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10024-89-2,MFCD09749953
Catalog No.:AA0001AF
10024-89-2 | Morpholine, hydrochloride (1:1)
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0001AF
Chemical Name:
Morpholine, hydrochloride (1:1)
CAS Number:
10024-89-2
Molecular Formula:
C4H10ClNO
Molecular Weight:
123.5813
MDL Number:
MFCD09749953
IUPAC Name:
morpholine;hydrochloride
InChI:
InChI=1S/C4H9NO.ClH/c1-3-6-4-2-5-1;/h5H,1-4H2;1H
InChI Key:
JXYZHMPRERWTPM-UHFFFAOYSA-N
SMILES:
C1CNCCO1.Cl
EC Number:
233-029-4
UNII:
28G373717I
Properties
Computed Properties
 
Complexity:
34.5  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
123.045g/mol
Formal Charge:
0
Heavy Atom Count:
7  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
123.58g/mol
Monoisotopic Mass:
123.045g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
21.3A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0

Synonyms
 
morpholine 
morpholine hydrochloride 
EINECS 233-029-4 
UNII-28G373717I 
28G373717I 
Morpholine HCl 
morpholine .HCl 
morpholinhydrochlorid 
morpholine HCl salt 
morphol hydrochloride 
morpholine mono HCl salt 
morpholinium hydrochloride 
morpholine hydroiodide 
SCHEMBL337059 
AC1L547N 
Morpholine hydrochloride (1:1) 
JXYZHMPRERWTPM-UHFFFAOYSA-N 
Morpholine, hydrochloride (1:1) 
KS-000000OM 
0133AA 
MFCD00035287 
AKOS015844537 
DS-4551 
morpholine phosphate 
MCULE-2533030492 
AK116221 
BC630685 
LS-93050 
SC-19184 
4CH-022117 
FT-0651753 
ST24048116 
72347-EP2298735A1 
72347-EP2308867A2 
morpholine phosphate (3:1) 
72347-EP2308870A2 
Hydrochlorid 
Morpholinumchlorid 
Morpholinium chloride 
C4H10ClNO 
Morpholine hydrochloride 1g 
4-Fluoropyridine hydrochloride 
C4-H9-N-O.Cl-H 
CID197884 
ACN-057403 
morpholine phosphonate (1:1) 
M-3056 
morpholine sulfite (1:1) 
Morpholine hydrochloride 
10024-89-2 
Morpholine, hydrochloride 
Literature

Title: Copper(I) (pseudo)halide complexes with neocuproine and aminomethylphosphines derived from morpholine and thiomorpholine - in vitro cytotoxic and antimicrobial activity and the interactions with DNA and serum albumins.

Journal: Chemical biology & drug design 20131101

Title: A mechanistic and kinetic study on the decomposition of morpholine.

Journal: The journal of physical chemistry. A 20120726

Title: Haloenol pyranones and morpholinones as antineoplastic agents of prostate cancer.

Journal: Bioorganic & medicinal chemistry letters 20120715

Title: Touch responsiveness in zebrafish requires voltage-gated calcium channel 2.1b.

Journal: Journal of neurophysiology 20120701

Title: A convenient route to optically pure α-alkyl-β-(sec-amino)alanines.

Journal: Amino acids 20120601

Title: 2-Morpholinoisoflav-3-enes as flexible intermediates in the synthesis of phenoxodiol, isophenoxodiol, equol and analogues: vasorelaxant properties, estrogen receptor binding and Rho/RhoA kinase pathway inhibition.

Journal: Bioorganic & medicinal chemistry 20120401

Title: Ultra-trace level analysis of morpholine, cyclohexylamine, and diethylaminoethanol in steam condensate by gas chromatography with multi-mode inlet, and flame ionization detection.

Journal: Journal of chromatography. A 20120316

Title: Metabolism and pharmacokinetics of morinidazole in humans: identification of diastereoisomeric morpholine N+-glucuronides catalyzed by UDP glucuronosyltransferase 1A9.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20120301

Title: Shedding light by cancer redox-human NAD(P)H:quinone oxidoreductase 1 activation of a cloaked fluorescent dye.

Journal: Chemical communications (Cambridge, England) 20111028

Title: Ceric ammonium nitrate-catalyzed azidation of 1,2-anhydro sugars: application in the synthesis of structurally diverse sugar-derived morpholine 1,2,3-triazoles and 1,4-oxazin-2-ones.

