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100643-71-8,MFCD00871949
Catalog No.:AA0002HH
100643-71-8 | 13-chloro-2-(piperidin-4-ylidene)-4-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaene
Pack Size
Purity
Availability
Price(USD)
Quantity
  
1g
98%
in stock  
$15.00   $10.00
- +
10g
98%
in stock  
$129.00   $90.00
- +
25g
98%
in stock  
$258.00   $180.00
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  • Technical Information
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Technical Information
Catalog Number:
AA0002HH
Chemical Name:
13-chloro-2-(piperidin-4-ylidene)-4-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaene
CAS Number:
100643-71-8
Molecular Formula:
C19H19ClN2
Molecular Weight:
310.8206
MDL Number:
MFCD00871949
IUPAC Name:
13-chloro-2-piperidin-4-ylidene-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaene
InChI:
InChI=1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2
InChI Key:
JAUOIFJMECXRGI-UHFFFAOYSA-N
SMILES:
Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1
UNII:
FVF865388R
Properties
Computed Properties
 
Complexity:
425  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
310.124g/mol
Formal Charge:
0
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
310.825g/mol
Monoisotopic Mass:
310.124g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
24.9A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4.5  

Synonyms
 
Aerius 
Clarinex 
Clarinex 
KS-1048 
MCULE-2975958622 
NC00412 
NSC 675447 
NSC-675447 
NSC-759824 
SB17503 
Desloratadine, powder, >=98% (HPLC) 
NCGC00159325-03 
NCGC00159325-04 
Descarboethoxyloratadine 
NCGC00159325-05 
AN-15105 
BC205533 
CC-26349 
SAM001246545 
SC-17296 
SBI-0206828.P001 
AB0012600 
LS-181814 
RT-012269 
Neoclarityn 
TL8000065 
D3787 
FT-0602522 
R3930 
ST24046429 
SW197792-3 
A19515 
D03693 
J10309 
AB00456701-11 
Sch-34117 
AB00456701-13 
AB00456701_14 
AB00456701_15 
643D718 
C-19255 
L001025 
I06-1866 
SR-01000668962-4 
SR-01000668962-5 
SR-01000668962-8 
Aerius 
BRD-K82357231-001-13-4 
Desloratadine, European Pharmacopoeia (EP) Reference Standard 
Desloratadine, United States Pharmacopeia (USP) Reference Standard 
4-(8-chloro-5,6-dihydro-11 H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine 
4-(8-chloro-5,6-dihydro-11H-benzo-[5,6]cyclohepta(1,2-b]pyridin-11-ylidene)-piperidine 
4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta [1,2-b]pyridin-11-ylidene) piperidine 
4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene) piperidine 
5H-Benzo(5,6)cyclohepta(1,2-b)pyridine,8-chloro-6,11-dihydro-11-(4-piperidinyllidene)- 
8-chloro-11-(4-piperidyliden)-6,11-dihydro-5H-benzo[5,6]cyclohepta [1,2-b]pyridine 
8-chloro-11-(4-piperidyliden)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine 
Azomyr 
8-chloro-11-(4-piperidylidene)-6,11-dihydro-5h-benzo[5.6]cyclohepta[1,2-b]pyridine 
8-chloro-6,11-dihydro-11-(4-piperdinylidene)-5h-benzo[5,6]cyclohepta[1,2-b]pyridine 
8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H- benzo[5,6]cyclohepta[1,2,b]pyridine 
8-chloro-6,11-dihydro-11-(4-piperidylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine 
Desloratadine for system suitability, European Pharmacopoeia (EP) Reference Standard 
Desloratidine, Pharmaceutical Secondary Standard; Certified Reference Material 
Loratadine Related Compound A, United States Pharmacopeia (USP) Reference Standard 
13-chloro-2-(piperidin-4-ylidene)-4-azatricyclo[9.4.0.0;{3,8}]pentadeca-1(11),3,5,7,12,14-hexaene 
8-CHLORO-11-(4-PIPERIDYLIDENE)-6,11-DIHYDRO-5H-BENZO[5,6]CYCLOHEPTA[1,2-b]PYRIDINE 
8-Chloro-11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine (Descarboethoxyloratadine; Desloratadine) 
Desloratidine 
delopedil 
Claritin 
Claritin-D 
Claramax (TN) 
NeoClarityn (TN) 
Aerius (TN) 
Desloratadine Actavis 
descarboethoxyloratidine 
D01GBY 
Desloratadine (USAN/INN) 
Denosin 
Essex brand of desloratadine 
Deoxycholic acid, sodium salt 
descarboethoxyloratadine acetate 
Schering brand of desloratadine 
C19-H19-Cl-N2 
Desloratadine, 98% - 1G 1g 
CID124087 
Schering-Plough brand of desloratadine 
ACN-046380 
BCP9000599 
Sch 34117 
CS-O-00556 
B1571 
C121345 
5h-benzo[5,6]ciclohepta[1,2-b]piridina, 8-cloro-6,11-dihidro-11-(4-piperidinilideno)- 
DCL 
Descarboethoxyoratidine 
descarboethoxyloratadine 
Clarinex RediTabs 
8-Chloro-11-piperidin-4-ylidene-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine 
UNII-FVF865388R 
MFCD00871949 
CHEMBL1172 
MLS000559042 
CHEBI:291342 
JAUOIFJMECXRGI-UHFFFAOYSA-N 
FVF865388R 
8-chloro-11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine 
descarboethoxyloratadine acetate 
8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo(5,6)cyclohepta(1,2-b)pyridine 
NCGC00159325-02 
AK163520 
CPD000149358 
SMR000149358 
Opulis 
Allex 
5H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 8-chloro-6,11-dihydro-11-(4-piperidinylidene)- 
8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine 
DSSTox_CID_24196 
desloratadine 
DSSTox_RID_80112 
DSSTox_GSID_44196 
C19H19ClN2 
Q-200936 
Desloratadine [USAN] 
Claramax 
Desalex 
5H-Benzo(5,6)cyclohepta(1,2-b)pyridine, 8-chloro-6,11-dihydro-11-(4-piperidinylidene)- 
8-chloro-11-piperidin-4-ylidene-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridine 
Clarinex (TN) 
Neoclarityn 
CAS-100643-71-8 
SR-01000668962 
Desloratadine [USAN:INN:BAN] 
Clarinex(R) 
4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta(1,2-b]pyridin-11-ylidene)-piperidine 
4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine 
4-{8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene}-piperidine 
4-{8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene}piperidine 
MK-4117 
AC1L3XUD 
SCH 34117 
Opera_ID_1891 
SCHEMBL4425 
MLS000759406 
MLS001201801 
MLS001424247 
BEN691 
GTPL7157 
ZINC1261 
Desloratadine (JAN/USAN/INN) 
DTXSID1044196 
SCH-34117 
CTK8B3353 
HMS2052H05 
HMS2090C06 
HMS2093F19 
HMS3394H05 
HMS3652O15 
HMS3715J15 
Pharmakon1600-01505393 
ALBB-027276 
BCP02340 
Desloratadine 
HY-B0539 
KS-00000G0C 
ZX-AN025785 
Tox21_111574 
ANW-42359 
BBL010777 
BDBM50073179 
BG0513 
CD0143 
NSC675447 
100643-71-8 
NSC759824 
s4012 
STK586537 
AKOS000280921 
Tox21_111574_1 
AC-1279 
API0002262 
CCG-101162 
CS-2639 
DB00967 
Literature

Title: Why are most phospholipidosis inducers also hERG blockers?

Journal: Archives of toxicology 20171201

Title: Elucidating mechanisms of toxicity using phenotypic data from primary human cell systems--a chemical biology approach for thrombosis-related side effects.

Journal: International journal of molecular sciences 20150101

Title: Loratadine and analogues: discovery and preliminary structure-activity relationship of inhibitors of the amino acid transporter B(0)AT2.

Journal: Journal of medicinal chemistry 20141126

Title: Mrp2 is involved in the efflux and disposition of fosinopril.

Journal: Journal of applied toxicology : JAT 20130601

Title: Design, synthesis and antihistamine evaluations of several N-hydroxyalkyl desloratadine analogues.

Journal: Medicinal chemistry (Shariqah (United Arab Emirates)) 20121101

Title: Solubility enhancement of desloratadine by solid dispersion in poloxamers.

Journal: International journal of pharmaceutics 20121015

Title: Synthesis and biological evaluation of cyanoguanidine derivatives of loratadine.

Journal: Bioorganic & medicinal chemistry letters 20121001

Title: H(1)-antihistamines and urticaria: how can we predict the best drug for our patient?

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20121001

Title: In with the new: the determinants of prescribing innovation by general practitioners in Ireland.

Journal: The European journal of health economics : HEPAC : health economics in prevention and care 20120801

Title: Severe ranitidine-induced anaphylaxis: a case report and literature review.

Journal: Journal of clinical pharmacy and therapeutics 20120801

Title: Bilastine: in allergic rhinitis and urticaria.

Journal: Drugs 20120618

Title: The impact of P-glycoprotein mediated efflux on absorption of 11 sedating and less-sedating antihistamines using Caco-2 monolayers.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20120601

Title: Uremic pruritus in hemodialysis patients: treatment with desloratidine versus gabapentin.

Journal: Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia 20120601

Title: Critical temperature threshold measurement for cold urticaria: a randomized controlled trial of H(1) -antihistamine dose escalation.

Journal: The British journal of dermatology 20120501

Title: Design and synthesis of thiourea derivatives containing a benzo[5,6]cyclohepta[1,2-b]pyridine moiety as potential antitumor and anti-inflammatory agents.

