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100-33-4,MFCD00599574
Catalog No.:AA00003R

100-33-4 | 4-{[5-(4-carbamimidoylphenoxy)pentyl]oxy}benzene-1-carboximidamide

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50mg
98
in stock  
$150.00   $105.00
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1g
98%
in stock  
$152.00   $107.00
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00003R
Chemical Name:
4-{[5-(4-carbamimidoylphenoxy)pentyl]oxy}benzene-1-carboximidamide
CAS Number:
100-33-4
Molecular Formula:
C19H24N4O2
Molecular Weight:
340.4195
MDL Number:
MFCD00599574
SMILES:
NC(=N)c1ccc(cc1)OCCCCCOc1ccc(cc1)C(=N)N
NSC Number:
9921
UN Number:
1664
Properties
Computed Properties
 
Complexity:
376  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
10  
XLogP3:
2.6  

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Title: Treatment of New World cutaneous leishmaniasis--a systematic review with a meta-analysis.

Journal: International journal of dermatology 20080201

Title: Carbamate prodrugs of N-alkylfuramidines.

Journal: European journal of medicinal chemistry 20080101

Title: Mucosal leishmaniasis . Current scenario and prospects for treatment.

Journal: Acta tropica 20080101

Title: Leishmanicidal and trypanocidal activities of 2-aminocyclohexanol and 1,2-cyclohexanediamine derivatives.

Journal: Bioorganic & medicinal chemistry letters 20080101

Title: Sequence and length dependent thermodynamic differences in heterocyclic diamidine interactions at AT base pairs in the DNA minor groove.

Journal: Biophysical chemistry 20071201

Title: The novel combination of chlorpromazine and pentamidine exerts synergistic antiproliferative effects through dual mitotic action.

Journal: Cancer research 20071201

Title: Synthesis and in vitro antiprotozoal activity of bisbenzofuran cations.

Journal: Journal of medicinal chemistry 20071115

Title: Design of DNA minor groove binding diamidines that recognize GC base pair sequences: a dimeric-hinge interaction motif.

Journal: Journal of the American Chemical Society 20071107

Title: Melarsoprol- and pentamidine-resistant Trypanosoma brucei rhodesiense populations and their cross-resistance.

Journal: International journal for parasitology 20071101

Title: Theoretical study on binding of S100B protein.

Journal: Journal of molecular modeling 20071101

Title: Post-kala-azar dermal leishmaniasis as an immune reconstitution inflammatory syndrome in a patient with acquired immune deficiency syndrome.

Journal: The British journal of dermatology 20071101

Title: Trypanocidal and antileishmanial dihydrochelerythrine derivatives from Garcinia lucida.

Journal: Journal of natural products 20071001

Title: Synthesis, biological evaluation, and molecular modeling of 3,5-substituted-N1-phenyl-N4,N4-di-n-butylsulfanilamides as antikinetoplastid antimicrotubule agents.

Journal: Bioorganic & medicinal chemistry 20070915

Title: Induction of apoptosis-like cell death by pentamidine and doxorubicin through differential inhibition of topoisomerase II in arsenite-resistant L. donovani.

Journal: Acta tropica 20070901

Title: Recurrent American cutaneous leishmaniasis.

Journal: Emerging infectious diseases 20070901

Title: Leishmania panamensis: comparative inhibition of nuclear DNA topoisomerase II enzymes from promastigotes and human macrophages reveals anti-parasite selectivity of fluoroquinolones, flavonoids and pentamidine.

Journal: Experimental parasitology 20070801

Title: Treatment of mucosal leishmaniasis in Latin America: systematic review.

Journal: The American journal of tropical medicine and hygiene 20070801

Title: Synthesis of marine alkaloid: 8,9-dihydrocoscinamide B and its analogues as Novel class of antileishmanial agents.

Journal: Bioorganic & medicinal chemistry letters 20070715

Title: An HIV-positive man with tattoo induration.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20070715

Title: Activity of 'reversed' diamidines against Trypanosoma cruzi 'in vitro'.

Journal: Biochemical pharmacology 20070615

Title: Synthesis of isoquinuclidine analogs of chloroquine: antimalarial and antileishmanial activity.

Journal: Bioorganic & medicinal chemistry 20070601

Title: Cellulose biosynthesis pathway is a potential target in the improved treatment of Acanthamoeba keratitis.

Journal: Applied microbiology and biotechnology 20070501

Title: Chemotherapy of leishmaniasis. Part V: Synthesis and in vitro bioevaluation of novel pyridinone derivatives.

Journal: European journal of medicinal chemistry 20070501

Title: Cutaneous leishmaniasis treatment.

Journal: Travel medicine and infectious disease 20070501

Title: Loss of the high-affinity pentamidine transporter is responsible for high levels of cross-resistance between arsenical and diamidine drugs in African trypanosomes.

Journal: Molecular pharmacology 20070401

Title: A background and critical analysis of the treatment of pneumocystis carinii pneumonia (PCP) in HIV/AIDS.

Journal: Australian nursing journal (July 1993) 20070401

Title: High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity.

Journal: Bioorganic & medicinal chemistry letters 20070301

Title: When the book is wrong.

Journal: Lancet (London, England) 20070203

Title: [Renal insufficiency caused by medicines, diagnostic processes, toxins].

Journal: Orvosi hetilap 20070121

Title: Synthesis, antimalarial, antileishmanial, antimicrobial, cytotoxicity, and methemoglobin (MetHB) formation activities of new 8-quinolinamines.

Journal: Bioorganic & medicinal chemistry 20070115

Title: Synthesis and evaluation of isosteres of N-methyl indolo[3,2-b]-quinoline (cryptolepine) as new antiinfective agents.

Journal: Bioorganic & medicinal chemistry 20070115

Title: Antiprotozoal and antimicrobial activities of O-alkylated and formylated acylphloroglucinols.

