Home Amines 102518-79-6
102518-79-6,MFCD01714949
Catalog No.:AA0007JW
102518-79-6 | (1R,9R)-1-amino-13-ethylidene-11-methyl-6-azatricyclo[7.3.1.0^{2,7}]trideca-2(7),3,10-trien-5-one
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5mg
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$122.00   $85.00
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10mg
98%
in stock  
$182.00   $128.00
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25mg
98%
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$376.00   $263.00
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100mg
98%
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$381.00   $267.00
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250mg
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$762.00   $534.00
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1g
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$1,508.00   $1,055.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0007JW
Chemical Name:
(1R,9R)-1-amino-13-ethylidene-11-methyl-6-azatricyclo[7.3.1.0^{2,7}]trideca-2(7),3,10-trien-5-one
CAS Number:
102518-79-6
Molecular Formula:
C15H18N2O
Molecular Weight:
242.3162
MDL Number:
MFCD01714949
IUPAC Name:
(1R,9R)-1-amino-13-ethylidene-11-methyl-6-azatricyclo[7.3.1.02,7]trideca-2(7),3,10-trien-5-one
InChI:
InChI=1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/t10-,15+/m0/s1
InChI Key:
ZRJBHWIHUMBLCN-ZUZCIYMTSA-N
SMILES:
C/C=C/1\[C@H]2C=C(C[C@]1(N)c1c(C2)[nH]c(=O)cc1)C
EC Number:
600-320-6
Properties
Computed Properties
 
Complexity:
551  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
0
Exact Mass:
242.142g/mol
Formal Charge:
0
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
242.322g/mol
Monoisotopic Mass:
242.142g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
55.1A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
1  
XLogP3:
0

Synonyms
 
huperzine A 
huperzine A, (5alpha,9beta,11Z)-(-)-isomer 
(-)-huperazine A; 
AC1LINDQ 
AC1L9MOL 
AC1LGYS6 
Spectrum2_000835 
Spectrum3_001074 
Spectrum4_001229 
Spectrum5_001701 
BSPBio_002688 
KBioGR_001698 
Huperzine A 
MLS001424307 
SPBio_000789 
SCHEMBL16789797 
BCBcMAP01_000072 
KBio3_001908 
EX-A282 
HMS2052D07 
BCP08891 
AC-488 
CCG-101168 
(-)-huperzine A 
NC00418 
SMP1_000153 
AN-15769 
BC677910 
SMR000469231 
FT-0627095 
18H796 
SR-01000781266-3 
SR-01000781266-4 
Huperzine 
102518-79-6 
Selagine 
Kimpukan A 
Hup A 
(-)-huperazine A 
HUPERAINE A 
D07DFF 
(-)- HUPPERZINE A 
C15-H18-N2-O 
CID449069 
CID854026 
(-)-Selagine 
UNII-0111871I23 
ACN-035610 
A1932 
huperzine A, (5alpha,9beta,11Z)-(-)-isomer 
C050426 
Huperzine A, 98%, from Huperzia serrata (Thunb.) Trevis. - 5MG 5mg 
120786-18-7 
Huperzine A; 
SR-01000781266 
5,9-Methanocycloocta[b]pyridin-2(1H)-one, 5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-, (5R,9R,11E)- 
Literature

Title: Abcb1a but not Abcg2 played a predominant role in limiting the brain distribution of Huperzine A in mice.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20170901

Title: Zebrafish is a predictive model for identifying compounds that protect against brain toxicity in severe acute organophosphorus intoxication.

Journal: Archives of toxicology 20170101

Title: Design and synthesis of N-substituted-2-hydroxyiminoacetamides and interactions with cholinesterases.

Journal: Chemico-biological interactions 20161125

Title: Human serum albumin reduces the potency of acetylcholinesterase inhibitor based drugs for Alzheimer's disease.

Journal: Chemico-biological interactions 20160405

Title: The role of cholinergic anti-inflammatory pathway in acetic acid-induced colonic inflammation in the rat.

