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118-08-1,MFCD00152561
Catalog No.:AA008TJB

118-08-1 | (-)-BETA-HYDRASTINE

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5mg
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10mg
≥98%
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25mg
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50mg
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008TJB
Chemical Name:
(-)-BETA-HYDRASTINE
CAS Number:
118-08-1
Molecular Formula:
C21H21NO6
Molecular Weight:
383.3945
MDL Number:
MFCD00152561
SMILES:
COc1c(OC)ccc2c1C(=O)O[C@@H]2[C@@H]1N(C)CCc2c1cc1OCOc1c2
NSC Number:
757430
Properties
Computed Properties
 
Complexity:
601  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
7  
Rotatable Bond Count:
3  
XLogP3:
2.7  

Literature

Title: Screening of a chemical library reveals novel PXR-activating pharmacologic compounds.

Journal: Toxicology letters 20150105

Title: Quorum quenching and antimicrobial activity of goldenseal (Hydrastis canadensis) against methicillin-resistant Staphylococcus aureus (MRSA).

Journal: Planta medica 20120901

Title: Antimalarial alkaloids from a Bhutanese traditional medicinal plant Corydalis dubia.

Journal: Journal of ethnopharmacology 20120830

Title: Analysis of goldenseal, Hydrastis canadensis L., and related alkaloids in urine using HPLC with UV detection.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120101

Title: Secondary Metabolites from Plants Inhibiting ABC Transporters and Reversing Resistance of Cancer Cells and Microbes to Cytotoxic and Antimicrobial Agents.

Journal: Frontiers in microbiology 20120101

Title: Goldenseal (Hydrastis canadensis L.) extracts synergistically enhance the antibacterial activity of berberine via efflux pump inhibition.

Journal: Planta medica 20110501

Title: Role of cerebellohypothalamic GABAergic projection in mediating cerebellar immunomodulation.

Journal: The International journal of neuroscience 20110501

Title: Protective effects of goldenseal (Hydrastis canadensis L.) on acetaminophen-induced hepatotoxicity through inhibition of CYP2E1 in rats.

Journal: Pharmacognosy research 20110101

Title: Seasonal variation of biomass and bioactive alkaloid content of goldenseal, Hydrastis canadensis.

Journal: Fitoterapia 20101001

Title: Problems, artifacts and solutions in the INADEQUATE NMR experiment.

Journal: Magnetic resonance in chemistry : MRC 20100801

Title: Toxicology and carcinogenesis studies of goldenseal root powder (Hydrastis Canadensis) in F344/N rats and B6C3F1 mice (feed studies).

Journal: National Toxicology Program technical report series 20100801

Title: BIAdb: a curated database of benzylisoquinoline alkaloids.

Journal: BMC pharmacology 20100101

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Validation of a liquid chromatography-tandem mass spectrometric assay for the quantitative determination of hydrastine and berberine in human serum.

Journal: Journal of pharmaceutical and biomedical analysis 20090501

Title: Expanding the repertoire of small molecule transcriptional activation domains.

Journal: Bioorganic & medicinal chemistry 20090201

Title: Significant differences in alkaloid content of Coptis chinensis (Huanglian), from its related American species.

Journal: Chinese medicine 20090101

Title: Determination of hydrastine and berberine in goldenseal raw materials, extracts, and dietary supplements by high-performance liquid chromatography with UV: collaborative study.

Journal: Journal of AOAC International 20080101

Title: Effects of herbal products and their constituents on human cytochrome P450(2E1) activity.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20071201

Title: Effects of (1R,9S)-beta-hydrastine on intracellular calcium concentration in PC12 cells.

Journal: Biological & pharmaceutical bulletin 20070801

Title: An in vitro evaluation of cytochrome P450 inhibition and P-glycoprotein interaction with goldenseal, Ginkgo biloba, grape seed, milk thistle, and ginseng extracts and their constituents.

