Home Amines 39026-63-6
39026-63-6,MFCD00132879
Catalog No.:AA00BXKQ

39026-63-6 | (+/-)-1-AMINOCYCLOPENTANE-CIS-1,3-DICARBOXYLIC ACID

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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00BXKQ
Chemical Name:
(+/-)-1-AMINOCYCLOPENTANE-CIS-1,3-DICARBOXYLIC ACID
CAS Number:
39026-63-6
Molecular Formula:
C7H11NO4
Molecular Weight:
173.1665
MDL Number:
MFCD00132879
SMILES:
C1CC(CC1C(=O)O)(C(=O)O)N
NSC Number:
27386
Properties
Computed Properties
 
Complexity:
227  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
12  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
2  
XLogP3:
-3.2  

Literature

Title: Astrocyte inositol triphosphate receptor type 2 and cytosolic phospholipase A2 alpha regulate arteriole responses in mouse neocortical brain slices.

Journal: PloS one 20120101

Title: Quantal amplitude at the cone ribbon synapse can be adjusted by changes in cytosolic glutamate.

Journal: Molecular vision 20110101

Title: Evaluation of cannabinoid receptor 2 and metabotropic glutamate receptor 1 functional responses using a cell impedance-based technology.

Journal: Journal of biomolecular screening 20101201

Title: Rose Bengal analogs and vesicular glutamate transporters (VGLUTs).

Journal: Bioorganic & medicinal chemistry 20100915

Title: A peripheral neuroimmune link: glutamate agonists upregulate NMDA NR1 receptor mRNA and protein, vimentin, TNF-alpha, and RANTES in cultured human synoviocytes.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20100301

Title: Involvement of Group II mGluRs in mossy fiber LTD.

Journal: Synapse (New York, N.Y.) 20091201

Title: Furthering pharmacological and physiological assessment of the glutamatergic receptors at the Drosophila neuromuscular junction.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20091101

Title: Dynamic metabotropic control of intrinsic firing in cerebellar unipolar brush cells.

Journal: Journal of neurophysiology 20081201

Title: Tone-dependent vascular responses to astrocyte-derived signals.

Journal: American journal of physiology. Heart and circulatory physiology 20080601

Title: The glutamate uptake system in presynaptic vesicles: further characterization of structural requirements for inhibitors and substrates.

Journal: Neurochemical research 20080201

Title: Dendritic properties of turtle pyramidal neurons.

Journal: Journal of neurophysiology 20080201

Title: Acute treatment with 17beta-estradiol attenuates astrocyte-astrocyte and astrocyte-neuron communication.

Journal: Glia 20071201

Title: Glutamate and its metabotropic receptor in Drosophila clock neuron circuits.

Journal: The Journal of comparative neurology 20071101

Title: Effect of exogenous glutamate and N-Methyl-D-aspartic acid on spontaneous activity of isolated human ureter.

Journal: International journal of urology : official journal of the Japanese Urological Association 20070901

Title: The role of defensins in the excitability of the peripheral vestibular system in the frog: evidence for the presence of communication between the immune and nervous systems.

Journal: Hearing research 20070801

Title: Estrogen evokes a rapid effect on intracellular calcium in neurons characterized by calcium oscillations in the arcuate nucleus.

Journal: Endocrine 20070601

Title: Involvement of hippocampal metabotropic glutamate receptors in radial maze performance.

Journal: Neuroreport 20070507

Title: Mechanisms of glutamate receptor induced proliferation of astrocytes.

Journal: Neuroreport 20061218

Title: Nucleus- and species-specific properties of the slow (<1 Hz) sleep oscillation in thalamocortical neurons.

Journal: Neuroscience 20060825

Title: Contribution of spinal glutamatergic receptors to the antinociception caused by agmatine in mice.

Journal: Brain research 20060606

Title: Neuronal basis of the slow (<1 Hz) oscillation in neurons of the nucleus reticularis thalami in vitro.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20060301

Title: Long-term modulation of electrical synapses in the mammalian thalamus.