Journal: The Journal of organic chemistry 20110805

Title: Morpholine catalyzed direct C3 alkenylation of indoles with α,β-unsaturated aldehydes.

Journal: Chemical communications (Cambridge, England) 20110728

Title: Synthesis, structural elucidation, DNA-PK inhibition, homology modelling and anti-platelet activity of morpholino-substituted-1,3-naphth-oxazines.

Journal: Bioorganic & medicinal chemistry 20110701

Title: Nickel-catalyzed amination of aryl sulfamates.

Journal: Angewandte Chemie (International ed. in English) 20110225

Title: Unexpected side products in the conjugation of an amine-derivatized morpholino oligomer with p-isothiocyanate benzyl DTPA and their removal.

Journal: Nuclear medicine and biology 20110201

Title: Analyses of gene function in amphioxus embryos by microinjection of mRNAs and morpholino oligonucleotides.

Journal: Methods in molecular biology (Clifton, N.J.) 20110101

Title: [Synthesis of 2'-aminometylmorpholino nucleoside analogues containing 4'-carboxymethyl lynker group].

Journal: Bioorganicheskaia khimiia 20110101

Title: Chemical genetics approach to identify new small molecule modulators of cell growth by phenotypic screening of Saccharomyces cerevisiae strains with a library of morpholine-derived compounds.

Journal: Organic & biomolecular chemistry 20101221

Title: A nanochannel array-based electrochemical device for quantitative label-free DNA analysis.

Journal: ACS nano 20101123

Title: Synthesis of enantiopure 3-substituted morpholines.

Journal: The Journal of organic chemistry 20101105

Title: Design of more potent squalene synthase inhibitors with multiple activities.

Journal: Bioorganic & medicinal chemistry 20101101

Title: Chalcogenides of the aminomethylphosphines derived from 1-methylpiperazine, 1-ethylpiperazine and morpholine: NMR, DFT and structural studies for determination of electronic and steric properties of the phosphines.

Journal: Dalton transactions (Cambridge, England : 2003) 20100828

Title: Synthesis, electrochemical studies and anticancer activity of ferrocenyl oxindoles.

Journal: Dalton transactions (Cambridge, England : 2003) 20100821

Title: Identification of microRNA-93 as a novel regulator of vascular endothelial growth factor in hyperglycemic conditions.

Journal: The Journal of biological chemistry 20100723

Title: Acortatarins A and B, two novel antioxidative spiroalkaloids with a naturally unusual morpholine motif from Acorus tatarinowii.

Journal: Organic letters 20100416

Title: Total regioselective transformation of aromatic aziridine 2-carboxamides into 2-aminoamides promoted by active manganese.

Journal: The Journal of organic chemistry 20100402

Title: Development of an in vitro system combining aqueous and lipid phases as a tool to understand gastric nitrosation.

Journal: Rapid communications in mass spectrometry : RCM 20100315

Title: Evaluation of stereochemically dense morpholine-based scaffolds as proline surrogates in beta-turn peptides.

Journal: Organic & biomolecular chemistry 20100221

Title: One-pot synthesis of 1,3-disubstituted allenes from 1-alkynes, aldehydes, and morpholine.

Journal: Journal of the American Chemical Society 20100217

Title: Synthesis, structural characterization and antiproliferative and toxic bio-activities of copper(II) and nickel(II) citronellal N4-ethylmorpholine thiosemicarbazonates.

Journal: Journal of inorganic biochemistry 20100201

Title: Spectroscopic characterization of charge-transfer complexes of morpholine with chloranilic and picric acids in organic media: crystal structure of bis(morpholinium 2,4,6-trinitrocyclohexanolate).

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20100201

Title: Modular synthesis and in vitro and in vivo antimalarial assessment of C-10 pyrrole mannich base derivatives of artemisinin.

Journal: Journal of medicinal chemistry 20100128

Title: Discovery of 3,6-dihydro-2H-pyran as a morpholine replacement in 6-aryl-1H-pyrazolo[3,4-d]pyrimidines and 2-arylthieno[3,2-d]pyrimidines: ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR).

Journal: Bioorganic & medicinal chemistry letters 20100115

Title: Catalytic SNAr reaction of non-activated fluoroarenes with amines via Ru eta6-arene complexes.

