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1429-50-1,MFCD00058893
Catalog No.:AA003QFY

1429-50-1 | Ethylenediaminetetra(methylenephosphonic acid)

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5g
95%
in stock  
$16.00   $12.00
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25g
95%
in stock  
$24.00   $17.00
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100g
95%
in stock  
$64.00   $45.00
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500g
96%
in stock  
$261.00   $183.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003QFY
Chemical Name:
Ethylenediaminetetra(methylenephosphonic acid)
CAS Number:
1429-50-1
Molecular Formula:
C6H20N2O12P4
Molecular Weight:
436.1242
MDL Number:
MFCD00058893
SMILES:
OP(=O)(CN(CP(=O)(O)O)CCN(CP(=O)(O)O)CP(=O)(O)O)O
Properties
Properties
 
BP:
878.7°C at 760 mmHg  
Form:
Solid  
MP:
228-231°C  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
486  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
14  
Hydrogen Bond Donor Count:
8  
Rotatable Bond Count:
11  
XLogP3:
-11.2  

Downstream Synthesis Route

[1]Uhlig,E.;Achilles,W.[JournalfurpraktischeChemie(Leipzig1954),1969,vol.311,p.529-538]

[1]Locationinpatent:experimentalpartVillemin,Didier;Moreau,Bernard;Elbilali,Abdelghani;Didi,Mohamed-Amine;Kaid,Mhamed;Jaffres,Paul-Alain[Phosphorus,SulfurandSiliconandtheRelatedElements,2010,vol.185,#12,p.2511-2519]

[2]Moedritzer,K.;Irani,R.R.[JournalofOrganicChemistry,1966,vol.31,p.1603-1607]

[3]Hassfjell;Hoff;Bruiand;Alstad[Journaloflabelledcompoundsandradiopharmaceuticals,1994,vol.34,#8,p.717-734]

[4]CurrentPatentAssignee:BAYERAG;Monsanto(in:Bayer)-EP1681294,2006,A1Locationinpatent:Page/Pagecolumn11

[5]CurrentPatentAssignee:BAYERAG;Monsanto(in:Bayer)-WO2014/12987,2014,A1Locationinpatent:Paragraph0084

[6]Nalbach,Martin;Moschona,Argyri;Demadis,KonstantinosD.;Klassen,Stefanie;Bechstein,Ralf;Kühnle,Angelika[CrystalGrowthandDesign,2017,vol.17,#11,p.5867-5874]

107-15-3   
CH3Cl2O2P 
  1429-50-1 

[1]Westerback,S.etal.[JournaloftheAmericanChemicalSociety,1965,vol.87,p.2567-2572]

1429-50-1   
C6H20N2O14P4 

[1]Croft,Susan;Gilbert,BruceC.;Smith,JohnR.Lindsay;Stell,JonathanK.;Sanderson,WilliamR.[JournaloftheChemicalSociety.PerkintransactionsII,1992,#2,p.153-160]

50-00-0    107-15-3    1429-50-1   
<<(2-aminoethyl)imino>bis(methylene)>biphosphonicacid 

[1]Redmore,Derek;Dhawan,Balram[PhosphorusandSulfurandtheRelatedElements,1983,vol.16,p.233-238]

Literature

Title: Is ¹⁵³Samarium-ethylene-diamine-tetramethyl-phosphonate (EDTMP) bone uptake influenced by bisphosphonates in patients with castration-resistant prostate cancer?

Journal: World journal of urology 20120401

Title: (153)Sm-EDTMP appears to accumulate only trivially within peritoneal ascites.

Journal: Journal of nuclear medicine technology 20120301

Title: Lanthanides caged by the organic chelates; structural properties.

Journal: Journal of physics. Condensed matter : an Institute of Physics journal 20110413

Title: Ethylene diamine tetramethylene phosphonic acid labeled with various β(-)-emitting radiometals: labeling optimization and animal biodistribution.

Journal: Cancer biotherapy & radiopharmaceuticals 20110401

Title: Strategy for bone metastases treatment in patients with impending cord compression or vertebral fractures: a pilot study.

Journal: World journal of nuclear medicine 20110101

Title: Multispecies animal investigation on biodistribution, pharmacokinetics and toxicity of 177Lu-EDTMP, a potential bone pain palliation agent.

Journal: Nuclear medicine and biology 20100201

Title: Production, quality control and pharmacokinetic studies of Ho-EDTMP for therapeutic applications.