Journal: Science (New York, N.Y.) 20051216

Title: Effects of glutamate transporter and receptor ligands on neuronal glutamate uptake.

Journal: Neuroscience research 20050901

Title: Immunocytochemical and pharmacological characterization of metabotropic glutamate receptors of the vestibular end organs in the frog.

Journal: Hearing research 20050601

Title: Novel alternative splicing predicts a truncated isoform of the NMDA receptor subunit 1 (NR1) in embryonic rat brain.

Journal: Neurochemical research 20050401

Title: Activation of metabotropic glutamate receptors inhibits high-voltage-gated calcium channel currents of chicken nucleus magnocellularis neurons.

Journal: Journal of neurophysiology 20050301

Title: Comparison of metabotropic glutamate receptor responses at segmental and descending inputs to motoneurons in neonatal rat spinal cord.

Journal: The Journal of pharmacology and experimental therapeutics 20050201

Title: Ca2+-dependent induction of intracellular Ca2+ oscillation in hippocampal astrocytes during metabotropic glutamate receptor activation.

Journal: Journal of pharmacological sciences 20050201

Title: Calcium dynamics in cortical astrocytes and arterioles during neurovascular coupling.

Journal: Circulation research 20041112

Title: Effects of metabotropic glutamate receptor stimulation on blood-brain barrier permeability during focal cerebral ischemia.

Journal: Neurochemical research 20041001

Title: Role of intracellular calcium stores on the effect of metabotropic glutamate receptors on phosphorylation of glial fibrillary acidic protein in hippocampal slices from immature rats.

Journal: Neurochemical research 20040801

Title: NMDA receptor antagonism blocks the cardiovascular responses to microinjection of trans-ACPD into the NTS of awake rats.

Journal: Experimental physiology 20040501

Title: NMDA receptors in nucleus tractus solitarii are linked to soluble guanylate cyclase.

Journal: American journal of physiology. Heart and circulatory physiology 20040401

Title: Expression and functional properties of group I metabotropic glutamate receptors in bovine chromaffin cells.

Journal: Journal of neuroscience research 20040115

Title: Glutamate causes a loss in human cerebral endothelial barrier integrity through activation of NMDA receptor.

Journal: American journal of physiology. Heart and circulatory physiology 20031201

Title: Glutamate-mediated cytosolic calcium oscillations regulate a pulsatile prostaglandin release from cultured rat astrocytes.

Journal: The Journal of physiology 20031201

Title: Nicotine recruits a local glutamatergic circuit to excite septohippocampal GABAergic neurons.

Journal: The European journal of neuroscience 20030901

Title: Hydroxyl radicals release in rat striatum involves metabotropic glutamate receptors.

Journal: Brain research bulletin 20030830

Title: Functional synaptic contacts by intranuclear axon collaterals of thalamic relay neurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20030820

Title: Endogenous zinc as a retinal neuromodulator: evidence from the skate (Raja erinacea).

Journal: Neuroscience letters 20030717

Title: Enhancement of low-voltage-activated calcium currents by group II metabotropic glutamate receptors in rat retinal ganglion cells.

Journal: Molecular and cellular neurosciences 20030701

Title: Expression of group I metabotropic glutamate receptors in rat hippocampal cells in culture and their characterization by intracellular calcium ion dynamics.

Journal: Journal of pharmacological sciences 20030701

Title: Synaptically activated Ca2+ waves in layer 2/3 and layer 5 rat neocortical pyramidal neurons.

Journal: The Journal of physiology 20030601

Title: The role of ionotropic receptors of glutaminic acid in cardiovascular system. A. The influence of ionotropic receptor NMDA agonist - 1R,3R-ACPD and antagonist - DL-AP7 on the systemic pressure in rats.

Journal: Amino acids 20030601

Title: Translation of clock rhythmicity into neural firing in suprachiasmatic nucleus requires mGluR-PLCbeta4 signaling.

