Home Pyridines 1005-24-9
1005-24-9,MFCD00060042
Catalog No.:AA00022Z
1005-24-9 | 3-Carbamyl-1-methylpyridinium chloride
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5g
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00022Z
Chemical Name:
3-Carbamyl-1-methylpyridinium chloride
CAS Number:
1005-24-9
Molecular Formula:
C7H9ClN2O
Molecular Weight:
172.6122
MDL Number:
MFCD00060042
IUPAC Name:
1-methylpyridin-1-ium-3-carboxamide;chloride
InChI:
InChI=1S/C7H8N2O.ClH/c1-9-4-2-3-6(5-9)7(8)10;/h2-5H,1H3,(H-,8,10);1H
InChI Key:
BWVDQVQUNNBTLK-UHFFFAOYSA-N
SMILES:
C[n+]1cccc(c1)C(=O)N.[Cl-]
EC Number:
463-670-7
UNII:
L54XNJ1D5G
Properties
Computed Properties
 
Complexity:
136  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
172.04g/mol
Formal Charge:
0
Heavy Atom Count:
11  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
172.612g/mol
Monoisotopic Mass:
172.04g/mol
Rotatable Bond Count:
1  
Topological Polar Surface Area:
47A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0

Synonyms
 
1-methyl-3-carbamoylpyridinium 
1-methylnicotinamide 
N(1)-methylnicotinamide methylsulfate 
N(1)-methylnicotinamide perchlorate 
N(1)-methylnicotinamide tetrafluoroborate (1-) 
N1-methylnicotinamide 
pyridinium, 3-(aminocarbonyl)-1-methyl- 
trigonellamide chloride 
trigonellinamide 
1005-24-9 
3-Carbamyl-1-methylpyridinium chloride 
1-Methylnicotinamide chloride 
3-(aminocarbonyl)-1-methylpyridinium 
Trigonellamide chloride 
3-carbamoyl-1-methylpyridin-1-ium chloride 
3-Carbamoyl-1-methylpyridinium chloride 
Nicotinamide methochloride 
Nipecotamide methochloride 
UNII-L54XNJ1D5G 
Nicotinamide methyl chloride 
N-Methylnicotinamide chloride 
Pyridinium, 3-(aminocarbonyl)-1-methyl-, chloride 
L54XNJ1D5G 
N(1)-methylnicotinamide 
Pyridinium, 3-carbamoyl-1-methyl-, chloride 
1-Methylpyridine-3-carboxylic acid amide chloride 
CHEMBL1209652 
1-methylpyridin-1-ium-3-carboxamide 
Nicotinamide Chloromethylate 
TRIA-662 
AC1Q1SDR 
ACMC-1BO3W 
AC1L2E7K 
SCHEMBL5145685 
N(1)-methylnicotinamide bromide 
EINECS 213-901-0 
ANW-14309 
MFCD00060042 
3-Carbamyl-1-methylpyridiniumChloride 
AKOS003368476 
VZ26532 
BC229164 
CC-14579 
LS-132155 
TC-103054 
N(1)-methylnicotinamide chloride 
FT-0633234 
M0375 
1-methylpyridin-1-ium-3-carboxamide chloride 
KS-00001241 
1-Methylnicotinamide chloride, analytical standard 
C-05644 
Pyridinium, 3-(aminocarbonyl)-1-methyl-, chloride (1:1) 
Pyridinium, 3-(aminocarbonyl)-1-methyl-,chloride (1:1) 
1-Methyl-2-(3-(1-methylnaphtho(1,2-d)thiazol-2(1H)-ylidene)-2-phenyl-1-propenyl)naphtho(1,2-d)thiazolium chloride 
n1-methylnicotinamide chloride 
N(1)-methylnicotinamide cyanide 
C7-H9-N2-O.Cl 
CID70495 
AR-1K7310 
3-(Aminocarbonyl)-1-methylpyridinium chloride 
1063-92-9 
5451-61-6 
Naphtho(1,2-d)thiazolium, 1-methyl-2-(3-(1-methylnaphtho(1,2-d)thiazol-2(1H)-ylidene)-2-phenyl-1-propen-1-yl)-, chloride (1:1) 
Naphtho(1,2-d)thiazolium, 1-methyl-2-(3-(1-methylnaphtho(1,2-d)thiazol-2(1H)-ylidene)-2-phenyl-1-propenyl)-, chloride 
N(1)-methylnicotinamide fluoride 
N(1)-methylnicotinamide iodide 
N(1)-methylnicotinamide iodide, 3-(aminocarbonyl-13C)-labeled 
Literature

Title: N-Methyl-2-pyridone-5-carboxamide is 1-methylnicotinamide metabolite of low cyclooxygenase-dependent vasodilating activity.

