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6989-98-6,MFCD00150157
Catalog No.:AA00FCQ7

6989-98-6 | (+)-TUBOCURARINE CHLORIDE PENTAHYDRATE

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1g
>98.0%(T)(HPLC)
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00FCQ7
Chemical Name:
(+)-TUBOCURARINE CHLORIDE PENTAHYDRATE
CAS Number:
6989-98-6
Molecular Formula:
C37H52Cl2N2O11
Molecular Weight:
771.7216
MDL Number:
MFCD00150157
SMILES:
COc1cc2CCN([C@@H]3c2cc1Oc1cc(ccc1O)C[C@@H]1c2c(CC[N+]1(C)C)cc(c(c2Oc1ccc(C3)cc1)O)OC)C.O.O.O.O.O.Cl.[Cl-]
Properties
Computed Properties
 
Complexity:
990  
Covalently-Bonded Unit Count:
8  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
52  
Hydrogen Bond Acceptor Count:
13  
Hydrogen Bond Donor Count:
8  
Rotatable Bond Count:
2  

Literature

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Title: The contribution of d-tubocurarine-sensitive and apamin-sensitive K-channels to EDHF-mediated relaxation of mesenteric arteries from eNOS-/- mice.

Journal: Journal of cardiovascular pharmacology 20120501

Title: Transmembrane potential polarization, calcium influx, and receptor conformational state modulate the sensitivity of the imidacloprid-insensitive neuronal insect nicotinic acetylcholine receptor to neonicotinoid insecticides.

Journal: The Journal of pharmacology and experimental therapeutics 20120501

Title: Postnatal changes in vagal control of esophageal muscle contractions in rats.

Journal: Life sciences 20120409

Title: Micromechanical measurement of AChBP binding for label-free drug discovery.

Journal: The Analyst 20120107

Title: Syntheses of strychnine, norfluorocurarine, dehydrodesacetylretuline, and valparicine enabled by intramolecular cycloadditions of Zincke aldehydes.

Journal: The Journal of organic chemistry 20120106

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Title: Gap junctions synchronize action potentials and Ca2+ transients in Caenorhabditis elegans body wall muscle.

Journal: The Journal of biological chemistry 20111223

Title: Identification of a cholinergic modulatory and rhythmogenic mechanism within the lamprey respiratory network.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110914

Title: From d-tubocurarine to sugammadex: the contributions of T. Cecil Gray to modern anaesthetic practice.

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Title: A structural and mutagenic blueprint for molecular recognition of strychnine and d-tubocurarine by different cys-loop receptors.

Journal: PLoS biology 20110301

Title: Muscarinic inhibition of recurrent glutamatergic excitation in frog tectum column prevents NMDA receptor activation on efferent neuron.

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Title: Mapping spatial relationships between residues in the ligand-binding domain of the 5-HT3 receptor using a molecular ruler.

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Title: Assessing the effects of the neonicotinoid insecticide imidacloprid in the cholinergic synapses of the stellate cells of the mouse cochlear nucleus using whole-cell patch-clamp recording.

Journal: Neurotoxicology 20100101

Title: Muscle contractions guide rohon-beard peripheral sensory axons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20091021

Title: A novel signaling pathway: fibroblast nicotinic receptor alpha1 binds urokinase and promotes renal fibrosis.

Journal: The Journal of biological chemistry 20091016

Title: The effect of plasma from muscle-specific tyrosine kinase myasthenia patients on regenerating endplates.

Journal: The American journal of pathology 20091001

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Journal: The European journal of neuroscience 20091001

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Journal: Cell and tissue research 20090501

Title: Resistance to D-tubocurarine of the rat diaphragm as compared to a limb muscle: influence of quantal transmitter release and nicotinic acetylcholine receptors.

Journal: Anesthesiology 20090501

Title: Positive inotropic effects of Tityus cambridgei and T. serrulatus scorpion venoms on skeletal muscle.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20090401

Title: Efficient access to the core of the Strychnos, Aspidosperma and Iboga alkaloids. A short synthesis of norfluorocurarine.