Journal: Chemico-biological interactions 20130905

Title: Development and validation of a simple assay for the determination of cholinesterase activity in whole blood of laboratory animals.

Journal: Journal of applied toxicology : JAT 20130401

Title: A combination of [+] and [-]-Huperzine A improves protection against soman toxicity compared to [+]-Huperzine A in guinea pigs.

Journal: Chemico-biological interactions 20130325

Title: Acetylcholinesterase deficiency decreases apoptosis in dopaminergic neurons in the neurotoxin model of Parkinson's disease.

Journal: The international journal of biochemistry & cell biology 20130201

Title: An efficient total synthesis of (-)-huperzine A.

Journal: Organic letters 20120907

Title: Huperzine A ameliorates cognitive deficits and oxidative stress in the hippocampus of rats exposed to acute hypobaric hypoxia.

Journal: Neurochemical research 20120901

Title: Simultaneously preparative purification of Huperzine A and Huperzine B from Huperzia serrata by macroporous resin and preparative high performance liquid chromatography.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120901

Title: Microemulsion-based patch for transdermal delivery of huperzine A and ligustrazine phosphate in treatment of Alzheimer's disease.

Journal: Drug development and industrial pharmacy 20120601

Title: Toxicological scoring of Alzheimer's disease drug huperzine in a guinea pig model.

Journal: Toxicology mechanisms and methods 20120401

Title: Symptomatic and nonamyloid/tau based pharmacologic treatment for Alzheimer disease.

Journal: Cold Spring Harbor perspectives in medicine 20120301

Title: Chiral separation of Huperzine A using CE - method validation and application in pharmaceutical formulations.

Journal: Electrophoresis 20120201

Title: Treatment with Huperzine A improves cognition in vascular dementia patients.

Journal: Cell biochemistry and biophysics 20120101

Title: Huperzine A derivative M3 protects PC12 cells against sodium nitroprusside-induced apoptosis.

Journal: Acta pharmacologica Sinica 20120101

Title: Examining the interactome of huperzine A by magnetic biopanning.

Journal: PloS one 20120101

Title: [+]-Huperzine A protects against soman toxicity in guinea pigs.

Journal: Neurochemical research 20111201

Title: Isolation and characterization of endophytic huperzine A-producing fungi from Huperzia serrata.

Journal: Journal of industrial microbiology & biotechnology 20110901

Title: An overview on natural cholinesterase inhibitors--a multi-targeted drug class--and their mass production.

Journal: Mini reviews in medicinal chemistry 20110901

Title: Bis(12)-hupyridone, a novel multifunctional dimer, promotes neuronal differentiation more potently than its monomeric natural analog huperzine A possibly through α7 nAChR.

Journal: Brain research 20110715

Title: The effects of huperzine A and IDRA 21 on visual recognition memory in young macaques.

Journal: Neuropharmacology 20110601

Title: Huperzine A activates Wnt/β-catenin signaling and enhances the nonamyloidogenic pathway in an Alzheimer transgenic mouse model.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20110401

Title: Binding of huperzine A and galanthamine to acetylcholinesterase, based on ONIOM method.

Journal: Nanomedicine : nanotechnology, biology, and medicine 20110201

Title: Improved thin-layer chromatography bioautographic assay for the detection of actylcholinesterase inhibitors in plants.

Journal: Phytochemical analysis : PCA 20110101

Title: Huperzine induces alteration in oxidative balance and antioxidants in a guinea pig model.

Journal: Neuro endocrinology letters 20110101

Title: Coadministration of huperzine A and ligustrazine phosphate effectively reverses scopolamine-induced amnesia in rats.

Journal: Pharmacology, biochemistry, and behavior 20101001

Title: Photohuperzine A-A new photoisomer of huperzine A: structure elucidation, formation kinetics and activity assessment.