Journal: Bioorganic & medicinal chemistry letters 20120415

Title: A randomized, double-blind, placebo-controlled study of the safety and tolerance of regadenoson in subjects with stage 3 or 4 chronic kidney disease.

Journal: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 20120401

Title: Management of chronic urticaria in Asia: 2010 AADV consensus guidelines.

Journal: Asia Pacific allergy 20120401

Title: [Observation on therapy efficacy of external auditory canal eczema by treatment of compound betamethasone and benzathine penicillin].

Journal: Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery 20120401

Title: Establishing the place in therapy of bilastine in the treatment of allergic rhinitis according to ARIA: evidence review.

Journal: Current medical research and opinion 20120101

Title: Urticaria and its subtypes: the role of second-generation antihistamines.

Journal: European journal of internal medicine 20120101

Title: [Facial angioedema following hyaluronic acid injection].

Journal: Annales de dermatologie et de venereologie 20120101

Title: Immunological characterization and transcription profiling of peripheral blood (PB) monocytes in children with autism spectrum disorders (ASD) and specific polysaccharide antibody deficiency (SPAD): case study.

Journal: Journal of neuroinflammation 20120101

Title: Prevalence of desloratadine poor metabolizer phenotype in healthy Jordanian males.

Journal: Biopharmaceutics & drug disposition 20120101

Title: Trends in qualifying biomarkers in drug safety. Consensus of the 2011 meeting of the spanish society of clinical pharmacology.

Journal: Frontiers in pharmacology 20120101

Title: A Validated Stability-Indicating RP-UPLC Method for Simultaneous Determination of Desloratadine and Sodium Benzoate in Oral Liquid Pharmaceutical Formulations.

Journal: Scientia pharmaceutica 20120101

Title: Histamine H1 antagonists and clinical characteristics of febrile seizures.

Journal: International journal of general medicine 20120101

Title: Recurrent facial urticaria following herpes simplex labialis.

Journal: Indian journal of dermatology 20120101

Title: A review of antihistamines used during pregnancy.

Journal: Journal of pharmacology & pharmacotherapeutics 20120101

Title: Bilateral scaly plaques in axillae: pityriasis rosea of Vidal.

Journal: Skinmed 20120101

Title: Clemastine causes immune suppression through inhibition of extracellular signal-regulated kinase-dependent proinflammatory cytokines.

Journal: The Journal of allergy and clinical immunology 20111201

Title: Second-generation H1-antihistamines in chronic urticaria: an evidence-based review.

Journal: American journal of clinical dermatology 20111201

Title: Rupatadine and levocetirizine in chronic idiopathic urticaria: a comparative study of efficacy and safety.

Journal: Journal of drugs in dermatology : JDD 20111201

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: Fexofenadine-induced urticaria.

Journal: Annals of dermatology 20111201

Title: Efficacy of second-generation antihistamines in patients with allergic rhinitis and comorbid asthma.

Journal: The Journal of asthma : official journal of the Association for the Care of Asthma 20111101

Title: Monoterpenes isolated from Minthostachys verticillata (Griseb.) Epling essential oil modulates immediate-type hypersensitivity responses in vitro and in vivo.

Journal: Planta medica 20111001

Title: Subcutaneous immunotherapy and pharmacotherapy in seasonal allergic rhinitis: a comparison based on meta-analyses.

Journal: The Journal of allergy and clinical immunology 20111001

Title: Rhinitis in children less than 6 years of age: current knowledge and challenges.

Journal: Asia Pacific allergy 20111001

Title: Pharmacokinetic evaluation of levocetirizine.

Journal: Expert opinion on drug metabolism & toxicology 20110801

Title: Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.

Journal: Journal of medicinal chemistry 20110714

Title: Intranasal steroids or radiofrequency turbinoplasty in persistent allergic rhinitis: effects on quality of life and objective parameters.

Journal: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20110601

Title: Petasol butenoate complex (Ze 339) relieves allergic rhinitis-induced nasal obstruction more effectively than desloratadine.

Journal: The Journal of allergy and clinical immunology 20110601

Title: Mastocytic enterocolitis as a rare cause of chronic diarrhea in a patient with rheumatoid arthritis.

Journal: Wiener klinische Wochenschrift 20110501

Title: The discovery of phthalazinone-based human H1 and H3 single-ligand antagonists suitable for intranasal administration for the treatment of allergic rhinitis.

Journal: Journal of medicinal chemistry 20110414

Title: Therapeutic effects of fermented red ginseng in allergic rhinitis: a randomized, double-blind, placebo-controlled study.

Journal: Allergy, asthma & immunology research 20110401

Title: Bilastine for the relief of allergy symptoms.

Journal: Drugs of today (Barcelona, Spain : 1998) 20110401

Title: Positive basophil activation test result in a patient with acute urticaria induced by cetirizine and desloratadine.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20110301

Title: Chronic idiopathic urticaria in Taiwan: a clinical study of demographics, aggravating factors, laboratory findings, serum autoreactivity and treatment response.

Journal: Journal of the Formosan Medical Association = Taiwan yi zhi 20110301

Title: Involvement of 5-lipoxygenase in the corticosteroid-dependent amyloid beta formation: in vitro and in vivo evidence.

Journal: PloS one 20110101

Title: Effects of antihistamines on innate immune responses to severe bacterial infection in mice.

Journal: International archives of allergy and immunology 20110101

Title: Mometasone and desloratadine additive effect on eosinophil survival and cytokine secretion from epithelial cells.

Journal: Respiratory research 20110101

Title: Assessment of efficacy and impact on work productivity and attendance after a mandatory switch to generic second-generation antihistamines: results of a patient survey in Norway.

Journal: Clinical and molecular allergy : CMA 20110101

Title: Treatment trends in allergic rhinitis and asthma: a British ENT survey.

Journal: BMC ear, nose, and throat disorders 20110101

Title: Stability-indicating micelle-enhanced spectrofluorimetric method for determination of loratadine and desloratadine in dosage forms.

Journal: Luminescence : the journal of biological and chemical luminescence 20110101

Title: Combination treatment of mice with CRx-153 (nortriptyline and desloratadine) decreases the severity of experimental autoimmune encephalomyelitis.

Journal: Cellular immunology 20110101

Title: Morning and evening efficacy evaluation of rupatadine (10 and 20 mg), compared with cetirizine 10 mg in perennial allergic rhinitis: a randomized, double-blind, placebo-controlled trial.

Journal: Journal of asthma and allergy 20110101

Title: Utility of certain nucleophilic aromatic substitution reactions for the assay of pregabalin in capsules.

Journal: Chemistry Central journal 20110101

Title: Use of montelukast alone or in combination with desloratadine or levocetirizine in patients with persistent allergic rhinitis.

Journal: American journal of rhinology & allergy 20110101

Title: A new validated liquid chromatographic method for the determination of loratadine and its impurities.

Journal: Scientia pharmaceutica 20110101

Title: Identification of novel functional inhibitors of acid sphingomyelinase.

Journal: PloS one 20110101

Title: H1-antihistamine up-dosing in chronic spontaneous urticaria: patients' perspective of effectiveness and side effects--a retrospective survey study.

Journal: PloS one 20110101

Title: Development and validation of stability indicating method for determination of sertraline following ICH guidlines and its determination in pharmaceuticals and biological fluids.

Journal: Chemistry Central journal 20110101

Title: Medication quality and quality of life in the elderly, a cohort study.

Journal: Health and quality of life outcomes 20110101

Title: Consensus statement on the management of urticaria.

Journal: Indian journal of dermatology 20110101

Title: Urticaria and angioedema.

Journal: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 20110101

Title: Effect of bilastine upon nasal obstruction.

Journal: Journal of investigational allergology & clinical immunology 20110101

Title: Bilastine and quality of life.

Journal: Journal of investigational allergology & clinical immunology 20110101

Title: Effect of bilastine upon the ocular symptoms of allergic rhinoconjunctivitis.

Journal: Journal of investigational allergology & clinical immunology 20110101

Title: Segmental lesions in pityriasis rosea: a rare presentation.

Journal: Skinmed 20110101

Title: [The role of disturbances of lipid metabolism in pathogenesis of allergic rhinitis].

Journal: Vestnik otorinolaringologii 20110101

Title: Chronic urticaria.

Journal: Indian journal of dermatology 20110101

Title: Allergic diseases in the elderly.

Journal: Clinical and translational allergy 20110101

Title: Diagnostic tools in Rhinology EAACI position paper.

Journal: Clinical and translational allergy 20110101

Title: [Atopic dermatitis: a modern view of pediatricians and pediatric allergologist].

Journal: Likars'ka sprava 20110101

Title: Efficacy and tolerability of rupatadine at four times the recommended dose against histamine- and platelet-activating factor-induced flare responses and ex vivo platelet aggregation in healthy males.

Journal: The British journal of dermatology 20101201

Title: QTc interval prolongation by fexofenadine in healthy human volunteers and its correlation with plasma levels of fexofenadine: A demonstration of anticlockwise hysteresis.

Journal: Indian journal of pharmacology 20101201

Title: A randomized, double-blind, active-controlled, parallel-group pilot study to compare the efficacy and sedative effects of desloratadine 5 mg with levocetirizine 5 mg in the treatment of chronic idiopathic urticaria.

Journal: Journal of the American Academy of Dermatology 20101101

Title: Dose finding of melatonin for chronic idiopathic childhood sleep onset insomnia: an RCT.

Journal: Psychopharmacology 20101001

Title: [Omalizumab for therapy-resistant chronic urticaria with angioedema].

Journal: Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20101001

Title: Airborne allergy to isophoronediamine and epoxy resin.

