Title: SIRT1 exhibits antioxidative effects in HT22 cells induced by tert-butyl alcohol.
Journal: Environmental toxicology 20180201
Title: Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20171001
Title: Protective effects of SRT1720 via the HNF1α/FXR signalling pathway and anti-inflammatory mechanisms in mice with estrogen-induced cholestatic liver injury.
Journal: Toxicology letters 20161215
Title: Dual Targeting of CDK4 and ARK5 Using a Novel Kinase Inhibitor ON123300 Exerts Potent Anticancer Activity against Multiple Myeloma.
Journal: Cancer research 20160301
Title: Concurrent acetylation of FoxO1/3a and p53 due to sirtuins inhibition elicit Bim/PUMA mediated mitochondrial dysfunction and apoptosis in berberine-treated HepG2 cells.
Journal: Toxicology and applied pharmacology 20160115
Title: Reverse chemomodulatory effects of the SIRT1 activators resveratrol and SRT1720 in Ewing's sarcoma cells: resveratrol suppresses and SRT1720 enhances etoposide- and vincristine-induced anticancer activity.
Journal: Journal of cancer research and clinical oncology 20160101
Title: The Histone Deacetylase Sirtuin 1 Is Reduced in Systemic Sclerosis and Abrogates Fibrotic Responses by Targeting Transforming Growth Factor β Signaling.
Journal: Arthritis & rheumatology (Hoboken, N.J.) 20150501
Title: Resveratrol reduces prostaglandin E1-stimulated osteoprotegerin synthesis in osteoblasts: suppression of stress-activated protein kinase/c-Jun N-terminal kinase.
Journal: Prostaglandins & other lipid mediators 20150101
Title: Down-regulation by resveratrol of basic fibroblast growth factor-stimulated osteoprotegerin synthesis through suppression of Akt in osteoblasts.
Journal: International journal of molecular sciences 20141001
Title: Suppression by resveratrol of prostaglandin D2-stimulated osteoprotegerin synthesis in osteoblasts.
Journal: Prostaglandins, leukotrienes, and essential fatty acids 20140901
Title: Class I to III histone deacetylases differentially regulate inflammation-induced matrix metalloproteinase 9 expression in primary amnion cells.
Journal: Reproductive sciences (Thousand Oaks, Calif.) 20140601
Title: SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism.
Journal: American journal of physiology. Lung cellular and molecular physiology 20140501
Title: Resveratrol inhibits BMP-4-stimulated VEGF synthesis in osteoblasts: suppression of S6 kinase.
Journal: International journal of molecular medicine 20140401
Title: Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21.
Journal: Gastroenterology 20140201
Title: Resveratrol suppresses prostaglandin F(2α)-induced osteoprotegerin synthesis in osteoblasts: inhibition of the MAP kinase signaling.
Journal: Archives of biochemistry and biophysics 20140115
Title: Impaired SIRT1 nucleocytoplasmic shuttling in the senescent heart during ischemic stress.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20131101
Title: Sirtuin 1 activator SRT1720 suppresses inflammation in an ovalbumin-induced mouse model of asthma.
Journal: Respirology (Carlton, Vic.) 20130201
Title: Nicotinamide-induced mitophagy: event mediated by high NAD+/NADH ratio and SIRT1 protein activation.
Journal: The Journal of biological chemistry 20120601
Title: Are sirtuins viable targets for improving healthspan and lifespan?
Journal: Nature reviews. Drug discovery 20120601
Title: A patent review of sirtuin activators: an update.
Journal: Expert opinion on therapeutic patents 20120401
Title: Preclinical evaluation of a novel SIRT1 modulator SRT1720 in multiple myeloma cells.
Journal: British journal of haematology 20111201
Title: Trans-resveratrol inhibits phosphorylation of Smad2/3 and represses FSHβ gene expression by a SirT1-independent pathway in LβT2 gonadotrope cells.
Journal: Reproductive toxicology (Elmsford, N.Y.) 20110701
Title: Fructose induces gluconeogenesis and lipogenesis through a SIRT1-dependent mechanism.
Journal: The Journal of endocrinology 20110301
Title: SIRT1 is a novel regulator of key pathways of human labor.
Journal: Biology of reproduction 20110101
Title: SRT1720 improves survival and healthspan of obese mice.
Journal: Scientific reports 20110101
Title: Differential effects of resveratrol and SRT1720 on lifespan of adult Caenorhabditis elegans.
Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20101101
Title: Biochemical effects of SIRT1 activators.
Journal: Biochimica et biophysica acta 20100801
Title: Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.
Journal: Genes & development 20100701
Title: SRT1720 induces mitochondrial biogenesis and rescues mitochondrial function after oxidant injury in renal proximal tubule cells.
Journal: The Journal of pharmacology and experimental therapeutics 20100501
Title: Sirt1 activation protects the mouse renal medulla from oxidative injury.
Journal: The Journal of clinical investigation 20100401
Title: SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1.
Journal: The Journal of biological chemistry 20100312
Title: Metabolic engineering of resveratrol and other longevity boosting compounds.
Journal: BioFactors (Oxford, England) 20100101
Title: Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice.
Journal: American journal of physiology. Endocrinology and metabolism 20091101
Title: Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3.
Journal: Protein science : a publication of the Protein Society 20090301
Title: Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo.
Journal: BMC systems biology 20090101
Title: A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange.
Journal: Nature 20081113
Title: Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation.
Journal: Cell metabolism 20081101
Title: Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.
Journal: Nature 20071129
100254-21-5 | Acetamide, N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-(ethylamino)- | AA0001BF | MFCD07700891
1005201-24-0 | 1,3,4-Oxadiazole, 2-methyl-5-[3-[4-(methylsulfinyl)phenyl]-5-benzofuranyl]- | AA00025B | MFCD15528930
1007882-58-7 | 1-Pyrrolidinecarboxylic acid, 2-(1H-imidazol-2-yl)-, 1,1-dimethylethyl ester, (2S)- | AA0002SQ | MFCD16660093