Home Imidazoles 102676-31-3
102676-31-3,MFCD00866239
Catalog No.:AA000800
102676-31-3 | Benzonitrile, 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)-, hydrochloride (1:1)
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1mg
≥98%
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5mg
99.22%
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10mg
99.22%
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$165.00   $115.00
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25mg
99.22%
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50mg
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100mg
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  • Technical Information
  • Properties
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA000800
Chemical Name:
Benzonitrile, 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)-, hydrochloride (1:1)
CAS Number:
102676-31-3
Molecular Formula:
C14H14ClN3
Molecular Weight:
259.7341
MDL Number:
MFCD00866239
IUPAC Name:
4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile;hydrochloride
InChI:
InChI=1S/C14H13N3.ClH/c15-8-11-4-6-12(7-5-11)14-3-1-2-13-9-16-10-17(13)14;/h4-7,9-10,14H,1-3H2;1H
InChI Key:
UKCVAQGKEOJTSR-UHFFFAOYSA-N
SMILES:
N#Cc1ccc(cc1)C1CCCc2n1cnc2.Cl
Properties
Computed Properties
 
Complexity:
311  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
259.088g/mol
Formal Charge:
0
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
259.737g/mol
Monoisotopic Mass:
259.088g/mol
Rotatable Bond Count:
1  
Topological Polar Surface Area:
41.6A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0

Synonyms
 
CGS 020286A 
CGS 16949A 
Fadrozole Hydrochloride 
Fadrozole Monohydrochloride 
Hydrochloride, Fadrozole 
Monohydrochloride, Fadrozole 
FADROZOLE HYDROCHLORIDE 
102676-31-3 
Afema 
Fadrozole HCl 
Fadrozole.HCl 
CGS 16949A 
CGS-020286A 
CGS 16949 
CCRIS 4597 
Fadrozole hydrochloride [USAN] 
4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile hydrochloride 
Fadrozole monohydrochloride 
CHEMBL468419 
4-(5,6,7,8-Tetrahydroimidazo(1,5-a)pyridin-5-yl)benzonitrile monohydrochloride 
Fadrozole hydrochloride (USAN) 
Benzonitrile, 4-(5,6,7,8-tetrahydroimidazo(1,5-a)pyridin-5-yl)-, monohydrochloride 
Arensin 
CGS-16949A 
4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)-Benzonitrile 
AC1L1RRB 
AC1Q3CEO 
DSSTox_CID_618 
SCHEMBL4143 
DSSTox_RID_75694 
DSSTox_GSID_20618 
DTXSID4020618 
CGS16949A 
CHEBI:31589 
CGS020286A 
CTK8E9343 
UKCVAQGKEOJTSR-UHFFFAOYSA-N 
BCP18654 
Tox21_303613 
ABP000972 
MFCD00866239 
AKOS025311475 
API0008423 
NCGC00257411-01 
Fadrozole hydrochloride, >=98% (HPLC) 
CGS16949A 
HY-14247 
LS-38785 
RT-012692 
CAS-102676-31-3 
CS-0002958 
D02451 
Fadrozole (hydrochloride) pound>>CGS 16949A 
J-000756 
5-(p-Cyanophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]-pyridine hydrochloride 
5-(p-Cyanophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine hydrochloride 
FAD 286 
5-p-Cyanophenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine hydrochloride 
5-p-Cyanophenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyridinehydrochloride 
Benzonitrile, 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)-, hydrochloride (1:1) 
Racemic 5-(p-cyanophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine hydrochloride 
FADROZOLE 
UNII-H0Q44H4ECQ 
H0Q44H4ECQ 
cc-416 
CGS-16949A 
C14-H13-N3.Cl-H 
FAD-286 
CID59694 
102676-96-0 
Benzonitrile, 4-(5,6,7,8-tetrahydroimidazo(1,5-a)pyridin-5-yl)-, monohydrochloride, (+-)- 
FAD286 
Fadrozole 
Literature

Title: Effects of bisphenol A and fadrozole exposures on cyp19a1 expression in the Murray rainbowfish, Melanotaenia fluviatilis.

Journal: Archives of environmental contamination and toxicology 20140801

Title: Neovascularization is attenuated with aldosterone synthase inhibition in rats with retinopathy.

Journal: Hypertension (Dallas, Tex. : 1979) 20120301

Title: Rapid and widespread effects of 17β-estradiol on intracellular signaling in the male songbird brain: a seasonal comparison.

Journal: Endocrinology 20120301

Title: Corncob bedding alters the effects of estrogens on aggressive behavior and reduces estrogen receptor-α expression in the brain.

Journal: Endocrinology 20120201

Title: Effects of lifetime chemical inhibition of aromatase on the sexual differentiation, sperm characteristics and fertility of medaka (Oryzias latipes) and zebrafish (Danio rerio).

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20111001

Title: Adipocyte-derived factors regulate vascular smooth muscle cells through mineralocorticoid and glucocorticoid receptors.

Journal: Hypertension (Dallas, Tex. : 1979) 20110901

Title: Neuroendocrine contributions to sexual partner preference in birds.

Journal: Frontiers in neuroendocrinology 20110401

Title: Intracerebral estrogen provision increases cytogenesis and neurogenesis in the injured zebra finch brain.

Journal: Developmental neurobiology 20110201

Title: Distribution and sexually dimorphic expression of steroid receptor coactivator-1 (SRC-1) in the zebra finch brain.

Journal: General and comparative endocrinology 20110115

Title: Species extrapolation for the 21st century.

