Home Amines 3947-65-7
3947-65-7,MFCD00023857
Catalog No.:AA00BXE5

3947-65-7 | (2R,3S,4R,5R,6R)-5-Amino-2-(aminomethyl)-6-(((1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl)oxy)tetrahydro-2H-pyran-3,4-diol

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1mg
98%(HPLC)
in stock  
$161.00   $113.00
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5mg
98%(HPLC)
in stock  
$385.00   $269.00
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10mg
98%(HPLC)
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$735.00   $515.00
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  • Technical Information
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA00BXE5
Chemical Name:
(2R,3S,4R,5R,6R)-5-Amino-2-(aminomethyl)-6-(((1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl)oxy)tetrahydro-2H-pyran-3,4-diol
CAS Number:
3947-65-7
Molecular Formula:
C12H26N4O6
Molecular Weight:
322.3580
MDL Number:
MFCD00023857
SMILES:
NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@H]([C@@H]([C@H]2O)O)N)[C@@H]([C@H]([C@@H]1O)O)N
Properties
Computed Properties
 
Complexity:
378  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
10  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
8  
Rotatable Bond Count:
3  
XLogP3:
-5.4  

Literature

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Title: Structure-function relationship of novel X4 HIV-1 entry inhibitors - L- and D-arginine peptide-aminoglycoside conjugates.

Journal: The FEBS journal 20071201

Title: Synthesis of a neamine dimer targeting the dimerization initiation site of HIV-1 RNA.

Journal: Organic letters 20071025

Title: Design and synthesis of a structurally constrained aminoglycoside.

Journal: The Journal of organic chemistry 20070706

Title: Unique O-ribosylation in the biosynthesis of butirosin.

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Title: Monitoring aminoglycoside-induced conformational changes in 16S rRNA through acrylamide quenching.

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Journal: Chembiochem : a European journal of chemical biology 20070212

Title: Determination of neomycin sulfate and impurities using high-performance anion-exchange chromatography with integrated pulsed amperometric detection.

Journal: Journal of pharmaceutical and biomedical analysis 20070104

Title: Mechanism of RNA cleavage catalyzed by sequence specific polyamide nucleic acid-neamine conjugate.

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Journal: Nucleic acids symposium series (2004) 20070101

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Journal: Bioorganic & medicinal chemistry letters 20061215

Title: Selectively guanidinylated derivatives of neamine. Syntheses and inhibition of anthrax lethal factor protease.

Journal: Bioorganic & medicinal chemistry letters 20061001

Title: Binding of aminoglycosidic antibiotics to the oligonucleotide A-site model and 30S ribosomal subunit: Poisson-Boltzmann model, thermal denaturation, and fluorescence studies.

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Title: The RNA-bound conformation of neamine as determined by transferred NOE experiments.

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Title: Fluorinated aminoglycosides and their mechanistic implication for aminoglycoside 3'-phosphotransferases from Gram-negative bacteria.

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Title: Design of novel antibiotics that bind to the ribosomal acyltransfer site.

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Title: Study of aminoglycoside-nucleic acid interactions by an HPLC method.

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Title: Aminoglycoside antibiotics, neamine and its derivatives as potent inhibitors for the RNA-protein interactions derived from HIV-1 activators.

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Title: Which aminoglycoside ring is most important for binding? A hydropathic analysis of gentamicin, paromomycin, and analogues.

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Title: Synthesis of biomimetic analogs of neomycin B: potential inhibitors of the HIV RNA Rev response element.

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SDS
Tags:3947-65-7 Molecular Formula|3947-65-7 MDL|3947-65-7 SMILES|3947-65-7 (2R,3S,4R,5R,6R)-5-Amino-2-(aminomethyl)-6-(((1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl)oxy)tetrahydro-2H-pyran-3,4-diol