Journal: Scientia pharmaceutica 20100101

Title: Studies on the development of 99mTc-labeled biphosphonate alginate beads.

Journal: Hellenic journal of nuclear medicine 20100101

Title: Background, reasons and benefits using the vienna protocol for the treatment of painful bone recurrences with 153Samarium-EDTMP.

Journal: Anticancer research 20090801

Title: [Bone-targeted ultradeformable nanoliposomes].

Journal: Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20090418

Title: Controlled size and morphology of EDTMP-doped hydroxyapatite nanoparticles as model for 153Samarium-EDTMP doping.

Journal: Journal of materials science. Materials in medicine 20080901

Title: 177Lu-EDTMP: a viable bone pain palliative in skeletal metastasis.

Journal: Cancer biotherapy & radiopharmaceuticals 20080401

Title: Preparation and pre-vivo evaluation of no-carrier-added, carrier-added and cross-complexed [(68)Ga]-EDTMP formulations.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20080201

Title: Pre vivo, ex vivo and in vivo evaluations of [68Ga]-EDTMP.

Journal: Nuclear medicine and biology 20070501

Title: From structural properties of the EuIII complex with ethylenediaminetetra(methylenephosphonic acid) (H8EDTMP) towards biomedical applications.

Journal: Dalton transactions (Cambridge, England : 2003) 20061021

Title: Clinical role of Sm-153 EDTMP in the treatment of painful bone metastatic disease.

Journal: Clinical nuclear medicine 20061001

Title: Competitive adsorption of phosphate and phosphonates onto goethite.

Journal: Water research 20060601

Title: Samarium-153 ethylenediamine tetramethylene phosphonate therapy for bone pain palliation in skeletal metastases.

Journal: Indian journal of cancer 20060101

Title: Binding studies of [18F]-fluoride and polyphosphonates radiolabelled with [99mTc], [111In], [153Sm] and [188Re] on bone compartments: verification of the pre vivo model?

Journal: Bone 20050901

Title: Modeling of immunoglobulin uptake by N,N,N',N'-ethylenediaminetetramethylenephosphonic acid-modified zirconia particles under static and dynamic conditions.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050705

Title: A pilot study of antitumor effect of gallium ethylenediaminetetramethylene phosphonate [Ga(III)-EDTMP] in tumor-bearing rats.

Journal: Advances in therapy 20050101

Title: Cytotoxic and genotoxic effect of the [166Dy]Dy/166Ho-EDTMP in vivo generator system in mice.

Journal: Nuclear medicine and biology 20041101

Title: 153 Samarium-EDTMP in myeloablative dosage followed by a second autotransplantation in patients with relapsed multiple myeloma.

Journal: Haematologica 20040901

Title: Preparation of (166)Dy/(166)Ho-EDTMP: a potential in vivo generator system for bone marrow ablation.

Journal: Nuclear medicine communications 20040601

Title: Labelling of EDTMP (Multibone) with [111In], [99mTc] and [188Re] using different carriers for 'cross complexation'.

Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20040501

Title: Bone lesion detection with carrier-added 99mTc-EDTMP in comparison with 99mTc-DPD.

Journal: Nuclear medicine communications 20040401

Title: Functional and structural study on chelator-induced suppression of S2/S1 FTIR spectrum in photosynthetic oxygen-evolving complex.

Journal: Journal of inorganic biochemistry 20031001

Title: Evaluation of a freeze-dried kit for EDTMP-based bone-seeking radiopharmaceuticals.

Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20030401

Title: Interaction of immunoglobulin G with N,N,N',N'-ethylenediaminetetramethylenephosphonic acid-modified zirconia.

Journal: Journal of chromatography. A 20030307

Title: Environmental risk assessment of phosphonates, used in domestic laundry and cleaning agents in The Netherlands.

Journal: Chemosphere 20020501

Title: Determination of strong binding chelators and their metal complexes by anion-exchange chromatography and inductively coupled plasma mass spectrometry.

Journal: Journal of chromatography. A 20020222

Title: 177Lu labelled polyaminophosphonates as potential agents for bone pain palliation.

Journal: Nuclear medicine communications 20020101

Title: Preparation and biological evaluation of 188Re-ethylenediamine-N,N,N',N'-tetrakis(methylene phosphonic acid) as a potential agent for bone pain palliation.

Journal: Nuclear medicine communications 20020101

Title: [153Sm-EDTMP in a patient suffering from colon cancer with bone metastasis].

Journal: Revista espanola de medicina nuclear 20010401

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