochondrial respiratory control in skeletal muscle.

Journal: The Biochemical journal 20110715

Title: Real-time cellular impedance measurements detect Ca(2+) channel-dependent oscillations of morphology in human H295R adrenoma cells.

Journal: Biochimica et biophysica acta 20110501

Title: Rho signaling pathway and apical constriction in the early lens placode.

Journal: Genesis (New York, N.Y. : 2000) 20110501

Title: Distinct cytoskeleton populations and extensive crosstalk control Ciona notochord tubulogenesis.

Journal: Development (Cambridge, England) 20110401

Title: Quantitative proteomics of the integrin adhesome show a myosin II-dependent recruitment of LIM domain proteins.

Journal: EMBO reports 20110303

Title: Correlation of dysfunction of nonmuscle myosin IIA with increased induction of Cyp1a1 in Hepa-1 cells.

Journal: Biochimica et biophysica acta 20110301

Title: Oncogenic BRAF induces melanoma cell invasion by downregulating the cGMP-specific phosphodiesterase PDE5A.

Journal: Cancer cell 20110118

Title: In vitro and in vivo relaxation of urinary bladder smooth muscle by the selective myosin II inhibitor, blebbistatin.

Journal: BJU international 20110101

Title: Chikungunya virus mobilizes the apoptotic machinery to invade host cell defenses.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110101

Title: Blebbing dynamics during endothelial cell spreading.

Journal: European journal of cell biology 20110101

Title: Blebbistain, a myosin II inhibitor, as a novel strategy to regulate detrusor contractility in a rat model of partial bladder outlet obstruction.

Journal: PloS one 20110101

Title: Myosin II activity dependent and independent vinculin recruitment to the sites of E-cadherin-mediated cell-cell adhesion.

Journal: BMC cell biology 20110101

Title: The elementary events underlying force generation in neuronal lamellipodia.

Journal: Scientific reports 20110101

Title: Intramolecular loop/tail interactions are essential for connexin 43-hemichannel activity.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20101101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Vesicle trafficking plays a novel role in erythroblast enucleation.

Journal: Blood 20101028

Title: Dupuytren's fibroblast contractility by sphingosine-1-phosphate is mediated through non-muscle myosin II.

Journal: The Journal of hand surgery 20101001

Title: Non-muscle myosin II regulates survival threshold of pluripotent stem cells.

Journal: Nature communications 20100907

Title: Effect of nonuniform muscle contraction on sustainability and frequency of triggered arrhythmias in rat cardiac muscle.

Journal: Circulation 20100629

Title: Extracellular signal-regulated kinase and GEF-H1 mediate depolarization-induced Rho activation and paracellular permeability increase.

Journal: American journal of physiology. Cell physiology 20100601

Title: Myosin II contributes to cell-scale actin network treadmilling through network disassembly.

Journal: Nature 20100520

Title: The kinetics of force-induced cell reorganization depend on microtubules and actin.

Journal: Cytoskeleton (Hoboken, N.J.) 20100401

Title: Blebbistatin effectively uncouples the excitation-contraction process in zebrafish embryonic heart.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100301

Title: Promigratory and procontractile growth factor environments differentially regulate cell morphogenesis.

Journal: Experimental cell research 20100115

Title: Myosin IIB isoform plays an essential role in the formation of two distinct types of macropinosomes.

Journal: Cytoskeleton (Hoboken, N.J.) 20100101

Title: Blebbistatin inhibits contraction and accelerates migration in mouse hepatic stellate cells.

Journal: British journal of pharmacology 20100101

Title: Reversible bleb formation in mast cells stimulated with antigen is Ca2+/calmodulin-dependent and bleb size is regulated by ARF6.

Journal: The Biochemical journal 20091214

Title: On the origins of the universal dynamics of endogenous granules in mammalian cells.

Journal: Molecular & cellular biomechanics : MCB 20091201

Title: Stabilization of anaphase midzone microtubules is regulated by Rho during cytokinesis in human fibrosarcoma cells.

Journal: Experimental cell research 20091001

Title: In vitro and in vivo relaxation of corpus cavernosum smooth muscle by the selective myosin II inhibitor, blebbistatin.

Journal: The journal of sexual medicine 20091001

Title: Cortical F-actin, the exocytic mode, and neuropeptide release in mouse chromaffin cells is regulated by myristoylated alanine-rich C-kinase substrate and myosin II.

Journal: Molecular biology of the cell 20090701

Title: 'Injecting' yeast.