Journal: Nature neuroscience 20030401

Title: Carbon monoxide mediates vasodilator effects of glutamate in isolated pressurized cerebral arterioles of newborn pigs.

Journal: American journal of physiology. Heart and circulatory physiology 20030401

Title: Glutamate receptors regulate Na/K-ATPase in cerebellum neurons.

Journal: Annals of the New York Academy of Sciences 20030401

Title: Antagonism of glutamatergic metabotropic receptors in the NTS of awake rats does not affect the gain of the baroreflex.

Journal: Autonomic neuroscience : basic & clinical 20030131

Title: Different roles of group I and group II metabotropic glutamate receptors on phencyclidine-induced dopamine release in the rat prefrontal cortex.

Journal: Neuroscience letters 20030123

Title: Effects of calcium and glutamate receptor agonists on leaf consumption by lepidopteran neonates.

Journal: Pharmacology, biochemistry, and behavior 20030101

Title: Actions of Group I and Group II metabotropic glutamate receptor ligands on 5-hydroxytryptamine release in the rat cerebral cortex in vivo: differential roles in the regulation of central serotonergic neurotransmission.

Journal: Neuroscience 20030101

Title: Metabotropic glutamate receptors (mGluRs) are involved in early phase of memory formation: possible role of modulation of glutamate release.

Journal: Neurochemistry international 20030101

Title: Dual modulation of gabaergic transmission by metabotropic glutamate receptors in rat ventral tegmental area.

Journal: Neuroscience 20030101

Title: Effects of a selective metabotropic glutamate receptor agonist on the micturition reflex pathway in urethane-anesthetized rats.

Journal: Neurourology and urodynamics 20030101

Title: Structure of glutamate analogs that activate the ON bipolar cell metabotropic glutamate receptor in vertebrate retina.

Journal: Visual neuroscience 20030101

Title: Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats.

Journal: Neuroscience 20030101

Title: Acamprosate inhibits the binding and neurotoxic effects of trans-ACPD, suggesting a novel site of action at metabotropic glutamate receptors.

Journal: Alcoholism, clinical and experimental research 20021201

Title: A pharmacological analysis of the contractile effects of glutamate on rat and human isolated gut smooth muscle strips.

Journal: Methods and findings in experimental and clinical pharmacology 20021201

Title: Cell type-selective expression of green fluorescent protein and the calcium indicating protein, yellow cameleon, in rat cortical primary cultures.

Journal: Brain research 20021129

Title: Enantioselective synthesis of the excitatory amino acid (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid.

Journal: The Journal of organic chemistry 20021101

Title: Carbon monoxide and metabotropic glutamate receptors in rat nucleus tractus solitarii: participation in cardiovascular effect.

Journal: European journal of pharmacology 20021101

Title: Synthesis and pharmacology of 3-hydroxy-delta2-isoxazoline-cyclopentane analogues of glutamic acid.

Journal: Farmaco (Societa chimica italiana : 1989) 20021101

Title: Group I metabotropic glutamate receptor-mediated enhancement of dopamine cell burst firing in rat ventral tegmental area in vitro.

Journal: Brain research 20020906

Title: Metabotropic glutamate receptors control gating of spike transmission in the hippocampus area CA1.

Journal: Pharmacology, biochemistry, and behavior 20020901

Title: Activation of brainstem metabotropic glutamate receptors inhibits spinal nociception in adult rats.

Journal: Pharmacology, biochemistry, and behavior 20020901

Title: Metabotropic and NMDA glutamate receptor interactions with osmotic stimuli in supraoptic neurons.

Journal: Pharmacology, biochemistry, and behavior 20020901

Title: Spatial segregation and interaction of calcium signalling mechanisms in rat hippocampal CA1 pyramidal neurons.

Journal: The Journal of physiology 20020901

Title: Activation of glutamate receptors inhibits Na/K-ATPase of cerebellum granule cells.

