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18828-58-5,MFCD00209823
Catalog No.:AA01ENCI

18828-58-5 | (±)-Propionylcarnitine chloride

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5mg
98%
1 week  
$101.00   $71.00
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10mg
98%
1 week  
$130.00   $91.00
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25mg
98%
1 week  
$177.00   $124.00
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50mg
98%
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$257.00   $180.00
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100mg
98%
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$416.00   $291.00
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  • Technical Information
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA01ENCI
Chemical Name:
(±)-Propionylcarnitine chloride
CAS Number:
18828-58-5
Molecular Formula:
C10H20ClNO4
Molecular Weight:
253.7231
MDL Number:
MFCD00209823
SMILES:
CCC(=O)OC(C[N+](C)(C)C)CC(=O)O.[Cl-]
Properties
Computed Properties
 
Complexity:
232  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
7  
Undefined Atom Stereocenter Count:
1  

Literature

Title: Propionyl-L-carnitine improves endothelial function, microcirculation and pain management in critical limb ischemia.

Journal: Cardiovascular drugs and therapy 20121001

Title: Propionyl-L-carnitine hydrochloride for treatment of mild to moderate colonic inflammatory bowel diseases.

Journal: World journal of gastroenterology 20120928

Title: Effect of short- and long-term treatment with valproate on carnitine homeostasis in humans.

Journal: Therapeutic drug monitoring 20120801

Title: Propionyl-L-carnitine, L-arginine and niacin in sexual medicine: a nutraceutical approach to erectile dysfunction.

Journal: Andrologia 20120501

Title: Living-donor liver transplantation for propionic acidemia.

Journal: Pediatric transplantation 20120501

Title: Carnitine derivatives: clinical usefulness.

Journal: Current opinion in gastroenterology 20120301

Title: Endothelial antioxidant compound prolonged the endothelial antiapoptotic effects registered after tadalafil treatment in patients with arterial erectile dysfunction.

Journal: Journal of andrology 20120101

Title: Propionyl-L-carnitine corrects metabolic and cardiovascular alterations in diet-induced obese mice and improves liver respiratory chain activity.

Journal: PloS one 20120101

Title: Carnitine administration reduces cytokine levels, improves food intake, and ameliorates body composition in tumor-bearing rats.

Journal: Cancer investigation 20111201

Title: Plasma pharmacokinetics and gastrointestinal transit of a new propionyl-L-carnitine controlled release formulation.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20111101

Title: Randomised clinical trial: the efficacy and safety of propionyl-L-carnitine therapy in patients with ulcerative colitis receiving stable oral treatment.

Journal: Alimentary pharmacology & therapeutics 20111101

Title: Combination therapy for erectile dysfunction: an update review.

Journal: Asian journal of andrology 20110501

Title: Pharmacological effects and clinical applications of propionyl-L-carnitine.

Journal: Nutrition reviews 20110501

Title: Expanded newborn screening for detection of vitamin B12 deficiency.

Journal: JAMA 20110323

Title: Effect of propionyl-L-carnitine on a background of monitored exercise in patients with claudication secondary to peripheral artery disease.

Journal: Journal of cardiopulmonary rehabilitation and prevention 20110101

Title: Whole blood propionylcarnitine in newborns with orofacial cleft.

Journal: Maternal & child nutrition 20110101

Title: Critical update for the clinical use of L-carnitine analogs in cardiometabolic disorders.

Journal: Vascular health and risk management 20110101

Title: Useful second-tier tests in expanded newborn screening of isovaleric acidemia and methylmalonic aciduria.

Journal: Journal of inherited metabolic disease 20101001

Title: Rehabilitative treatment in peripheral artery disease: protocol application and follow-up.

Journal: Minerva cardioangiologica 20101001

Title: Newborn screening for methylmalonic aciduria by tandem mass spectrometry: 7 years' experience from two centers in Taiwan.

Journal: Journal of the Chinese Medical Association : JCMA 20100601

Title: Comparison of amino acids and acylcarnitines assay methods used in newborn screening assays by tandem mass spectrometry.

Journal: Clinica chimica acta; international journal of clinical chemistry 20100502

Title: Stabilization of blood methylmalonic acid level in methylmalonic acidemia after liver transplantation.

Journal: Pediatric transplantation 20100501

Title: Propionyl-L-carnitine improves postischemic blood flow recovery and arteriogenetic revascularization and reduces endothelial NADPH-oxidase 4-mediated superoxide production.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20100301

Title: Enhancement of shortening velocity, power, and acto-myosin crossbridge (CB) kinetics following long-term treatment with propionyl-L-carnitine, coenzyme Q10, and omega-3 fatty acids in BIO TO-2 cardiomyopathic Syrian hamsters papillary muscle.