Journal: Journal of pharmaceutical and biomedical analysis 20100605

Title: Preparation, optimization and characteristic of huperzine a loaded nanostructured lipid carriers.

Journal: Chemical & pharmaceutical bulletin 20100501

Title: Huperzine a improves chronic inflammation and cognitive decline in rats with cerebral hypoperfusion.

Journal: Journal of neuroscience research 20100301

Title: Intrathecal huperzine A increases thermal escape latency and decreases flinching behavior in the formalin test in rats.

Journal: Neuroscience letters 20100205

Title: Systemic administration of the potential countermeasure huperzine reversibly inhibits central and peripheral acetylcholinesterase activity without adverse cognitive-behavioral effects.

Journal: Pharmacology, biochemistry, and behavior 20100101

Title: Effectiveness of donepezil, rivastigmine, and (+/-)huperzine A in counteracting the acute toxicity of organophosphorus nerve agents: comparison with galantamine.

Journal: The Journal of pharmacology and experimental therapeutics 20091201

Title: Rational design and synthesis of highly potent anti-acetylcholinesterase activity huperzine A derivatives.

Journal: Bioorganic & medicinal chemistry 20091001

Title: Matrine determination and pharmacokinetics in human plasma using LC/MS/MS.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20091001

Title: Clinical use of an herbal-derived compound (Huperzine A) to treat putative complex partial seizures in a dog.

Journal: Epilepsy & behavior : E&B 20090801

Title: Green tea polyphenol (-)-epigallocatechin-3-gallate enhances the inhibitory effect of huperzine A on acetylcholinesterase by increasing the affinity with serum albumin.

Journal: Nutritional neuroscience 20090801

Title: Cholinergic deficiency involved in vascular dementia: possible mechanism and strategy of treatment.

Journal: Acta pharmacologica Sinica 20090701

Title: [Release mechanism of huperzine-A swelling sustained-release tablets].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090701

Title: BZYX, a novel acetylcholinesterase inhibitor, significantly improved chemicals-induced learning and memory impairments on rodents and protected PC12 cells from apoptosis induced by hydrogen peroxide.

Journal: European journal of pharmacology 20090624

Title: Huperzine A protects isolated rat brain mitochondria against beta-amyloid peptide.

Journal: Free radical biology & medicine 20090601

Title: Two-dimensional turbulent flow chromatography coupled on-line to liquid chromatography-mass spectrometry for solution-based ligand screening against multiple proteins.

Journal: Journal of chromatography. A 20090320

Title: Lycojapodine A, a novel alkaloid from Lycopodium japonicum.

Journal: Organic letters 20090319

Title: Brain acetylcholinesterase activity controls systemic cytokine levels through the cholinergic anti-inflammatory pathway.

Journal: Brain, behavior, and immunity 20090101

Title: Huperzine A for vascular dementia.

Journal: The Cochrane database of systematic reviews 20090101

Title: Development of a sensitive high-performance liquid chromatographic method with simple extraction for simultaneous determination of huperzine A and huperzine B in the species containing lycopodium alkaloids.

Journal: Journal of AOAC International 20090101

Title: Protection of red blood cell acetylcholinesterase by oral huperzine A against ex vivo soman exposure: next generation prophylaxis and sequestering of acetylcholinesterase over butyrylcholinesterase.

Journal: Chemico-biological interactions 20080925

Title: Anti-acetylcholinesterase activities of traditional Chinese medicine for treating Alzheimer's disease.

Journal: Chemico-biological interactions 20080925

Title: [+]-Huperzine A treatment protects against N-methyl-D-aspartate-induced seizure/status epilepticus in rats.

Journal: Chemico-biological interactions 20080925

Title: The combination of huperzine A and imidazenil is an effective strategy to prevent diisopropyl fluorophosphate toxicity in mice.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20080916

Title: Huperzine A attenuates mitochondrial dysfunction after middle cerebral artery occlusion in rats.