Journal: Biochemistry. Biokhimiia 20020901

Title: The activation of metabotropic glutamate receptors differentially affects GABA and alpha-melanocyte stimulating hormone release from the hypothalamus and the posterior pituitary of male rats.

Journal: Neuroscience letters 20020719

Title: Effects of excitatory modulation on intrinsic properties of turtle motoneurons.

Journal: Journal of neurophysiology 20020701

Title: Ionotropic glutamate receptors mediate juvenile hormone synthesis in the cockroach, Diploptera punctata.

Journal: Insect biochemistry and molecular biology 20020601

Title: Effect of ionotropic and metabotropic glutamate agonists and D-aspartate on prolactin release from anterior pituitary cells.

Journal: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20020501

Title: Modulation of dendritic release of dopamine by metabotropic glutamate receptors in rat substantia nigra.

Journal: Biochemical pharmacology 20020401

Title: Stereoselective synthesis of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid via C-H insertion of alkylidenecarbene.

Journal: Bioscience, biotechnology, and biochemistry 20020401

Title: Cellular mechanisms of the slow (<1 Hz) oscillation in thalamocortical neurons in vitro.

Journal: Neuron 20020314

Title: Chronic ethanol treatment and withdrawal alter ACPD-evoked calcium signals in developing Purkinje neurons.

Journal: Alcoholism, clinical and experimental research 20020301

Title: Neuroprotective effects of N-acetylaspartylglutamate in a neonatal rat model of hypoxia-ischemia.

Journal: European journal of pharmacology 20020222

Title: Presynaptic inhibition of GABAergic miniature currents by metabotropic glutamate receptor in the rat CNS.

Journal: Neuroscience 20020101

Title: Glutamate induces different neuronal conditioned responses than ACPD when used as a locally ionophoresed unconditioned stimulus in the cat motor cortex.

Journal: Physiological research 20020101

Title: Magnesium decreases arterial pressure and inhibits cardiovascular responses induced by N-methyl-D-aspartate and metabotropic glutamate receptors stimulation in rostral ventrolateral medulla.

Journal: Journal of hypertension 20011201

Title: Retrograde modulation of transmitter release by postsynaptic subtype 1 metabotropic glutamate receptors in the rat cerebellum.

Journal: The Journal of physiology 20011115

Title: (1R,3S)-1-Aminocyclopentane-1,3-dicarboxylic acid (RS-ACPD) reduces intracellular glutamate levels in astrocytes.

Journal: Journal of neurochemistry 20011101

Title: Visualization of IP(3) dynamics reveals a novel AMPA receptor-triggered IP(3) production pathway mediated by voltage-dependent Ca(2+) influx in Purkinje cells.

Journal: Neuron 20011011

Title: Metabotropic glutamate receptors stimulate phospholipase D via different pathways in the adult and neonate rat hippocampus.

Journal: Neurochemical research 20011001

Title: Activation of a latent respiratory motor pathway by stimulation of neurons in the medullary chemoreceptor area of the rat.

Journal: Experimental neurology 20010901

Title: Activation of metabotropic glutamate receptor 1 accelerates NMDA receptor trafficking.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20010815

Title: Role of metabotropic glutamate receptors in vasopressin and oxytocin release.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20010801

Title: Changes in rat serum corticosterone after treatment with metabotropic glutamate receptor agonists or antagonists.

Journal: Journal of neuroendocrinology 20010801

Title: Ca2+-dependent regulation of synaptic delta2 glutamate receptor density in cultured rat Purkinje neurons.

Journal: The European journal of neuroscience 20010701

Title: mGluR1-mediated potentiation of NMDA receptors involves a rise in intracellular calcium and activation of protein kinase C.

Journal: Neuropharmacology 20010601

Title: Stimulation of Na-K-2Cl cotransporter in neurons by activation of Non-NMDA ionotropic receptor and group-I mGluRs.

Journal: Journal of neurophysiology 20010601

Title: The M1 receptor is required for muscarinic activation of mitogen-activated protein (MAP) kinase in murine cerebral cortical neurons.