Journal: BioFactors (Oxford, England) 20100101

Title: Propionyl l-carnitine: intermittent claudication and peripheral arterial disease.

Journal: Expert opinion on pharmacotherapy 20091101

Title: Oral supplementation of propionyl-l-carnitine reduces body weight and hyperinsulinaemia in obese Zucker rats.

Journal: The British journal of nutrition 20091001

Title: Effect of propionyl-L-carnitine, L-arginine and nicotinic acid on the efficacy of vardenafil in the treatment of erectile dysfunction in diabetes.

Journal: Current medical research and opinion 20090901

Title: Pharmacological treatment of patients with chronic critical limb ischemia: L-propionyl-carnitine enhances the short-term effects of PGE-1.

Journal: Cardiovascular drugs and therapy 20090801

Title: Glycine propionyl-L-carnitine modulates lipid peroxidation and nitric oxide in human subjects.

Journal: International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 20090501

Title: Comparison of pharmacokinetics of L-carnitine, acetyl-L-carnitine and propionyl-L-carnitine after single oral administration of L-carnitine in healthy volunteers.

Journal: Clinical and investigative medicine. Medecine clinique et experimentale 20090201

Title: Propionyl-L-carnitine prevents early graft dysfunction in allogeneic rat kidney transplantation.

Journal: Kidney international 20081201

Title: Increased C3-carnitine in a healthy premature infant.

Journal: Clinical chemistry 20081101

Title: Evaluation of the efficacy of propionyl-L-carnitine versus pulsed muscular compressions in diabetic and non-diabetic patients affected by obliterating arteriopathy Leriche stage II.

Journal: International angiology : a journal of the International Union of Angiology 20080601

Title: Neonatal vitamin B12 deficiency secondary to maternal subclinical pernicious anemia: identification by expanded newborn screening.

Journal: The Journal of pediatrics 20080501

Title: Prenatal diagnosis of methylmalonic aciduria by analysis of organic acids and total homocysteine in amniotic fluid.

Journal: Chinese medical journal 20080205

Title: Effect of glycine propionyl-L-carnitine on aerobic and anaerobic exercise performance.

Journal: International journal of sport nutrition and exercise metabolism 20080201

Title: ATP production and TCA activity are stimulated by propionyl-L-carnitine in the diabetic rat heart.

Journal: Drugs in R&D 20080101

Title: Levo-propionyl-carnitine improves the effectiveness of supervised physical training on the absolute claudication distance in patients with intermittent claudication.

Journal: Angiology 20080101

Title: Propionyl-L-carnitine in Leriche-Fontaine stage II peripheral arterial obstructive disease.

Journal: Annals of vascular surgery 20080101

Title: Positive inotropic effect of coenzyme Q10, omega-3 fatty acids and propionyl-L-carnitine on papillary muscle force-frequency responses of BIO TO-2 cardiomyopathic Syrian hamsters.

Journal: BioFactors (Oxford, England) 20080101

Title: Antioxidant treatment associated with sildenafil reduces monocyte activation and markers of endothelial damage in patients with diabetic erectile dysfunction: a double-blind, placebo-controlled study.

Journal: European urology 20071201

Title: Editorial comment on: Antioxidant treatment associated with sildenafil reduces monocyte activation and markers of endothelial damage in patients with diabetic erectile dysfunction: a double-blind, placebo-controlled study.

Journal: European urology 20071201

Title: Editorial comment on: Antioxidant treatment associated with sildenafil reduces monocyte activation and markers of endothelial damage in patients with diabetic erectile dysfunction: a double-blind, placebo-controlled study.

Journal: European urology 20071201

Title: Metabolomics identifies perturbations in human disorders of propionate metabolism.

Journal: Clinical chemistry 20071201

Title: Reversal of cisplatin-induced carnitine deficiency and energy starvation by propionyl-L-carnitine in rat kidney tissues.

Journal: Clinical and experimental pharmacology & physiology 20071201

Title: Subacute presentation of propionic acidemia.

Journal: Journal of child neurology 20071201

Title: Comparison of vitamin E and propionyl-L-carnitine, separately or in combination, in patients with early chronic Peyronie's disease: a double-blind, placebo controlled, randomized study.

Journal: The Journal of urology 20071001

Title: l-carnitine and its propionate: improvement of endothelial function in SHR through superoxide dismutase-dependent mechanisms.

Journal: Free radical research 20070801

Title: Propionyl-L-carnitine prevents age-related myocardial remodeling in the rabbit.

Journal: Journal of cardiovascular pharmacology 20070801

Title: Rapid 2nd-tier test for measurement of 3-OH-propionic and methylmalonic acids on dried blood spots: reducing the false-positive rate for propionylcarnitine during expanded newborn screening by liquid chromatography-tandem mass spectrometry.