Journal: Journal of neuroscience research 20080815

Title: Huperzine A exhibits anti-inflammatory and neuroprotective effects in a rat model of transient focal cerebral ischemia.

Journal: Journal of neurochemistry 20080801

Title: Huperzine A for Alzheimer's disease.

Journal: The Cochrane database of systematic reviews 20080416

Title: Determination of huperzine A in human plasma by liquid chromatography-electrospray tandem mass spectrometry: application to a bioequivalence study on Chinese volunteers.

Journal: Biomedical chromatography : BMC 20080401

Title: Investigation of the mechanism of enhanced effect of EGCG on huperzine A's inhibition of acetylcholinesterase activity in rats by a multispectroscopic method.

Journal: Journal of agricultural and food chemistry 20080213

Title: Non-cholinergic effects of huperzine A: beyond inhibition of acetylcholinesterase.

Journal: Cellular and molecular neurobiology 20080201

Title: [Effects of huperzine A on cognitive function of rats recovering from general anesthesia].

Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20080201

Title: Huperzine A reverses cholinergic and monoaminergic dysfunction induced by bilateral nucleus basalis magnocellularis injection of beta-amyloid peptide (1-40) in rats.

Journal: Cellular and molecular neurobiology 20080101

Title: Huperzine A provides neuroprotection against several cell death inducers using in vitro model systems of motor neuron cell death.

Journal: Neurotoxicity research 20080101

Title: Huperzine A regulates amyloid precursor protein processing via protein kinase C and mitogen-activated protein kinase pathways in neuroblastoma SK-N-SH cells over-expressing wild type human amyloid precursor protein 695.

Journal: Neuroscience 20071205

Title: East meets West in the search for Alzheimer's therapeutics - novel dimeric inhibitors from tacrine and huperzine A.

Journal: Current Alzheimer research 20070901

Title: Determination of Huperzine A in rat plasma by high-performance liquid chromatography with a fluorescence detector.

Journal: Journal of pharmaceutical and biomedical analysis 20070509

Title: Involvement of M1-muscarinic acetylcholine receptors, protein kinase C and mitogen-activated protein kinase in the effect of huperzine A on secretory amyloid precursor protein-alpha.

Journal: Neuroreport 20070507

Title: Huperzine A as add-on therapy in patients with treatment-resistant schizophrenia: an open-labeled trial.

Journal: Schizophrenia research 20070501

Title: Reversible inhibition of acetylcholinesterase by carbamates or huperzine A increases residual activity of the enzyme upon soman challenge.

Journal: Toxicology 20070420

Title: Sensitivity of butyrylcholinesterase knockout mice to (--)-huperzine A and donepezil suggests humans with butyrylcholinesterase deficiency may not tolerate these Alzheimer's disease drugs and indicates butyrylcholinesterase function in neurotransmission.

Journal: Toxicology 20070420

Title: The effects of Liuwei Dihuang decoction on the gene expression in the hippocampus of senescence-accelerated mouse.

Journal: Fitoterapia 20070401

Title: Prolonged effects of poly(lactic-co-glycolic acid) microsphere-containing huperzine A on mouse memory dysfunction induced by scopolamine.

Journal: Basic & clinical pharmacology & toxicology 20070301

Title: Huperzine A protects C6 rat glioma cells against oxygen-glucose deprivation-induced injury.

Journal: FEBS letters 20070220

Title: Preparative isolation of huperzines A and B from Huperzia serrata by displacement centrifugal partition chromatography.

Journal: Journal of chromatography. A 20070126

Title: Simple determination of huperzine A in human plasma by liquid chromatographic-tandem mass spectrometric method.

Journal: Biomedical chromatography : BMC 20070101

Title: Bivalent ligands derived from Huperzine A as acetylcholinesterase inhibitors.

Journal: Current topics in medicinal chemistry 20070101

Title: Binding of 13-amidohuprines to acetylcholinesterase: exploring the ligand-induced conformational change of the gly117-gly118 peptide bond in the oxyanion hole.

