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1020412-43-4,MFCD11041176
Catalog No.:AA008XZ9

1020412-43-4 | GardiquiMod

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥95%
in stock  
$70.00   $49.00
- +
10mg
≥95%
in stock  
$132.00   $92.00
- +
25mg
≥95%
in stock  
$240.00   $168.00
- +
50mg
≥95%
in stock  
$443.00   $310.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008XZ9
Chemical Name:
GardiquiMod
CAS Number:
1020412-43-4
Molecular Formula:
C17H23N5O
Molecular Weight:
313.3974
MDL Number:
MFCD11041176
SMILES:
CCNCc1nc2c(n1CC(O)(C)C)c1ccccc1nc2N
Properties
Computed Properties
 
Complexity:
404  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
5  
XLogP3:
1  

Literature

Title: Intraperitoneal gardiquimod protects against hepatotoxicity through inhibition of oxidative stress and inflammation in mice with sepsis.

Journal: Journal of biochemical and molecular toxicology 20170801

Title: Selective IRAK4 Inhibition Attenuates Disease in Murine Lupus Models and Demonstrates Steroid Sparing Activity.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20170201

Title: [Inhibitory effect of toll-like receptor 7 agonist on K562 cells].

Journal: Zhongguo shi yan xue ye xue za zhi 20120601

Title: Poly I:C enhances susceptibility to secondary pulmonary infections by gram-positive bacteria.

Journal: PloS one 20120101

Title: Diesel exhaust particle exposure in vitro alters monocyte differentiation and function.

Journal: PloS one 20120101

Title: Transcriptional profiling of TLR-4/7/8-stimulated guinea pig splenocytes and whole blood by bDNA assay.

Journal: Journal of immunological methods 20111028

Title: Painful pathways induced by TLR stimulation of dorsal root ganglion neurons.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20110601

Title: The TLR7/8 ligand resiquimod targets monocyte-derived dendritic cell differentiation via TLR8 and augments functional dendritic cell generation.

Journal: Cellular immunology 20110101

Title: An intranasally delivered Toll-like receptor 7 agonist elicits robust systemic and mucosal responses to Norwalk virus-like particles.

Journal: Clinical and vaccine immunology : CVI 20101201

Title: The TLR7 agonists imiquimod and gardiquimod improve DC-based immunotherapy for melanoma in mice.

Journal: Cellular & molecular immunology 20100901

Title: TLR8 agonists stimulate newly recruited monocyte-derived cells into potent APCs that enhance HBsAg immunogenicity.

Journal: Vaccine 20100831

Title: Structure-activity relationships in human toll-like receptor 7-active imidazoquinoline analogues.

Journal: Journal of medicinal chemistry 20100610

Title: Signaling through TLR7 enhances the immunosuppressive activity of murine CD4+CD25+ T regulatory cells.

Journal: Journal of leukocyte biology 20100101

Title: Porcine TLR8 and TLR7 are both activated by a selective TLR7 ligand, imiquimod.

Journal: Molecular immunology 20080601

Title: Buitendijk M, et al. Gardiquimod: a Toll-like receptor-7 agonist that inhibits HIV type 1 infection of human macrophages and activated T cells. AIDS Res Hum Retroviruses. 2013 Jun;29(6):907-18.

Title: Zhou Z, et al. TLR7/8 agonists promote NK-DC cross-talk to enhance NK cell anti-tumor effects in hepatocellular carcinoma. Cancer Lett. 2015 Dec 28;369(2):298-306.

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