Journal: Clinical chemistry 20070701

Title: Carnitine deficiency provokes cisplatin-induced hepatotoxicity in rats.

Journal: Basic & clinical pharmacology & toxicology 20070301

Title: Propionyl-L-carnitine reduces proliferation and potentiates Bax-related apoptosis of aortic intimal smooth muscle cells by modulating nuclear factor-kappaB activity.

Journal: The Journal of biological chemistry 20070216

Title: L-Propionyl carnitine, homocysteine and S-adenosylhomocysteine in hemodialysis.

Journal: Journal of nephrology 20070101

Title: Effect of a single IV administration of L-propionylcarnitine on myocardial microcirculation assessed by coronary flow velocity reserve measurement in patients with systemic sclerosis: a pilot study.

Journal: Clinical therapeutics 20070101

Title: Effect of L-carnitine and propionyl-L-carnitine on endothelial function of small mesenteric arteries from SHR.

Journal: Journal of vascular research 20070101

Title: Imbalance between nitric oxide generation and oxidative stress in patients with peripheral arterial disease: effect of an antioxidant treatment.

Journal: Journal of vascular surgery 20060901

Title: Carnitine esters prevent oxidative stress damage and energy depletion following transient forebrain ischaemia in the rat hippocampus.

Journal: Clinical and experimental pharmacology & physiology 20060801

Title: Effect of PLC on functional parameters and oxidative profile in type 2 diabetes-associated PAD.

Journal: Diabetes research and clinical practice 20060601

Title: Antioxidant activity of propionyl-L-carnitine in liver and heart of spontaneously hypertensive rats.

Journal: Life sciences 20060320

Title: Propionyl-L-carnitine prevents the progression of cisplatin-induced cardiomyopathy in a carnitine-depleted rat model.

Journal: Pharmacological research 20060301

Title: Protective effect of L-propionylcarnitine in chronic cyclosporine-a induced nephrotoxicity.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20060201

Title: Changes of plasma fasting carnitine ester profile in patients with ulcerative colitis.

Journal: World journal of gastroenterology 20060107

Title: Supplemental conditionally essential nutrients in cardiovascular disease therapy.

Journal: The Journal of cardiovascular nursing 20060101

Title: Effect of propionylcarnitine on changes in endothelial function and plasma levels of adhesion molecules induced by acute exercise in patients with intermittent claudication.

Journal: Angiology 20060101

Title: A randomised, controlled clinical trial evaluating changes in therapeutic efficacy and oxidative parameters after treatment with propionyl L-carnitine in patients with peripheral arterial disease requiring haemodialysis.

Journal: Drugs & aging 20060101

Title: Propionyl-L-carnitine therapy: effects on endothelin-1 and homocysteine levels in patients with peripheral arterial disease and end-stage renal disease.

Journal: Kidney & blood pressure research 20060101

Title: Two newborns with nutritional vitamin B12 deficiency: challenges in newborn screening for vitamin B12 deficiency.

Journal: Haematologica 20051201

Title: Acetyl-L-carnitine plus propionyl-L-carnitine improve efficacy of sildenafil in treatment of erectile dysfunction after bilateral nerve-sparing radical retropubic prostatectomy.

Journal: Urology 20051101

Title: Uptake of L-carnitine and its short-chain ester propionyl-L-carnitine in the isolated perfused rat liver.

Journal: The Journal of pharmacology and experimental therapeutics 20051001

Title: L-carnitine and propionyl-L-carnitine improve endothelial dysfunction in spontaneously hypertensive rats: different participation of NO and COX-products.

Journal: Life sciences 20050909

Title: Prenatal diagnosis for organic acid disorders using two mass spectrometric methods, gas chromatography mass spectrometry and tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050825

Title: Propionyl-L-carnitine improves hemodynamics and metabolic markers of cardiac perfusion during coronary surgery in diabetic patients.

Journal: Cardiovascular drugs and therapy 20050801

Title: Enantio- and chemo-selective HPLC separations by chiral-achiral tandem-columns approach: the combination of CHIROBIOTIC TAG and SCX columns for the analysis of propionyl carnitine and related impurities.

Journal: Journal of chromatography. A 20041224

Title: Therapeutic effects of L-carnitine and propionyl-L-carnitine on cardiovascular diseases: a review.

Journal: Annals of the New York Academy of Sciences 20041101

Title: Carnitine and peripheral arterial disease.

Journal: Annals of the New York Academy of Sciences 20041101

Title: Preliminary observations on the use of propionyl-L-carnitine in combination with sildenafil in patients with erectile dysfunction and diabetes.

Journal: Current medical research and opinion 20040901

Title: Improvement of cardiac function and beta-adrenergic signal transduction by propionyl L-carnitine in congestive heart failure due to myocardial infarction.

