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795-38-0
Catalog No.:AA00GPJD

795-38-0 | (-)-Dihydroisocodeine

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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00GPJD
Chemical Name:
(-)-Dihydroisocodeine
CAS Number:
795-38-0
Molecular Formula:
C18H23NO3
Molecular Weight:
301.3801
SMILES:
COc1ccc2c3c1O[C@@H]1[C@@]43CCN([C@H](C2)[C@@H]4CC[C@H]1O)C
Properties
Computed Properties
 
Complexity:
471  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
5  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
1  
XLogP3:
2.2  

Literature

Title: Analgesia and serum assays of controlled-release dihydrocodeine and metabolites in cancer patients with pain.

Journal: Pharmacological reports : PR 20120101

Title: Deaths of opiate/opioid misusers involving dihydrocodeine, UK, 1997-2007.

Journal: British journal of clinical pharmacology 20110801

Title: [Q & A. A patient brought in a comatose state, displaying acute hepatic disorder and an area of high absorption in the stomach in CT images].

Journal: Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 20110401

Title: Quantitation of opioids in whole blood by electron impact-gas chromatography-mass spectrometry.

Journal: Journal of analytical toxicology 20110301

Title: Analgesic effects and assays of controlled-release tramadol and o-desmethyltramadol in cancer patients with pain.

Journal: Current pharmaceutical biotechnology 20110201

Title: A simple and sensitive liquid chromatography method for the determination of low dihydrocodeine concentrations in human plasma: its application in Chinese healthy volunteers.

Journal: Arzneimittel-Forschung 20110101

Title: The impact of tramadol and dihydrocodeine treatment on quality of life of patients with cancer pain.

Journal: International journal of clinical practice 20101101

Title: The role of dihydrocodeine (DHC) metabolites in dihydrocodeine-related deaths.

Journal: Journal of analytical toxicology 20101001

Title: Erythema multiforme major putatively induced by dihydrocodeine phosphate.

Journal: Clinical and experimental dermatology 20100801

Title: Dihydrocodeine as an opioid analgesic for the treatment of moderate to severe chronic pain.

Journal: Current drug metabolism 20100701

Title: Urine testing for norcodeine, norhydrocodone, and noroxycodone facilitates interpretation and reduces false negatives.

Journal: Forensic science international 20100520

Title: Utilization characteristics and treatment persistence in patients prescribed low-dose buprenorphine patches in primary care in the United Kingdom: a retrospective cohort study.

Journal: Clinical therapeutics 20090801

Title: Prevalence of dihydrocodeine in hydrocodone positive postmortem specimens.

Journal: Journal of forensic and legal medicine 20090201

Title: Criteria for opiate identification using liquid chromatography linked to tandem mass spectrometry: problems in routine practice.

Journal: Annals of clinical biochemistry 20090101

Title: The Leeds Evaluation of Efficacy of Detoxification Study (LEEDS) prisons project: a randomised controlled trial comparing dihydrocodeine and buprenorphine for opiate detoxification.

Journal: Substance abuse treatment, prevention, and policy 20090101

Title: Cautious advice.

Journal: Deutsches Arzteblatt international 20090101

Title: [Indication and usage of opioids except morphine for chronic non-malignant intractable pain].

Journal: Masui. The Japanese journal of anesthesiology 20081101

Title: Inhibitory effects of opioids on compound action potentials in frog sciatic nerves and their chemical structures.

Journal: Life sciences 20080801

Title: Comparative study of posttonsillectomy hemorrhage with the use of diclofenac versus dihydrocodeine for postoperative analgesia and review of the literature.

Journal: Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale 20080801

Title: Resolution of secondary amenorrhoea following withdrawal of dihydocodeine.

Journal: Clinical endocrinology 20080401

Title: Comparison of analgesic effects and patient tolerability of nabilone and dihydrocodeine for chronic neuropathic pain: randomised, crossover, double blind study.

Journal: BMJ (Clinical research ed.) 20080126

Title: Intoxication with over-the-counter antitussive medication containing dihydrocodeine and chlorpheniramine causes generalized convulsion and mixed acidosis.

Journal: Internal medicine (Tokyo, Japan) 20080101

Title: Intoxication with over-the-counter antitussive medication containing dihydrocodeine and chlorpheniramine causes generalized convulsion and mixed acidosis.

Journal: Internal medicine (Tokyo, Japan) 20080101

Title: Pharmacokinetic-pharmacodynamic modeling of the miotic effects of dihydrocodeine in humans.

Journal: European journal of clinical pharmacology 20071101

Title: Distribution of drugs of abuse within specific regions of the human brain.

Journal: Forensic science international 20070806

Title: [Transient sick sinus syndrome by oral intake of high dose dehydrocodeine for postherpetic neuralgia].

Journal: Masui. The Japanese journal of anesthesiology 20070401

Title: Buprenorphine versus dihydrocodeine for opiate detoxification in primary care: a randomised controlled trial.

Journal: BMC family practice 20070101

Title: Hemodynamic effects of methadone and dihydrocodeine in overdose.

Journal: Clinical toxicology (Philadelphia, Pa.) 20070101

Title: Addressing the efficacy of dihydrocodeine versus methadone as an alternative maintenance treatment for opiate dependence: A randomized controlled trial.

Journal: Addiction (Abingdon, England) 20061201

Title: Substance abuse in pregnancy: opioid substitution in a northern Ireland maternity unit.

Journal: The Ulster medical journal 20060901

Title: Treatment of pain during medical abortion.

