Home Quinolines 101910-24-1
101910-24-1,MFCD00211150
Catalog No.:AA0005U8
101910-24-1 | Benzenemethanol, α-pentyl-3-(2-quinolinylmethoxy)-
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5mg
≥98%
1 week  
$92.00   $64.00
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10mg
≥98%
1 week  
$128.00   $90.00
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50mg
≥98%
1 week  
$369.00   $259.00
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100mg
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$607.00   $425.00
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  • Technical Information
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Technical Information
Catalog Number:
AA0005U8
Chemical Name:
Benzenemethanol, α-pentyl-3-(2-quinolinylmethoxy)-
CAS Number:
101910-24-1
Molecular Formula:
C22H25NO2
Molecular Weight:
335.4394
MDL Number:
MFCD00211150
IUPAC Name:
1-[3-(quinolin-2-ylmethoxy)phenyl]hexan-1-ol
InChI:
InChI=1S/C22H25NO2/c1-2-3-4-12-22(24)18-9-7-10-20(15-18)25-16-19-14-13-17-8-5-6-11-21(17)23-19/h5-11,13-15,22,24H,2-4,12,16H2,1H3
InChI Key:
JRLOEMCOOZSCQP-UHFFFAOYSA-N
SMILES:
CCCCCC(c1cccc(c1)OCc1ccc2c(n1)cccc2)O
Properties
Computed Properties
 
Complexity:
375  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
335.189g/mol
Formal Charge:
0
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
335.447g/mol
Monoisotopic Mass:
335.189g/mol
Rotatable Bond Count:
8  
Topological Polar Surface Area:
42.4A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0
XLogP3:
5.2  

Synonyms
 
alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol 
PF 5901 
PF 5901 
RG 5901 
alpha-Pentyl-3-(2-quinolinylmethoxy)benzenemethanol 
1-[3-(quinolin-2-ylmethoxy)phenyl]hexan-1-ol 
CHEMBL8747 
MLS000069771 
REV-901 
PF-5901 
Benzenemethanol, alpha-pentyl-3-(2-quinolinylmethoxy)- 
SMR000058509 
PF-5901 
alpha-Pentyl-3-[2-quinolinylmethoxy]benzyl alcohol 
1-(3-(quinolin-2-ylmethoxy)phenyl)hexan-1-ol 
SR-01000076105 
ACMC-20d0wb 
Opera_ID_512 
UNII-WNW5RYD8MG 
WNW5RYD8MG 
AC1L1JIU 
CBiol_001910 
Lopac0_001042 
REV 5901 
BSPBio_001522 
KBioGR_000242 
KBioSS_000242 
MLS001076522 
SCHEMBL678489 
AC1Q777J 
BML2-G04 
CHEBI:91821 
CTK4A0391 
KBio2_000242 
REV-5901 
KBio2_002810 
KBio2_005378 
KBio3_000483 
KBio3_000484 
JRLOEMCOOZSCQP-UHFFFAOYSA-N 
Bio1_000196 
Bio1_000685 
Bio1_001174 
Bio2_000242 
Bio2_000722 
RG 5901 
HMS1361M04 
HMS1791M04 
HMS1989M04 
HMS2232F10 
HMS3370K08 
HMS3402M04 
HMS3649O15 
BDBM50012434 
MFCD00211150 
AKOS000278774 
RG-5901 
AKOS032953945 
CCG-205119 
LP01042 
IDI1_033992 
SMP2_000318 
NCGC00015895-02 
NCGC00015895-03 
NCGC00015895-04 
NCGC00015895-05 
NCGC00015895-06 
Rev 5901 
NCGC00094327-01 
NCGC00094327-02 
NCGC00094327-03 
NCGC00094327-04 
[3-(1-hydroxyhexyl)phenoxymethyl]quinoline 
LS-186839 
LS-187501 
EU-0101042 
2-[3-(1-hydroxyhexyl)phenoxymethyl]quinoline 
R 5523 
REV-5901 
1-[3-(Quinolin-2-ylmethoxy)-phenyl]-hexan-1-ol 
Benzenemethanol,a-pentyl-3-(2-quinolinylmethoxy)- 
Benzenemethanol,|A-pentyl-3-(2-quinolinylmethoxy)- 
SR-01000076105-2 
SR-01000076105-7 
Benzenemethanol,alpha-pentyl-3-(2-quinolinylmethoxy)- 
BRD-A68281735-001-03-8 
(REV-5,901)1-[3-(Quinolin-2-ylmethoxy)-phenyl]-hexan-1-ol 
1-[3-(Quinolin-2-ylmethoxy)-phenyl]-hexan-1-ol (RG 5901) 
1-[3-(Quinolin-2-ylmethoxy)-phenyl]-hexan-1-ol(Rev-5901) 
101910-24-1 
D0O8ZE 
CID5059 
KST-1A9572 
AR-1B9166 
C22-H25-N-O2 
RG-5901 
|A-Pentyl-3-[2-quinolinylmethoxy]benzyl alcohol 
C049740 
Benzenemethanol, a-pentyl-3-(2-quinolinylmethoxy)- 
102417-21-0 
Literature

Title: The effects of REV5901 on intracellular calcium signalling in freshly isolated bovine articular chondrocytes.