Journal: Journal of medicinal chemistry 20061116

Title: [Effect of huperzine A on cerebral cholinesterase and acetylcholine in elderly patients during recovery from general anesthesia].

Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20061101

Title: Editorial: natural products chemistry in China.

Journal: Natural product reports 20061001

Title: Effects of huperzine A on amyloid precursor protein processing and beta-amyloid generation in human embryonic kidney 293 APP Swedish mutant cells.

Journal: Journal of neuroscience research 20060901

Title: Comparative studies of huperzine A, donepezil, and rivastigmine on brain acetylcholine, dopamine, norepinephrine, and 5-hydroxytryptamine levels in freely-moving rats.

Journal: Acta pharmacologica Sinica 20060901

Title: Harmless herbs? Think again: merits of a complete medication history.

Journal: Journal of the American Medical Directors Association 20060901

Title: Effective countermeasure against poisoning by organophosphorus insecticides and nerve agents.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20060829

Title: Kinetic analysis of the protection afforded by reversible inhibitors against irreversible inhibition of acetylcholinesterase by highly toxic organophosphorus compounds.

Journal: Biochemical pharmacology 20060728

Title: Acetylcholinesterase triggers the aggregation of PrP 106-126.

Journal: Biochemical and biophysical research communications 20060721

Title: Position statement of the American Association for Geriatric Psychiatry regarding principles of care for patients with dementia resulting from Alzheimer disease.

Journal: The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 20060701

Title: Discovery of huperzine A-tacrine hybrids as potent inhibitors of human cholinesterases targeting their midgorge recognition sites.

Journal: Journal of medicinal chemistry 20060601

Title: [Experimental study on protective effects of HupA in the treatment of isocarbophos poisoning].

Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20060601

Title: Huperzine A attenuates mitochondrial dysfunction in beta-amyloid-treated PC12 cells by reducing oxygen free radicals accumulation and improving mitochondrial energy metabolism.

Journal: Journal of neuroscience research 20060501

Title: [Effect of HuperzineA on neurophathologic change of mouse exposed by isocarbophos and phoxim].

Journal: Wei sheng yan jiu = Journal of hygiene research 20060501

Title: Molecular lipophilicity determination of a huperzine series by HPLC: comparison of C18 and IAM stationary phases.

Journal: Journal of pharmaceutical and biomedical analysis 20060411

Title: Quantification of huperzine A in Huperzia serrata by HPLC-UV and identification of the major constituents in its alkaloid extracts by HPLC-DAD-MS-MS.

Journal: Journal of pharmaceutical and biomedical analysis 20060303

Title: Simultaneous determination of ZT-1 and its metabolite Huperzine A in plasma by high-performance liquid chromatography with ultraviolet detection.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060102

Title: Effects of a memory enhancing peptide on cognitive abilities of brain-lesioned mice: additivity with huperzine A and relative potency to tacrine.

Journal: Journal of peptide science : an official publication of the European Peptide Society 20060101

Title: Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine.

Journal: Acta pharmacologica Sinica 20060101

Title: In vitro and in vivo characterization of huperzine a loaded microspheres made from end-group uncapped poly(d,l-lactide acid) and poly(d,l-lactide-co-glycolide acid).

Journal: Chemical & pharmaceutical bulletin 20060101

Title: Herbal medicine in the treatment of Alzheimer's disease.

Journal: American journal of Alzheimer's disease and other dementias 20060101

Title: Towards a unifying hypothesis of Alzheimer's disease: cholinergic system linked to plaques, tangles and neuroinflammation.

Journal: Current medicinal chemistry 20060101

Title: Oral administration of pyridostigmine bromide and huperzine A protects human whole blood cholinesterases from ex vivo exposure to soman.

Journal: Chemico-biological interactions 20051215

Title: Molecular and pharmacological characterization of muscarinic receptors in retinal pigment epithelium: role in light-adaptive pigment movements.