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Title: Effects of nicotine and lipopolysaccharide on the expression of matrix metalloproteinases, plasminogen activators, and their inhibitors in human osteoblasts.

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Title: Design and expression of human alpha7 nicotinic acetylcholine receptor extracellular domain mutants with enhanced solubility and ligand-binding properties.

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Journal: Journal of bone and mineral metabolism 20090101

Title: Effects of sepsis on the neuromuscular blocking actions of d-tubocurarine on rat adductor and abductor laryngeal muscles.

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Title: Role of alpha7-nicotinic acetylcholine receptor in human non-small cell lung cancer proliferation.

Journal: Cell proliferation 20081201

Title: Plasmodium falciparum: growth response to potassium channel blocking compounds.

Journal: Experimental parasitology 20081101

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Title: Greater hypoxia-induced cell death in prenatal brain after bacterial-endotoxin pretreatment is not because of enhanced cerebral energy depletion: a chicken embryo model of the intrapartum response to hypoxia and infection.

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Title: The kinetics of competitive antagonism of nicotinic acetylcholine receptors at physiological temperature.

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Title: Serotonergic modulation of afterhyperpolarization in a neuron that contributes to learning in the leech.

Journal: Journal of neurophysiology 20080201

Title: Ultrastructural visualization of the transmembranous and cytomatrix-related part of nicotinic acetylcholine receptor of frog motor endplate by means of an immunochemical avidity of IgG for d-tubocurarine.

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Title: [A comparative analysis of contractile responses induced by acetylcholine and choline in twich and tonic frog skeletal muscle fibres].

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Title: Characteristics of biphasic slow depolarizing and slow hyperpolarizing potential in frog taste cell induced by parasympathetic efferent stimulation.

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Journal: Acta anaesthesiologica Scandinavica 20070901

Title: Open syntaxin docks synaptic vesicles.

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Title: Cholinergic and GABAergic innervation regulate activity of electrogenic ionic pump in earthworm somatic muscle cells.

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Title: Stimulation pulse characteristics and electrode configuration determine site of excitation in isolated mammalian skeletal muscle: implications for fatigue.

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Title: Roles of amino acids and subunits in determining the inhibition of nicotinic acetylcholine receptors by competitive antagonists.

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Title: The non-neuronal cholinergic system in peripheral blood cells: effects of nicotinic and muscarinic receptor antagonists on phagocytosis, respiratory burst and migration.

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Title: Reevaluation of indirect field stimulation technique to demonstrate oxime effectiveness in OP-poisoning in muscles in vitro.

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Title: Key role of mucosal primary afferents in mediating the inhibitory influence of capsaicin on vagally mediated contractions in the mouse esophagus.

Journal: The Journal of veterinary medical science 20070401

Title: Vasoconstrictor effect of acetylcholine in veins of the liver.

Journal: Bulletin of experimental biology and medicine 20070301

Title: Glutamatergic synaptic depression by synthetic amyloid beta-peptide in the medial septum.

Journal: Journal of neuroscience research 20070215

Title: The role of loop F residues in determining differential d-tubocurarine potencies in mouse and human 5-hydroxytryptamine 3A receptors.

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Title: Influence of agonists and antagonists on the segmental motion of residues near the agonist binding pocket of the acetylcholine-binding protein.

Journal: The Journal of biological chemistry 20061222

Title: Thymosin alpha1 suppresses proliferation and induces apoptosis in human leukemia cell lines.

Journal: Peptides 20060901

Title: Cholinergic sensory inputs to command neurons in edible snail.

Journal: Bulletin of experimental biology and medicine 20060901

Title: Tryptophan 86 of the alpha subunit in the Torpedo nicotinic acetylcholine receptor is important for channel activation by the bisquaternary ligand suberyldicholine.

Journal: Biochemistry 20060829

Title: Effect of D-serine on the serotonin receptors of human platelets.