Journal: Planta medica 20070701

Title: Inhibitory effects of (1R,9S)-beta-Hydrastine on calcium transport in PC12 cells.

Journal: Archives of pharmacal research 20070101

Title: Photochemistry and photocytotoxicity of alkaloids from Goldenseal (Hydrastis canadensis L.) 3: effect on human lens and retinal pigment epithelial cells.

Journal: Photochemistry and photobiology 20070101

Title: Photochemistry and photocytotoxicity of alkaloids from Goldenseal (Hydrastis canadensis L.). 2. Palmatine, hydrastine, canadine, and hydrastinine.

Journal: Chemical research in toxicology 20060601

Title: Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.

Journal: Current drug metabolism 20051001

Title: Capillary zone electrophoresis as a tool for the quality control of goldenseal extracts.

Journal: Electrophoresis 20050601

Title: Enantio-selective inhibition of (1R,9S)- and (1S,9R)-beta-hydrastines on dopamine biosynthesis in PC12 cells.

Journal: Neuropharmacology 20041201

Title: A new glucosyl feruloyl quinic acid as a potential marker for roots and rhizomes of goldenseal, Hydrastis canadensis.

Journal: Journal of natural products 20041101

Title: 1H and 13C NMR signal assignment of benzylisoquinoline alkaloids from Fumaria officinalis L. (Papaveraceae).

Journal: Magnetic resonance in chemistry : MRC 20041001

Title: Effects of (1R,9S)-beta-hydrastine on l-DOPA-induced cytotoxicity in PC12 cells.

Journal: European journal of pharmacology 20040319

Title: [Extraction and HPLC analysis of alkaloids in goldenseal].

Journal: Sheng wu gong cheng xue bao = Chinese journal of biotechnology 20040301

Title: Chemical comparison of goldenseal (Hydrastis canadensis L.) root powder from three commercial suppliers.

Journal: Journal of agricultural and food chemistry 20031203

Title: Human cytochrome p450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20031101

Title: Microbial transformation of the phthalideisoquinoline alkaloid, (-)-beta-hydrastine.

Journal: Natural product research 20030801

Title: Variations in alkaloid content of herbal products containing goldenseal.

Journal: Journal of the American Pharmacists Association : JAPhA 20030101

Title: Method validation for determination of alkaloid content in goldenseal root powder.

Journal: Journal of AOAC International 20030101

Title: Individual and combined effect of (+/-)-alpha-hydrastine and (+/-)-beta-hydrastine on spore germination of some fungi.

Journal: Folia microbiologica 20030101

Title: A validated high performance liquid chromatographic method for the analysis of Goldenseal.

Journal: The Journal of pharmacy and pharmacology 20020301

Title: Pharmacological properties of nicotinic acetylcholine receptors in isolated Locusta migratoria neurones.

Journal: Microscopy research and technique 20020215

Title: Differential modulation of respiratory neuronal discharge patterns by GABA(A) receptor and apamin-sensitive K(+) channel antagonism.

Journal: Journal of neurophysiology 20011101

Title: Effects of hydrastine derivatives on dopamine biosynthesis in PC12 cells.

Journal: Planta medica 20011001

Title: High-performance liquid chromatography determination of hydrastine and berberine in dietary supplements containing goldenseal.

Journal: Journal of pharmaceutical sciences 20010701

Title: Antitubercular natural products: berberine from the roots of commercial Hydrastis canadensis powder. Isolation of inactive 8-oxotetrahydrothalifendine, canadine, beta-hydrastine, and two new quinic acid esters, hycandinic acid esters-1 and -2.

Journal: Journal of natural products 19981001

Title: Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase.

Journal: Journal of natural products 19910101

Title: Screening for new compounds with antiherpes activity.

Journal: Antiviral research 19841001

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Tags:118-08-1 Molecular Formula|118-08-1 MDL|118-08-1 SMILES|118-08-1 (-)-BETA-HYDRASTINE