Journal: Immunopharmacology and immunotoxicology 20100901

Title: CD203c-based basophil activation test in allergy diagnosis: characteristics and differences to CD63 upregulation.

Journal: Cytometry. Part B, Clinical cytometry 20100901

Title: Protective effect of desloratadine against oxidative stress in human erythrocytes in vitro.

Journal: Environmental toxicology and pharmacology 20100901

Title: Influence of desloratadine on selected oxidative stress markers in patients between 3 and 10 years of age with allergic perennial rhinitis.

Journal: European journal of pharmacology 20100825

Title: Effect of levothyroxine treatment on clinical symptoms and serum cytokine levels in euthyroid patients with chronic idiopathic urticaria and thyroid autoimmunity.

Journal: Clinical and experimental dermatology 20100801

Title: The cost-effectiveness of treatment with desloratadine in patients with persistent allergic rhinitis.

Journal: Current medical research and opinion 20100601

Title: Dynamic switch of negative feedback regulation in Drosophila Akt-TOR signaling.

Journal: PLoS genetics 20100601

Title: Second-generation antihistamines for the treatment of chronic idiopathic urticaria.

Journal: Journal of drugs in dermatology : JDD 20100501

Title: [Diagnostic and physiopathological innovations related to chronic urticaria].

Journal: Annales de dermatologie et de venereologie 20100501

Title: Deinococcus aetherius sp. nov., isolated from the stratosphere.

Journal: International journal of systematic and evolutionary microbiology 20100401

Title: A high-throughput, cell-based screening method for siRNA and small molecule inhibitors of mTORC1 signaling using the In Cell Western technique.

Journal: Assay and drug development technologies 20100401

Title: The pathophysiology, diagnosis and treatment of allergic rhinitis.

Journal: Allergy, asthma & immunology research 20100401

Title: Prediction and evaluation of protein farnesyltransferase inhibition by commercial drugs.

Journal: Journal of medicinal chemistry 20100325

Title: The effectiveness of levocetirizine and desloratadine in up to 4 times conventional doses in difficult-to-treat urticaria.

Journal: The Journal of allergy and clinical immunology 20100301

Title: Stereoselective synthesis of desloratadine derivatives as antagonist of histamine.

Journal: Bioorganic & medicinal chemistry 20100215

Title: A validated stability-indicating UPLC method for desloratadine and its impurities in pharmaceutical dosage forms.

Journal: Journal of pharmaceutical and biomedical analysis 20100205

Title: A retrospective, open-label analysis of the population pharmacokinetics of a single 10-mg dose of loratadine in healthy white Jordanian male volunteers.

Journal: Clinical therapeutics 20100201

Title: Cetirizine and loratadine: minimal risk of QT prolongation.

Journal: Prescrire international 20100201

Title: Loratadine versus levocetirizine in chronic idiopathic urticaria: A comparative study of efficacy and safety.

Journal: Indian journal of pharmacology 20100201

Title: Rapid separation of desloratadine and related compounds in solid pharmaceutical formulation using gradient ion-pair chromatography.

Journal: Journal of pharmaceutical and biomedical analysis 20100105

Title: Characterization of anti-inflammatory properties and evidence for no sedation liability for the novel antihistamine SUN-1334H.

Journal: International archives of allergy and immunology 20100101

Title: LC-MS-ESI for the determination of loratadine and descarboethoxyloratadine in human plasma.

Journal: Journal of chromatographic science 20100101

Title: Safety and efficacy of desloratadine in subjects with seasonal allergic rhinitis or chronic urticaria: results of four postmarketing surveillance studies.

Journal: Clinical drug investigation 20100101

Title: Treatment of congestion in upper respiratory diseases.

Journal: International journal of general medicine 20100101

Title: Efficacy of desloratadine in persistent allergic rhinitis - a GA²LEN study.

Journal: International archives of allergy and immunology 20100101

Title: Oral and inhaled sodium cromoglicate in the management of systemic mastocytosis: a case report.

Journal: Journal of medical case reports 20100101

Title: Giant pityriasis rosea.

Journal: Indian journal of dermatology 20100101

Title: [Desloratadine and mouth ulcers].

Journal: Annales de dermatologie et de venereologie 20100101

Title: Hypersensitivity reactions associated with platinum antineoplastic agents: a systematic review.

Journal: Metal-based drugs 20100101

Title: The employment of leukotriene antagonists in cutaneous diseases belonging to allergological field.

Journal: Mediators of inflammation 20100101

Title: Clinical utility and patient adherence with ebastine for allergic rhinitis.

Journal: Patient preference and adherence 20100101

Title: Hypotension, Syncope, and Fever in Systemic Mastocytosis without Skin Infiltration and Rapid Response to Corticosteroid and Cyclosporin: A Case Report.

Journal: Case reports in medicine 20100101

Title: Aquagenic urticaria in 2 adolescents.

Journal: Journal of investigational allergology & clinical immunology 20100101

Title: Design, Synthesis and Evaluation of Novel 1-(Substituted Acetyl)-4-(10-Bromo-8-Chloro-5,6-Dihydro-11H-Benzo[5,6]Cyclohepta[1,2-B]Pyridine-11-Ylidene)piperidines as Antitumor Agents and Farnesyl Protein Transferase Inhibitors.

Journal: Indian journal of pharmaceutical sciences 20100101

Title: Pityriasis amiantacea-like eruptions in scalp: a novel manifestation of pityriasis rosea in a child.

Journal: International journal of trichology 20100101

Title: Paradoxical exacerbation of chronic urticaria by H1-antihistamines and montelukast.

Journal: European annals of allergy and clinical immunology 20091201

Title: Rupatadine: pharmacological profile and its use in the treatment of allergic rhinitis.

Journal: Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India 20091201

Title: Desloratadine inhibits human skin mast cell activation and histamine release.

Journal: The Journal of investigative dermatology 20091101

Title: Desloratadine relieves nasal congestion and improves quality-of-life in persistent allergic rhinitis.

Journal: Allergy 20091101

Title: Mast cell stabilizing properties of antihistamines.

Journal: The Journal of investigative dermatology 20091101

Title: A quantitative RNAi screen for JNK modifiers identifies Pvr as a novel regulator of Drosophila immune signaling.

Journal: PLoS pathogens 20091101

Title: Azelastine nasal spray for the treatment of allergic and nonallergic rhinitis.

Journal: Expert review of clinical immunology 20091101

Title: Efficacy of desloratadine in intermittent allergic rhinitis: a GA(2)LEN study.

Journal: Allergy 20091001

Title: Effects of montelukast-desloratadine combination on early and late asthma responses Davis BE, Illamperuma C, Gauvreau GM, et al. Single-dose desloratadine and montelukast and allergen-induced late airway responses. Eur Respir J 2009;33(6):1302-308.

Journal: Expert opinion on pharmacotherapy 20091001

Title: Allergen-induced airway inflammation and its therapeutic intervention.

Journal: Allergy, asthma & immunology research 20091001

Title: The basophil activation test in the diagnosis of allergy: technical issues and critical factors.

Journal: Allergy 20090901

Title: Desloratadine for the treatment of cypress pollen-induced allergic rhinitis.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20090901

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20090901

Title: Use of, satisfaction with, and willingness to switch prescription and over-the-counter treatments for chronic urticaria: an online survey.

Journal: The patient 20090901

Title: Parental attitudes toward new dosage forms of desloratadine in an online survey: results from four European countries.

Journal: Current medical research and opinion 20090801

Title: Metabolism of loratadine and further characterization of its in vitro metabolites.

Journal: Drug metabolism letters 20090801

Title: Levocetirizine for the treatment of allergic rhinitis and chronic idiopathic urticaria in adults and children.

Journal: Clinical therapeutics 20090801

Title: Evaluation of desloratadine on conjunctival allergen challenge-induced ocular symptoms.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20090701

Title: The occurrence of antihistamines in sewage waters and in recipient rivers.

Journal: Environmental science and pollution research international 20090701

Title: [Antipruritic efficacy of a high-dosage antihistamine therapy. Results of a retrospectively analysed case series].

Journal: Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20090701

Title: Single-dose desloratadine and montelukast and allergen-induced late airway responses.

Journal: The European respiratory journal 20090601

Title: Unsuspected polymorphic metabolism of rupatadine via its primary metabolite, desloratadine.

Journal: Primary care respiratory journal : journal of the General Practice Airways Group 20090601

Title: Desloratadine and pseudoephedrine combination therapy as a comprehensive treatment for allergic rhinitis and nasal congestion.

Journal: Expert opinion on drug metabolism & toxicology 20090601

Title: Suppression of histamine- and allergen-induced skin reactions: comparison of first- and second-generation antihistamines.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20090601

Title: A review of the efficacy of desloratadine, fexofenadine, and levocetirizine in the treatment of nasal congestion in patients with allergic rhinitis.

Journal: Clinical therapeutics 20090501

Title: Comparison of the efficacy of levocetirizine 5 mg and desloratadine 5 mg in chronic idiopathic urticaria patients.

Journal: Allergy 20090401

Title: Chronic urticaria: do urticaria nonexperts implement treatment guidelines? A survey of adherence to published guidelines by nonexperts.

Journal: The British journal of dermatology 20090401

Title: How to prescribe antihistamines for chronic idiopathic urticaria: desloratadine daily vs PRN and quality of life.

Journal: Allergy 20090401

Title: High-dose desloratadine decreases wheal volume and improves cold provocation thresholds compared with standard-dose treatment in patients with acquired cold urticaria: a randomized, placebo-controlled, crossover study.