Journal: Chemical communications (Cambridge, England) 20100114

Title: Discovery of 2-arylthieno[3,2-d]pyrimidines containing 8-oxa-3-azabi-cyclo[3.2.1]octane in the 4-position as potent inhibitors of mTOR with selectivity over PI3K.

Journal: Bioorganic & medicinal chemistry letters 20100101

Title: Novel orally active morpholine N-arylsulfonamides gamma-secretase inhibitors with low CYP 3A4 liability.

Journal: Bioorganic & medicinal chemistry letters 20091101

Title: Novel 4-(morpholin-4-yl)-N'-(arylidene)benzohydrazides: synthesis, antimycobacterial activity and QSAR investigations.

Journal: European journal of medicinal chemistry 20091001

Title: Malonyl-CoA decarboxylase inhibition is selectively cytotoxic to human breast cancer cells.

Journal: Oncogene 20090820

Title: Muscarinic receptor 1 agonist activity of novel N-aryl carboxamide substituted 3-morpholino arecoline derivatives in Alzheimer's presenile dementia models.

Journal: Bioorganic & medicinal chemistry 20090801

Title: Synthesis of some new 1,3,4-thiadiazol-2-ylmethyl-1,2,4-triazole derivatives and investigation of their antimicrobial activities.

Journal: European journal of medicinal chemistry 20090701

Title: Exploring the PI3K alpha and gamma binding sites with 2,6-disubstituted isonicotinic derivatives.

Journal: Bioorganic & medicinal chemistry letters 20090415

Title: Morpholine containing CB2 selective agonists.

Journal: Bioorganic & medicinal chemistry letters 20090315

Title: Morpholine-based RGD-cyclopentapeptides as alphavbeta3/alphavbeta5 integrin ligands: role of configuration towards receptor binding affinity.

Journal: Bioorganic & medicinal chemistry 20090215

Title: The effect of bacterial glutathione S-transferase on morpholine degradation.

Journal: Biotechnology journal 20090201

Title: Practical synthesis of a p38 MAP kinase inhibitor.

Journal: The Journal of organic chemistry 20090116

Title: Synthesis and structure-activity studies of novel homomorpholine oxazolidinone antibacterial agents.

Journal: Bioorganic & medicinal chemistry letters 20090115

Title: Bromoethylsulfonium salt--a more effective annulation agent for the synthesis of 6- and 7-membered 1,4-heterocyclic compounds.

Journal: Organic letters 20090115

Title: Intercalating, cytotoxic, antitumour activity of 8-chloro and 4-morpholinopyrimido [4',5':4,5]thieno(2,3-b)quinolines.

Journal: Journal of photochemistry and photobiology. B, Biology 20090109

Title: Quantum chemical studies for oxidation of morpholine by Cytochrome P450.

Journal: Journal of inorganic biochemistry 20090101

Title: Zebrafish dorsal root ganglia neural precursor cells adopt a glial fate in the absence of neurogenin1.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20081119

Title: Chromatographic behavior of zwitterionic enalapril-exploring the conditions for lipophilicity assessment.

Journal: Journal of pharmaceutical and biomedical analysis 20081104

Title: Design and synthesis of reboxetine analogs morpholine derivatives as selective norepinephrine reuptake inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20081015

Title: Stereoselective cyclopropanation of serine- and threonine-derived oxazines to access new morpholine-based scaffolds.

Journal: Organic & biomolecular chemistry 20080921

Title: Development of a practical Buchwald-Hartwig amine arylation protocol using a conveniently prepared (NHC)Pd(R-allyl)Cl catalyst.

Journal: Organic & biomolecular chemistry 20080807

Title: Design and synthesis of morpholine derivatives. SAR for dual serotonin & noradrenaline reuptake inhibition.

Journal: Bioorganic & medicinal chemistry letters 20080415

Title: Morpholine-based immonium and halogenoamidinium salts as coupling reagents in Peptide synthesis1.

Journal: The Journal of organic chemistry 20080404

Title: New stimuli-responsive polymers derived from morpholine and pyrrolidine.

Journal: Journal of materials science. Materials in medicine 20080401

Title: Sampling and analytical methodology development for the determination of primary and secondary low molecular weight amines in ambient air.

Journal: Journal of environmental monitoring : JEM 20080301

Title: CNS-derived glia ensheath peripheral nerves and mediate motor root development.