Journal: Journal of neurochemistry 20051201

Title: Nicotinic-receptor potentiator drugs, huprine X and galantamine, increase ACh release by blocking AChE activity but not acting on nicotinic receptors.

Journal: Brain research 20051109

Title: A cyanopropyl reversed phase chromatography enables resolution of huperzine A and B on analytical and preparative scales.

Journal: Journal of separation science 20051101

Title: Huperzine A protects SHSY5Y neuroblastoma cells against oxidative stress damage via nerve growth factor production.

Journal: European journal of pharmacology 20050905

Title: Optimization of the capillary zone electrophoresis method for Huperzine A determination using experimental design and artificial neural networks.

Journal: Journal of chromatography. A 20050819

Title: Huperzine A--human serum albumin association: chromatographic and thermodynamic approach.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050625

Title: Effects of huperzine A on secretion of nerve growth factor in cultured rat cortical astrocytes and neurite outgrowth in rat PC12 cells.

Journal: Acta pharmacologica Sinica 20050601

Title: Ion-pair reverse-phase high performance liquid chromatography method for determination of Huperzine-A in beagle dog serum.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050325

Title: Effect of acidic oligosaccharide sugar chain on scopolamine-induced memory impairment in rats and its related mechanisms.

Journal: Neuroscience letters 20050221

Title: Effects of acetylcholinesterase and butyrylcholinesterase inhibition on breathing in mice adapted or not to reduced acetylcholinesterase.

Journal: Pharmacology, biochemistry, and behavior 20050101

Title: Neuroprotective effects of huperzine A. A natural cholinesterase inhibitor for the treatment of Alzheimer's disease.

Journal: Neuro-Signals 20050101

Title: The Lycopodium alkaloids.

Journal: Natural product reports 20041201

Title: (+/-)-huprine Y, (-)-huperzine A and tacrine do not show neuroprotective properties in an apoptotic model of neuronal cytoskeletal alteration.

Journal: Journal of Alzheimer's disease : JAD 20041201

Title: Recent pharmacological studies on natural products in China.

Journal: European journal of pharmacology 20041001

Title: Comparative effects of huperzine A, donepezil and rivastigmine on cortical acetylcholine level and acetylcholinesterase activity in rats.

Journal: Neuroscience letters 20040506

Title: Apoptosis induced by beta-amyloid25-35 in acetylcholinesterase-overexpressing neuroblastoma cells.

Journal: Acta pharmacologica Sinica 20030901

Title: A convergent approach to huperzine A and analogues.

Journal: Organic & biomolecular chemistry 20030821

Title: Effects of huperzine A on liver cytochrome P-450 in rats.

Journal: Acta pharmacologica Sinica 20030801

Title: [Studies on analogues of huperzine A for treatment of senile dementia. VI. Asymmetric total synthesis of 14-nor-huperzine A and its inhibitory activity of acetylcholinesterase].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20030501

Title: Huperzine A attenuates the neurotoxic effect of staurosporine in primary rat cortical neurons.

Journal: Neuroscience letters 20030410

Title: Potentiation of acetylcholine action by huperzine-A and physostigmine on some vertebrate effectors, including human iris sphincter muscle.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20030401

Title: Acute effects of huperzine A and tacrine on rat liver.

Journal: Acta pharmacologica Sinica 20030301

Title: Determination of huperzine A in formulated products by reversed-phase-liquid chromatography using diode array and electrospray ionization mass spectrometric detection.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20030301

Title: Identification of cytochrome P450 1A2 as enzyme involved in the microsomal metabolism of Huperzine A.

Journal: European journal of pharmacology 20030214

Title: Enantiomer effects of huperzine A on the aryl acylamidase activity of human cholinesterases.

Journal: Cellular and molecular neurobiology 20030201

Title: Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders.