Journal: The Journal of allergy and clinical immunology 20090301

Title: Update on prescription and over-the-counter histamine inverse agonists in rhinitis therapy.

Journal: Current allergy and asthma reports 20090301

Title: Effect of desloratadine on patients with allergic rhinitis and exercise-induced bronchoconstriction: a placebo controlled study.

Journal: The Journal of asthma : official journal of the Association for the Care of Asthma 20090301

Title: Safety and efficacy of desloratadine in chronic idiopathic urticaria in clinical practice: an observational study of 9246 patients.

Journal: Journal of the European Academy of Dermatology and Venereology : JEADV 20090301

Title: Psychoactive medication and traffic safety.

Journal: International journal of environmental research and public health 20090301

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20090301

Title: Simultaneous determination of rupatadine and its metabolite desloratadine in human plasma by a sensitive LC-MS/MS method: application to the pharmacokinetic study in healthy Chinese volunteers.

Journal: Journal of pharmaceutical and biomedical analysis 20090220

Title: Oral ulcerations caused by incorrect administration of desloratadine.

Journal: Journal of the European Academy of Dermatology and Venereology : JEADV 20090201

Title: Structural characterization of in vitro rat liver microsomal metabolites of antihistamine desloratadine using LTQ-Orbitrap hybrid mass spectrometer in combination with online hydrogen/deuterium exchange HR-LC/MS.

Journal: Journal of mass spectrometry : JMS 20090201

Title: Acid-base equilibria and solubility of loratadine and desloratadine in water and micellar media.

Journal: Journal of pharmaceutical and biomedical analysis 20090115

Title: Comparison of the efficacy and safety of bilastine 20 mg vs desloratadine 5 mg in seasonal allergic rhinitis patients.

Journal: Allergy 20090101

Title: Examining the tolerability of the non-sedating antihistamine desloratadine: a prescription-event monitoring study in England.

Journal: Drug safety 20090101

Title: The concept of receptor occupancy to predict clinical efficacy: a comparison of second generation H1 antihistamines.

Journal: Allergy and asthma proceedings 20090101

Title: Upregulation of Toll-like receptor (TLR) expression and release of cytokines from P815 mast cells by GM-CSF.

Journal: BMC cell biology 20090101

Title: Efficacy and safety of desloratadine/pseudoephedrine combination vs its components in seasonal allergic rhinitis.

Journal: Journal of investigational allergology & clinical immunology 20090101

Title: Loratadine and montelukast administered in combination produce decongestion in an experimental feline model of nasal congestion.

Journal: American journal of rhinology & allergy 20090101

Title: Drugs associated with more suicidal ideations are also associated with more suicide attempts.

Journal: PloS one 20090101

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20090101

Title: Local cytokines and clinical symptoms in children with allergic rhinitis after different treatments.

Journal: Biologics : targets & therapy 20090101

Title: Treatment of allergic rhinitis in infants and children: efficacy and safety of second-generation antihistamines and the leukotriene receptor antagonist montelukast.

Journal: Drugs 20090101

Title: No difference in between-country variability in use of newly approved orphan and non- orphan medicinal products--a pilot study.

Journal: Orphanet journal of rare diseases 20090101

Title: Treating rhinitis in the older population: special considerations.

Journal: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 20090101

Title: The anti-inflammatory effects of levocetirizine--are they clinically relevant or just an interesting additional effect?

Journal: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 20090101

Title: Chronic urticaria and treatment options.

Journal: Indian journal of dermatology 20090101

Title: New spectrophotometric and fluorimetric methods for determination of fluoxetine in pharmaceutical formulations.

Journal: International journal of analytical chemistry 20090101

Title: Management of difficult urticaria.

Journal: Indian journal of dermatology 20090101

Title: Leukotriene receptor antagonists in monotherapy or in combination with antihistamines in the treatment of chronic urticaria: a systematic review.

Journal: Journal of asthma and allergy 20090101

Title: Once daily levocetirizine for the treatment of allergic rhinitis and chronic idiopathic urticaria.

Journal: Journal of asthma and allergy 20090101

Title: Ebastine in the light of CONGA recommendations for the development of third-generation antihistamines.

Journal: Journal of asthma and allergy 20090101

Title: Oral bioavailability and pharmacokinetic study of cetrizine HCl in Iranian healthy volunteers.

Journal: Research in pharmaceutical sciences 20090101

Title: Patch tests with desloratadine at 10% induce false-positive results: test at 1%.

Journal: Journal of the European Academy of Dermatology and Venereology : JEADV 20081201

Title: Ebastine in allergic rhinitis and chronic idiopathic urticaria.

Journal: Allergy 20081201

Title: Cryptococcus keelungensis sp. nov., an anamorphic basidiomycetous yeast isolated from the sea-surface microlayer of the north-east coast of Taiwan.

Journal: International journal of systematic and evolutionary microbiology 20081201

Title: Effectiveness of twice daily azelastine nasal spray in patients with seasonal allergic rhinitis.

Journal: Therapeutics and clinical risk management 20081001

Title: Pharmacokinetic and safety profile of rupatadine when coadministered with azithromycin at steady-state levels: a randomized, open-label, two-way, crossover, Phase I study.

Journal: Clinical therapeutics 20080901

Title: Antihistamine effects on experimental middle ear inflammatory model.

Journal: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20080801

Title: Non-sedating antihistamines in the treatment of chronic idiopathic urticaria using patient-reported outcomes.

Journal: Current medical research and opinion 20080801

Title: Circadian time-effect of orally administered loratadine on plasma pharmacokinetics in mice.

Journal: Chronobiology international 20080701

Title: Histamine H1-receptor antagonists inhibit nuclear factor-kappaB and activator protein-1 activities via H1-receptor-dependent and -independent mechanisms.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20080601

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20080601

Title: Intact cell binding for in vitro prediction of sedative and non-sedative histamine H1-receptor antagonists based on receptor internalization.

Journal: Journal of pharmacological sciences 20080501

Title: [The effect of desloratadine on quality of life of patients with seasonal allergic rhinitis].

Journal: Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery 20080501

Title: Efficacy and safety of desloratadine combined with dipyridamole in the treatment of chronic urticaria.

Journal: Journal of the European Academy of Dermatology and Venereology : JEADV 20080401

Title: Prospective randomized non-blinded clinical trial on the use of dapsone plus antihistamine vs. antihistamine in patients with chronic idiopathic urticaria.

Journal: Journal of the European Academy of Dermatology and Venereology : JEADV 20080401

Title: Eosinophilic angiocentric fibrosis of the orbit.

Journal: Clinical & experimental ophthalmology 20080401

Title: [The investigation of efficacy and safety of Aerius to seasonal allergic rhinitis].

Journal: Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery 20080401

Title: New treatment options in allergic rhinitis: patient considerations and the role of ciclesonide.

Journal: Therapeutics and clinical risk management 20080401

Title: Efficacy of nasal corticosteroids alone or combined with antihistamines or montelukast in treatment of allergic rhinitis.

Journal: Auris, nasus, larynx 20080301

Title: Drug treatments for skin disease introduced in 2007.

Journal: Skin therapy letter 20080301

Title: Inhibition of allergen-induced wheal and flare reactions by levocetirizine and desloratadine.

Journal: British journal of clinical pharmacology 20080201

Title: Rasagiline in treatment of Parkinson's disease.

Journal: Neuropsychiatric disease and treatment 20080201

Title: Quality of life in adults with chronic idiopathic urticaria receiving desloratadine: a randomized, double-blind, multicentre, placebo-controlled study.

Journal: Journal of the European Academy of Dermatology and Venereology : JEADV 20080101

Title: A new evaluation method for +Gz tolerance with loratadine by using a near-infrared spectroscopy.

Journal: Dynamic medicine : DM 20080101

Title: Clinical pharmacokinetics and pharmacodynamics of desloratadine, fexofenadine and levocetirizine : a comparative review.

Journal: Clinical pharmacokinetics 20080101

Title: Non-interventional study comparing treatment satisfaction in patients treated with antihistamines.

Journal: Clinical drug investigation 20080101

Title: Individual case safety reports in children in commonly used drug groups - signal detection.

Journal: BMC clinical pharmacology 20080101

Title: Quantitative evaluation of signaling events in Drosophila S2 cells.

Journal: Biological procedures online 20080101

Title: Behavioral conditioning of antihistamine effects in patients with allergic rhinitis.

Journal: Psychotherapy and psychosomatics 20080101

Title: Antihistaminic effects of rupatadine and PKPD modelling.

Journal: European journal of drug metabolism and pharmacokinetics 20080101

Title: [Linear verrucous lesions of the trunk and limbs].

Journal: Annales de dermatologie et de venereologie 20080101

Title: Comparative efficacy of levocetirizine, desloratidine and fexofenadine by histamine wheal suppression test.

Journal: Indian journal of dermatology, venereology and leprology 20080101

Title: Quality of life in patients with persistent allergic rhinitis treated with montelukast alone or in combination with levocetirizine or desloratadine.

Journal: Journal of investigational allergology & clinical immunology 20080101

Title: Neurotrophins: are they meaningful in chronic spontaneous urticaria?

Journal: Asian Pacific journal of allergy and immunology 20080101

Title: In vitro effects of budesonide on eosinophil-basophil lineage commitment.

Journal: The open respiratory medicine journal 20080101

Title: New spectrofluorimetric method with enhanced sensitivity for determination of paroxetine in dosage forms and plasma.

Journal: Analytical chemistry insights 20080101

Title: Psychological factors in asthma.