Journal: Contraception 20060701

Title: The effect of non-steroidal anti-inflammatory drugs on medical abortion with mifepristone and misoprostol at 13-22 weeks gestation.

Journal: Human reproduction (Oxford, England) 20051101

Title: The clinical management of substance misusers in police custody -- a survey of current practice.

Journal: Journal of clinical forensic medicine 20050801

Title: The prescribing of methadone and other opioids to addicts: national survey of GPs in England and Wales.

Journal: The British journal of general practice : the journal of the Royal College of General Practitioners 20050601

Title: Staff nurse who was drug-dependent and stole from the ward stock.

Journal: British journal of nursing (Mark Allen Publishing) 20050301

Title: ECG abnormalities in co-proxamol (paracetamol/dextropropoxyphene) poisoning.

Journal: Clinical toxicology (Philadelphia, Pa.) 20050101

Title: Activation of G-proteins by morphine and codeine congeners: insights to the relevance of O- and N-demethylated metabolites at mu- and delta-opioid receptors.

Journal: The Journal of pharmacology and experimental therapeutics 20040201

Title: The Leeds Evaluation of Efficacy of Detoxification Study (LEEDS) project: an open-label pragmatic randomised control trial comparing the efficacy of differing therapeutic agents for primary care detoxification from either street heroin or methadone [ISRCTN07752728].

Journal: BMC family practice 20040101

Title: Development of a directly compressible poly(ethylene oxide) matrix for the sustained-release of dihydrocodeine bitartrate.

Journal: Drug development and industrial pharmacy 20031101

Title: Effects of second generation of histamine H1 antagonists, cetirizine and ebastine, on the antitussive and rewarding effects of dihydrocodeine in mice.

Journal: Psychopharmacology 20030301

Title: The role of active metabolites in dihydrocodeine effects.

Journal: International journal of clinical pharmacology and therapeutics 20030301

Title: The cholecystokinin antagonist proglumide enhances the analgesic effect of dihydrocodeine.

Journal: The Clinical journal of pain 20030101

Title: Affinities of dihydrocodeine and its metabolites to opioid receptors.

Journal: Pharmacology & toxicology 20020801

Title: Prolonged erections produced by dihydrocodeine and sildenafil.

Journal: BMJ (Clinical research ed.) 20020629

Title: A rapid GC-MS method for the determination of dihydrocodeine, codeine, norcodeine, morphine, normorphine and 6-MAM in urine.

Journal: Forensic science international 20020625

Title: Inhaled pinacidil, an ATP-sensitive K+ channel opener, and moguisteine have potent antitussive effects in guinea pigs.

Journal: Japanese journal of pharmacology 20020601

Title: [Paliative treatment: Treatment of chronic cancer pain (ii): the use of opiates].

Journal: Atencion primaria 20020515

Title: Postmortem diffusion of drugs from the bladder into femoral venous blood.

Journal: Forensic science international 20011201

Title: Novel dynamic polymer coating for capillary electrophoresis in nonaqueous methanolic background electrolytes.

Journal: Electrophoresis 20011001

Title: The role of dihydrocodeine in causing death among drug users in the west of Scotland.

Journal: Scottish medical journal 20011001

Title: Randomized placebo controlled trial of lofexidine hydrochloride for chronic pelvic pain in women.

Journal: Human reproduction (Oxford, England) 20010801

Title: Contribution of dihydrocodeine and dihydromorphine to analgesia following dihydrocodeine administration in man: a PK-PD modelling analysis.

Journal: British journal of clinical pharmacology 20010701

Title: Dihydrocodeine--drug of use or misuse?

Journal: The British journal of general practice : the journal of the Royal College of General Practitioners 20010501

Title: Evaluation of urinary dihydrocodeine excretion in human by gas chromatography-mass spectrometry.

Journal: Journal of chromatography. B, Biomedical sciences and applications 20010305

Title: Treatment of severe pain from osteoarthritis with slow-release tramadol or dihydrocodeine in combination with NSAID's: a randomised study comparing analgesia, antinociception and gastrointestinal effects.

Journal: Pain 20010301

Title: Audit of pain management at home following tonsillectomy in children.

Journal: The Journal of laryngology and otology 20010301

Title: Myocardial Infarction associated with methadone and/or dihydrocodeine.

Journal: European addiction research 20010301

Title: Dose-related effects of controlled release dihydrocodeine on oro-cecal transit and pupillary light reflex. A study in human volunteers.

Journal: Arzneimittel-Forschung 20010101

Title: Saliva testing after single and chronic administration of dihydrocodeine.

Journal: International journal of legal medicine 20010101

Title: Pharmacokinetics of dihydrocodeine and its active metabolite after single and multiple oral dosing.

Journal: British journal of clinical pharmacology 19990901

Title: [The use of dihydrocodeine for postoperative analgesia in gynecological operations].

Journal: Akusherstvo i ginekologiia 19960101

Title: A multiple dose comparison of ibuprofen and dihydrocodeine after third molar surgery.

Journal: The British journal of oral & maxillofacial surgery 19930401

Title: Dihydrocodeine--a reversible cause of renal failure?

Journal: European journal of anaesthesiology 19890701

Title: High-dose dihydrocodeine produces hyperalgesia.

Journal: Journal of the Royal Society of Medicine 19850801

Title: Effect of the centrally acting antitussives on ascites tumor cells.

Journal: Japanese journal of pharmacology 19830401

Title: Pharmacokinetics of intravenous and oral dihydrocodeine and its acid metabolites.

Journal: European journal of clinical pharmacology 19830101

Title: Dihydrocodeine increases dental pain.

Journal: Lancet (London, England) 19820724

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