Journal: Bioorganic & medicinal chemistry 20070101

Title: Perioral numbness associated with intravenous pentamidine administration.

Journal: The Annals of pharmacotherapy 20070101

Title: Synthesis and evaluation of new difluoromethyl azoles as antileishmanial agents.

Journal: European journal of medicinal chemistry 20070101

Title: Carbocyclic analogues of lexitropsin--DNA affinity and endonuclease inhibition.

Journal: Acta poloniae pharmaceutica 20070101

Title: Genotypic and phenotypic characterization of Trypanosoma brucei gambiense isolates from Ibba, South Sudan, an area of high melarsoprol treatment failure rate.

Journal: Acta tropica 20070101

Title: Combined effect of the essential oil from Chenopodium ambrosioides and antileishmanial drugs on promastigotes of Leishmania amazonensis.

Journal: Revista do Instituto de Medicina Tropical de Sao Paulo 20070101

Title: [Cutaneous leishmaniasis--an import from Belize].

Journal: Wiener klinische Wochenschrift 20070101

Title: The role of Leishmania enriettii multidrug resistance protein 1 (LeMDR1) in mediating drug resistance is iron-dependent.

Journal: Molecular and biochemical parasitology 20061201

Title: Structurally diverse 5-substituted pyrimidine nucleosides as inhibitors of Leishmania donovani promastigotes in vitro.

Journal: Bioorganic & medicinal chemistry letters 20061001

Title: Treatment outcomes and risk factors for relapse in patients with early-stage human African trypanosomiasis (HAT) in the Republic of the Congo.

Journal: Bulletin of the World Health Organization 20061001

Title: [Efficacy and tolerance of pentamidine for treatment of cutaneous leishmaniasis caused by por L. (V) panamensis in Colombia].

Journal: Biomedica : revista del Instituto Nacional de Salud 20061001

Title: [Diabetes mellitus induced by drugs and chemical agents].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20060928

Title: A woman with fever and rash after African safari.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20060901

Title: Synthesis, DNA affinity, and antiprotozoal activity of linear dications: Terphenyl diamidines and analogues.

Journal: Journal of medicinal chemistry 20060824

Title: Anti-plasmodial and anti-leishmanial activity of conformationally restricted pentamidine congeners.

Journal: The Journal of pharmacy and pharmacology 20060801

Title: Development of a semi-automated colorimetric assay for screening anti-leishmanial agents.

Journal: Journal of microbiological methods 20060701

Title: Novel synthesis of nicotinamide derivatives of cytotoxic properties.

Journal: Bioorganic & medicinal chemistry 20060701

Title: Antiparasitic activity of aromatic diamidines is related to apoptosis-like death in Trypanosoma cruzi.

Journal: Parasitology 20060701

Title: In vitro selection and in vivo efficacy of piperazine- and alkanediamide-linked bisbenzamidines against Pneumocystis pneumonia in mice.

Journal: Antimicrobial agents and chemotherapy 20060701

Title: Manzamine B and E and ircinal A related alkaloids from an Indonesian Acanthostrongylophora sponge and their activity against infectious, tropical parasitic, and Alzheimer's diseases.

Journal: Journal of natural products 20060701

Title: A high-throughput, high-resolution strategy for the study of site-selective DNA binding agents: analysis of a 'highly twisted' benzimidazole-diamidine.

Journal: Journal of the American Chemical Society 20060621

Title: Efficacy of short-course intramuscular pentamidine isethionate treatment on Old World localized cutaneous leishmaniasis in 2 patients.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20060615

Title: DNA binding affinity of bisguanidine and bis(2-aminoimidazoline) derivatives with in vivo antitrypanosomal activity.

Journal: Journal of medicinal chemistry 20060615

Title: Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20060601

Title: 2H-benzimidazole 1,3-dioxide derivatives: a new family of water-soluble anti-trypanosomatid agents.

Journal: Journal of medicinal chemistry 20060601

Title: Beneficial effect of erythropoietin administration on murine infection with Trypanosoma congolense.

Journal: The American journal of tropical medicine and hygiene 20060601

Title: Comparison between one and two injections of pentamidine isethionate, at 7 mg/kg in each injection, in the treatment of cutaneous leishmaniasis in French Guiana.

Journal: Annals of tropical medicine and parasitology 20060601

Title: Pneumocystis pneumonia in people with HIV.

Journal: Clinical evidence 20060601

Title: Arylanthranilodinitriles: a new biaryl class of antileishmanial agents.

Journal: Bioorganic & medicinal chemistry letters 20060515

Title: 3D QSAR on a library of heterocyclic diamidine derivatives with antiparasitic activity.

Journal: Bioorganic & medicinal chemistry 20060501

Title: The elimination of Trypanosoma brucei gambiense sleeping sickness in the focus of Luba, Bioko Island, Equatorial Guinea.

Journal: Tropical medicine & international health : TM & IH 20060501

Title: New administration model of trans-chalcone biodegradable polymers for the treatment of experimental leishmaniasis.

Journal: Acta tropica 20060401

Title: Aromatic constituents of Uvaria grandiflora.

Journal: Journal of natural products 20060401

Title: Identification of novel parasitic cysteine protease inhibitors by use of virtual screening. 2. The available chemical directory.

Journal: Journal of medicinal chemistry 20060309

Title: Comparative evaluation of HERG currents and QT intervals following challenge with suspected torsadogenic and nontorsadogenic drugs.

Journal: The Journal of pharmacology and experimental therapeutics 20060301

Title: Alkyl-linked bis-THTT derivatives as potent in vitro trypanocidal agents.

Journal: Bioorganic & medicinal chemistry letters 20060301

Title: Visceral leishmaniasis - current therapeutic modalities.

Journal: The Indian journal of medical research 20060301

Title: Diamidines as antitrypanosomal, antileishmanial and antimalarial agents.