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Title: Mapping residues in the ligand-binding domain of the 5-HT(3) receptor onto d-tubocurarine structure.

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Title: Untranslated region-dependent exclusive expression of high-sensitivity subforms of alpha4beta2 and alpha3beta2 nicotinic acetylcholine receptors.

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Title: Tachykinins are involved in local reflex modulation of vagally mediated striated muscle contractions in the rat esophagus via tachykinin NK1 receptors.

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Title: Interaction of d-tubocurarine with potassium channels: molecular modeling and ligand binding.

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Title: Activation of the Torpedo nicotinic acetylcholine receptor. The contribution of residues alphaArg55 and gammaGlu93.

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Title: Site specificity of agonist-induced opening and desensitization of the Torpedo californica nicotinic acetylcholine receptor.

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Journal: Neuropharmacology 20060101

Title: Neuromuscular block.

Journal: British journal of pharmacology 20060101

Title: Interaction between P2X and nicotinic acetylcholine receptors in glutamate nerve terminals of the rat hippocampus.

Journal: Journal of molecular neuroscience : MN 20060101

Title: Nicotinic and PDGF-receptor function are essential for nicotine-stimulated mitogenesis in human vascular smooth muscle cells.

Journal: Journal of cellular biochemistry 20051201

Title: Reversible sequential-binding probe receptor-ligand interactions in single cells.

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Title: The properties of ACh-induced BK currents in guinea pig type II vestibular hair cells.

Journal: Hearing research 20051101

Title: Taste cell responses in the frog are modulated by parasympathetic efferent nerve fibers.

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Title: Cholinesterases and the resistance of the mouse diaphragm to the effect of tubocurarine.

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Title: Partial nicotinic receptor blockade unmasks a modulatory role of nitric oxide on urethral striated neuromuscular transmission.

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Title: Antiemetics of the 5-hydroxytryptamine 3A antagonist class inhibit muscle nicotinic acetylcholine receptors.

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Title: The theaflavin fraction is responsible for the facilitatory effect of black tea at the skeletal myoneural junction.

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Title: The effect of cooling on the acetylcholine-induced current of identified Helix pomatia Br neuron.

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Title: Ligand-induced conformational change in the alpha7 nicotinic receptor ligand binding domain.

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Title: Sepsis stage dependently and differentially attenuates the effects of nondepolarizing neuromuscular blockers on the rat diaphragm in vitro.

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Journal: Journal of neurobiology 20041201

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Title: Iodo-alpha-conotoxin MI selectively binds the alpha/delta subunit interface of muscle nicotinic acetylcholine receptors.

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Title: Differential modulation of glutamatergic and cholinergic synapses by calcineurin in hippocampal CA1 fast-spiking interneurons.

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Journal: The Journal of biological chemistry 20040326

Title: An apamin- and scyllatoxin-insensitive isoform of the human SK3 channel.

Journal: Molecular pharmacology 20040301

Title: Ganglion cells from chick retina display multiple functional nAChR subtypes.

Journal: Neuroreport 20040209

Title: Electrophysiological and pharmacological properties of nucleus basalis magnocellularis neurons in rats.

Journal: Acta pharmacologica Sinica 20040201

Title: Identification of nicotinic acetylcholine receptor amino acids photolabeled by the volatile anesthetic halothane.

Journal: Biochemistry 20031125

Title: Direct chemically mediated synaptic transmission from mechanosensory afferents contributes to habituation of crayfish lateral giant escape reaction.

Journal: Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology 20031001

Title: Monitoring neuronal calcium signalling using a new method for ratiometric confocal calcium imaging.

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Journal: Annals of the New York Academy of Sciences 20030901

Title: Neuromuscular transmission of pectoral fin muscles of the goldfish Carassius auratus.

Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20030701

Title: Curariform antagonists bind in different orientations to acetylcholine-binding protein.

Journal: The Journal of biological chemistry 20030620

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Journal: Toxicon : official journal of the International Society on Toxinology 20030501

Title: Proliferative effect of acetylcholine on rat trachea epithelial cells is mediated by nicotinic receptors and muscarinic receptors of the M1-subtype.