Journal: Phytotherapy research : PTR 20030101

Title: Effects of huperzine A on acetylcholinesterase isoforms in vitro: comparison with tacrine, donepezil, rivastigmine and physostigmine.

Journal: European journal of pharmacology 20021129

Title: Ginkgolide A, B, and huperzine A inhibit nitric oxide-induced neurotoxicity.

Journal: International immunopharmacology 20021001

Title: X-ray structures of Torpedo californica acetylcholinesterase complexed with (+)-huperzine A and (-)-huperzine B: structural evidence for an active site rearrangement.

Journal: Biochemistry 20020903

Title: [Advances in search for acetylcholinesterase inhibitor based on the double active sites hypothesis].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20020901

Title: Subchronic administration of pyridostigmine or huperzine to primates: compared efficacy against soman toxicity.

Journal: Drug and chemical toxicology 20020801

Title: Huperzine A, a nootropic agent, inhibits fast transient potassium current in rat dissociated hippocampal neurons.

Journal: Neuroscience letters 20020510

Title: Review of the value of huperzine as pretreatment of organophosphate poisoning.

Journal: Neurotoxicology 20020501

Title: 3D structure of Torpedo californica acetylcholinesterase complexed with huprine X at 2.1 A resolution: kinetic and molecular dynamic correlates.

Journal: Biochemistry 20020305

Title: Spermidine antagonizes the inhibitory effect of huperzine A on [3H]dizocilpine (MK-801) binding in synaptic membrane of rat cerebral cortex.

Journal: Neuroscience letters 20020215

Title: Stereoselectivities of enantiomers of huperzine A in protection against beta-amyloid(25-35)-induced injury in PC12 and NG108-15 cells and cholinesterase inhibition in mice.

Journal: Neuroscience letters 20020114

Title: Huperzine A attenuates amyloid beta-peptide fragment 25-35-induced apoptosis in rat cortical neurons via inhibiting reactive oxygen species formation and caspase-3 activation.

Journal: Journal of neuroscience research 20020101

Title: Effect of huperzine A on working memory in reserpine- or yohimbine-treated monkeys.

Journal: European journal of pharmacology 20011221

Title: The NMDA receptor ion channel: a site for binding of Huperzine A.

Journal: Journal of applied toxicology : JAT 20011201

Title: Huperzine A attenuates cognitive deficits and hippocampal neuronal damage after transient global ischemia in gerbils.

Journal: Neuroscience letters 20011109

Title: Tacrine-huperzine A hybrids (huprines): a new class of highly potent and selective acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease.

Journal: Mini reviews in medicinal chemistry 20010701

Title: Huperzine A and donepezil protect rat pheochromocytoma cells against oxygen-glucose deprivation.

Journal: Neuroscience letters 20010622

Title: Subchronic administration of various pretreatments of nerve agent poisoning. I. Protection of blood and central cholinesterases, innocuousness towards blood-brain barrier permeability.

Journal: Drug and chemical toxicology 20010501

Title: Subchronic administration of various pretreatments of nerve agent poisoning. II. Compared efficacy against soman toxicity.

Journal: Drug and chemical toxicology 20010501

Title: Long-term potentiation in hippocampus of rats is enhanced by endogenous acetylcholine in a way that is independent of N-methyl-D-aspartate receptors.

Journal: Neuroscience letters 20010316

Title: Effects of Huperzine used as pre-treatment against soman-induced seizures.

Journal: Neurotoxicology 20010201

Title: Huperzine A, a nootropic alkaloid, inhibits N-methyl-D-aspartate-induced current in rat dissociated hippocampal neurons.

Journal: Neuroscience 20010101

Title: Reversal of scopolamine-induced deficits in radial maze performance by (-)-huperzine A: comparison with E2020 and tacrine.

Journal: European journal of pharmacology 19980522

Title: Effect of huperzine A, a novel acetylcholinesterase inhibitor, on radial maze performance in rats.

Journal: Pharmacology, biochemistry, and behavior 19950101

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