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Catalog No.:AA00022Z

1005-24-9 | 3-Carbamyl-1-methylpyridinium chloride

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  • Technical Information
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Technical Information
Catalog Number:
Chemical Name:
3-Carbamyl-1-methylpyridinium chloride
CAS Number:
Molecular Formula:
Molecular Weight:
MDL Number:
207-209℃ (water acetone )  
H2O: soluble15mg/mL, clear  
Inert atmosphere;Room Temperature;  

Computed Properties
Covalently-Bonded Unit Count:
Heavy Atom Count:
Hydrogen Bond Acceptor Count:
Hydrogen Bond Donor Count:
Rotatable Bond Count:


Title: N-Methyl-2-pyridone-5-carboxamide is 1-methylnicotinamide metabolite of low cyclooxygenase-dependent vasodilating activity.

Journal: Journal of physiology and biochemistry 20120901

Title: Toxic effects of nicotinamide methylation on mouse brain striatum neuronal cells and its relation to manganese.

Journal: Environmental health and preventive medicine 20120901

Title: Excess nicotinamide inhibits methylation-mediated degradation of catecholamines in normotensives and hypertensives.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20120201

Title: Effects of N1-methylnicotinamide on oxidative and glycooxidative stress markers in rats with streptozotocin-induced diabetes mellitus.

Journal: Redox report : communications in free radical research 20120101

Title: Developmental changes of aldehyde oxidase activity and protein expression in human liver cytosol.

Journal: Drug metabolism and pharmacokinetics 20120101

Title: Decreased skin-mediated detoxification contributes to oxidative stress and insulin resistance.

Journal: Experimental diabetes research 20120101

Title: The expression of nicotinamide N-methyltransferase increases ATP synthesis and protects SH-SY5Y neuroblastoma cells against the toxicity of Complex I inhibitors.

Journal: The Biochemical journal 20110515

Title: ¹H nuclear magnetic resonance based metabolic urinary profiling of patients with ischemic heart failure.

Journal: Clinical biochemistry 20110301

Title: Effect of tea beverages on aldehyde oxidase activity.

Journal: Drug metabolism and pharmacokinetics 20110101

Title: Effects of 1-methylnicotinamide and its metabolite N-methyl-2-pyridone-5-carboxamide on streptozotocin-induced toxicity in murine insulinoma MIN6 cell line.

Journal: Acta biochimica Polonica 20110101

Title: Effect of selected NAD+ analogues on mitochondria activity and proliferation of endothelial EA.hy926 cells.

Journal: European journal of pharmacology 20100825

Title: 1-methylnicotinamide effects on the selected markers of endothelial function, inflammation and haemostasis in diabetic rats.

Journal: European journal of pharmacology 20100825

Title: 3-D-QSAR and docking studies on the neuronal choline transporter.

Journal: Bioorganic & medicinal chemistry letters 20100815

Title: [Effect of 1-methylnicotinamide on prooxidant-antioxidant balance parameters in rats during hepatic ischemia-reperfusion].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20100401

Title: 1-methylnicotinamide (MNA) in prevention of diabetes-associated brain disorders.

Journal: Neurochemistry international 20100101

Title: Nicotinamide N-methyltransferase (NNMT) and 1-methylnicotinamide (MNA) in experimental hepatitis induced by concanavalin A in the mouse.

Journal: Pharmacological reports : PR 20100101

Title: Effect of nicotinamide and its two derivatives on the generation of reactive oxygen species in human monocytes cooperating with platelets.

Journal: Acta poloniae pharmaceutica 20100101

Title: Nicotinamide overload may play a role in the development of type 2 diabetes.

Journal: World journal of gastroenterology 20091207

Title: Adipose tissue as a source of nicotinamide N-methyltransferase and homocysteine.

Journal: Atherosclerosis 20090601

Title: Activation of nicotinamide N-methyltrasferase and increased formation of 1-methylnicotinamide (MNA) in atherosclerosis.

Journal: Pharmacological reports : PR 20090101

Title: Anti-diabetic effects of 1-methylnicotinamide (MNA) in streptozocin-induced diabetes in rats.

Journal: Pharmacological reports : PR 20090101

Title: Matrix metaloproteinases activity during the evolution of hypoxic-ischemic brain damage in the immature rat. The effect of 1-methylnicotinamide (MNA).