Journal: Life sciences 20030328

Title: Endogenous adenosine prevents post-tetanic release facilitation mediated by alpha3beta2 nicotinic autoreceptors.

Journal: European journal of pharmacology 20030319

Title: D-tubocurarine reduces GABA responses in rat substantia nigra dopamine neurons.

Journal: Synapse (New York, N.Y.) 20030301

Title: Wasp venom blocks central cholinergic synapses to induce transient paralysis in cockroach prey.

Journal: Journal of neurobiology 20030301

Title: Task-dependent presynaptic inhibition.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20030301

Title: Chronic intraperitoneal endotoxin treatment in rats induces resistance to d-tubocurarine, but does not produce up-regulation of acetylcholine receptors.

Journal: Acta anaesthesiologica Scandinavica 20030301

Title: A comparison of tubocurarine, rocuronium, and cisatracurium in the prevention and reduction of succinylcholine-induced muscle fasciculations.

Journal: AANA journal 20030201

Title: A novel class of ligand-gated ion channel is activated by Zn2+.

Journal: The Journal of biological chemistry 20030110

Title: Nicotinic activation of reticulospinal cells involved in the control of swimming in lampreys.

Journal: The European journal of neuroscience 20030101

Title: Synthesis and biological evaluation of 16 beta-pyrrolidinosteroidal derivatives.

Journal: Arzneimittel-Forschung 20030101

Title: Comparative fading responses induced by mivacurium, cisatracurium, and d-tubocurarine in the evoked muscular compound action potentials of the cat.

Journal: Journal of anesthesia 20030101

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Journal: Bioorganicheskaia khimiia 20030101

Title: Starburst cells nondirectionally facilitate the responses of direction-selective retinal ganglion cells.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20021215

Title: Mechanism of nicotine-evoked release of 3H-noradrenaline in human cerebral cortex slices.

Journal: British journal of pharmacology 20021201

Title: Orientation of d-tubocurarine in the muscle nicotinic acetylcholine receptor-binding site.

Journal: The Journal of biological chemistry 20021101

Title: Nicotinic receptors regulate the release of glycine onto lamina X neurones of the rat spinal cord.

Journal: Neuropharmacology 20021101

Title: Sex difference in urethral response to electrical stimulation of efferent nerves in the pudendal sensory branch of rats.

Journal: International journal of urology : official journal of the Japanese Urological Association 20021001

Title: Effects of nicotine exposure on T cell development in fetal thymus organ culture: arrest of T cell maturation.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20020915

Title: Interaction of d-tubocurarine analogs with mutant 5-HT(3) receptors.

Journal: Neuropharmacology 20020901

Title: Nicotine modulation of apoptosis in human coronary artery endothelial cells.

Journal: International immunopharmacology 20020901

Title: Electrophysiological analysis of synaptic transmission in central neurons of Drosophila larvae.

Journal: Journal of neurophysiology 20020801

Title: Nicotine increases hepatic oxygen uptake in the isolated perfused rat liver by inhibiting glycolysis.

Journal: The Journal of pharmacology and experimental therapeutics 20020601

Title: The nature of the acetylcholine and 5-hydroxytryptamine receptors in buccal smooth muscle of the pest slug Deroceras reticulatum.

Journal: Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20020401

Title: A purinergic signal transduction pathway in mammalian skeletal muscle cells in culture.

Journal: Pflugers Archiv : European journal of physiology 20020301

Title: Group I metabotropic glutamate receptors activate burst firing in rat midbrain dopaminergic neurons.

Journal: Neuropharmacology 20020301

Title: Isobolographic analysis of non-depolarising muscle relaxant interactions at their receptor site.

Journal: European journal of pharmacology 20020301

Title: Luminescence in ophiuroids (Echinodermata) does not share a common nervous control in all species.

Journal: The Journal of experimental biology 20020301

Title: Acceleration of Drosophila melanogaster acetylcholinesterase methanesulfonylation: peripheral ligand D-tubocurarine enhances the affinity for small methanesulfonylfluoride.

