Home Other Building Blocks 100-09-4
100-09-4,MFCD00002542
Catalog No.:AA000037

100-09-4 | 4-Methoxybenzoic acid

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Purity
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Price(USD)
Quantity
  
5g
98%
in stock  
$12.00   $8.00
- +
25g
98%
in stock  
$14.00   $10.00
- +
100g
98%
in stock  
$23.00   $16.00
- +
500g
98%
in stock  
$29.00   $21.00
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  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Application
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA000037
Chemical Name:
4-Methoxybenzoic acid
CAS Number:
100-09-4
Molecular Formula:
C8H8O3
Molecular Weight:
152.1473
MDL Number:
MFCD00002542
SMILES:
COc1ccc(cc1)C(=O)O
FEMA Number:
3945
Properties
Properties
 
BP:
275-280°C at 760 mmHg  
Form:
Solid  
MP:
182-185 °C  
Refractive Index:
1.571-1.576  
Solubility:
H2O: soluble2500 parts  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
136  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
11  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  
XLogP3:
2  

Upstream Synthesis Route

[1]ChemicalandPharmaceuticalBulletin,1985,vol.33,#4,p.1351-1359

[1]JournalofOrganicChemistry,2016,vol.81,#1,p.238-249

[1]AngewandteChemie-InternationalEdition,2012,vol.51,#19,p.4666-4670

[2]ChemicalCommunications(Cambridge,UnitedKingdom),2012,vol.48,#92,p.11307-11309,3

