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101477-54-7,MFCD01703867
Catalog No.:AA0004I3
101477-54-7 | Lomerizine hydrochloride
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200mg
>98.0%(T)(HPLC)
1 week  
$146.00   $102.00
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Technical Information
Catalog Number:
AA0004I3
Chemical Name:
Lomerizine hydrochloride
CAS Number:
101477-54-7
Molecular Formula:
C27H32Cl2F2N2O3
Molecular Weight:
541.4574
MDL Number:
MFCD01703867
IUPAC Name:
1-[bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]piperazine;dihydrochloride
InChI:
InChI=1S/C27H30F2N2O3.2ClH/c1-32-24-13-8-21(26(33-2)27(24)34-3)18-30-14-16-31(17-15-30)25(19-4-9-22(28)10-5-19)20-6-11-23(29)12-7-20;;/h4-13,25H,14-18H2,1-3H3;2*1H
InChI Key:
LOGVKVSFYBBUAJ-UHFFFAOYSA-N
SMILES:
COc1c(ccc(c1OC)OC)CN1CCN(CC1)C(c1ccc(cc1)F)c1ccc(cc1)F.Cl.Cl
UNII:
3W473D5LIY
Properties
Computed Properties
 
Complexity:
568  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
3  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
540.176g/mol
Formal Charge:
0
Heavy Atom Count:
36  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
541.461g/mol
Monoisotopic Mass:
540.176g/mol
Rotatable Bond Count:
8  
Topological Polar Surface Area:
34.2A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0

Synonyms
 
1-(bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride 
KB 2796 
LOMERIZINE 2HCL 
UNII-3W473D5LIY 
KB 2796 
KB-2796 
1-[BIS(4-FLUOROPHENYL)METHYL]-4-(2,3,4-TRIMETHOXYBENZYL)PIPERAZINE DIHYDROCHLORIDE 
1-[bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]piperazine dihydrochloride 
3W473D5LIY 
MFCD01703867 
1-(bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride 
1-(2,3,4-Trimethoxybenzyl)-4-(bis(4-fluorophenyl)methyl)piperazine dihydrochloride 
KB-2796 
1-(Bis(4-fluorophenyl)methyl)-4-((2,3,4-trimethoxyphenyl)methyl)piperazine dihydrochloride 
DSSTox_CID_26427 
DSSTox_RID_81605 
DSSTox_GSID_46427 
Piperazine, 1-(bis(4-fluorophenyl)methyl)-4-((2,3,4-trimethoxyphenyl)methyl)-, dihydrochloride 
CAS-101477-54-7 
NCGC00164543-01 
lomerizine-hcl 
Migsis 
1-(2,3,4-trimethoxybenzyl)-4-[bis(4-fluorophenyl)methyl]piperazine dihydrochloride 
lomerizine 
Terranas (TN) 
Lomerizine Hydrochlortde 
AC1L3U0Y 
C27H32Cl2F2N2O3 
Lomerizine hydrochloride (JAN) 
SCHEMBL1153647 
CHEMBL2356978 
DTXSID1046427 
C27H30F2N2O3.2HCl 
CTK6J4130 
lomerizine dihydrochloride 
HY-B0768A 
LOGVKVSFYBBUAJ-UHFFFAOYSA-N 
BCP12061 
Tox21_112172 
DE-090 
s4084 
AKOS015900365 
Tox21_112172_1 
AC-2040 
NCGC00164543-02 
Lomerizine hydrochloride 
AN-14347 
H763 
LS-110465 
RT-013592 
CS-0012057 
FT-0627971 
L0245 
SW197640-2 
A16599 
D02633 
101477-54-7 
477L547 
A800394 
I14-0643 
J-000407 
Lomerizine dihydrochloride, >=98% (HPLC), powder 
101477-54-7, 101477-55-8(free base) 
1-(bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine hydrochloride 
Piperazine, 1-[bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]-, hydrochloride (1:2) 
lomerizine 
C27H30F2N2O3.2ClH 
Lomerizine dihydrochloride 
ACN-S001256 
CID122125 
CL0043 
C27-H30-F2-N2-O3.2Cl-H 
B1782 
C052424 
Lomerizine dihydrochloride, 99%, a new L- and T-type calcium channel blocker - 1G 1g 
Lomerizine HCl 
Terranas 
Literature

Title: Why are most phospholipidosis inducers also hERG blockers?

