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1021868-76-7,MFCD00083183
Catalog No.:AA008S23

1021868-76-7 | (+/-)-4-([3,4-DICHLOROBENZOYL]AMINO)-5-(DIPENTYLAMINO)-5-OXOPENTANOIC ACID SODIUM

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5mg
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$46.00   $32.00
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10mg
≥98%
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$72.00   $50.00
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25mg
≥98%
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50mg
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008S23
Chemical Name:
(+/-)-4-([3,4-DICHLOROBENZOYL]AMINO)-5-(DIPENTYLAMINO)-5-OXOPENTANOIC ACID SODIUM
CAS Number:
1021868-76-7
Molecular Formula:
C22H31Cl2N2NaO4
Molecular Weight:
481.3883
MDL Number:
MFCD00083183
SMILES:
CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)[O-])CCCCC.[Na+]
Properties
Computed Properties
 
Complexity:
544  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
14  
Undefined Atom Stereocenter Count:
1  

Literature

Title: Novel CCK-dependent vasorelaxing dipeptide, Arg-Phe, decreases blood pressure and food intake in rodents.

Journal: Molecular nutrition & food research 20120901

Title: Development and validation of an LC-MS/MS-ESI method for the determination of lorglumide, a CCK-1 antagonist in mouse plasma: application to a pharmacokinetic study.

Journal: Biomedical chromatography : BMC 20120701

Title: Morphological evidence that pentagastrin regulates secretion in the human parotid gland.

Journal: Journal of anatomy 20120501

Title: Potential of the gastric motility drug lorglumide in prostate cancer imaging.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120411

Title: Additive effects of cannabinoid CB1 receptors blockade and cholecystokinin on feeding inhibition.

Journal: Pharmacology, biochemistry, and behavior 20110401

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: CCK mediated the inhibitory effect of oxytocin on the contraction of longitudinal muscle strips of duodenum in male rats.

Journal: Pflugers Archiv : European journal of physiology 20101101

Title: Anti-inflammatory action of cholecystokinin and melatonin in the rat parotid gland.

Journal: Oral diseases 20101001

Title: Rapakinin, an anti-hypertensive peptide derived from rapeseed protein, dilates mesenteric artery of spontaneously hypertensive rats via the prostaglandin IP receptor followed by CCK(1) receptor.

Journal: Peptides 20100501

Title: Gastric leptin: a novel role in cardiovascular regulation.

Journal: American journal of physiology. Heart and circulatory physiology 20100201

Title: Electroacupuncture induces Fos expression in the nucleus tractus solitarius via cholecystokinin A receptor signaling in rats.

Journal: Neurological research 20100201

Title: Reducing effect of a Phaseolus vulgaris dry extract on food intake, body weight, and glycemia in rats.

Journal: Journal of agricultural and food chemistry 20091014

Title: Cholecystokinin regulates expression of Y2 receptors in vagal afferent neurons serving the stomach.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20081105

Title: Melatonin-evoked in vivo secretion of protein and amylase from the parotid gland of the anaesthetised rat.

Journal: Journal of pineal research 20081101

Title: Responses of human sling and clasp fibers to cholecystokinin (CCK) and gastrin through CCK receptors.

Journal: Journal of gastroenterology and hepatology 20081001

Title: Localization of CCK-1R in the omasum and role of CCK in the regulation of omasal contractions in sheep.

Journal: Domestic animal endocrinology 20080801

Title: The endogenous CCK mediation of electroacupuncture stimulation-induced satiety in rats.

Journal: Peptides 20080401

Title: Involvement of cholecystokinin receptor in the inhibition of gastrointestinal motility by oxytocin in ovariectomized rats.

Journal: European journal of pharmacology 20080212

Title: Parasympathetic non-adrenergic, non-cholinergic transmission in rat parotid glands: effects of cholecystokinin-A and -B receptor antagonists on the secretory response.

Journal: Regulatory peptides 20080207

Title: Estrogen receptor alpha-induced cholecystokinin type A receptor expression in the female mouse pituitary.

Journal: The Journal of endocrinology 20071201

Title: Involvement of vagal nerves in the pancreatostimulatory effects of luminal melatonin, or its precursor L-tryptophan. Study in the rats.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20071201

Title: The effect of luminal ghrelin on pancreatic enzyme secretion in the rat.

Journal: Regulatory peptides 20071004

Title: Interaction of apolipoprotein AIV with cholecystokinin on the control of food intake.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20071001

Title: Vagally mediated, nonparacrine effects of cholecystokinin-8s on rat pancreatic exocrine secretion.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20070801

Title: Cholecystokinin-8s excites identified rat pancreatic-projecting vagal motoneurons.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20070801

Title: Enterostatin (APGPR) enhances memory consolidation in mice.

Journal: Peptides 20070301

Title: Mechanism of the induction of brain c-Fos-positive neurons by lipid absorption.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20070101

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: [Receptor mechanisms underlying the modulation of lipopolysaccharide-induced nuclear factor-kappaB expression in vascular endothelial cells by cholecystokinin octapeptide].