Journal: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 20080101

Title: Development and validation of high-throughput liquid chromatography-tandem mass spectrometric method for simultaneous quantification of loratadine and desloratadine in human plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071215

Title: Rhinitis symptoms and quality of life in patients with chronic perennial rhinitis treated with desloratadine.

Journal: The Journal of laryngology and otology 20071201

Title: Spectrophotometric, spectrofluorometric and HPLC determination of desloratadine in dosage forms and human plasma.

Journal: Chemical & pharmaceutical bulletin 20071201

Title: Comparison of inhibition of cutaneous histamine reaction of ebastine fast-dissolving tablet [20 mg] versus desloratadine capsule [5 mg]: a randomized, double-blind, double-dummy, placebo-controlled, three-period crossover study in healthy, nonatopic adults.

Journal: Clinical therapeutics 20071201

Title: Simultaneous determination of desloratadine and its active metabolite 3-hydroxydesloratadine in human plasma by LC/MS/MS and its application to pharmacokinetics and bioequivalence.

Journal: Journal of pharmaceutical and biomedical analysis 20071130

Title: Desloratadine improves quality of life and symptom severity in patients with allergic rhinitis.

Journal: Allergy 20071101

Title: Validated ion pair liquid chromatography/fluorescence detection method for assessing the variability of the loratadine metabolism occurring in bioequivalence studies.

Journal: Biomedical chromatography : BMC 20071001

Title: Response normalized liquid chromatography nanospray ionization mass spectrometry.

Journal: Journal of the American Society for Mass Spectrometry 20071001

Title: Multiple-dose pharmacokinetics and safety of desloratadine in subjects with moderate hepatic impairment.

Journal: Journal of clinical pharmacology 20071001

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20070901

Title: Desloratadine treatment for intermittent and persistent allergic rhinitis: a review.

Journal: Clinical therapeutics 20070901

Title: Desloratadine dose selection in children aged 6 months to 2 years: comparison of population pharmacokinetics between children and adults.

Journal: British journal of clinical pharmacology 20070801

Title: Determination of loratadine and its active metabolite in human plasma by high-performance liquid chromatography with mass spectrometry detection.

Journal: Journal of pharmaceutical and biomedical analysis 20070727

Title: Disposition of loratadine in healthy volunteers.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20070701

Title: Disposition of desloratadine in healthy volunteers.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20070701

Title: The effect of regular versus on-demand desloratadine treatment in children with allergic rhinitis.

Journal: International journal of pediatric otorhinolaryngology 20070601

Title: Pharmacokinetics of desloratadine in children between 2 and 11 years of age.

Journal: British journal of clinical pharmacology 20070501

Title: Comparison of inhibition of cutaneous histamine reaction of ebastine fast-dissolving tablet (20 mg) versus desloratadine capsule (5 mg): a randomized, double-blind, double-dummy, placebo-controlled, three-period crossover study in healthy, nonatopic adults.

Journal: Clinical therapeutics 20070501

Title: Influence of food on the oral bioavailability of rupatadine tablets in healthy volunteers: a single-dose, randomized, open-label, two-way crossover study.

Journal: Clinical therapeutics 20070501

Title: The nose - from symptoms to evidence-based medicine.

Journal: Allergy 20070401

Title: Efficacy of desloratadine in the treatment of allergic rhinitis: a meta-analysis of randomized, double-blind, controlled trials.

Journal: Allergy 20070401

Title: Simultaneous determination of loratadine and desloratadine in pharmaceutical preparations using liquid chromatography with a microemulsion as eluent.

Journal: Journal of pharmaceutical and biomedical analysis 20070312

Title: Quantitative determination of amantadine in human plasma by liquid chromatography-mass spectrometry and the application in a bioequivalence study.

Journal: Journal of pharmaceutical and biomedical analysis 20070312

Title: Selective inhibition of Kir currents by antihistamines.

Journal: European journal of pharmacology 20070308

Title: Effectiveness of desloratadine 5 mg once daily in patients with symptoms of seasonal allergic rhinitis: results of a Canadian multicenter, open-label trial.

Journal: Clinical therapeutics 20070301

Title: Efficacy of Bacillus clausii spores in the prevention of recurrent respiratory infections in children: a pilot study.

Journal: Therapeutics and clinical risk management 20070301

Title: Effects of desloratadine and alcohol coadministration on psychomotor performance.

Journal: Current medical research and opinion 20070201

Title: The effect of 4 weeks treatment with desloratadine (5mg daily) on levels of interleukin (IL)-4, IL-10, IL-18 and TGF beta in patients suffering from seasonal allergic rhinitis.

Journal: Pulmonary pharmacology & therapeutics 20070101

Title: Efficacy and safety of desloratadine in adults with chronic idiopathic urticaria: a randomized, double-blind, placebo-controlled, multicenter trial.

Journal: American journal of clinical dermatology 20070101

Title: Efficacy of fexofenadine versus desloratadine in suppressing histamine-induced wheal and flare.

Journal: Allergy and asthma proceedings 20070101

Title: A sensitive spectrophotometric method for the determination of desloratadine in tablets.

Journal: Journal of AOAC International 20070101

Title: Direct injection liquid chromatographic technique for simultaneous determination of two antihistaminic drugs and their main metabolites in serum.

Journal: Journal of AOAC International 20070101

Title: Premedication with montelukast reduces local reactions of allergen immunotherapy.

Journal: International archives of allergy and immunology 20070101

Title: A comparison of ebastine 10 mg fast-dissolving tablet with oral desloratadine and placebo in inhibiting the cutaneous reaction to histamine in healthy adults.

Journal: Clinical drug investigation 20070101

Title: Simultaneous determination of desloratadine and pseudoephedrine in human plasma using micro solid-phase extraction tips and aqueous normal-phase liquid chromatography/tandem mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20070101

Title: Diphenhydramine versus nonsedating antihistamines for acute allergic reactions: a literature review.

Journal: Allergy and asthma proceedings 20070101

Title: Desloratadine for chronic idiopathic urticaria: a review of clinical efficacy.

Journal: American journal of clinical dermatology 20070101

Title: Eosinophil recruiting chemokines are down-regulated in peripheral blood mononuclear cells of allergic patients treated with deflazacort or desloratadine.

Journal: International journal of immunopathology and pharmacology 20070101

Title: [Antihistamines in allergic rhinitis].

Journal: Otolaryngologia polska = The Polish otolaryngology 20070101

Title: Verapamil, but not probenecid, co-administration can convert desloratadine to a sedating antihistamine in mice.

Journal: Drug metabolism letters 20070101

Title: Desloratadine in combination with montelukast suppresses the dermographometer challenge test papule, and is effective in the treatment of delayed pressure urticaria: a randomized, double-blind, placebo-controlled study.

Journal: The British journal of dermatology 20061201

Title: Long QT syndrome in a patient with allergic rhinoconjunctivitis and auto-immune diabetes: focus on the choice of anti-H1 drugs.

Journal: European annals of allergy and clinical immunology 20061201

Title: New antihistamines: a critical view.

Journal: Jornal de pediatria 20061101

Title: Montelukast with desloratadine or levocetirizine for the treatment of persistent allergic rhinitis.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20061101

Title: [Inhibition of histamine-induced wheel after a recommended single dose administration of 10 mg cetirizine, 5 mg desloratadine, 120 i 180 mg fexofenadine, 5 mg levocetirizine and 10 mg loratadine--a randomized, double-blind, placebo controlled trial].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20061101

Title: [The effect of 5-days of cetirizine, desloratadine, fexofenadine 120 and 180 mg, levocetirizine, loratadine treatment on the histamine-induced skin reaction and skin blood flow--a randomized, double-blind, placebo controlled trial].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20061101

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20060901

Title: Bacillus aerius sp. nov., Bacillus aerophilus sp. nov., Bacillus stratosphericus sp. nov. and Bacillus altitudinis sp. nov., isolated from cryogenic tubes used for collecting air samples from high altitudes.

Journal: International journal of systematic and evolutionary microbiology 20060701

Title: Diphenhydramine vs desloratadine comparisons must consider risk-benefit ratio.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20060701

Title: Combining desloratadine and pseudoephedrine in the treatment of seasonal allergic rhinitis.

Journal: Expert review of clinical immunology 20060701

Title: Form I of desloratadine, a tricyclic antihistamine.

Journal: Acta crystallographica. Section C, Crystal structure communications 20060601

Title: The relative bioavailability of loratadine administered as a chewing gum formulation in healthy volunteers.

Journal: European journal of clinical pharmacology 20060601

Title: Efficacy and central nervous system impairment of newer-generation prescription antihistamines in seasonal allergic rhinitis.

Journal: Southern medical journal 20060601

Title: Effect of a Chinese herbal formula, Shi-Bi-Lin, on an experimental model of allergic rhinitis.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20060601

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20060601

Title: A comparison of levocetirizine and desloratadine in the histamine-induced wheal and flare response in human skin in vivo.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20060601

Title: Antimuscarinic actions of antihistamines on the heart.

Journal: Journal of biomedical science 20060501

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20060501

Title: Influence of desloratadine on oxidative stress markers in patients with chronic idiopathic urticaria.

Journal: International journal of dermatology 20060401

Title: Efficacy of diphenhydramine vs desloratadine and placebo in patients with moderate-to-severe seasonal allergic rhinitis.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20060401

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20060401

Title: Adult and paediatric poor metabolisers of desloratadine: an assessment of pharmacokinetics and safety.

Journal: Expert opinion on drug safety 20060301

Title: Desloratadine 5 mg once daily improves the quality of life of patients with chronic idiopathic urticaria.

Journal: Journal of the European Academy of Dermatology and Venereology : JEADV 20060301

Title: Evaluation of product switching after a state Medicaid program began covering loratadine OTC 1 year after market availability.