Journal: Journal of physiology and biochemistry 20120901

Title: Toxic effects of nicotinamide methylation on mouse brain striatum neuronal cells and its relation to manganese.

Journal: Environmental health and preventive medicine 20120901

Title: Excess nicotinamide inhibits methylation-mediated degradation of catecholamines in normotensives and hypertensives.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20120201

Title: Effects of N1-methylnicotinamide on oxidative and glycooxidative stress markers in rats with streptozotocin-induced diabetes mellitus.

Journal: Redox report : communications in free radical research 20120101

Title: Developmental changes of aldehyde oxidase activity and protein expression in human liver cytosol.

Journal: Drug metabolism and pharmacokinetics 20120101

Title: Decreased skin-mediated detoxification contributes to oxidative stress and insulin resistance.

Journal: Experimental diabetes research 20120101

Title: The expression of nicotinamide N-methyltransferase increases ATP synthesis and protects SH-SY5Y neuroblastoma cells against the toxicity of Complex I inhibitors.

Journal: The Biochemical journal 20110515

Title: ¹H nuclear magnetic resonance based metabolic urinary profiling of patients with ischemic heart failure.

Journal: Clinical biochemistry 20110301

Title: Effect of tea beverages on aldehyde oxidase activity.

Journal: Drug metabolism and pharmacokinetics 20110101

Title: Effects of 1-methylnicotinamide and its metabolite N-methyl-2-pyridone-5-carboxamide on streptozotocin-induced toxicity in murine insulinoma MIN6 cell line.

Journal: Acta biochimica Polonica 20110101

Title: Effect of selected NAD+ analogues on mitochondria activity and proliferation of endothelial EA.hy926 cells.

Journal: European journal of pharmacology 20100825

Title: 1-methylnicotinamide effects on the selected markers of endothelial function, inflammation and haemostasis in diabetic rats.

Journal: European journal of pharmacology 20100825

Title: 3-D-QSAR and docking studies on the neuronal choline transporter.

Journal: Bioorganic & medicinal chemistry letters 20100815

Title: [Effect of 1-methylnicotinamide on prooxidant-antioxidant balance parameters in rats during hepatic ischemia-reperfusion].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20100401

Title: 1-methylnicotinamide (MNA) in prevention of diabetes-associated brain disorders.

Journal: Neurochemistry international 20100101

Title: Nicotinamide N-methyltransferase (NNMT) and 1-methylnicotinamide (MNA) in experimental hepatitis induced by concanavalin A in the mouse.

Journal: Pharmacological reports : PR 20100101

Title: Effect of nicotinamide and its two derivatives on the generation of reactive oxygen species in human monocytes cooperating with platelets.

Journal: Acta poloniae pharmaceutica 20100101

Title: Nicotinamide overload may play a role in the development of type 2 diabetes.

Journal: World journal of gastroenterology 20091207

Title: Adipose tissue as a source of nicotinamide N-methyltransferase and homocysteine.

Journal: Atherosclerosis 20090601

Title: Activation of nicotinamide N-methyltrasferase and increased formation of 1-methylnicotinamide (MNA) in atherosclerosis.

Journal: Pharmacological reports : PR 20090101

Title: Anti-diabetic effects of 1-methylnicotinamide (MNA) in streptozocin-induced diabetes in rats.

Journal: Pharmacological reports : PR 20090101

Title: Matrix metaloproteinases activity during the evolution of hypoxic-ischemic brain damage in the immature rat. The effect of 1-methylnicotinamide (MNA).

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20080901

Title: Aldehyde oxidase-catalyzed metabolism of N1-methylnicotinamide in vivo and in vitro in chimeric mice with humanized liver.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20080701

Title: Therapeutic potential of 1-methylnicotinamide against acute gastric lesions induced by stress: role of endogenous prostacyclin and sensory nerves.