Journal: Nature methods 20090701

Title: Megalin and nonmuscle myosin heavy chain IIA interact with the adaptor protein Disabled-2 in proximal tubule cells.

Journal: Kidney international 20090601

Title: The collagen receptor DDR1 regulates cell spreading and motility by associating with myosin IIA.

Journal: Journal of cell science 20090515

Title: Stabilization of helical order in the thick filaments by blebbistatin: further evidence of coexisting multiple conformations of myosin.

Journal: Biophysical journal 20090506

Title: Mertk drives myosin II redistribution during retinal pigment epithelial phagocytosis.

Journal: Investigative ophthalmology & visual science 20090501

Title: Roles of focal adhesions and fibronectin-mediated cohesion in proliferation of confluent fibroblasts.

Journal: Journal of cellular physiology 20090401

Title: Programmed subcellular release for studying the dynamics of cell detachment.

Journal: Nature methods 20090301

Title: F-actin and myosin II accelerate catecholamine release from chromaffin granules.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20090121

Title: Panoramic imaging reveals basic mechanisms of induction and termination of ventricular tachycardia in rabbit heart with chronic infarction: implications for low-voltage cardioversion.

Journal: Heart rhythm 20090101

Title: The myosin II ATPase inhibitor blebbistatin prevents thrombin-induced inhibition of intercellular calcium wave propagation in corneal endothelial cells.

Journal: Investigative ophthalmology & visual science 20081101

Title: Dual role for myosin II in GLUT4-mediated glucose uptake in 3T3-L1 adipocytes.

Journal: Experimental cell research 20081015

Title: Blebbistatin stabilizes the helical order of myosin filaments by promoting the switch 2 closed state.

Journal: Biophysical journal 20081001

Title: The translocation of signaling molecules in dark adapting mammalian rod photoreceptor cells is dependent on the cytoskeleton.

Journal: Cell motility and the cytoskeleton 20081001

Title: Extracellular matrix rigidity promotes invadopodia activity.

Journal: Current biology : CB 20080909

Title: Propofol causes neurite retraction in neurones.

Journal: British journal of anaesthesia 20080901

Title: Regulation of polarity in cells devoid of actin bundle system after treatment with inhibitors of myosin II activity.

Journal: Cell motility and the cytoskeleton 20080901

Title: Plectin deposition at podosome rings requires myosin contractility.

Journal: Cell motility and the cytoskeleton 20080801

Title: Identification of a fibrin-independent platelet contractile mechanism regulating primary hemostasis and thrombus growth.

Journal: Blood 20080701

Title: Roles of basolateral solute uptake via NKCC1 and of myosin II in vasopressin-induced cell swelling in inner medullary collecting duct.

Journal: American journal of physiology. Renal physiology 20080701

Title: Myosin II regulates the shape of three-dimensional intestinal epithelial cysts.

Journal: Journal of cell science 20080601

Title: Blebbistatin inhibits the chemotaxis of vascular smooth muscle cells by disrupting the myosin II-actin interaction.

Journal: American journal of physiology. Heart and circulatory physiology 20080501

Title: Images in cardiovascular medicine. Optical mapping of the human atrioventricular junction.

Journal: Circulation 20080318

Title: Blebbistatin: use as inhibitor of muscle contraction.

Journal: Pflugers Archiv : European journal of physiology 20080301

Title: A cytoskeletal demolition worker: myosin II acts as an actin depolymerization agent.

Journal: Journal of molecular biology 20080111

Title: Atrial cardiomyocyte tachycardia alters cardiac fibroblast function: a novel consideration in atrial remodeling.

Journal: Cardiovascular research 20071201

Title: Myosin II and Rho kinase activity are required for melanosome aggregation in fish retinal pigment epithelial cells.

Journal: Cell motility and the cytoskeleton 20071101

Title: Attenuation of actinomyosinII contractile activity in growth cones accelerates filopodia-guided and microtubule-based neurite elongation.

Journal: Brain research 20071024

Title: Membrane associated nonmuscle myosin II functions as a motor for actin-based vesicle transport in clam oocyte extracts.

Journal: Cell motility and the cytoskeleton 20071001

Title: Forced unfolding of proteins within cells.

Journal: Science (New York, N.Y.) 20070803

Title: Hepatic stellate cell protrusions couple platelet-derived growth factor-BB to chemotaxis.

Journal: Hepatology (Baltimore, Md.) 20070601

Title: Myosin IIA regulates cell motility and actomyosin-microtubule crosstalk.