Journal: Current opinion in investigational drugs (London, England : 2000) 20060201

Title: Roles for mitochondria in pentamidine susceptibility and resistance in Leishmania donovani.

Journal: Molecular and biochemical parasitology 20060101

Title: Leishmania donovani: differential activities of classical topoisomerase inhibitors and antileishmanials against parasite and host cells at the level of DNA topoisomerase I and in cytotoxicity assays.

Journal: Experimental parasitology 20060101

Title: A diminazene-resistant strain of Trypanosoma brucei brucei isolated from a dog is cross-resistant to pentamidine in experimentally infected albino rats.

Journal: Parasitology 20060101

Title: Isoflavonoids and other compounds from Psorothamnus arborescens with antiprotozoal activities.

Journal: Journal of natural products 20060101

Title: Irreversible inactivation of trypanothione reductase by unsaturated Mannich bases: a divinyl ketone as key intermediate.

Journal: Journal of medicinal chemistry 20051117

Title: Prednisone-free maintenance immunosuppression-a 5-year experience.

Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20051001

Title: Pentamidine is an antiparasitic and apoptotic drug that selectively modifies ubiquitin.

Journal: Chemistry & biodiversity 20051001

Title: Use of Leishmania donovani field isolates expressing the luciferase reporter gene in in vitro drug screening.

Journal: Antimicrobial agents and chemotherapy 20050901

Title: Antileishmanial activity of polycyclic derivatives.

Journal: Parasite (Paris, France) 20050901

Title: Synthesis, DNA affinity, and antiprotozoal activity of fused ring dicationic compounds and their prodrugs.

Journal: Journal of medicinal chemistry 20050825

Title: Design and synthesis of a series of melamine-based nitroheterocycles with activity against Trypanosomatid parasites.

Journal: Journal of medicinal chemistry 20050825

Title: Early-onset pentamidine-associated second-degree heart block and sinus bradycardia: case report and review of the literature.

Journal: Pharmacotherapy 20050601

Title: Challenges in the management of visceral leishmaniasis.

Journal: Indian pediatrics 20050601

Title: Pneumocystis pneumonia in people with HIV.

Journal: Clinical evidence 20050601

Title: Protein trafficking abnormalities: a new mechanism in drug-induced long QT syndrome.

Journal: British journal of pharmacology 20050501

Title: Identification and characterization of a polyamine permease from the protozoan parasite Leishmania major.

Journal: The Journal of biological chemistry 20050415

Title: Search of chemical scaffolds for novel antituberculosis agents.

Journal: Journal of biomolecular screening 20050401

Title: A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20050201

Title: Dual molecules as new antimalarials.

Journal: Combinatorial chemistry & high throughput screening 20050201

Title: Comparison of meglumine antimoniate and pentamidine for peruvian cutaneous leishmaniasis.

Journal: The American journal of tropical medicine and hygiene 20050201

Title: Amidine derivatives and Leishmania amazonensis: an evaluation of the effect of nitric oxide (NO) production on the parasite-macrophage interaction.

Journal: Journal of enzyme inhibition and medicinal chemistry 20050201

Title: Detection of immunotoxicity using T-cell based cytokine reporter cell lines ('Cell Chip').

Journal: Toxicology 20050115

Title: Pentamidine-induced long QT syndrome and block of hERG trafficking.

Journal: The Journal of pharmacology and experimental therapeutics 20050101

Title: Changing pattern of imported cutaneous leishmaniasis in the Netherlands.

Journal: Clinical and experimental dermatology 20050101

Title: Antiprotozoal compounds from Psorothamnus polydenius.

Journal: Journal of natural products 20050101

Title: Identification of novel parasitic cysteine protease inhibitors using virtual screening. 1. The ChemBridge database.

Journal: Journal of medicinal chemistry 20041216

Title: Challenges and new discoveries in the treatment of leishmaniasis.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20041201

Title: Characterization of the choline carrier of Plasmodium falciparum: a route for the selective delivery of novel antimalarial drugs.

Journal: Blood 20041115

Title: Synthesis, anti-Trypanosoma cruzi activity and micelle interaction studies of bisguanylhydrazones analogous to pentamidine.

Journal: European journal of medicinal chemistry 20041101

Title: Thiophene-based diamidine forms a 'super' at binding minor groove agent.

Journal: Journal of the American Chemical Society 20041027

Title: Novel bisbenzamidines as potential drug candidates for the treatment of Pneumocystis carinii pneumonia.

Journal: Bioorganic & medicinal chemistry letters 20040906

Title: Balamuthia mandrillaris from soil samples.

Journal: Microbiology (Reading, England) 20040901

Title: A convenient and biogenetic type synthesis of few naturally occurring chromeno dihydrochalcones and their in vitro antileishmanial activity.

Journal: Bioorganic & medicinal chemistry letters 20040802

Title: The DNA double-stranded break repair protein endo-exonuclease as a therapeutic target for cancer.

Journal: Molecular cancer therapeutics 20040801

Title: Three new manzamine alkaloids from a common Indonesian sponge and their activity against infectious and tropical parasitic diseases.

Journal: Journal of natural products 20040801

Title: Novel dicationic imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines as antiprotozoal agents.

Journal: Journal of medicinal chemistry 20040701

Title: Pneumocystis carinii pneumonia treatment in people infected with HIV.

Journal: Clinical evidence 20040601

Title: Parallel solution-phase synthesis of conformationally restricted congeners of pentamidine and evaluation of their antiplasmodial activities.

Journal: Journal of medicinal chemistry 20040506

Title: A new antimalarial quassinoid from Simaba orinocensis.

Journal: Journal of natural products 20040501

Title: Bloodstream form-specific up-regulation of silent vsg expression sites and procyclin in Trypanosoma brucei after inhibition of DNA synthesis or DNA damage.

