Home Pyridines 1007-18-7
1007-18-7,MFCD11174156
Catalog No.:AA0002KU
1007-18-7 | 3-Pyridinecarboxamide, 1,6-dihydro-N-methyl-6-oxo-
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250mg
95.0%
3 weeks  
$152.00   $107.00
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500mg
95.0%
3 weeks  
$224.00   $157.00
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1g
95.0%
3 weeks  
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  • Technical Information
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Technical Information
Catalog Number:
AA0002KU
Chemical Name:
3-Pyridinecarboxamide, 1,6-dihydro-N-methyl-6-oxo-
CAS Number:
1007-18-7
Molecular Formula:
C7H8N2O2
Molecular Weight:
152.1506
MDL Number:
MFCD11174156
IUPAC Name:
N-methyl-6-oxo-1H-pyridine-3-carboxamide
InChI:
InChI=1S/C7H8N2O2/c1-8-7(11)5-2-3-6(10)9-4-5/h2-4H,1H3,(H,8,11)(H,9,10)
InChI Key:
NBUNJDAKVMXXEF-UHFFFAOYSA-N
SMILES:
CNC(=O)c1ccc(=O)[nH]c1
UNII:
C2M49S613F
Properties
Computed Properties
 
Complexity:
253  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
152.059g/mol
Formal Charge:
0
Heavy Atom Count:
11  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
152.153g/mol
Monoisotopic Mass:
152.059g/mol
Rotatable Bond Count:
1  
Topological Polar Surface Area:
58.2A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-0.8  

Synonyms
 
1-methyl-5-carboxylamide-2-pyridone 
N'-methyl-2-pyridone-5-carboxamide 
AC1Q40LO 
SCHEMBL447082 
SCHEMBL13451410 
CTK3J9191 
DTXSID70143458 
ZINC2004530 
AKOS008933334 
NE62005 
N-methyl-6-oxo-1H-pyridine-3-carboxamide 
EN300-52144 
n-methyl-6-oxo-1,6-dihydropyridine-3-carboxamide 
1,6-Dihydro-N-methyl-6-oxo-3-pyridinecarboxamide 
3-Pyridinecarboxamide,1,6-dihydro-N-methyl-6-oxo- 
C7-H8-N2-O2 
CID70510 
AR-1K7600 
3-Pyridinecarboxamide, 1,6-dihydro-N-methyl-6-oxo- 
56654-53-6 
1007-18-7 
1,6-Dihydro-N-methyl-6-oxonicotinamide 
UNII-C2M49S613F 
C2M49S613F 
AC1Q5BBZ 
Nicotinamide, 1,6-dihydro-N-methyl-6-oxo- 
AC1L2E8Q 
Literature

Title: N-Methyl-2-pyridone-5-carboxamide is 1-methylnicotinamide metabolite of low cyclooxygenase-dependent vasodilating activity.

Journal: Journal of physiology and biochemistry 20120901

Title: Simultaneous quantification of niacin and its three main metabolites in human plasma by LC-MS/MS.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120901

Title: Effects of 1-methylnicotinamide and its metabolite N-methyl-2-pyridone-5-carboxamide on streptozotocin-induced toxicity in murine insulinoma MIN6 cell line.

Journal: Acta biochimica Polonica 20110101

Title: Simultaneous determination of niacin and its metabolites--nicotinamide, nicotinuric acid and N-methyl-2-pyridone-5-carboxamide--in human plasma by LC-MS/MS and its application to a human pharmacokinetic study.

Journal: Biomedical chromatography : BMC 20101001

Title: Distribution of purine nucleotides in uremic fluids and tissues.

Journal: Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation 20100901

Title: Urinary metabolic phenotyping differentiates children with autism from their unaffected siblings and age-matched controls.

Journal: Journal of proteome research 20100604

Title: Metabonomics study of urine and plasma in depression and excess fatigue rats by ultra fast liquid chromatography coupled with ion trap-time of flight mass spectrometry.

Journal: Molecular bioSystems 20100501

Title: Development of a hydrophilic liquid interaction chromatography-high-performance liquid chromatography-tandem mass spectrometry based stable isotope dilution analysis and pharmacokinetic studies on bioactive pyridines in human plasma and urine after coffee consumption.

Journal: Analytical chemistry 20100215

Title: Are so-called uremic toxins always toxic?

Journal: Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation 20080101

Title: Nicotinamide metabolites accumulate in the tissues of uremic rats.

Journal: Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation 20080101

Title: The comparative bioavailability of an extended-release niacin and lovastatin fixed dose combination tablet versus extended-release niacin tablet, lovastatin tablet and a combination of extended-release niacin tablet and lovastatin tablet.

Journal: Biopharmaceutics & drug disposition 20070901

Title: Plasma and urine pharmacokinetics of niacin and its metabolites from an extended-release niacin formulation.

Journal: International journal of clinical pharmacology and therapeutics 20070801

Title: Effect of the rate of niacin administration on the plasma and urine pharmacokinetics of niacin and its metabolites.

Journal: Journal of clinical pharmacology 20070601

Title: A metabolomic comparison of urinary changes in type 2 diabetes in mouse, rat, and human.

Journal: Physiological genomics 20070424

Title: Relationship between uremic toxins and oxidative stress in patients with chronic renal failure.

Journal: Scandinavian journal of urology and nephrology 20070101

Title: Accumulation of poly(ADP-ribose) polymerase inhibitors in children with chronic renal failure.

Journal: Pediatric nephrology (Berlin, Germany) 20060601

Title: Estimation of aldehyde oxidase activity in vivo from conversion ratio of N1-methylnicotinamide to pyridones, and intraspecies variation of the enzyme activity in rats.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20060201

Title: The novel nucleotide 4KNTP, in high concentrations in erythrocytes of renal failure children: a comparison with accumulation of other putative precursors in the plasma.

Journal: Nucleosides, nucleotides & nucleic acids 20060101

Title: The effect of N-methyl-2-pyridone-5-carboxamide--A nicotinamide catabolite on poly ADP-rybosylation and oxidative stress injury in endothelial cells.

Journal: Nucleosides, nucleotides & nucleic acids 20050101

Title: The age-related increase in N-methyl-2-pyridone-5-carboxamide (NAD catabolite) in human plasma.

Journal: Molecular and cellular biochemistry 20041201

Title: An unusual pyridine nucleotide accumulating in erythrocytes: its identity and positive correlation with degree of renal failure.

Journal: Nucleosides, nucleotides & nucleic acids 20041001

Title: Disturbances of purine nucleotide metabolism in uremia.

Journal: Seminars in nephrology 20040901

Title: Origin and characteristics of an unusual pyridine nucleotide accumulating in erythrocytes: positive correlation with degree of renal failure.

Journal: Clinica chimica acta; international journal of clinical chemistry 20030901

Title: N-methyl-2-pyridone-5-carboxamide: a novel uremic toxin?

Journal: Kidney international. Supplement 20030501

Title: Accumulation of plasma N-methyl-2-pyridone-5-carboxamide in patients with chronic renal failure.

Journal: Molecular and cellular biochemistry 20020201

Title: The metabolism of nicotinamide in human liver cirrhosis: a study on N-methylnicotinamide and 2-pyridone-5-carboxamide production.

Journal: The American journal of gastroenterology 20010401

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