Journal: Nature neuroscience 20080201

Title: Evaluation of radioiodinated (2S,alphaS)-2-(alpha-(2-iodophenoxy)benzyl)morpholine as a radioligand for imaging of norepinephrine transporter in the heart.

Journal: Nuclear medicine and biology 20080201

Title: Arachidonic acid as a retrograde signal controlling growth and dynamics of retinotectal arbors.

Journal: Developmental neurobiology 20080101

Title: Isostructural materials achieved by using structurally equivalent donors and acceptors in halogen-bonded cocrystals.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20080101

Title: Spirocyclic oxetanes: synthesis and properties.

Journal: Angewandte Chemie (International ed. in English) 20080101

Title: New oligonucleotide analogues based on morpholine subunits joined by oxalyl diamide tether.

Journal: Bioorganic chemistry 20070601

Title: Convenient route to enantiopure fmoc-protected morpholine-3-carboxylic acid.

Journal: The Journal of organic chemistry 20070525

Title: Spectroscopic and kinetic evidence for an accumulating intermediate in an SNV reaction with amine nucleophiles. Reaction of methyl beta-methylthio-alpha-nitrocinnamate with piperidine and morpholine.

Journal: The Journal of organic chemistry 20070427

Title: Synthesis of novel quinolone and quinoline-2-carboxylic acid (4-morpholin-4-yl-phenyl)amides: a late-stage diversification approach to potent 5HT1B antagonists.

Journal: Bioorganic & medicinal chemistry 20070115

Title: Physiological, biochemical, and genetic characterization of an alicyclic amine-degrading Mycobacterium sp. strain THO100 isolated from a morpholine-containing culture of activated sewage sludge.

Journal: Archives of microbiology 20061101

Title: Rhodococcus sp. strain TM1 plays a synergistic role in the degradation of piperidine by Mycobacterium sp. strain THO100.

Journal: Archives of microbiology 20060901

Title: Asymmetric synthesis of 1-(2- and 3-haloalkyl)azetidin-2-ones as precursors for novel piperazine, morpholine, and 1,4-diazepane annulated beta-lactams.

Journal: The Journal of organic chemistry 20060901

Title: Nyctalopin is essential for synaptic transmission in the cone dominated zebrafish retina.

Journal: The European journal of neuroscience 20060901

Title: Asymmetric synthesis of enantioenriched (+)-elaeokanine A.

Journal: The Journal of organic chemistry 20060721

Title: Photoaddition of N-substituted piperazines to C60: an efficient approach to the synthesis of water-soluble fullerene derivatives.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20060717

Title: Palladium-catalyzed intermolecular alpha-arylation of zinc amide enolates under mild conditions.

Journal: Journal of the American Chemical Society 20060419

Title: PET modulated fluorescent sensing from the BF2 chelated azadipyrromethene platform.

Journal: Organic & biomolecular chemistry 20060307

Title: Comments on the ring-opening polymerization of morpholine-2,5-dione derivatives by various metal catalysts and characterization of the products formed in the reactions involving R2SnX2, where X = OPr(i) and NMe2 and R = Bu(n), Ph and p-Me2NC6H4.

Journal: Dalton transactions (Cambridge, England : 2003) 20060214

Title: Synthesis of new nitrogen analogues of salacinol and deoxynojirimycin and their evaluation as glycosidase inhibitors.

Journal: The Journal of organic chemistry 20060203

Title: Aminolysis of 2,4-dinitrophenyl X-substituted benzoates and Y-substituted phenyl benzoates in MeCN: effect of the reaction medium on rate and mechanism.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20060123

Title: Stress evoked by opiate withdrawal facilitates hippocampal LTP in vivo.

Journal: Hippocampus 20060101

Title: Polarization and orientation of retinal ganglion cells in vivo.

Journal: Neural development 20060101

Title: Kinetic and binding studies with purified recombinant proteins ferredoxin reductase, ferredoxin and cytochrome P450 comprising the morpholine mono-oxygenase from Mycobacterium sp. strain HE5.

Journal: The FEBS journal 20050301

Title: Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX.

Journal: Bioorganic & medicinal chemistry letters 20050117

Title: Arginine-rich peptide conjugation to morpholino oligomers: effects on antisense activity and specificity.

Journal: Bioconjugate chemistry 20050101

Title: From hydrocolloids to high specific surface area porous supports for catalysis.

Journal: Biomacromolecules 20050101

Title: Synthesis, enantiomeric resolution, and selective C-11 methylation of a highly selective radioligand for imaging the norepinephrine transporter with positron emission tomography.