Journal: The Journal of biological chemistry 20040402

Title: Crystal structures of QacR-diamidine complexes reveal additional multidrug-binding modes and a novel mechanism of drug charge neutralization.

Journal: The Journal of biological chemistry 20040402

Title: Balamuthia mandrillaris meningoencephalitis in an immunocompetent patient: an unusual clinical course and a favorable outcome.

Journal: Archives of pathology & laboratory medicine 20040401

Title: Synthesis and antitubulin activity of N1- and N4-substituted 3,5-dinitro sulfanilamides against African trypanosomes and Leishmania.

Journal: Journal of medicinal chemistry 20040325

Title: Apoptotic death in Leishmania donovani promastigotes in response to respiratory chain inhibition: complex II inhibition results in increased pentamidine cytotoxicity.

Journal: The Journal of biological chemistry 20040319

Title: The synthesis of dicationic extended bis-benzimidazoles.

Journal: Molecules (Basel, Switzerland) 20040227

Title: Localized cutaneous leishmaniasis imported into Paris: a review of 39 cases.

Journal: International journal of dermatology 20040201

Title: New agents active against Mycobacterium avium complex selected by molecular topology: a virtual screening method.

Journal: The Journal of antimicrobial chemotherapy 20040101

Title: Retaking sleeping sickness control in Angola.

Journal: Tropical medicine & international health : TM & IH 20040101

Title: Aromatic analogues of DNA minor groove binders--synthesis and biological evaluation.

Journal: European journal of medicinal chemistry 20040101

Title: The effect of inducing agents on the metabolism of trypanocidal diamidines by isolated rat hepatocytes.

Journal: Chemico-biological interactions 20031215

Title: Tender subcutaneous nodules in a patient with AIDS.

Journal: Archives of dermatology 20031201

Title: A reverse turn structure induced by a D,L-alpha-aminoxy acid dimer.

Journal: Journal of the American Chemical Society 20031126

Title: Synthesis and antiprotozoal activity of aza-analogues of furamidine.

Journal: Journal of medicinal chemistry 20031023

Title: Current treatment approaches to leishmaniasis.

Journal: Current opinion in infectious diseases 20031001

Title: Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei.

Journal: Eukaryotic cell 20031001

Title: Structure-activity relationships of the antimalarial agent artemisinin. 8. design, synthesis, and CoMFA studies toward the development of artemisinin-based drugs against leishmaniasis and malaria.

Journal: Journal of medicinal chemistry 20030925

Title: Characterization of pentamidine excretion in the isolated perfused rat kidney.

Journal: The Journal of antimicrobial chemotherapy 20030901

Title: Functional genetic identification of PRP1, an ABC transporter superfamily member conferring pentamidine resistance in Leishmania major.

Journal: Molecular and biochemical parasitology 20030831

Title: Antiparasitic alkaloids from Psychotria klugii.

Journal: Journal of natural products 20030701

Title: The activity of diguanidino and 'reversed' diamidino 2,5-diarylfurans versus Trypanosoma cruzi and Leishmania donovani.

Journal: Bioorganic & medicinal chemistry letters 20030616

Title: Current chemotherapy of human African trypanosomiasis.

Journal: Parasitology research 20030601

Title: Aerosolized pentamidine prophylaxis against AIDS-related Pneumocystis carinii pneumonia and its short- and long-term effects on pulmonary function in the Japanese.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20030601

Title: Antimicrobial and antiparasitic (+)-trans-hexahydrodibenzopyrans and analogues from Machaerium multiflorum.

Journal: Journal of natural products 20030601

Title: New manzamine alkaloids with activity against infectious and tropical parasitic diseases from an Indonesian sponge.

Journal: Journal of natural products 20030601

Title: Efficacy of a diarylheptanoid derivative against Leishmania amazonensis.

Journal: Memorias do Instituto Oswaldo Cruz 20030601

Title: Pharmacology of delta2 glutamate receptors: effects of pentamidine and protons.

Journal: The Journal of pharmacology and experimental therapeutics 20030501

Title: Rhabdomyolysis associated with pentamidine isethionate therapy for American cutaneous leishmaniasis.

Journal: The Journal of antimicrobial chemotherapy 20030501

Title: Arsenicals (melarsoprol), pentamidine and suramin in the treatment of human African trypanosomiasis.

Journal: Parasitology research 20030501

Title: Antileishmanial drugs cause up-regulation of interferon-gamma receptor 1, not only in the monocytes of visceral leishmaniasis cases but also in cultured THP1 cells.

Journal: Annals of tropical medicine and parasitology 20030401

Title: Trypanocidal activity of conformationally restricted pentamidine congeners.

Journal: Journal of medicinal chemistry 20030313

Title: Trypanocidal diarylheptanoids from Aframomum letestuianum.

Journal: Journal of natural products 20030301

Title: Effect of amidine derivatives on nitric oxide production by Leishmania amazonensis promastigotes and axenic amastigotes.

Journal: Nitric oxide : biology and chemistry 20030201

Title: [Pneumocystis carinii pneumonia].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20030201

Title: [Management of American cutaneous leishmaniasis. Outcome apropos of 326 cases treated with high-dose pentamidine isethionate].

Journal: Medecine tropicale : revue du Corps de sante colonial 20030101

Title: [A comparative study between the efficacy of pentamidine isothionate given in three doses for one week and N-methil-glucamine in a dose of 20mgSbV/day for 20 days to treat cutaneous leishmaniasis].

Journal: Revista da Sociedade Brasileira de Medicina Tropical 20030101

Title: [The return of sleeping sickness in an epidemic form: international action for drugs].

Journal: Nederlands tijdschrift voor geneeskunde 20021228

Title: Pentamidine is an inhibitor of PRL phosphatases with anticancer activity.

Journal: Molecular cancer therapeutics 20021201

Title: Development of novel assays for proteolytic enzymes using rhodamine-based fluorogenic substrates.