Journal: Archives of toxicology 20171201

Title: Changes in optic nerve head circulation in response to vasoactive agents: intereye comparison in monkeys with experimental unilateral glaucoma.

Journal: Investigative ophthalmology & visual science 20120822

Title: Neuroprotection by lomerizine, a prophylactic drug for migraine, against hydrogen peroxide-induced hippocampal neurotoxicity.

Journal: Molecular and cellular biochemistry 20111201

Title: Development of spontaneous neuropathy in NF-κBp50-deficient mice by calcineurin-signal involving impaired NF-κB activation.

Journal: Molecular vision 20110101

Title: Interaction of CJZ3, a lomerizine derivative, with ATPase activity of human P-glycoprotein in doxorubicin-resistant human myelogenous leukemia (K562/DOX) cells.

Journal: Die Pharmazie 20100701

Title: Lomerizine, a Ca2+ channel blocker, protects against neuronal degeneration within the visual center of the brain after retinal damage in mice.

Journal: CNS neuroscience & therapeutics 20100401

Title: Limited restoration of visual function after partial optic nerve injury; a time course study using the calcium channel blocker lomerizine.

Journal: Brain research bulletin 20100316

Title: A case of ocular hypertension complicated by SUNCT syndrome.

Journal: Annals of ophthalmology (Skokie, Ill.) 20100101

Title: Secondary retinal ganglion cell death and the neuroprotective effects of the calcium channel blocker lomerizine.

Journal: Investigative ophthalmology & visual science 20091101

Title: Inhibitory effect of lomerizine, a prophylactic drug for migraines, on serotonin-induced contraction of the basilar artery.

Journal: Journal of pharmacological sciences 20091001

Title: [Calcium antagonists in the prophylactic treatment of migraine].

Journal: Brain and nerve = Shinkei kenkyu no shinpo 20091001

Title: Secondary degeneration of the optic nerve following partial transection: the benefits of lomerizine.

Journal: Experimental neurology 20090301

Title: Cognitive impairment and cerebral hypoperfusion in a CADASIL patient improved during administration of lomerizine.

Journal: Clinical neuropharmacology 20090101

Title: [CADASIL].

Journal: Brain and nerve = Shinkei kenkyu no shinpo 20081101

Title: Goshuyuto, a traditional Japanese medicine for migraine, inhibits platelet aggregation in guinea-pig whole blood.

Journal: Journal of pharmacological sciences 20080901

Title: Atypical depression as a premonitory symptom of migraine managed by an oral contraceptive.

Journal: Psychiatry and clinical neurosciences 20080601

Title: Migraine-associated vertigo: clinical characteristics of Japanese patients and effect of lomerizine, a calcium channel antagonist.

Journal: Acta oto-laryngologica. Supplementum 20071201

Title: CJZ3, a lomerizine derivative, modulates P-glycoprotein function in rat brain microvessel endothelial cells.

Journal: Acta pharmacologica Sinica 20060401

Title: A new calcium channel antagonist, lomerizine, alleviates secondary retinal ganglion cell death after optic nerve injury in the rat.

Journal: Current eye research 20060301

Title: [Reversal of multidrug resistance by lomerizine in K562/ADM cells].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20040501

Title: Clinical potential of lomerizine, a Ca2+ channel blocker as an anti-glaucoma drug: effects on ocular circulation and retinal neuronal damage.

Journal: Cardiovascular drug reviews 20040101

Title: [Effects of changes in conformation and configuration of N-containing compounds on NMR spactra].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20031201

Title: Effects of lomerizine, a calcium channel antagonist, on retinal and optic nerve head circulation in rabbits and humans.

Journal: Investigative ophthalmology & visual science 20031101

Title: Increase in doxorubicin cytotoxicity by inhibition of P-glycoprotein activity with lomerizine.

Journal: Biological & pharmaceutical bulletin 20010501

Title: Effects of lomerizine, a novel Ca2+ channel blocker, on the normal and endothelin-1-disturbed circulation in the optic nerve head of rabbits.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20010401

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