Journal: Chirality 20040801

Title: Ruthenium-catalyzed anti-Markovnikov hydroamination of vinylarenes.

Journal: Journal of the American Chemical Society 20040310

Title: Role of aryl hydrocarbon receptor in mesencephalic circulation failure and apoptosis in zebrafish embryos exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20040101

Title: Molecular cloning, nucleotide sequencing and expression of genes encoding a cytochrome P450 system involved in secondary amine utilization in Mycobacterium sp. strain RP1.

Journal: Research in microbiology 20040101

Title: [Polyfunctional molecules and their components in the processes of aromatic nucleophilic substitution. II. Nucleophilic modification of 3',5'-bis-O-(alpha,beta,alpha',beta'-tetrafluoropyridyl-gamma)thymidine].

Journal: Bioorganicheskaia khimiia 20040101

Title: Interactions of novel morpholine and hexamethylene derivatives of anthracycline antibiotics with DNA.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20040101

Title: Insights into the origin of high activity and stability of catalysts derived from bulky, electron-rich monophosphinobiaryl ligands in the Pd-catalyzed C-N bond formation.

Journal: Journal of the American Chemical Society 20031119

Title: [Antithrombotic effects of morpholine and piperazine ring derivatives and their molecular mechanism].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20030901

Title: Detection of in vivo genotoxicity of endogenously formed N-nitroso compounds and suppression by ascorbic acid, teas and fruit juices.

Journal: Mutation research 20030805

Title: Rhodium-catalyzed anti-Markovnikov hydroamination of vinylarenes.

Journal: Journal of the American Chemical Society 20030514

Title: Determination of the DS and substituent distribution of cationic alkyl polyglycosides and cationic starch ethers by GLC after dealkylation with morpholine.

Journal: Carbohydrate research 20030404

Title: Trichloroacetylation of some cyclic enamines.

Journal: Chemical & pharmaceutical bulletin 20030401

Title: [Research concerning rutin semisynthetic derivatives, synthesis and pharmaco-toxicological properties of some new morpholine and piperidine derivatives].

Journal: Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20030101

Title: Enantiopure beta-hydroxy morpholine amides from terminal epoxides by carbonylation at 1 atm.

Journal: Angewandte Chemie (International ed. in English) 20021216

Title: The formation of paracetamol (acetaminophen) adducts with hydrogen-bond acceptors.

Journal: Acta crystallographica. Section B, Structural science 20021201

Title: Natural abundance nitrogen-15 nuclear magnetic resonance spectral studies on selected donors.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20021001

Title: An amino alcohol ligand for highly enantioselective addition of organozinc reagents to aldehydes: serendipity rules.

Journal: Organic letters 20020627

Title: Helicobacter pylori does not mediate the formation of carcinogenic N-nitrosamines.

Journal: Helicobacter 20020601

Title: Tumor pretargeting in mice using (99m)Tc-labeled morpholino, a DNA analog.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20020301

Title: [Influence of thyroid hormones on memory imprinting of chemical signals in early development of sturgeon Acipenser gueldenstaedti].

Journal: Zhurnal evoliutsionnoi biokhimii i fiziologii 20020101

Title: A cytochrome P450 and a ferredoxin isolated from Mycobacterium sp. strain HE5 after growth on morpholine.

Journal: Applied microbiology and biotechnology 20010801

Title: Comparison of morpholino based translational inhibition during the development of Xenopus laevis and Xenopus tropicalis.

Journal: Genesis (New York, N.Y. : 2000) 20010701

Title: Determination of morpholine in air by derivatisation with 1-naphthylisothiocyanate and HPLC analysis.

Journal: The Analyst 20010201

Title: Final report on the safety assessment of Cetethyl Morpholinium Ethosulfate.

Journal: International journal of toxicology 20010101

Title: Thiomorpholine and morpholine oxidation by a cytochrome P450 in Mycobacterium aurum MO1. Evidence of the intermediates by in situ 1H NMR.

Journal: Biodegradation 19980101

Title: [Pharmacological studies on yohimbic acid ethyl ester (A 38) and 4-=2-(p-butoxyphenyl)-1,3-dioxolan-2-ylmethyl=-morpholine methobromide (Q 160) as well as the influence of these substances on reserpine action].

Journal: Arzneimittel-Forschung 19550801

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