Journal: Journal of biomolecular screening 20021201

Title: Strong binding in the DNA minor groove by an aromatic diamidine with a shape that does not match the curvature of the groove.

Journal: Journal of the American Chemical Society 20021120

Title: Pentamidine, the drug of choice for the treatment of cutaneous leishmaniasis in Surinam.

Journal: International journal of dermatology 20021101

Title: Assessment of the antiprotozoal activity of Galphimia glauca and the isolation of new nor-secofriedelanes and nor-friedelanes.

Journal: Journal of natural products 20021001

Title: Antileishmanial dinitroaniline sulfonamides with activity against parasite tubulin.

Journal: Bioorganic & medicinal chemistry letters 20020902

Title: T wave alternans and Torsades de Pointes after the use of intravenous pentamidine.

Journal: Journal of cardiovascular electrophysiology 20020901

Title: Promising therapeutic targets for antileishmanial drugs.

Journal: Expert opinion on therapeutic targets 20020801

Title: [Pneumocystis carinii pneumonia in patients with connective tissue diseases].

Journal: Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology 20020801

Title: In vitro activities of pentamidine, pyrimethamine, trimethoprim, and sulfonamides against Aspergillus species.

Journal: Antimicrobial agents and chemotherapy 20020601

Title: Prophylaxis for human immunodeficiency virus-related Pneumocystis carinii pneumonia: using simulation modeling to inform clinical guidelines.

Journal: Archives of internal medicine 20020422

Title: Leishmaniases and HIV/AIDS co-infections: review of common features and management experiences.

Journal: Ethiopian medical journal 20020401

Title: Intravenous pentamidine induced megaloblastic anaemia.

Journal: Haematologica 20020101

Title: [Rhabdomyolysis induced by pentamidine (Pentacarinat) during treatment of cutaneous leishmaniasis: 2 cases].

Journal: Annales de dermatologie et de venereologie 20020101

Title: Pneumocystis carinii pneumonia in patients with Diamond-Blackfan anemia receiving high-dose corticosteroids.

Journal: Journal of pediatric hematology/oncology 20020101

Title: A novel HPLC assay for pentamidine: comparative effects of creatinine and inulin on GFR estimation and pentamidine renal excretion in the isolated perfused rat kidney.

Journal: Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20020101

Title: Uptake of pentamidine in Trypanosoma brucei brucei is mediated by the P2 adenosine transporter and at least one novel, unrelated transporter.

Journal: Acta tropica 20011221

Title: High intralesional interleukin-10 messenger RNA expression in localized cutaneous leishmaniasis is associated with unresponsiveness to treatment.

Journal: The Journal of infectious diseases 20011215

Title: Seasonal fluctuations of incubation, healing delays, and clinical presentation of cutaneous leishmaniasis in French Guiana.

Journal: The Journal of parasitology 20011201

Title: Pentamidine isethionate as treatment and secondary prophylaxis for disseminated cutaneous leishmaniasis during HIV infection: case report.

Journal: Journal of chemotherapy (Florence, Italy) 20011201

Title: New insights into transmission, diagnosis, and drug treatment of Pneumocystis carinii pneumonia.

Journal: JAMA 20011121

Title: Anti-human immunodeficiency virus drugs are ineffective against Pneumocystis carinii in vitro and in vivo.

Journal: The Journal of infectious diseases 20011115

Title: Drug resistance in Indian visceral leishmaniasis.

Journal: Tropical medicine & international health : TM & IH 20011101

Title: Availability and affordability of treatment for Human African Trypanosomiasis.

Journal: Tropical medicine & international health : TM & IH 20011101

Title: Treatment of visceral leishmaniasis.

Journal: Medical microbiology and immunology 20011101

Title: N,N'-bis[4-(N-alkylamidino)phenyl]homopiperazines as anti-Pneumocystis carinii agents.

Journal: Bioorganic & medicinal chemistry letters 20011022

Title: Antiprotozoal and cytotoxicity evaluation of sulfonamide and urea analogues of quinacrine.

Journal: Bioorganic & medicinal chemistry letters 20011008

Title: Flow cytometry, a useful tool for detecting the lethal effect of pentamidine on Leishmania viannia complex promastigote forms.

Journal: Pharmacological research 20011001

Title: [Guidelines for Prevention of Pneumocystis carinii Pneumonitis in Children and Adolescents with Cancer].

Journal: Klinische Padiatrie 20010901

Title: Leishmanicidal activity of some stilbenoids and related heterocyclic compounds.

Journal: Bioorganic & medicinal chemistry letters 20010820

Title: A meta-analysis of salvage therapy for Pneumocystis carinii pneumonia.

Journal: Archives of internal medicine 20010625

Title: Adenosine analogues as selective inhibitors of glyceraldehyde-3-phosphate dehydrogenase of Trypanosomatidae via structure-based drug design.

Journal: Journal of medicinal chemistry 20010621

Title: Trypanocidal withanolides and withanolide glycosides from Dunalia brachyacantha.

Journal: Journal of natural products 20010601

Title: Influence of clinical presentation on the efficacy of a short course of pentamidine in the treatment of cutaneous leishmaniasis in French Guiana.

Journal: Annals of tropical medicine and parasitology 20010601

Title: Trypanocidal activity of dicationic compounds related to pentamidine.

Journal: European journal of medicinal chemistry 20010601

Title: A randomized clinical trial of low dosage combination of pentamidine and allopurinol in the treatment of antimony unresponsive cases of visceral leishmaniasis.

Journal: The Journal of the Association of Physicians of India 20010601

Title: Prevention of invasive aspergillosis in AIDS by sulfamethoxazole.

Journal: AIDS (London, England) 20010525

Title: Diamidine compounds: selective uptake and targeting in Plasmodium falciparum.

Journal: Molecular pharmacology 20010501

Title: Transporters in African trypanosomes: role in drug action and resistance.