Journal: Chemico-biological interactions 20020220

Title: Membrane effects of toxins isolated from a cyanobacterium, Cylindrospermopsis raciborskii, on identified molluscan neurones.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20020201

Title: Activity- and target-dependent regulation of large-conductance Ca2+-activated K+ channels in developing chick lumbar motoneurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20020101

Title: Involvement of nicotinic acetylcholine receptors in suppression of antimicrobial activity and cytokine responses of alveolar macrophages to Legionella pneumophila infection by nicotine.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20011201

Title: IgG isolated from LP-BM5 infected mouse brain activates ionotropic glutamate receptors.

Journal: Neurobiology of disease 20011201

Title: Cholinergic transmission via central synapses in the locust nervous system.

Journal: Journal of comparative physiology. A, Sensory, neural, and behavioral physiology 20011201

Title: Cell membrane transport of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the liver and systemic bioavailability.

Journal: Biochemical and biophysical research communications 20011123

Title: Nicotine inhibition of apoptosis in murine immune cells.

Journal: Experimental biology and medicine (Maywood, N.J.) 20011101

Title: Nicotine-induced phosphorylation of extracellular signal-regulated protein kinase and CREB in PC12h cells.

Journal: Journal of neurochemistry 20011101

Title: Ongoing nicotinic and non-nicotinic inputs to inhibitory neurons in the mouse colon.

Journal: Clinical and experimental pharmacology & physiology 20011001

Title: The kinetics of inhibition of nicotinic acetylcholine receptors by (+)-tubocurarine and pancuronium.

Journal: Molecular pharmacology 20011001

Title: Crosstalk between p38, Hsp25 and Akt in spinal motor neurons after sciatic nerve injury.

Journal: Brain research. Molecular brain research 20010930

Title: Characterization of vagal input to the rat esophageal muscle.

Journal: Autonomic neuroscience : basic & clinical 20010813

Title: Differential effects of chronic drug treatment on alpha3* and alpha7 nicotinic receptor binding sites, in hippocampal neurones and SH-SY5Y cells.

Journal: British journal of pharmacology 20010801

Title: Increased sensitivity to depolarization and nondepolarizing neuromuscular blocking agents in young rat hemidiaphragms.

Journal: Anesthesiology 20010801

Title: Giant multimodal heart motoneurons of Achatina fulica: a new cardioregulatory input in pulmonates.

Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20010801

Title: Early onset of glutamatergic and GABAergic synaptic activity in the visual layers of the rodent superior colliculus.

Journal: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20010601

Title: Nicotinic regulation of c-fos and osteopontin expression in human-derived osteoblast-like cells and human trabecular bone organ culture.

Journal: Bone 20010601

Title: Aldosterone upregulates purinergic responses in larval amphibian skin epithelium.

Journal: Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20010601

Title: A pertussis toxin-sensitive 8-lipoxygenase pathway is activated by a nicotinic acetylcholine receptor in aplysia neurons.

Journal: Journal of neurophysiology 20010501

Title: Effect of cholinergic agonists on resting membrane potential of earthworm body wall muscle cells.

Journal: Bulletin of experimental biology and medicine 20010401

Title: Receptor protection studies to characterize neuronal nicotinic receptors: tubocurarine prevents alkylation of adrenal nicotinic receptors.

Journal: Brain research 20010209

Title: Interaction of Drosophila acetylcholinesterases with D-tubocurarine: an explanation of the activation by an inhibitor.

Journal: Biochemistry 20010206

Title: Contributions of Torpedo nicotinic acetylcholine receptor gamma Trp-55 and delta Trp-57 to agonist and competitive antagonist function.

Journal: The Journal of biological chemistry 20010126

Title: Betahistine produces post-synaptic inhibition of the excitability of the primary afferent neurons in the vestibular endorgans.

