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1009298-59-2,MFCD22628784
Catalog No.:AA00035A
1009298-59-2 | Azd2014
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1mg
≥98%
1 week  
$92.00   $64.00
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5mg
≥98%
1 week  
$171.00   $120.00
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10mg
≥98%
1 week  
$242.00   $170.00
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25mg
≥98%
1 week  
$449.00   $314.00
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  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00035A
Chemical Name:
Azd2014
CAS Number:
1009298-59-2
Molecular Formula:
C25H30N6O3
Molecular Weight:
462.5441
MDL Number:
MFCD22628784
IUPAC Name:
3-[2,4-bis[(3S)-3-methylmorpholin-4-yl]pyrido[2,3-d]pyrimidin-7-yl]-N-methylbenzamide
InChI:
InChI=1S/C25H30N6O3/c1-16-14-33-11-9-30(16)23-20-7-8-21(18-5-4-6-19(13-18)24(32)26-3)27-22(20)28-25(29-23)31-10-12-34-15-17(31)2/h4-8,13,16-17H,9-12,14-15H2,1-3H3,(H,26,32)/t16-,17-/m0/s1
InChI Key:
JUSFANSTBFGBAF-IRXDYDNUSA-N
SMILES:
CNC(=O)c1cccc(c1)c1ccc2c(n1)nc(nc2N1CCOC[C@@H]1C)N1CCOC[C@@H]1C
UNII:
0BSC3P4H5X
Properties
Computed Properties
 
Complexity:
698  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
0
Exact Mass:
462.238g/mol
Formal Charge:
0
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
462.554g/mol
Monoisotopic Mass:
462.238g/mol
Rotatable Bond Count:
4  
Topological Polar Surface Area:
92.7A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.8  

Synonyms
 
AZD2014 
AZD2014 
3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide 
CHEMBL2336325 
3-[2,4-Bis((3S)-3-methyLmorpholin-4-yl)pyrido-[5,6-e]pyrimidin-7-yl]-N-methylbenzamide 
C25H30N6O3 
3-(2,4-bis((S)-3-methylmorpholino)pyrido[2,3-d]pyrimidin-7-yl)-N-methylbenzamide 
3-[2,4-bis[(3S)-3-methylmorpholin-4-yl]pyrido[2,3-d]pyrimidin-7-yl]-N-methylbenzamide 
Benzamide, 3-(2,4-bis((3S)-3-methyl-4-morpholinyl)pyrido(2,3-d)pyrimidin-7-yl)-N-methyl- 
Vistusertib [INN] 
Benzamide, 3-[2,4-bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-N-methyl- 
Vistusertib [USAN] 
1009298-59-2 
Vistusertib (JAN/INN) 
MLS006011011 
SCHEMBL290672 
GTPL7699 
AOB3574 
DTXSID20143584 
EX-A155 
SYN1167 
BCP05748 
KS-000000YA 
Vistusertib 
BDBM50429701 
MFCD22628784 
s2783 
ZINC59258964 
AKOS024464879 
BCP9000362 
CS-0701 
DB11925 
QC-4554 
SB16565 
AZD-2014 
NCGC00346698-11 
4CA-0223 
AC-28425 
AS-16302 
BC600520 
HY-15247 
SC-62590 
SMR004702809 
AB0095803 
SW219704-1 
AZD 2014 
X3569 
D10887 
W-5962 
J-000268 
3-[2,4-Bis-[(3S)-3-methyl-4-morpholinyl]-pyrido[2,3-d]pyrimidin-7-yl]-N-methylbenzamide 
D0Z2UQ 
A8373 
Vistusertib, 98%, a novel mTOR inhibitor - 100MG 100mg 
UNII-0BSC3P4H5X 
vistusertib (AZD2014) 
0BSC3P4H5X 
cc-551 
Literature

Title: Vistusertib (dual m-TORC1/2 inhibitor) in combination with paclitaxel in patients with high-grade serous ovarian and squamous non-small-cell lung cancer.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20180901

Title: Evaluation of the combination of the dual m-TORC1/2 inhibitor vistusertib (AZD2014) and paclitaxel in ovarian cancer models.

Journal: Oncotarget 20171226

Title: mTOR/p70S6K signaling distinguishes routine, maintenance-level autophagy from autophagic cell death during influenza A infection.

Journal: Virology 20140301

Title: Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: the discovery of AZD8055 and AZD2014.

Journal: Bioorganic & medicinal chemistry letters 20130301

Title: TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO.

Journal: Cell metabolism 20120502

Title: Mammalian autophagy: core molecular machinery and signaling regulation.

Journal: Current opinion in cell biology 20100401

Title: Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.

Journal: Nature 20090716

Title: Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.

Journal: Current biology : CB 20040727

Title: Regulation of longevity and stress resistance by Sch9 in yeast.

Journal: Science (New York, N.Y.) 20010413

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