Journal: International journal for parasitology 20010501

Title: Structure-based approach for the discovery of bis-benzamidines as novel inhibitors of matriptase.

Journal: Journal of medicinal chemistry 20010426

Title: Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy.

Journal: Journal of medicinal chemistry 20010315

Title: Uptake of pentamidine in Trypanosoma brucei brucei is mediated by three distinct transporters: implications for cross-resistance with arsenicals.

Journal: Molecular pharmacology 20010301

Title: Antitrypanosomal properties of cis-platinum-pentamidine bromide, thiocyanate and seleniocyanate on Trypanosoma brucei brucei mouse and sheep models.

Journal: Journal of chemotherapy (Florence, Italy) 20010201

Title: A disubstituted NAD+ analogue is a nanomolar inhibitor of trypanosomal glyceraldehyde-3-phosphate dehydrogenase.

Journal: Bioorganic & medicinal chemistry letters 20010122

Title: Application of higher throughput screening (HTS) inhibition assays to evaluate the interaction of antiparasitic drugs with cytochrome P450s.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20010101

Title: [Human African trypanosomiasis from Trypanosoma brucei gambiense with inoculation chancre in a French expatriate].

Journal: Medecine tropicale : revue du Corps de sante colonial 20010101

Title: In vitro effect of diamidines on intracellular polyamines of Acanthamoeba polyphaga.

Journal: Drugs under experimental and clinical research 20010101

Title: Standardization of an in vitro drug screening assay by use of cryopreserved and characterized Pneumocystis carinii populations.

Journal: The Journal of eukaryotic microbiology 20010101

Title: Prophylactic effect of FK463, a novel antifungal lipopeptide, against Pneumocystis carinii infection in mice.

Journal: Antimicrobial agents and chemotherapy 20000901

Title: Effects of atovaquone and diospyrin-based drugs on the cellular ATP of Pneumocystis carinii f. sp. carinii.

Journal: Antimicrobial agents and chemotherapy 20000301

Title: Serum neopterin concentrations during treatment of leishmaniasis: useful as test of cure?

Journal: FEMS immunology and medical microbiology 20000101

Title: Prodrugs for amidines: synthesis and anti-Pneumocystis carinii activity of carbamates of 2,5-bis(4-amidinophenyl)furan.

Journal: Journal of medicinal chemistry 19990923

Title: Atovaquone suspension compared with aerosolized pentamidine for prevention of Pneumocystis carinii pneumonia in human immunodeficiency virus-infected subjects intolerant of trimethoprim or sulfonamides.

Journal: The Journal of infectious diseases 19990801

Title: Prognostic value of serum C-reactive protein in kala-azar.

Journal: Journal of tropical pediatrics 19990801

Title: Pentamidine is a potent inhibitor of [3H]idazoxan binding to imidazoline I2 receptors.

Journal: Annals of the New York Academy of Sciences 19990621

Title: 2,4-Diphenyl furan diamidines as novel anti-Pneumocystis carinii pneumonia agents.

Journal: Journal of medicinal chemistry 19990617

Title: Pentamidine-induced hemolytic anemia in an AIDS patient.

Journal: The Annals of pharmacotherapy 19990401

Title: [American cutaneous leishmaniasis in the Federal District].

Journal: Revista da Sociedade Brasileira de Medicina Tropical 19990101

Title: Synthesis and anti-Pneumocystis carinii pneumonia activity of novel dicationic dibenzothiophenes and orally active prodrugs.

Journal: European journal of medicinal chemistry 19990101

Title: In vitro antimicrobial activity of aromatic diamidines and diimidazolines related to pentamidine.

Journal: European journal of medicinal chemistry 19990101

Title: Structure-in vitro activity relationships of pentamidine analogues and dication-substituted bis-benzimidazoles as new antifungal agents.

Journal: Antimicrobial agents and chemotherapy 19981001

Title: Extended aromatic furan amidino derivatives as anti-Pneumocystis carinii agents.

Journal: Journal of medicinal chemistry 19980924

Title: Highly potent synthetic polyamides, bisdistamycins, and lexitropsins as inhibitors of human immunodeficiency virus type 1 integrase.

Journal: Molecular pharmacology 19980801

Title: 1,5-Bis(4-amidinophenoxy)pentane (pentamidine) is a potent inhibitor of [3H]idazoxan binding to imidazoline I2 binding sites.

Journal: European journal of pharmacology 19980717

Title: Anti-Pneumocystis activities of aromatic diamidoxime prodrugs.

Journal: Antimicrobial agents and chemotherapy 19980301

Title: 2,5-bis[4-(N-alkylamidino)phenyl]furans as anti-Pneumocystis carinii agents.

Journal: Journal of medicinal chemistry 19980101

Title: Torsades de pointes complicating pentamidine therapy of Pneumocystis carinii pneumonia in acute myelogenous leukemia.

Journal: Internal medicine (Tokyo, Japan) 19971001

Title: A prospective study of the effect of I.V. pentamidine therapy on ventricular arrhythmias and QTc prolongation in HIV-infected patients.

Journal: Chest 19970901

Title: Modulation of the Rev-RRE interaction by aromatic heterocyclic compounds.

Journal: Bioorganic & medicinal chemistry 19970601

Title: Immunodeficient and immunosuppressed mice as models to test anti-Pneumocystis carinii drugs.

Journal: Antimicrobial agents and chemotherapy 19970201

Title: A man with AIDS experiences near-syncope.

Journal: Chest 19970201

Title: [Sinus bradycardia secondary to systemic pentamidine].

Journal: Revista espanola de cardiologia 19961201

Title: Efficacy of 101 antimicrobials and other agents on the development of Cryptosporidium parvum in vitro.

Journal: Annals of tropical medicine and parasitology 19961201

Title: Treatment of New World cutaneous and mucosal leishmaniases.