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20080901

Title: Aldehyde oxidase-catalyzed metabolism of N1-methylnicotinamide in vivo and in vitro in chimeric mice with humanized liver.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20080701

Title: Therapeutic potential of 1-methylnicotinamide against acute gastric lesions induced by stress: role of endogenous prostacyclin and sensory nerves.

Journal: The Journal of pharmacology and experimental therapeutics 20080701

Title: 1-Methylnicotinamide and nicotinamide: two related anti-inflammatory agents that differentially affect the functions of activated macrophages.

Journal: Archivum immunologiae et therapiae experimentalis 20080401

Title: Anti-inflammatory effect of 1-methylnicotinamide in contact hypersensitivity to oxazolone in mice; involvement of prostacyclin.

Journal: European journal of pharmacology 20080114

Title: 1-Methylnicotinamide (MNA) prevents endothelial dysfunction in hypertriglyceridemic and diabetic rats.

Journal: Pharmacological reports : PR 20080101

Title: Neuroprotective effects of nicotinamide and 1-methylnicotinamide in acute excitotoxicity in vitro.

Journal: Folia neuropathologica 20080101

Title: Nicotinamide and 1-methylnicotinamide reduce homocysteine neurotoxicity in primary cultures of rat cerebellar granule cells.

Journal: Acta neurobiologiae experimentalis 20080101

Title: 1-Methylnicotinamide stimulates cell growth and inhibits hemoglobin synthesis in differentiating murine erythroleukemia cells.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20071201

Title: 1-Methylnicotinamide (MNA), a primary metabolite of nicotinamide, exerts anti-thrombotic activity mediated by a cyclooxygenase-2/prostacyclin pathway.

Journal: British journal of pharmacology 20070901

Title: Developmental changes of aldehyde oxidase in postnatal rat liver.

Journal: Drug metabolism and pharmacokinetics 20070401

Title: Metabolites of the radiosensitizer nicotinamide are unlikely to contribute to the degree of emesis observed with the parent drug.

Journal: Oncology research 20070101

Title: Spectrofluorimetric determination of drugs containing active methylene group using N1-methyl nicotinamide chloride as a fluorigenic agent.

Journal: Chemical & pharmaceutical bulletin 20060701

Title: Estimation of aldehyde oxidase activity in vivo from conversion ratio of N1-methylnicotinamide to pyridones, and intraspecies variation of the enzyme activity in rats.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20060201

Title: Search for drugs of the combined anti-inflammatory and anti-bacterial properties: 1-methyl-N'-(hydroxymethyl)nicotinamide.

Journal: Pharmacological reports : PR 20060101

Title: [The effect of magnesium pool isotopy on reactivation of mitochondrial ATP synthesis suppressed by 1-methyl-nicotine amide].

Journal: Biomeditsinskaia khimiia 20060101

Title: Topical application of 1-methylnicotinamide in the treatment of rosacea: a pilot study.

Journal: Clinical and experimental dermatology 20051101

Title: Quantitation of the niacin metabolites 1-methylnicotinamide and l-methyl-2-pyridone-5-carboxamide in random spot urine samples, by ion-pairing reverse-phase HPLC with UV detection, and the implications for the use of spot urine samples in the assessment of niacin status.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050325

Title: Spectrofluorimetric determination of warfarin sodium by using N1-methylnicotinamide chloride as a fluorigenic agent.

Journal: Journal of AOAC International 20050101

Title: 1-Methylnicotinamide: a potent anti-inflammatory agent of vitamin origin.

Journal: Polish journal of pharmacology 20030101

Title: Potential urinary and plasma biomarkers of peroxisome proliferation in the rat: identification of N-methylnicotinamide and N-methyl-4-pyridone-3-carboxamide by 1H nuclear magnetic resonance and high performance liquid chromatography.

Journal: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20030101

Title: [Elucidation of paraquat poisoning mechanism and development of the neuronal death model].

Journal: Nihon eiseigaku zasshi. Japanese journal of hygiene 20020401

Title: Possible role of 1-methylnicotinamide in the pathogenesis of Parkinson's disease.

Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20020201

Title: Rapid calmodulin-dependent interdomain electron transfer in neuronal nitric-oxide synthase measured by pulse radiolysis.

Journal: The Journal of biological chemistry 20011026

Title: Validation of an HPLC method for the determination of urinary and plasma levels of N1-methylnicotinamide, an endogenous marker of renal cationic transport and plasma flow.

Journal: Journal of pharmaceutical and biomedical analysis 20010101

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