Journal: Nature cell biology 20070301

Title: Association of CD38 with nonmuscle myosin heavy chain IIA and Lck is essential for the internalization and activation of CD38.

Journal: The Journal of biological chemistry 20070223

Title: Analysis of mitotic phosphorylation of borealin.

Journal: BMC cell biology 20070101

Title: A unique role for nonmuscle myosin heavy chain IIA in regulation of epithelial apical junctions.

Journal: PloS one 20070101

Title: Blebbistatin inhibits sphingosylphosphorylcholine-induced contraction of collagen-gel fiber populated by vascular smooth-muscle cells.

Journal: Journal of pharmacological sciences 20061101

Title: Myosin-based contraction is not necessary for cardiac c-looping in the chick embryo.

Journal: Anatomy and embryology 20061001

Title: Myosin light chain kinase plays a role in the regulation of epithelial cell survival.

Journal: Journal of cell science 20060601

Title: Actomyosin tension is required for correct recruitment of adherens junction components and zonula occludens formation.

Journal: Experimental cell research 20060515

Title: Catch force links and the low to high force transition of myosin.

Journal: Biophysical journal 20060501

Title: The interaction of Phe472 with a fluorescent inhibitor bound to the complex of myosin subfragment-1 with nucleotide.

Journal: Biochemistry 20060131

Title: Antagonists of myosin light chain kinase and of myosin II inhibit specific events of egg activation in fertilized mouse eggs.

Journal: Biology of reproduction 20060101

Title: Rho kinase regulates fragmentation and phagocytosis of apoptotic cells.

Journal: Experimental cell research 20060101

Title: Myosin 2 is a key Rho kinase target necessary for the local concentration of E-cadherin at cell-cell contacts.

Journal: Molecular biology of the cell 20051001

Title: Redundant mechanisms for anaphase chromosome movements: crane-fly spermatocyte spindles normally use actin filaments but also can function without them.

Journal: Protoplasma 20051001

Title: Myosin II regulatory light chain is required for trafficking of bile salt export protein to the apical membrane in Madin-Darby canine kidney cells.

Journal: The Journal of biological chemistry 20050624

Title: A novel role for myosin II in insulin-stimulated glucose uptake in 3T3-L1 adipocytes.

Journal: Biochemical and biophysical research communications 20050617

Title: NCAM 180 acting via a conserved C-terminal domain and MLCK is essential for effective transmission with repetitive stimulation.

Journal: Neuron 20050616

Title: Cortical actin turnover during cytokinesis requires myosin II.

Journal: Current biology : CB 20050426

Title: A GIT1/PIX/Rac/PAK signaling module regulates spine morphogenesis and synapse formation through MLC.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050330

Title: Rho-kinase and myosin II activities are required for cell type and environment specific migration.

Journal: Genes to cells : devoted to molecular & cellular mechanisms 20050201

Title: Myosin regulation in the migration of tumor cells and leukocytes within a three-dimensional collagen matrix.

Journal: Cellular and molecular life sciences : CMLS 20050101

Title: Mammalian cells lack checkpoints for tetraploidy, aberrant centrosome number, and cytokinesis failure.

Journal: BMC cell biology 20050101

Title: Brain-derived neurotrophic factor regulation of retinal growth cone filopodial dynamics is mediated through actin depolymerizing factor/cofilin.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20041124

Title: Kinetic mechanism of blebbistatin inhibition of nonmuscle myosin IIb.

Journal: Biochemistry 20041123

Title: Cell type-specific regulation of RhoA activity during cytokinesis.

Journal: The Journal of biological chemistry 20041022

Title: Mechanism of blebbistatin inhibition of myosin II.

Journal: The Journal of biological chemistry 20040820

Title: Inhibition of pancreatic adenocarcinoma cellular invasiveness by blebbistatin: a novel myosin II inhibitor.

Journal: Biochemical and biophysical research communications 20040123

Title: Specificity of blebbistatin, an inhibitor of myosin II.

Journal: Journal of muscle research and cell motility 20040101

Title: Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor.

Journal: Science (New York, N.Y.) 20030314

Title: Ho WT, et al. Targeting non-muscle myosin II promotes corneal endothelial migration through regulating lamellipodial dynamics. J Mol Med (Berl). 2019 Sep;97(9):1345-1357.

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Tags:674289-55-5 Molecular Formula|674289-55-5 MDL|674289-55-5 SMILES|674289-55-5 (±)-Blebbistatin