Journal: Journal of managed care pharmacy : JMCP 20060301

Title: Desloratadine therapy for symptoms associated with perennial allergic rhinitis.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20060301

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20060301

Title: Desloratadine for allergic rhinitis.

Journal: Expert review of clinical immunology 20060301

Title: Orthogonal extraction/chromatography and UPLC, two powerful new techniques for bioanalytical quantitation of desloratadine and 3-hydroxydesloratadine at 25 pg/mL.

Journal: Journal of pharmaceutical and biomedical analysis 20060224

Title: Effect of desloratadine therapy on symptom scores and measures of nasal patency in seasonal allergic rhinitis: results of a single-center, placebo-controlled trial.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20060201

Title: Changes in pH differently affect the binding properties of histamine H1 receptor antagonists.

Journal: European journal of pharmacology 20060120

Title: Effect of desloratadine on epithelial cell granulocyte-macrophage colony-stimulating factor secretion and eosinophil survival.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20060101

Title: Azelastine nasal spray and desloratadine tablets in pollen-induced seasonal allergic rhinitis: a pharmacodynamic study of onset of action and efficacy.

Journal: Current medical research and opinion 20060101

Title: A review of the evidence from comparative studies of levocetirizine and desloratadine for the symptoms of allergic rhinitis.

Journal: Clinical therapeutics 20060101

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20060101

Title: The role of antihistamines in asthma management.

Journal: Treatments in respiratory medicine 20060101

Title: Levocetirizine: a review of its use in the management of allergic rhinitis and skin allergies.

Journal: Drugs 20060101

Title: Impact of desloratadine and loratadine on the crosstalk between human keratinocytes and leukocytes: Implications for anti-inflammatory activity of antihistamines.

Journal: International archives of allergy and immunology 20060101

Title: Stimulating effects of H1-antagonists.

Journal: Current pharmaceutical design 20060101

Title: Efficacy of desloratadine, 5 mg, compared with fexofenadine, 180 mg, in patients with symptomatic seasonal allergic rhinitis.

Journal: Allergy and asthma proceedings 20060101

Title: Comparison of the risk of drowsiness and sedation between levocetirizine and desloratadine: a prescription-event monitoring study in England.

Journal: Drug safety 20060101

Title: Effect of desloratadine on the control of morning symptoms in patients with seasonal and perennial allergic rhinitis.

Journal: Allergy and asthma proceedings 20060101

Title: Selecting the optimal oral antihistamine for patients with allergic rhinitis.

Journal: Drugs 20060101

Title: A comparative study on the cost of new antibiotics and drugs of other therapeutic categories.

Journal: PloS one 20060101

Title: Relationship between human leucocyte antigen class I and class II and chronic idiopathic urticaria associated with aspirin and/or NSAIDs hypersensitivity.

Journal: Mediators of inflammation 20060101

Title: Desloratadine and levocetirizine improve nasal symptoms, airflow, and allergic inflammation in patients with perennial allergic rhinitis: a pilot study.

Journal: International immunopharmacology 20051201

Title: Treatment for allergic rhinitis and chronic idiopathic urticaria: focus on oral antihistamines.

Journal: The Annals of pharmacotherapy 20051201

Title: Sexual dysfunction in patients with allergic rhinoconjunctivitis.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20051201

Title: Management of persistent allergic rhinitis: evidence-based treatment with levocetirizine.

Journal: Therapeutics and clinical risk management 20051201

Title: The effect of desloratadine on eosinophil/basophil progenitors and other inflammatory markers in seasonal allergic rhinitis: a placebo-controlled randomized study.

Journal: International archives of allergy and immunology 20051101

Title: Review of desloratadine for the treatment of allergic rhinitis, chronic idiopathic urticaria and allergic inflammatory disorders.

Journal: Expert opinion on pharmacotherapy 20051101

Title: [Isotachophoretic determination of desloratadine in tablets and syrup].

Journal: Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti 20051101

Title: Desloratadine reduces systemic allergic inflammation following nasal provocation in allergic rhinitis and asthma patients.

Journal: Allergy 20051001

Title: Effect of combined montelukast and desloratadine on the early asthmatic response to inhaled allergen.

Journal: The Journal of allergy and clinical immunology 20051001

Title: Acute bacterial rhinosinusitis causes hyperresponsiveness to histamine challenge in mice.

Journal: Archives of otolaryngology--head & neck surgery 20051001

Title: Effect of cyp2d6*10 allele on the pharmacokinetics of loratadine in chinese subjects.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20050901

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20050901

Title: Histamine H1 receptor occupancy and pharmacodynamics of second generation H1-antihistamines.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20050901

Title: Management of seasonal allergic rhinitis: comparative efficacy of the newer-generation prescription antihistamines.

Journal: Journal of the American Academy of Nurse Practitioners 20050801

Title: [Desloratadine for chronic idiopathic urticaria].

Journal: Harefuah 20050801

Title: Review of H1 antihistamines in the treatment of chronic idiopathic urticaria.

Journal: Cutis 20050801

Title: A treatment for allergic rhinitis: a view on the role of levocetirizine.

Journal: Current medical research and opinion 20050701

Title: [Study on determination of desloratadine in human serum and its pharmacokinetics by HPLC/MS].

Journal: Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20050701

Title: A review of the evidence from comparative studies of levocetirizine and desloratadine for the symptoms of allergic rhinitis.

Journal: Clinical therapeutics 20050701

Title: Acute cholestasis related to desloratidine.

Journal: World journal of gastroenterology 20050621

Title: Determination of desloratadine in drug substance and pharmaceutical preparations by liquid chromatography.

Journal: Journal of pharmaceutical and biomedical analysis 20050615

Title: Histamine-mediated mechanisms in the human nasal airway.

Journal: Current opinion in pharmacology 20050601

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20050601

Title: [The effect of desloratadine on the TXB2 and leukotrienes levels in the nasal lavage fluid of allergic rhinitis animal model].

Journal: Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology 20050401

Title: Evidence of desloratadine syrup efficacy and tolerability in children with pollen-induced allergic rhinitis.

Journal: Allergy 20050301

Title: Co-administration of ketoconazole with H1-antagonists ebastine and loratadine in healthy subjects: pharmacokinetic and pharmacodynamic effects.

Journal: British journal of clinical pharmacology 20050301

Title: Increased nasal airflow with budesonide compared with desloratadine during the allergy season.

Journal: Archives of otolaryngology--head & neck surgery 20050301

Title: Efficacy and safety of an extended-release formulation of desloratadine and pseudoephedrine vs the individual components in the treatment of seasonal allergic rhinitis.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20050301

Title: [The immunohistochemical observations of NOS in the nasal mucosa of allergic rhinitis animal model of guinea pigs].

Journal: Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology 20050301

Title: Metabolism and excretion of loratadine in male and female mice, rats and monkeys.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20050201

Title: [Effects of budesonide, desloratadine and dexamethasone on interleukine-4 release and expression from human mast cell line].

Journal: Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery 20050201

Title: [The effect of desloratadine on use of rescue beta2-agonists and symptoms in patients suffering from seasonal allergic rhinitis and asthma].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20050201

Title: [The influence of desloratadine on course of intermittens allergic rhinitis].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20050201

Title: Inhibition of nasal polyp mast cell and eosinophil activation by desloratadine.

Journal: Allergy 20050101

Title: Desloratadine prevents compound 48/80-induced mast cell degranulation: visualization using a vital fluorescent dye technique.

Journal: Allergy 20050101

Title: Efficacy and tolerability of newer antihistamines in the treatment of allergic conjunctivitis.

Journal: Drugs 20050101

Title: Effects of first and second generation antihistamines on muscarinic induced mucus gland cell ion transport.

Journal: BMC pharmacology 20050101

Title: Pharmacological management of allergic rhinitis in the elderly: safety issues with oral antihistamines.

Journal: Drugs & aging 20050101

Title: [Preliminary clinical study of fubiding in treatment of perennial allergic rhinitis].

Journal: Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology 20050101

Title: Fetal safety of drugs used in the treatment of allergic rhinitis: a critical review.

Journal: Drug safety 20050101

Title: In vivo antimuscarinic actions of the third generation antihistaminergic agent, desloratadine.

Journal: BMC pharmacology 20050101

Title: [Therapeutic options in idiopathic chronic urticaria].

Journal: Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) 20050101

Title: The safety and efficacy of desloratadine for the management of allergic disease.

Journal: Drug safety 20050101

Title: Efficacy and safety of desloratadine/pseudoephedrine tablet, 2.5/120 mg two times a day, versus individual components in the treatment of patients with seasonal allergic rhinitis.

Journal: Allergy and asthma proceedings 20050101

Title: Predicting and establishing the clinical efficacy of a histamine h(1)-receptor antagonist : desloratadine, the model paradigm.

Journal: Clinical drug investigation 20050101

Title: Desloratadine inhibits constitutive and histamine-stimulated nuclear factor-kappaB activity consistent with inverse agonism at the histamine H1 Receptor.

Journal: International archives of allergy and immunology 20041201

Title: Inhibitory effects of budesonide, desloratadine and dexamethasone on cytokine release from human mast cell line (HMC-1).

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20041201

Title: Safety of desloratadine syrup in children.

Journal: Current medical research and opinion 20041201

Title: Cetirizine and loratadine-based antihistamines with 5-lipoxygenase inhibitory activity.

Journal: Bioorganic & medicinal chemistry letters 20041115

Title: Pharmacokinetics/pharmacodynamics of desloratadine and fluoxetine in healthy volunteers.