Journal: Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20060301

Title: Estrogen and CCK1 receptor modification of mu-opioid receptor binding in the cortex of female rats.

Journal: Brain research 20060216

Title: Effect of cholecystokinin octapeptide on diacylglycerol-PKC signaling pathway in rat pulmonary interstitial macrophages stimulated by lipopolysaccharide.

Journal: Acta pharmacologica Sinica 20051201

Title: Cholecystokinin octapeptide increases spontaneous glutamatergic synaptic transmission to neurons of the nucleus tractus solitarius centralis.

Journal: Journal of neurophysiology 20051001

Title: Selective CCK-A but not CCK-B receptor antagonists inhibit HT-29 cell proliferation: synergism with pharmacological levels of melatonin.

Journal: Journal of pineal research 20051001

Title: Cholecystokinin1 receptors mediate the increase in Fos-like immunoreactivity in the rat myenteric plexus following intestinal oleate infusion.

Journal: Physiology & behavior 20050915

Title: Mechanisms of oleoylethanolamide-induced changes in feeding behavior and motor activity.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20050901

Title: Proopiomelanocortin neurons in nucleus tractus solitarius are activated by visceral afferents: regulation by cholecystokinin and opioids.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050406

Title: Effects of juice from Morinda citrifolia (Noni) on gastric emptying in male rats.

Journal: The Chinese journal of physiology 20041231

Title: Pharmacological study of IQM-97,423, a potent and selective CCK1 receptor antagonist with protective effect in experimental acute pancreatitis.

Journal: Pharmacology 20041001

Title: Effect of lipopolysaccharide on expression and characterization of cholecystokinin receptors in rat pulmonary interstitial macrophages.

Journal: Acta pharmacologica Sinica 20041001

Title: Cholecystokinin-induced satiety is mediated through interdependent cooperation of CCK-A and 5-HT3 receptors.

Journal: Physiology & behavior 20040930

Title: Suppression of food intake by GI fatty acid infusions: roles of celiac vagal afferents and cholecystokinin.

Journal: Physiology & behavior 20040801

Title: Analysis of strain difference in behavior to Cholecystokinin (CCK) receptor mediated drugs in PVG hooded and Sprague-Dawley rats using elevated plus-maze test apparatus.

Journal: Neuroscience letters 20040401

Title: Expression of cannabinoid CB1 receptors by vagal afferent neurons is inhibited by cholecystokinin.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20040317

Title: Anxiogenic effect of cholecystokinin in the dorsal periaqueductal gray.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20040101

Title: Circulating ethanol does not stimulate pancreatic secretion in conscious rats.

Journal: Pancreas 20031101

Title: Enterostatin inhibition of dietary fat intake is dependent on CCK-A receptors.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20030801

Title: Effect of Dai-kenchu-to (Da-Jian-Zhong-Tang) on the delayed intestinal propulsion induced by chlorpromazine in mice.

Journal: Journal of ethnopharmacology 20030501

Title: Pharmacological effects of oxytocin on gastric emptying and intestinal transit of a non-nutritive liquid meal in female rats.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20030401

Title: Cholecystokinin reduces ethanol consumption in golden hamsters.

Journal: Alcohol (Fayetteville, N.Y.) 20030401

Title: Role for the cholecystokinin-A receptor in fever: a study of a mutant rat strain and a pharmacological analysis.

Journal: The Journal of physiology 20030315

Title: Involvement of cholecystokinin receptor in the inhibition of gastrointestinal motility by estradiol in ovariectomized rats.

Journal: Scandinavian journal of gastroenterology 20021001

Title: Puerperal blockade of cholecystokinin (CCK1) receptors disrupts maternal behavior in lactating rats.

Journal: Journal of molecular neuroscience : MN 20020101

Title: CCK1 central receptor antagonist prevented the intestinal stress symptoms in sheep.

Journal: Polish journal of veterinary sciences 20020101

Title: Effect of three nonpeptide cholecystokinin antagonists on human isolated gallbladder.

Journal: Digestive diseases and sciences 20011201

Title: Pharmacological properties of lorglumide as a member of a new class of cholecystokinin antagonists.

Journal: Arzneimittel-Forschung 19871101

Title: CR-1409: a potent inhibitor of cholecystokinin-stimulated amylase release and cholecystokinin binding in rat pancreatic acini.

Journal: Pancreas 19870101

Title: Scarpignato C, et al. Effect of a new potent CCK antagonist, lorglumide, on caerulein- and bombesin-induced pancreatic secretion and growth in the rat. Br J Pharmacol. 1989 Mar;96(3):661-9.

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Tags:1021868-76-7 Molecular Formula|1021868-76-7 MDL|1021868-76-7 SMILES|1021868-76-7 (+/-)-4-([3,4-DICHLOROBENZOYL]AMINO)-5-(DIPENTYLAMINO)-5-OXOPENTANOIC ACID SODIUM