Journal: Clinics in dermatology 19960101

Title: New drug developments for opportunistic infections in immunosuppressed patients: Pneumocystis carinii.

Journal: Journal of medicinal chemistry 19951124

Title: Acute severe autonomic insufficiency during pentamidine therapy.

Journal: Southern medical journal 19951001

Title: Problems in the treatment of kala-azar: case report.

Journal: East African medical journal 19950601

Title: [Macroscopic hematuria secondary to the administration of intravenous pentamidine].

Journal: Enfermedades infecciosas y microbiologia clinica 19950501

Title: Indian kala-azar caused by Leishmania tropica.

Journal: Lancet (London, England) 19950415

Title: Dicationic diarylfurans as anti-Pneumocystis carinii agents.

Journal: Journal of medicinal chemistry 19950317

Title: Successful treatment of Pneumocystis carinii Pneumonia in mice with benanomicin A (ME1451).

Journal: Antimicrobial agents and chemotherapy 19950301

Title: Effects of atovaquone and other inhibitors on Pneumocystis carinii dihydroorotate dehydrogenase.

Journal: Antimicrobial agents and chemotherapy 19950201

Title: Changes in taste associated with intravenous administration of pentamidine.

Journal: The Journal of the Association of Nurses in AIDS Care : JANAC 19950101

Title: Pentamidine congeners. 2. 2-butene-bridged aromatic diamidines and diimidazolines as potential anti-Pneumocystis carinii pneumonia agents.

Journal: Journal of medicinal chemistry 19941223

Title: Activity of terbinafine against Pneumocystis carinii in vitro and its efficacy in the treatment of experimental pneumonia.

Journal: The Journal of antimicrobial chemotherapy 19941101

Title: Torsade de pointes and elevated magnesium and calcium requirements associated with intravenous pentamidine.

Journal: Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition 19941001

Title: Relative potency of 10 drugs with anti-Pneumocystis carinii activity in an animal model.

Journal: The Journal of infectious diseases 19941001

Title: [An atrioventricular block secondary to pentamidine treatment].

Journal: Medicina clinica 19940924

Title: Effect of pentamidine on the growth of Cryptococcus neoformans.

Journal: The Journal of antimicrobial chemotherapy 19940601

Title: DNA-binding activity and biological effects of aromatic polyamidines.

Journal: Biochemical pharmacology 19940211

Title: Incidence of cardiac arrhythmias during intravenous pentamidine therapy in HIV-infected patients.

Journal: Chest 19940201

Title: Cardiac arrest after intravenous pentamidine in an infant.

Journal: The Pediatric infectious disease journal 19930801

Title: The accumulation of pentamidine and the toxic effects of the drug, its selected analogues and metabolites on isolated alveolar cells.

Journal: Toxicology 19930604

Title: Case report: pentamidine and polymorphic ventricular tachycardia revisited.

Journal: The American journal of the medical sciences 19930401

Title: Assessment of candidate anticryptosporidial agents in an immunosuppressed rat model.

Journal: The Journal of infectious diseases 19930301

Title: [Myocardial stunning during treatment with pentamidine isethionate].

Journal: Annales de medecine interne 19930101

Title: Dideoxyinosine-associated nephrotoxicity.

Journal: AIDS (London, England) 19930101

Title: Torsade de pointes after inhaled pentamidine.

Journal: Annals of emergency medicine 19921101

Title: Prolonged recurrence of pentamidine-induced torsades de pointes.

Journal: The Annals of pharmacotherapy 19921101

Title: Treatment of experimental pneumocystosis: review of 7 years of experience and development of a new system for classifying antimicrobial drugs.

Journal: Antimicrobial agents and chemotherapy 19920901

Title: Higher pentamidine levels in AIDS patients with hypoglycemia and azotemia during treatment of Pneumocystis carinii pneumonia.

Journal: The American review of respiratory disease 19920901

Title: High pentamidine levels associated with hypoglycemia and azotemia in a patient with Pneumocystis carinii pneumonia.

Journal: Diagnostic microbiology and infectious disease 19920801

Title: Hematuria associated with pentamidine therapy for Pneumocystis carinii pneumonia.

Journal: AIDS (London, England) 19920601

Title: Cardiac arrest during treatment of Pneumocystis carinii pneumonia with intravenous pentamidine isethionate.

Journal: Scandinavian journal of infectious diseases 19920101

Title: Pentamidine-associated nephrotoxicity and hyperkalemia in patients with AIDS.

Journal: DICP : the annals of pharmacotherapy 19911101

Title: [Infantile visceral leishmaniasis in Morocco. A review of 67 cases managed at the Rabat Hospital for children (1979-1988)].

Journal: Annales de pediatrie 19910901

Title: Inhibition of Cryptosporidium parvum in neonatal Hsd:(ICR)BR Swiss miceby polyether ionophores and aromatic amidines.

Journal: Antimicrobial agents and chemotherapy 19910701

Title: [Transitory acute kidney insufficiency and insulin-dependent after treatment of kala-azar with pentamidine and N-methylglucamine antimony].

Journal: Archives francaises de pediatrie 19910501

Title: Pentamidine-induced facial numbness.

Journal: Clinical pharmacy 19910401

Title: Inhibition of topoisomerases from Pneumocystis carinii by aromatic dicationic molecules.

Journal: The Journal of protozoology 19910101

Title: Treatment of experimental Pneumocystis carinii pneumonia with 1,3-di(4-imidazolino-2-methoxyphenoxy)propane lactate.

Journal: The Journal of protozoology 19910101

Title: Anti-cryptosporidial drug activity screened with an immunosuppressed rat model.

Journal: The Journal of protozoology 19910101

Title: Effects of pentamidine alone and in combination with ketoconazole or itraconazole on the growth of Candida albicans.