Journal: General physiology and biophysics 20120901

Title: Inhibition of aldose reductase prevents endotoxin-induced inflammation by regulating the arachidonic acid pathway in murine macrophages.

Journal: Free radical biology & medicine 20111101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: 4-Hydroxynonenal enhances MMP-9 production in murine macrophages via 5-lipoxygenase-mediated activation of ERK and p38 MAPK.

Journal: Toxicology and applied pharmacology 20100115

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Overexpression of 5-lipoxygenase in colon polyps and cancer and the effect of 5-LOX inhibitors in vitro and in a murine model.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20081015

Title: Mechanism of leukotriene D4 inhibition of Na-alanine cotransport in intestinal epithelial cells.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20080701

Title: Control of chondrocyte regulatory volume decrease (RVD) by [Ca2+]i and cell shape.

Journal: Osteoarthritis and cartilage 20080301

Title: The role of arachidonic acid and its metabolites in insulin secretion from human islets of langerhans.

Journal: Diabetes 20070101

Title: Simultaneous inhibition of COX-2 and 5-LOX activities augments growth arrest and death of premalignant and malignant human lung cell lines.

Journal: Journal of experimental therapeutics & oncology 20070101

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: 5-Lipoxygenase, a marker for early pancreatic intraepithelial neoplastic lesions.

Journal: Cancer research 20050715

Title: Stimulation of regulatory volume decrease (RVD) by isolated bovine articular chondrocytes following F-actin disruption using latrunculin B.

Journal: Biorheology 20050101

Title: Inverse agonist activity of selected ligands of the cysteinyl-leukotriene receptor 1.

Journal: The Journal of pharmacology and experimental therapeutics 20040401

Title: Toxicity of human monocytic THP-1 cells and microglia toward SH-SY5Y neuroblastoma cells is reduced by inhibitors of 5-lipoxygenase and its activating protein FLAP.

Journal: Journal of leukocyte biology 20030301

Title: Inhibition by eicosapentaenoic acid of IL-1beta-induced PGHS-2 expression in human microvascular endothelial cells: involvement of lipoxygenase-derived metabolites and p38 MAPK pathway.

Journal: Biochimica et biophysica acta 20030220

Title: Actions of cysteinyl leukotrienes in the enteric nervous system of guinea-pig stomach and small intestine.

Journal: European journal of pharmacology 20030110

Title: Lipoxygenase inhibitors attenuate growth of human pancreatic cancer xenografts and induce apoptosis through the mitochondrial pathway.

Journal: Molecular cancer therapeutics 20020901

Title: Enhanced activity of Ca2+-activated K+ channels by 1-[2-hydroxy-3-propyl-4-[(1H-tetrazol-5-yl)butoxyl]phenyl] ethanone (LY-171883) in neuroendocrine and neuroblastoma cell lines.

Journal: Journal of cellular physiology 20020801

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Early vascular permeability in murine experimental peritonitis is co-mediated by resident peritoneal macrophages and mast cells: crucial involvement of macrophage-derived cysteinyl-leukotrienes.

Journal: Inflammation 20020401

Title: The role of a swelling-activated taurine transport pathway in the regulation of articular chondrocyte volume.

Journal: Pflugers Archiv : European journal of physiology 20010801

Title: Regulatory volume decrease (RVD) by isolated and in situ bovine articular chondrocytes.

Journal: Journal of cellular physiology 20010601

Title: Cyclo-oxygenase and lipoxygenase pathways in mast cell dependent-neurogenic inflammation induced by electrical stimulation of the rat saphenous nerve.

Journal: British journal of pharmacology 20010401

Title: Novel effects of 5,8,11-eicosatriynoic acid, a lipoxygenase inhibitor, on Ca2+ mobilization in Madin Darby canine kidney cells.

Journal: Pharmacology & toxicology 20010101

Title: Pharmacological investigation of the role of leukotrienes in the pathogenesis of experimental NSAID gastropathy.

Journal: Inflammation 19920601

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