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1002304-34-8,MFCD17215205
Catalog No.:AA000180

1002304-34-8 | AMG-208

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
in stock  
$12.00   $9.00
- +
5mg
98+%
in stock  
$29.00   $20.00
- +
10mg
98+%
in stock  
$43.00   $30.00
- +
25mg
98+%
in stock  
$70.00   $49.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA000180
Chemical Name:
AMG-208
CAS Number:
1002304-34-8
Molecular Formula:
C22H17N5O2
Molecular Weight:
383.4027
MDL Number:
MFCD17215205
SMILES:
COc1ccc2c(c1)nccc2OCc1nnc2n1nc(cc2)c1ccccc1
Properties
Computed Properties
 
Complexity:
531  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
6  
Rotatable Bond Count:
5  
XLogP3:
3.1  

Literature

Title: Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20091115

Title: Albrecht BK, et al. Discovery and optimization of triazolopyridazines as potent and selective inhibitors of the c-Met kinase. J Med Chem. 2008, 51(10), 2879-2882.

Title: Boezio AA, et al. Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors. Bioorg Med Chem Lett. 2009, 19(22), 6307-6312.

Title: Liu X, et al. Developing c-MET pathway inhibitors for cancer therapy: progress and challenges. Trends Mol Med. 2010,16(1), 37-45.

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SDS
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