Journal: Coronary artery disease 20040201

Title: Exploratory open label, randomized study of acetyl- and propionylcarnitine in chronic fatigue syndrome.

Journal: Psychosomatic medicine 20040101

Title: Effects of propionyl-carnitine in patients with type 2 diabetes and peripheral vascular disease: results of a pilot trial.

Journal: Drugs in R&D 20040101

Title: Effects of propionyl-carnitine on mitochondrial respiration and post-ischaemic cardiac function in the ischaemic underperfused diabetic rat heart.

Journal: Drugs in R&D 20040101

Title: Filter paper cards contaminated with EMLA cream produce artefacts on acylcarnitine analysis.

Journal: Journal of inherited metabolic disease 20040101

Title: Effects of L-carnitine and its derivatives on postischemic cardiac function, ventricular fibrillation and necrotic and apoptotic cardiomyocyte death in isolated rat hearts.

Journal: Molecular and cellular biochemistry 20031201

Title: Protective role of carnitine esters against alcohol-induced gastric lesions in rats.

Journal: Pharmacological research 20030901

Title: Metabolic modulation and optimization of energy consumption in heart failure.

Journal: The Medical clinics of North America 20030301

Title: Exercise intolerance during post-MI heart failure in rats: prevention with supplemental dietary propionyl-L-carnitine.

Journal: Cardiovascular drugs and therapy 20030101

Title: Effects of propionyl-L-carnitine topical irrigation in distal ulcerative colitis: a preliminary report.

Journal: Hepato-gastroenterology 20030101

Title: Unexpectedly high prevalence of the mild form of propionic acidemia in Japan: presence of a common mutation and possible clinical implications.

Journal: Human genetics 20020801

Title: Serum acylcarnitines and vitamin B12 deficiency.

Journal: Clinical chemistry 20020701

Title: Oral propionyl-l-carnitine and intraplaque verapamil in the therapy of advanced and resistant Peyronie's disease.

Journal: BJU international 20020601

Title: Enhancement of muscular performance by a coformulation of propionyl-L-carnitine, coenzyme Q10, nicotinamide, riboflavin and pantothenic acid in the rat.

Journal: Physiology & behavior 20020601

Title: Gas chromatographic-mass spectrometric newborn screening for propionic acidaemia by targeting methylcitrate in dried filter-paper urine samples.

Journal: Journal of inherited metabolic disease 20020501

Title: Propionyl-L-carnitine prevents renal function deterioration due to ischemia/reperfusion.

Journal: Kidney international 20020301

Title: Propionyl-L-carnitine reduces intimal hyperplasia after injury in normocholesterolemic rabbit carotid artery by modulating proliferation and caspase 3-dependent apoptosis of vascular smooth muscle cells.

Journal: Atherosclerosis 20020101

Title: Rapid diagnosis of methylmalonic and propionic acidemias: quantitative tandem mass spectrometric analysis of propionylcarnitine in filter-paper blood specimens obtained from newborns.

Journal: Clinical chemistry 20011101

Title: Pharmacotherapy of intermittent claudication.

Journal: Expert opinion on pharmacotherapy 20011101

Title: Effects of ischaemic stress on leukocyte activation processes in patients with chronic peripheral occlusive arterial disease: role of L-propionyl carnitine administration.

Journal: Pharmacological research 20011001

Title: Effect of propionyl-L-carnitine on exercise performance in peripheral arterial disease.

Journal: Medicine and science in sports and exercise 20010901

Title: Effects of propionyl-L-carnitine on isolated mitochondrial function in the reperfused diabetic rat heart.

Journal: Diabetes research and clinical practice 20010701

Title: Influence of L-carnitine and its derivatives on myocardial metabolism and function in ischemic heart disease and during cardiopulmonary bypass.

Journal: Cardiovascular research 20010701

Title: Effects of propyonil-l-carnitine topical irrigation in distal ulcerative colitis: a preliminary report.

Journal: The American journal of gastroenterology 20010701

Title: Propionyl-L-carnitine improves exercise performance and functional status in patients with claudication.

Journal: The American journal of medicine 20010601

Title: Propionyl-L-carnitine as protector against adriamycin-induced cardiomyopathy.

Journal: Pharmacological research 20010601

Title: New treatment options in intermittent claudication: the US experience.

Journal: International journal of clinical practice. Supplement 20010401

Title: [Treatment of chronic arterial occlusive disease of the lower limbs with propionyl-1-carnitine in elderly patients].

Journal: Minerva medica 20010201

Title: beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter.

Journal: The Journal of biological chemistry 20000121

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Tags:18828-58-5 Molecular Formula|18828-58-5 MDL|18828-58-5 SMILES|18828-58-5 (±)-Propionylcarnitine chloride