[3]EuropeanJournalofMedicinalChemistry,2013,vol.65,p.276-283

[1]BioorganicandMedicinalChemistry,2008,vol.16,#14,p.6663-6668

[2]Tetrahedron,2018,vol.74,#31,p.4161-4167

[3]BioorganicandMedicinalChemistry,2014,vol.22,#21,p.5766-5775

[4]MedicinalChemistry,2014,vol.10,#4,p.376-381

[5]MedicinalChemistryResearch,2012,vol.21,#6,p.816-824

[6]BulletinoftheKoreanChemicalSociety,2010,vol.31,#8,p.2345-2350

[7]BulletinoftheKoreanChemicalSociety,2011,vol.32,#3,p.1011-1016

[8]DyesandPigments,2017,vol.145,p.152-159

[9]AsianJournalofChemistry,2010,vol.22,#7,p.5289-5296

[10]JournalofChemicalResearch,2014,vol.38,#6,p.347-350

[11]MolecularCrystalsandLiquidCrystals,2014,vol.593,#1,p.34-42

[12]BulletinoftheChemicalSocietyofJapan,1982,vol.55,#2,p.637-638

[13]HeterocyclicCommunications,2007,vol.13,#6,p.387-392

[14]EuropeanJournalofMedicinalChemistry,2009,vol.44,#7,p.2782-2786

[15]JournalofChemicalResearch,2009,#11,p.674-676

[16]JournalofChemicalResearch,2009,#11,p.671-673

[17]ChineseChemicalLetters,2010,vol.21,#3,p.301-304

[18]JournalofChemicalResearch,2010,vol.34,#12,p.719-721

[19]SyntheticCommunications,2011,vol.41,#6,p.864-870

[20]JournalofChemicalResearch,2011,vol.35,#8,p.442-443

[21]BioorganicandMedicinalChemistry,2012,vol.20,#3,p.1181-1187

[22]OrientalJournalofChemistry,2011,vol.27,#2,p.373-383

[23]BioorganicandMedicinalChemistry,2012,vol.20,#9,p.2789-2795

[24]AsianJournalofChemistry,2012,vol.24,#6,p.2739-2743

[25]JournalofChemicalResearch,2012,vol.36,#4,p.218-221

[26]EuropeanJournalofMedicinalChemistry,2012,vol.56,p.56-69,14

[27]IndianJournalofHeterocyclicChemistry,2011,vol.20,#4,p.403-404

[28]RSCAdvances,2014,vol.4,#99,p.55827-55831

[29]LettersinDrugDesignandDiscovery,2015,vol.12,#4,p.314-318

[30]RSCAdvances,2014,vol.4,#27,p.14248-14253

[31]ChemicalandPharmaceuticalBulletin,2014,vol.62,#6,p.524-527

[32]OrientalJournalofChemistry,2015,vol.31,#4,p.1873-1885

[33]Pharmazie,2018,vol.73,#3,p.123-127

[34]BioorganicChemistry,2018,vol.81,p.88-92

[35]Molecules,2018,vol.23,#10,

[1]AsianJournalofChemistry,2014,vol.26,#7,p.2092-2098

Downstream Synthesis Route

[1]JournaloftheAmericanChemicalSociety,1940,vol.62,p.346

[1]JournaloftheChemicalSociety,1955,p.3845,3847

[1]JournalofOrganicChemistry,2017,vol.82,p.7529-7537

[2]Patent:WO2010/42998,2010,A1.Locationinpatent:Page/Pagecolumn51;52

[3]EuropeanJournalofOrganicChemistry,2019,vol.2019,p.2812-2818

[4]JournalofMedicinalChemistry,1987,vol.30,p.1798-1806

[5]CanadianJournalofResearch,SectionB:ChemicalSciences,1946,vol.24,p.208

[1]Tetrahedron,2017,vol.73,p.7105-7114

[2]JournalofOrganicChemistry,2019,vol.84,p.7405-7410

[3]Chemistry-AEuropeanJournal,2017,vol.23,p.1044-1047

[4]SyntheticCommunications,2020,vol.50,p.813-822

[5]JournalofChemicalResearch,Miniprint,1982,p.1649-1660

[6]Synlett,2011,p.1563-1566

[7]SyntheticCommunications,2014,vol.44,p.181-187

[8]JournalofMedicinalChemistry,1987,vol.30,p.1798-1806

[9]JournaloftheIndianChemicalSociety,1983,vol.60,p.953-957

[10]JournaloftheIndianChemicalSociety,1930,vol.7,p.503

[11]JustusLiebigsAnnalenderChemie,1845,vol.56,p.308    AnnalesdeChimie(Cachan,France),1845,vol.<3>14,p.486

[12]AustralianJournalofChemistry,1977,vol.30,p.293-304

[13]JournaloftheAmericanChemicalSociety,1997,vol.119,p.5413-5424

[14]Molecules,2011,vol.16,p.4897-4911

[15]MedicinalChemistry,2013,vol.9,p.303-311

55996-28-6    100-09-4   
4-Methoxy-benzoicacid2-methoxy-6-methyl-pyrimidin-4-ylester 

[1]Tetrahedron,1994,vol.50,p.3603-3618

Literature

Title: DeWeerd K, et al. Metabolism of the 18O-methoxy substituent of 3-methoxybenzoic acid and other unlabeled methoxybenzoic acids by anaerobic bacteria. Appl Environ Microbiol. 1988 May;54(5):1237-42.

Application
The utilization of 4-Methoxybenzoic acid in the oxidation and reduction of cytochrome c presents a notable application within the realm of electrochemistry, specifically in studies involving self-assembled monolayers (SAMs) on gold electrodes. Employing cyclic voltammetry, a sophisticated electrochemical technique, researchers investigate the behavior of cytochrome c in solution when subjected to oxidation and reduction processes facilitated by distinct SAMs on gold electrodes. 4-Methoxybenzoic acid plays a pivotal role in modulating the redox reactions of cytochrome c, thereby contributing to the elucidation of its electrochemical properties and interactions with SAMs. This experimental approach provides valuable insights into the molecular mechanisms governing the electrochemical behavior of biomolecules, facilitating advancements in fields such as bioelectronics and biosensing. Thus, the application of 4-Methoxybenzoic acid in this context underscores its significance as a molecular tool for probing and manipulating biomolecular interactions at electrode interfaces, furthering our understanding of fundamental biological processes.
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