Journal: The Journal of biological chemistry 20010511

Title: Inhibition of choline acetyltransferase by excitatory amino acids as a possible mechanism for cholinergic dysfunction in the central nervous system.

Journal: Journal of neurochemistry 20010501

Title: [The protective effect of puerarin on cultured rat cerebral cortical astrocytes].

Journal: Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20010501

Title: The metabotropic glutamate receptor agonist 1S,3R-ACPD stimulates and modulates NMDA receptor mediated excitotoxicity in organotypic hippocampal slice cultures.

Journal: Brain research 20010413

Title: Group I metabotropic glutamate receptors are expressed in the chicken retina and by cultured retinal amacrine cells.

Journal: Journal of neurochemistry 20010401

Title: Expression and regulation of Na pump isoforms in cultured cerebellar granule cells.

Journal: Neuroreport 20010326

Title: Tetanic stimulation and metabotropic glutamate receptor agonists modify synaptic responses and protein kinase activity in rat auditory cortex.

Journal: Brain research 20010316

Title: Protein kinase C activation modulates alpha-calmodulin kinase II binding to NR2A subunit of N-methyl-D-aspartate receptor complex.

Journal: The Journal of biological chemistry 20010309

Title: PLC-beta1, activated via mGluRs, mediates activity-dependent differentiation in cerebral cortex.

Journal: Nature neuroscience 20010301

Title: Activation of metabotropic glutamate receptors induces gamma frequency oscillations in the rat dentate gyrus in vivo.

Journal: Neuropharmacology 20010301

Title: Task-dependent role for dorsal striatum metabotropic glutamate receptors in memory.

Journal: Learning & memory (Cold Spring Harbor, N.Y.) 20010301

Title: Upregulation of preprodynorphin and preproenkephalin mRNA expression by selective activation of group I metabotropic glutamate receptors in characterized primary cultures of rat striatal neurons.

Journal: Brain research. Molecular brain research 20010131

Title: Regional distribution and pharmacological characteristics of [3H]N-acetyl-aspartyl-glutamate (NAAG) binding sites in rat brain.

Journal: Neurochemistry international 20010101

Title: Slow dorsal-ventral rhythm generator in the lamprey spinal cord.

Journal: Journal of neurophysiology 20010101

Title: cAMP-dependent presynaptic regulation of spontaneous glycinergic IPSCs in mechanically dissociated rat spinal cord neurons.

Journal: Journal of neurophysiology 20010101

Title: Sustained L-type calcium currents in dissociated deep dorsal horn neurons of the rat: characteristics and modulation.

Journal: Neuroscience 20010101

Title: Traumatic injury of cultured astrocytes alters inositol (1,4,5)-trisphosphate-mediated signaling.

Journal: Glia 20010101

Title: Metabotropic glutamate receptors modify ionotropic glutamate responses in neocortical pyramidal cells and interneurons.

Journal: Experimental brain research 20010101

Title: Developmental changes in the modulation of cyclic amp accumulation by activation of metabotropic glutamate receptors.

Journal: Polish journal of pharmacology 20010101

Title: Locomotor activity and accumbens Fos expression driven by ventral hippocampal stimulation require D1 and D2 receptors.

Journal: Neuroscience 19990101

Title: Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes.

Journal: Journal of medicinal chemistry 19970912

Title: Behavioral activity of 1S,3R-ACPD, an agonist of metabotropic glutamate receptors.

Journal: Polish journal of pharmacology 19970801

Title: Pharmacological characterization of 1-aminoindan-1,5-dicarboxylic acid, a potent mGluR1 antagonist.

Journal: The Journal of pharmacology and experimental therapeutics 19970501

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Tags:39026-63-6 Molecular Formula|39026-63-6 MDL|39026-63-6 SMILES|39026-63-6 (+/-)-1-AMINOCYCLOPENTANE-CIS-1,3-DICARBOXYLIC ACID