Journal: Journal of clinical pharmacology 20041101

Title: Homology modelling and binding site mapping of the human histamine H1 receptor.

Journal: European journal of medicinal chemistry 20041101

Title: Comparative pharmacology of guinea pig cardiac myocyte and cloned hERG (I(Kr)) channel.

Journal: Journal of cardiovascular electrophysiology 20041101

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20041101

Title: Current concepts and therapeutic strategies for allergic rhinitis in school-age children.

Journal: Clinical therapeutics 20041101

Title: Comparison of the effects in the nose and skin of a single dose of desloratadine and levocetirizine over 24 hours.

Journal: International archives of allergy and immunology 20041001

Title: Desloratadine partially inhibits the augmented bacterial responses in the sinuses of allergic and infected mice.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20041001

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20041001

Title: Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of 3-hydroxydesloratadine.

Journal: Biopharmaceutics & drug disposition 20040901

Title: Anti-inflammatory properties of desloratadine.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20040901

Title: Desloratadine in combination with montelukast in the treatment of chronic urticaria: a randomized, double-blind, placebo-controlled study.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20040901

Title: Randomized placebo-controlled trial comparing desloratadine and montelukast in monotherapy and desloratadine plus montelukast in combined therapy for chronic idiopathic urticaria.

Journal: The Journal of allergy and clinical immunology 20040901

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20040901

Title: Modern histamine H1-receptor antagonists in the unified airway.

Journal: The Journal of allergy and clinical immunology 20040901

Title: Antihistamines: do they work? Further well-controlled trials involving larger samples are needed.

Journal: Allergy 20040801

Title: Comparison of pharmacokinetics and metabolism of desloratadine, fexofenadine, levocetirizine and mizolastine in humans.

Journal: Fundamental & clinical pharmacology 20040801

Title: [Nasal obstruction on the decline. Antihistamine allows allergic patients to breathe].

Journal: MMW Fortschritte der Medizin 20040708

Title: Effects of desloratadine, diphenhydramine, and placebo on driving performance and psychomotor performance measurements.

Journal: European journal of clinical pharmacology 20040701

Title: Oral administration of desloratadine prior to sensitization prevents allergen-induced airway inflammation and hyper-reactivity in mice.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20040701

Title: Levocetirizine improves nasal obstruction and modulates cytokine pattern in patients with seasonal allergic rhinitis: a pilot study.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20040601

Title: Comparative activity of cetirizine and desloratadine on histamine-induced wheal-and-flare responses during 24 hours.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20040601

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20040601

Title: [Combination therapy of allergic rhinitis. So that from hay fever asthma won't come].

Journal: MMW Fortschritte der Medizin 20040527

Title: Influx and efflux transport of H1-antagonist epinastine across the blood-brain barrier.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20040501

Title: Desloratadine shows no effect on performance during 6 h at 8,000 ft simulated cabin altitude.

Journal: Aviation, space, and environmental medicine 20040501

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20040501

Title: [Not a minor illness. Hay fever therapy should not be left to the patient].

Journal: MMW Fortschritte der Medizin 20040408

Title: Improvements in simulated real-world relevant performance for patients with seasonal allergic rhinitis: impact of desloratadine.

Journal: Allergy 20040401

Title: Comparative effects of desloratadine, fexofenadine, and levocetirizine on nasal adenosine monophosphate challenge in patients with perennial allergic rhinitis.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20040401

Title: Levocetirizine better protects than desloratadine in a nasal provocation with allergen.

Journal: The Journal of allergy and clinical immunology 20040401

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20040401

Title: High-performance liquid chromatographic method for the bioequivalence evaluation of desloratadine fumarate tablets in dogs.

Journal: Journal of pharmaceutical and biomedical analysis 20040310

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20040301

Title: Assessing patient satisfaction with desloratadine after conversion from loratadine, fexofenadine, or cetirizine.

Journal: Managed care interface 20040201

Title: Comparative clinical efficacy, onset and duration of action of levocetirizine and desloratadine for symptoms of seasonal allergic rhinitis in subjects evaluated in the Environmental Exposure Unit (EEU).

Journal: International journal of clinical practice 20040201

Title: Antihistamines added to an antileukotriene in treating seasonal allergic rhinitis: histamine and leukotriene antagonism.

Journal: European annals of allergy and clinical immunology 20040201

Title: Anti-inflammatory activity of H1-receptor antagonists: review of recent experimental research.

Journal: Current medical research and opinion 20040101

Title: Inhibition of cold urticaria by desloratadine.

Journal: The Journal of dermatological treatment 20040101

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20040101

Title: Evaluation of the utilization patterns of leukotriene modifiers in a large managed care health plan.

Journal: Journal of managed care pharmacy : JMCP 20040101

Title: Pharmacokinetics and bioequivalence study of a generic desloratadine tablet formulation in healthy male volunteers.

Journal: Arzneimittel-Forschung 20040101

Title: Onset of action for the relief of allergic rhinitis symptoms with second-generation antihistamines.

Journal: Allergy and asthma proceedings 20040101

Title: The ARIA/EAACI criteria for antihistamines: an assessment of the efficacy, safety and pharmacology of desloratadine.

Journal: Allergy 20040101

Title: Reported case of severe hepatotoxicity likely due to fluconazole and not desloratadine.

Journal: Acta haematologica 20040101

Title: Chronic urticaria: aetiology, management and current and future treatment options.

Journal: Drugs 20040101

Title: Direct injection of 96-well organic extracts onto a hydrophilic interaction chromatography/tandem mass spectrometry system using a silica stationary phase and an aqueous/organic mobile phase.

Journal: Rapid communications in mass spectrometry : RCM 20040101

Title: [Autoimmune urticaria. Treatment with methotrexate].

Journal: Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) 20040101

Title: Interactions of olopatadine and selected antihistamines with model and natural membranes.

Journal: Ocular immunology and inflammation 20031201

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20031201

Title: Desloratadine for allergic rhinitis.

Journal: American family physician 20031115

Title: [Modern antihistaminics against allergic rhinitis. Better breathing without side effects].

Journal: MMW Fortschritte der Medizin 20031030

Title: Reliable and specific high-performance liquid chromatographic method for simultaneous determination of loratadine and its metabolite in human plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20031025

Title: Twenty-four-hour activity and consistency of activity of levocetirizine and desloratadine in the skin.

Journal: British journal of clinical pharmacology 20031001

Title: Comparison of the effects of desloratadine and levocetirizine on histamine-induced wheal, flare and itch in human skin.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20031001

Title: Efficacy and safety profile of fexofenadine HCl: a unique therapeutic option in H1-receptor antagonist treatment.

Journal: The Journal of allergy and clinical immunology 20031001

Title: A comparison of the effect of diphenhydramine and desloratadine on vigilance and cognitive function during treatment of ragweed-induced allergic rhinitis.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20031001

Title: Loratadine, desloratadine and pregnancy: don't use, risk of hypospadias.

Journal: Prescrire international 20031001

Title: Studies on performance and sleepiness with the H1-antihistamine, desloratadine.

Journal: Aviation, space, and environmental medicine 20030801

Title: Efficacy of azelastine nasal spray in patients with an unsatisfactory response to loratadine.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20030801

Title: Pharmacokinetic properties of single-dose loratadine and ambroxol alone and combined in tablet formulations in healthy men.

Journal: Clinical therapeutics 20030801

Title: Validation of a sensitive and automated 96-well solid-phase extraction liquid chromatography-tandem mass spectrometry method for the determination of desloratadine and 3-hydroxydesloratadine in human plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030725

Title: Desloratadine inhibits allergen-induced airway inflammation and bronchial hyperresponsiveness and alters T-cell responses in murine models of asthma.

Journal: The Journal of allergy and clinical immunology 20030701

Title: Pharmacokinetics of loratadine and its active metabolite descarboethoxyloratadine in healthy Chinese subjects.

Journal: Acta pharmacologica Sinica 20030701

Title: Comparison of ketotifen fumarate ophthalmic solution alone, desloratadine alone, and their combination for inhibition of the signs and symptoms of seasonal allergic rhinoconjunctivitis in the conjunctival allergen challenge model: a double-masked, placebo- and active-controlled trial.

Journal: Clinical therapeutics 20030701

Title: Comparison of the effects of desloratadine 5-mg daily and placebo on nasal airflow and seasonal allergic rhinitis symptoms induced by grass pollen exposure.

Journal: Allergy 20030601

Title: Effects of mediator antagonism on mannitol and adenosine monophosphate challenges.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20030601

Title: The effects of histamine and leukotriene receptor antagonism on nasal mannitol challenge in allergic rhinitis.

Journal: British journal of clinical pharmacology 20030601

Title: [Clinical aspects of anti-inflammatory action of antihistamines].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20030601

Title: [Safety of new antihistamines].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20030601

Title: [Multicenter study of the effectiveness and tolerability of desloratadine in seasonal allergic rhinitis].

Journal: Orvosi hetilap 20030525

Title: First do no harm: managing antihistamine impairment in patients with allergic rhinitis.

Journal: The Journal of allergy and clinical immunology 20030501

Title: Efficacy and safety of desloratadine 5 mg once daily in the treatment of chronic idiopathic urticaria: a double-blind, randomized, placebo-controlled trial.

Journal: Journal of the American Academy of Dermatology 20030401

Title: Comparative effects of desloratadine versus montelukast on asthma symptoms and use of beta 2-agonists in patients with seasonal allergic rhinitis and asthma.

Journal: International archives of allergy and immunology 20030401

Title: [Older antihistaminics often act as sedatives. Hay fever gone -- reaction capacity, too].