Journal: Antimicrobial agents and chemotherapy 19901201

Title: Ventricular tachycardia and torsades de pointes complicating pentamidine therapy of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome.

Journal: The American journal of cardiology 19901001

Title: Symptomatic hypocalcemia and hypomagnesemia with renal magnesium wasting associated with pentamidine therapy in a patient with AIDS.

Journal: The American journal of medicine 19900901

Title: Structure-activity relationships of analogs of pentamidine against Plasmodium falciparum and Leishmania mexicana amazonensis.

Journal: Antimicrobial agents and chemotherapy 19900701

Title: Reye's syndrome in adult with AIDS.

Journal: Lancet (London, England) 19900616

Title: Novel pentamidine analogs in the treatment of experimental Pneumocystis carinii pneumonia.

Journal: Antimicrobial agents and chemotherapy 19900601

Title: Analogues of 1,5-bis(4-amidinophenoxy)pentane (pentamidine) in the treatment of experimental Pneumocystis carinii pneumonia.

Journal: Journal of medicinal chemistry 19900401

Title: Pentamidine-induced torsades de pointes in a renal transplant recipient with Pneumocystis carinii pneumonia.

Journal: Southern medical journal 19900401

Title: Acute, rapidly progressive renal failure with simultaneous use of amphotericin B and pentamidine.

Journal: Antimicrobial agents and chemotherapy 19900301

Title: Renal insufficiency with nebulised pentamidine.

Journal: Lancet (London, England) 19891028

Title: Nephrotoxicity and hyperkalemia in patients with acquired immunodeficiency syndrome treated with pentamidine.

Journal: The American journal of medicine 19890901

Title: Acute renal failure after nebulised pentamidine.

Journal: Lancet (London, England) 19890603

Title: Torsades de pointes during intravenous pentamidine isethionate therapy.

Journal: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 19890115

Title: Recurrent ventricular tachycardia due to pentamidine-induced cardiotoxicity.

Journal: Chest 19881201

Title: Trimethoprim-sulfamethoxazole compared with pentamidine for treatment of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. A prospective, noncrossover study.

Journal: Annals of internal medicine 19880815

Title: Risk factors for hypoglycemia associated with pentamidine therapy for Pneumocystis pneumonia.

Journal: JAMA 19880715

Title: Tremor induced by trimethoprim-sulfamethoxazole in patients with the acquired immunodeficiency syndrome (AIDS).

Journal: Annals of internal medicine 19880701

Title: Cationic antitrypanosomal and other antimicrobial agents in the therapy of experimental Pneumocystis carinii pneumonia.

Journal: Antimicrobial agents and chemotherapy 19880601

Title: Comparison of dosages, intervals, and drugs in the prevention of Pneumocystis carinii pneumonia.

Journal: Antimicrobial agents and chemotherapy 19880501

Title: Ventricular tachycardia due to pentamidine isethionate.

Journal: The American journal of medicine 19880501

Title: Aggressive psychosis in AIDS patient on high-dose steroids.

Journal: Lancet (London, England) 19870926

Title: Torsade de pointes during administration of pentamidine isethionate.

Journal: The American journal of medicine 19870901

Title: Potent effect of trimetrexate, a lipid-soluble antifolate, on Toxoplasma gondii.

Journal: The Journal of infectious diseases 19870501

Title: Adverse reactions associated with pentamidine isethionate in AIDS patients: recommendations for monitoring therapy.

Journal: Drug intelligence & clinical pharmacy 19861101

Title: Pentamidine and hematuria.

Journal: Annals of internal medicine 19860701

Title: Hypoglycemic coma from pentamadine in an AIDS patient.

Journal: The American journal of emergency medicine 19860701

Title: Pentamidine-induced hypoglycemia in patients with the acquired immune deficiency syndrome.

Journal: Clinical pharmacology and therapeutics 19860301

Title: Pentamidine treatment of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. Association with acute renal failure and myoglobinuria.

Journal: Archives of internal medicine 19851201

Title: Extrapyramidal symptoms in AIDS patients given low-dose metoclopramide or chlorpromazine.

Journal: Lancet (London, England) 19851123

Title: Sciatic nerve damage associated with pentamidine.

Journal: Drug intelligence & clinical pharmacy 19851001

Title: Pentamidine and renal toxicity.

Journal: The New England journal of medicine 19850912

Title: Pentamidine-associated hypotension and route of administration.

Journal: Annals of internal medicine 19850901

Title: Visceral leishmaniasis unresponsive to antimonial drugs. II. Response to high dosage sodium stibogluconate or prolonged treatment with pentamidine.

Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 19850101

Title: Evaluation of diamidine compound (pentamidine isethionate) in the treatment resistant cases of kala-azar occurring in North Bihar, India.

Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 19830101

Title: Response of babesiosis to pentamidine therapy.

Journal: Annals of internal medicine 19810301

Title: Antifungal and antibacterial activities of diarylamidine derivatives.

Journal: Antimicrobial agents and chemotherapy 19800801

Title: [Nephrotoxic effect of pentamidine in the treatment of interstitial pneumonia in 2 children with acute lymphoblastic leukemia].

Journal: Ceskoslovenska pediatrie 19791201

Title: [Kidney failure during treatment of T. rhodesiense trypanosomiasis with pentamidin].

Journal: Annales de la Societe belge de medecine tropicale 19770101

Title: [Severe renal and pancreatic complications during treatment with pentamidine in African trypanosomiasis].

Journal: Annales de medecine interne 19750101

Title: Efficacy of trimethoprim and sulfamethoxazole in the prevention and treatment of Pneumocystis carinii pneumonitis.

Journal: Antimicrobial agents and chemotherapy 19740301

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Tags:100-33-4 Molecular Formula|100-33-4 MDL|100-33-4 SMILES|100-33-4 4-{[5-(4-carbamimidoylphenoxy)pentyl]oxy}benzene-1-carboximidamide