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1025720-94-8,MFCD16495773
Catalog No.:AA0007PD
1025720-94-8 | BMS-777607
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1mg
≥98%
1 week  
$98.00   $69.00
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5mg
99%
1 week  
$184.00   $129.00
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10mg
99%
1 week  
$279.00   $195.00
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50mg
99%
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$717.00   $502.00
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100mg
99%
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$1,231.00   $862.00
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  • Technical Information
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  • Technical Information
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Technical Information
Catalog Number:
AA0007PD
Chemical Name:
BMS-777607
CAS Number:
1025720-94-8
Molecular Formula:
C25H19ClF2N4O4
Molecular Weight:
512.8926
MDL Number:
MFCD16495773
IUPAC Name:
N-[4-(2-amino-3-chloropyridin-4-yl)oxy-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-2-oxopyridine-3-carboxamide
InChI:
InChI=1S/C25H19ClF2N4O4/c1-2-35-19-10-12-32(16-6-3-14(27)4-7-16)25(34)21(19)24(33)31-15-5-8-18(17(28)13-15)36-20-9-11-30-23(29)22(20)26/h3-13H,2H2,1H3,(H2,29,30)(H,31,33)
InChI Key:
VNBRGSXVFBYQNN-UHFFFAOYSA-N
SMILES:
CCOc1ccn(c(=O)c1C(=O)Nc1ccc(c(c1)F)Oc1ccnc(c1Cl)N)c1ccc(cc1)F
UNII:
A3MMS6HDO1
Properties
Computed Properties
 
Complexity:
867  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
512.106g/mol
Formal Charge:
0
Heavy Atom Count:
36  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
512.898g/mol
Monoisotopic Mass:
512.106g/mol
Rotatable Bond Count:
7  
Topological Polar Surface Area:
107A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4  

Synonyms
 
BMS 777607 
BMS-777607 
N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide 
UNII-A3MMS6HDO1 
A3MMS6HDO1 
BMS 817378 
3-Pyridinecarboxamide, N-[4-[(2-amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-1,2-dihydro-2-oxo- 
N-(4-((2-amino-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide 
N-[4-[(2-Amino-3-chloropyridin-4-yl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide 
3-Pyridinecarboxamide, N-[4-[(2-amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-1,2-dihydro-2-oxo-;3-Pyridinecarboxamide, N-[4-[(2-amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-1,2-dihydro-2-oxo- 
N-[4-(2-amino-3-chloropyridin-4-yl)oxy-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-2-oxopyridine-3-carboxamide 
N-[4-[(2-Amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-1,2-dihydro-2-oxo-3-pyridinecarboxamide 
BMS777607 
N-{4-[(2-Amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl}-4-ethoxy -1-(4-fluorophenyl)-2-oxo-1,2-dihydro-3-pyridinecarboxamide 
N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorophenyl}-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide 
ASLAN002 
VNBRGSXVFBYQNN-UHFFFAOYSA-N 
BMS777606 
MLS006010958 
C25H19ClF2N4O4 
CHEMBL460702 
GTPL7953 
SCHEMBL2588311 
N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide 
BDBM28031 
CHEBI:91409 
DTXSID50145278 
EX-A004 
3f82 
HMS3655C05 
AOB87395 
BCP02303 
ABP000925 
MFCD16495773 
BMS-777607 
s1561 
ZINC39716080 
AKOS026750587 
BCP9000432 
CS-0227 
DB12064 
EBD2206992 
EX-7213 
QC-7244 
RL00120 
1025720-94-8 
RL00767 
SB16607 
KS-0000063B 
ASLAN-002; BMS 777607 
NCGC00263157-01 
NCGC00263157-09 
4CA-0303 
AK311167 
AN-16984 
AS-17034 
BMS 777607 
BC600375 
HY-12076 
SMR004702762 
FT-0701277 
FT-0722977 
SW219298-1 
X7495 
BMS-777607/BMS777607/ 
W-5638 
BMS-777607, >=98% (HPLC) 
1196681-44-3 
J-004169 
J-523337 
BRD-K40738845-001-01-9 
BMS 777607, BMS777607, 1196681-44-3 
N-(4-(2-amino-3-chloropyridin-4-yloxy )-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide 
N-[4-[(2-Amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-1,2-dihydro-2-oxo-3-pyridinecarboxamide, 
N-[4-[(2-amino-3-chloro-4-pyridyl)oxy]-3-fluoro-phenyl]-4-ethoxy-1-(4-fluorophenyl)-2-oxo-pyridine-3-carboxamide 
N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorophenyl}-4-ethoxy-1-(4-fluorophenyl)-2-oxopyridine-3-carboxamide 
D0O6WV 
cc-417 
BMS777607 
ACN-031551 
A5703 
A10153 
C550356 
ASLAN-002 
Literature

Title: Prevention of BMS-777607-induced polyploidy/senescence by mTOR inhibitor AZD8055 sensitizes breast cancer cells to cytotoxic chemotherapeutics.

Journal: Molecular oncology 20140501

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: Impact of the small molecule Met inhibitor BMS-777607 on the metastatic process in a rodent tumor model with constitutive c-Met activation.

Journal: Clinical & experimental metastasis 20120301

Title: Constitutively active c-Met kinase in PC-3 cells is autocrine-independent and can be blocked by the Met kinase inhibitor BMS-777607.

Journal: BMC cancer 20120101

Title: Design, Synthesis and Biological Evaluation of a Series of Novel Axl Kinase Inhibitors.

Journal: ACS medicinal chemistry letters 20111208

Title: BMS-777607, a small-molecule met kinase inhibitor, suppresses hepatocyte growth factor-stimulated prostate cancer metastatic phenotype in vitro.

Journal: Molecular cancer therapeutics 20100601

Title: Discovery of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a selective and orally efficacious inhibitor of the Met kinase superfamily.

Journal: Journal of medicinal chemistry 20090312

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