Journal: MMW Fortschritte der Medizin 20030327

Title: P-glycoprotein limits the brain penetration of nonsedating but not sedating H1-antagonists.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20030301

Title: Efficacy and safety of desloratadine in the treatment of perennial allergic rhinitis.

Journal: The Journal of allergy and clinical immunology 20030301

Title: Decongestant effects of antihistamines: a class effect?

Journal: The Journal of allergy and clinical immunology 20030301

Title: Double-stranded RNA viruses in a mycocinogenic strain of Cystofilobasidium infirmominiatum.

Journal: FEMS yeast research 20030301

Title: Gateways to clinical trials. March 2003.

Journal: Methods and findings in experimental and clinical pharmacology 20030301

Title: Desloratadine: a nonsedating antihistamine.

Journal: The Annals of pharmacotherapy 20030201

Title: Comparative in vivo bioactivity of modern H1-antihistamines on AMP challenge in atopic asthma.

Journal: The Journal of allergy and clinical immunology 20030201

Title: The effect of ketotifen on inflammatory markers in allergic conjunctivitis: an open, uncontrolled study.

Journal: BMC ophthalmology 20030101

Title: Chronic urticaria: a role for newer immunomodulatory drugs?

Journal: American journal of clinical dermatology 20030101

Title: Assessing satisfaction with desloratadine and fexofenadine in allergy patients who report dissatisfaction with loratadine.

Journal: BMC family practice 20030101

Title: Desloratadine: an update of its efficacy in the management of allergic disorders.

Journal: Drugs 20030101

Title: Severe hepatotoxicity after application of desloratadine and fluconazole.

Journal: Acta haematologica 20030101

Title: Antihistamines in the treatment of dermatitis.

Journal: Journal of cutaneous medicine and surgery 20030101

Title: Treatment of allergic rhinitis.

Journal: The American journal of medicine 20021216

Title: Comparative pharmacology of H1 antihistamines: clinical relevance.

Journal: The American journal of medicine 20021216

Title: [The place of new antihistamines in allergy management. Apropos of desloratadine].

Journal: Allergie et immunologie 20021201

Title: The new antihistamines--desloratadine and levocetirizine: a review.

Journal: Journal of drugs in dermatology : JDD 20021201

Title: Clinical pharmacology of H1-antihistamines in the skin.

Journal: The Journal of allergy and clinical immunology 20021101

Title: Safety and efficacy of desloratadine 5 mg in asthma patients with seasonal allergic rhinitis and nasal congestion.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20021101

Title: Effects of fexofenadine and desloratadine on subjective and objective measures of nasal congestion in seasonal allergic rhinitis.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20021001

Title: Desloratadine reduces allergen challenge-induced mucinous secretion and plasma exudation in allergic rhinitis.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20021001

Title: Desloratidine for the treatment of chronic urticaria.

Journal: Skin therapy letter 20021001

Title: Biochemical characterization of desloratadine, a potent antagonist of the human histamine H(1) receptor.

Journal: European journal of pharmacology 20020809

Title: [The result of neglected or erroneous treatment. Mentally handicapped by hay fever].

Journal: MMW Fortschritte der Medizin 20020711

Title: Effect of desloratadine versus placebo on nasal airflow and subjective measures of nasal obstruction in subjects with grass pollen-induced allergic rhinitis in an allergen-exposure unit.

Journal: The Journal of allergy and clinical immunology 20020601

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20020501

Title: Desloratadine (Clarinex).

Journal: The Medical letter on drugs and therapeutics 20020318

Title: Synthesis of 5,6-dihydro-11H-benzo[5,6]-cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidine-N-cyanoguanidine derivatives as inhibitors of ras farnesyl protein transferase.

Journal: Bioorganic & medicinal chemistry letters 20020225

Title: [The third-generation antihistaminics. Can they prevent the tier change?].

Journal: MMW Fortschritte der Medizin 20020214

Title: Antihistamines in late-phase clinical development for allergic disease.

Journal: Expert opinion on investigational drugs 20020201

Title: Are antihistamines useful in managing asthma?

Journal: Current opinion in allergy and clinical immunology 20020201

Title: Grapefruit juice reduces the oral bioavailability of fexofenadine but not desloratadine.

Journal: Clinical pharmacokinetics 20020101

Title: 24-hour efficacy of once-daily desloratadine therapy in patients with seasonal allergic rhinitis [ISRCTN32042139].

Journal: BMC family practice 20020101

Title: Desloratadine demonstrates dose proportionality in healthy adults after single doses.

Journal: Clinical pharmacokinetics 20020101

Title: Oral bioavailability of desloratadine is unaffected by food.

Journal: Clinical pharmacokinetics 20020101

Title: A pharmacokinetic profile of desloratadine in healthy adults, including elderly.

Journal: Clinical pharmacokinetics 20020101

Title: Effect of race and sex on single and multiple dose pharmacokinetics of desloratadine.

Journal: Clinical pharmacokinetics 20020101

Title: Lack of clinically relevant interaction between desloratadine and erythromycin.

Journal: Clinical pharmacokinetics 20020101

Title: Desloratadine has no clinically relevant electrocardiographic or pharmacodynamic interactions with ketoconazole.

Journal: Clinical pharmacokinetics 20020101

Title: Investigation of an enhanced resolution triple quadrupole mass spectrometer for high-throughput liquid chromatography/tandem mass spectrometry assays.

Journal: Rapid communications in mass spectrometry : RCM 20020101

Title: Efficacy of once-daily desloratadine/pseudoephedrine for relief of nasal congestion.

Journal: Allergy and asthma proceedings 20020101

Title: Therapeutic points of intervention and clinical implications: role of desloratadine.

Journal: Allergy 20020101

Title: Chronic urticaria: impact of allergic inflammation.

Journal: Allergy 20020101

Title: Impact and modulation of nasal obstruction.

Journal: Allergy 20020101

Title: Advances in allergy management.

Journal: Allergy 20020101

Title: Poor sleep and daytime somnolence in allergic rhinitis: significance of nasal congestion.

Journal: American journal of respiratory medicine : drugs, devices, and other interventions 20020101

Title: Second-generation antihistamines in asthma therapy: is there a protective effect?

Journal: American journal of respiratory medicine : drugs, devices, and other interventions 20020101

Title: Desloratadine reduces nasal congestion in patients with intermittent allergic rhinitis.

Journal: Allergy 20011101

Title: In vitro characterization of the inhibition profile of loratadine, desloratadine, and 3-OH-desloratadine for five human cytochrome P-450 enzymes.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20010901

Title: Inhibition of cytokine generation and mediator release by human basophils treated with desloratadine.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20010901

Title: Applications of new liquid chromatography-tandem mass spectrometry technologies for drug development support.

Journal: Journal of chromatography. A 20010810

Title: Evaluation of the interaction of loratadine and desloratadine with P-glycoprotein.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20010801

Title: Effect of desloratadine and loratadine on rhinovirus-induced intercellular adhesion molecule 1 upregulation and promoter activation in respiratory epithelial cells.

Journal: The Journal of allergy and clinical immunology 20010801

Title: [Urticaria. Finally undisturbed sleep].

Journal: MMW Fortschritte der Medizin 20010726

Title: Sensitive liquid chromatography-tandem mass spectrometry method for the determination of loratadine and its major active metabolite descarboethoxyloratadine in human plasma.

Journal: Journal of chromatography. A 20010420

Title: Evaluation of a four-channel multiplexed electrospray triple quadrupole mass spectrometer for the simultaneous validation of LC/MS/MS methods in four different preclinical matrixes.

Journal: Analytical chemistry 20010415

Title: [A new antihistamine. Inhibiting inflammation in rhinorrhea and nasal congestion].

Journal: MMW Fortschritte der Medizin 20010405

Title: Desloratadine: A new, nonsedating, oral antihistamine.

Journal: The Journal of allergy and clinical immunology 20010401

Title: Loratadine and terfenadine interaction with nefazodone: Both antihistamines are associated with QTc prolongation.

Journal: Clinical pharmacology and therapeutics 20010301

Title: Pharmacokinetic and safety profile of desloratadine and fexofenadine when coadministered with azithromycin: a randomized, placebo-controlled, parallel-group study.

Journal: Clinical therapeutics 20010301

Title: Pharmacology and clinical efficacy of desloratadine as an anti-allergic and anti-inflammatory drug.

Journal: Expert opinion on investigational drugs 20010301

Title: Decongestant efficacy of desloratadine in patients with seasonal allergic rhinitis.

Journal: Allergy 20010101

Title: Desloratadine activity in concurrent seasonal allergic rhinitis and asthma.

Journal: Allergy 20010101

Title: Desloratadine in the treatment of chronic idiopathic urticaria.

Journal: Allergy 20010101

Title: Desloratadine: a new approach in the treatment of allergy as a systematic disease--pharmacology and clinical overview. Introduction.

Journal: Allergy 20010101

Title: The pharmacologic profile of desloratadine: a review.

Journal: Allergy 20010101

Title: Once-daily desloratadine improves the signs and symptoms of chronic idiopathic urticaria: a randomized, double-blind, placebo-controlled study.

Journal: International journal of dermatology 20010101

Title: Desloratadine.

Journal: Drugs 20010101

Title: [The effect of second generation histamine antagonists on the heart].

Journal: Pneumonologia i alergologia polska 20010101

Title: Chronic idiopathic urticaria treatment.

Journal: Allergologia et immunopathologia 20010101

Title: Mediator antagonists in the treatment of allergic disease.

Journal: Allergy and asthma proceedings 20010101

Title: Sedation with 'non-sedating' antihistamines: four prescription-event monitoring studies in general practice.

Journal: BMJ (Clinical research ed.) 20000429

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