Journal: The Journal of pharmacology and experimental therapeutics 20080701

Title: 1-Methylnicotinamide and nicotinamide: two related anti-inflammatory agents that differentially affect the functions of activated macrophages.

Journal: Archivum immunologiae et therapiae experimentalis 20080401

Title: Anti-inflammatory effect of 1-methylnicotinamide in contact hypersensitivity to oxazolone in mice; involvement of prostacyclin.

Journal: European journal of pharmacology 20080114

Title: 1-Methylnicotinamide (MNA) prevents endothelial dysfunction in hypertriglyceridemic and diabetic rats.

Journal: Pharmacological reports : PR 20080101

Title: Neuroprotective effects of nicotinamide and 1-methylnicotinamide in acute excitotoxicity in vitro.

Journal: Folia neuropathologica 20080101

Title: Nicotinamide and 1-methylnicotinamide reduce homocysteine neurotoxicity in primary cultures of rat cerebellar granule cells.

Journal: Acta neurobiologiae experimentalis 20080101

Title: 1-Methylnicotinamide stimulates cell growth and inhibits hemoglobin synthesis in differentiating murine erythroleukemia cells.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20071201

Title: 1-Methylnicotinamide (MNA), a primary metabolite of nicotinamide, exerts anti-thrombotic activity mediated by a cyclooxygenase-2/prostacyclin pathway.

Journal: British journal of pharmacology 20070901

Title: Developmental changes of aldehyde oxidase in postnatal rat liver.

Journal: Drug metabolism and pharmacokinetics 20070401

Title: Metabolites of the radiosensitizer nicotinamide are unlikely to contribute to the degree of emesis observed with the parent drug.

Journal: Oncology research 20070101

Title: Spectrofluorimetric determination of drugs containing active methylene group using N1-methyl nicotinamide chloride as a fluorigenic agent.

Journal: Chemical & pharmaceutical bulletin 20060701

Title: Estimation of aldehyde oxidase activity in vivo from conversion ratio of N1-methylnicotinamide to pyridones, and intraspecies variation of the enzyme activity in rats.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20060201

Title: Search for drugs of the combined anti-inflammatory and anti-bacterial properties: 1-methyl-N'-(hydroxymethyl)nicotinamide.

Journal: Pharmacological reports : PR 20060101

Title: [The effect of magnesium pool isotopy on reactivation of mitochondrial ATP synthesis suppressed by 1-methyl-nicotine amide].

Journal: Biomeditsinskaia khimiia 20060101

Title: Topical application of 1-methylnicotinamide in the treatment of rosacea: a pilot study.

Journal: Clinical and experimental dermatology 20051101

Title: Quantitation of the niacin metabolites 1-methylnicotinamide and l-methyl-2-pyridone-5-carboxamide in random spot urine samples, by ion-pairing reverse-phase HPLC with UV detection, and the implications for the use of spot urine samples in the assessment of niacin status.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050325

Title: Spectrofluorimetric determination of warfarin sodium by using N1-methylnicotinamide chloride as a fluorigenic agent.

Journal: Journal of AOAC International 20050101

Title: 1-Methylnicotinamide: a potent anti-inflammatory agent of vitamin origin.

Journal: Polish journal of pharmacology 20030101

Title: Potential urinary and plasma biomarkers of peroxisome proliferation in the rat: identification of N-methylnicotinamide and N-methyl-4-pyridone-3-carboxamide by 1H nuclear magnetic resonance and high performance liquid chromatography.

Journal: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20030101

Title: [Elucidation of paraquat poisoning mechanism and development of the neuronal death model].

Journal: Nihon eiseigaku zasshi. Japanese journal of hygiene 20020401

Title: Possible role of 1-methylnicotinamide in the pathogenesis of Parkinson's disease.

Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20020201

Title: Rapid calmodulin-dependent interdomain electron transfer in neuronal nitric-oxide synthase measured by pulse radiolysis.

Journal: The Journal of biological chemistry 20011026

Title: Validation of an HPLC method for the determination of urinary and plasma levels of N1-methylnicotinamide, an endogenous marker of renal cationic transport and plasma flow.

Journal: Journal of pharmaceutical and biomedical analysis 20010101

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