Journal: Acta oto-laryngologica. Supplementum 20010101

Title: N-cholinergic facilitation of glutamate release from an individual retinotectal fiber in frog.

Journal: Visual neuroscience 20010101

Title: Is succinylcholine after pretreatment with d-tubocurarine and lidocaine contraindicated for outpatient anesthesia?

Journal: Anesthesia and analgesia 20000801

Title: Prednisolone-induced muscle dysfunction is caused more by atrophy than by altered acetylcholine receptor expression.

Journal: Anesthesia and analgesia 20000801

Title: Cloning, expression, and characterization of ferret 5-HT(3) receptor subunit.

Journal: European journal of pharmacology 20000707

Title: Pharmacological characterization of small-conductance Ca(2+)-activated K(+) channels stably expressed in HEK 293 cells.

Journal: British journal of pharmacology 20000301

Title: The pharmacology of hSK1 Ca2+-activated K+ channels expressed in mammalian cell lines.

Journal: British journal of pharmacology 20000201

Title: Effects of pretreatment with cisatracurium, rocuronium, and d-tubocurarine on succinylcholine-induced fasciculations and myalgia: a comparison with placebo.

Journal: Journal of clinical anesthesia 19991201

Title: Inducible, heterologous expression of human alpha7-nicotinic acetylcholine receptors in a native nicotinic receptor-null human clonal line.

Journal: Brain research 19990417

Title: Gain of function mutation of the alpha7 nicotinic receptor: distinct pharmacology of the human alpha7V274T variant.

Journal: European journal of pharmacology 19990205

Title: Promiscuous coassembly of serotonin 5-HT3 and nicotinic alpha4 receptor subunits into Ca(2+)-permeable ion channels.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19980915

Title: Interaction of D-tubocurarine analogs with the 5HT3 receptor.

Journal: Neuropharmacology 19980101

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Title: Binding of the labelled muscarinic toxin 125I-MT1 to rat brain muscarinic M1 receptors.

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Title: Pretreatment with sedative-hypnotics, but not with nondepolarizing muscle relaxants, attenuates alfentanil-induced muscle rigidity.

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Title: The best prophylaxis for succinylcholine myalgias: extension of a previous meta-analysis.

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Title: Muscle pains and biochemical changes following suxamethonium administration after six pretreatment regimens.

Journal: Anaesthesia 19920301

Title: Atracurium and D-tubocurarine pretreatment in the prevention of succinylcholine myalgias: a study in vaginal hysterectomies.

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Title: Contribution of prostacyclin to D-tubocurarine-induced hypotension in humans.

Journal: Anesthesiology 19900101

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Journal: AANA journal 19890401

Title: Inhibitory effect of intravenous GABA antagonists on gastric acid secretion stimulated by secretagogues in rats.

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Title: Involvement of ion channels in the induction of proenkephalin A gene expression by nicotine and cAMP in bovine chromaffin cells.

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Journal: Acta anaesthesiologica Scandinavica 19841001

Title: Attenuation of fentanyl-induced truncal rigidity.

Journal: Anesthesiology 19830601

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Journal: British journal of anaesthesia 19810501

Title: Does diazepam pretreatment prevent succinylcholine-induced fasciculations?--a double-blind comparison of diazepam and tubocurarine pretreatments.

Journal: Anesthesia and analgesia 19801201

Title: Diazepam prevents some adverse effects of succinylcholine.

Journal: Clinical pharmacology and therapeutics 19790901

Title: Relation of precurarization to suxamethonium to provide ease of intubation and to prevent post-suxamethonium muscle pains.

Journal: Canadian Anaesthetists' Society journal 19790301

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Journal: Archives of physical medicine and rehabilitation 19780701

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Journal: Anesthesiology 19741001

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Journal: Anesthesia and analgesia 19740101

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Journal: Paraplegia 19731101

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Title: Gentamicin, tubocurarine, lignocaine and neuromuscular blockade. A case report.

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Journal: Anaesthesia 19720101

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Title: Severe bronchospasm and circulatory collapse following the administration of d-tubocurarine.

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