Journal: Environmental toxicology and chemistry 20110101

Title: Expression profiles of reproduction- and thyroid hormone-related transcripts in the brains of chemically-induced intersex frogs.

Journal: Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation 20110101

Title: FAD286, an aldosterone synthase inhibitor, reduced atherosclerosis and inflammation in apolipoprotein E-deficient mice.

Journal: Journal of hypertension 20100901

Title: Temporal expression and steroidal regulation of piRNA pathway genes (mael, piwi, vasa) during Silurana (Xenopus) tropicalis embryogenesis and early larval development.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20100801

Title: Central neuronal activation and pressor responses induced by circulating ANG II: role of the brain aldosterone-'ouabain' pathway.

Journal: American journal of physiology. Heart and circulatory physiology 20100801

Title: Sexual incentive motivation in male rats requires both androgens and estrogens.

Journal: Hormones and behavior 20100701

Title: Pharmacodynamic and pharmacokinetic characterization of the aldosterone synthase inhibitor FAD286 in two rodent models of hyperaldosteronism: comparison with the 11beta-hydroxylase inhibitor metyrapone.

Journal: The Journal of pharmacology and experimental therapeutics 20100701

Title: 17beta-Estradiol levels in male zebra finch brain: combining Palkovits punch and an ultrasensitive radioimmunoassay.

Journal: General and comparative endocrinology 20100515

Title: Fadrozole and finasteride exposures modulate sex steroid- and thyroid hormone-related gene expression in Silurana (Xenopus) tropicalis early larval development.

Journal: General and comparative endocrinology 20100401

Title: Testosterone metabolites differentially maintain adult morphology in a sexually dimorphic neuromuscular system.

Journal: Developmental neurobiology 20100301

Title: Sensitivity of New Zealand mudsnail Potamopyrgus antipodarum (Gray) to a specific aromatase inhibitor.

Journal: Chemosphere 20100301

Title: Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2).

Journal: Journal of medicinal chemistry 20100225

Title: Elevated plasma endoglin (CD105) predicts decreased response and survival in a metastatic breast cancer trial of hormone therapy.

Journal: Breast cancer research and treatment 20100201

Title: Expression of estrogen receptor beta and phosphorylation of estrogen receptor alpha serine 167 correlate with progression-free survival in patients with metastatic breast cancer treated with aromatase inhibitors.

Journal: Oncology 20100101

Title: Profiling neuroendocrine gene expression changes following fadrozole-induced estrogen decline in the female goldfish.

Journal: Physiological genomics 20090807

Title: Altered gene expression in the brain and ovaries of zebrafish (Danio rerio) exposed to the aromatase inhibitor fadrozole: microarray analysis and hypothesis generation.

Journal: Environmental toxicology and chemistry 20090801

Title: In situ hybridization to detect spatial gene expression in medaka.

Journal: Ecotoxicology and environmental safety 20090501

Title: Short term treatment with aromatase inhibitor induces sex change in the protogynous wrasse, Halichoeres trimaculatus.

Journal: General and comparative endocrinology 20090501

Title: Direct effects, compensation, and recovery in female fathead minnows exposed to a model aromatase inhibitor.

Journal: Environmental health perspectives 20090401

Title: Recovery of motor and cognitive function after cerebellar lesions in a songbird: role of estrogens.

Journal: The European journal of neuroscience 20090301

Title: Sex reversal of the amphibian, Xenopus tropicalis, following larval exposure to an aromatase inhibitor.

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20090131

Title: Estradiol induces sexual behavior in female túngara frogs.

Journal: Hormones and behavior 20090101

Title: Masculinization of the European sea bass (Dicentrarchus labrax) by treatment with an androgen or aromatase inhibitor involves different gene expression and has distinct lasting effects on maturation.

Journal: General and comparative endocrinology 20090101

Title: The aromatase inhibitor fadrozole and the 5-reductase inhibitor finasteride affect gonadal differentiation and gene expression in the frog Silurana tropicalis.

Journal: Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation 20090101

Title: Time-dependent transcriptional profiles of genes of the hypothalamic-pituitary-gonadal axis in medaka (Oryzias latipes) exposed to fadrozole and 17beta-trenbolone.

Journal: Environmental toxicology and chemistry 20081201

Title: Forebrain steroid levels fluctuate rapidly during social interactions.

Journal: Nature neuroscience 20081101

Title: Aldosterone synthase inhibition improves cardiovascular function and structure in rats with heart failure: a comparison with spironolactone.

Journal: European heart journal 20080901

Title: Synthesis of 6- or 4-functionalized indoles via a reductive cyclization approach and evaluation as aromatase inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20080815

Title: Role of estrogen receptors and aromatase on brain protein synthesis rates in ovariectomized female rats fed genistein.

Journal: Nutritional neuroscience 20080801

Title: Benzo(a)pyrene decreases brain and ovarian aromatase mRNA expression in Fundulus heteroclitus.

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20080730

Title: Ovarian P450 aromatase activity in the catfish Heteropneustes fossilis: seasonal changes and effects of catecholestrogens.

Journal: General and comparative endocrinology 20080501

Title: DNA microarray application in ecotoxicology: experimental design, microarray scanning, and factors affecting transcriptional profiles in a small fish species.

Journal: Environmental toxicology and chemistry 20080301

Title: DNA microarray-based ecotoxicological biomarker discovery in a small fish model species.

Journal: Environmental toxicology and chemistry 20080301

Title: The adaptive significance of temperature-dependent sex determination in a reptile.

Journal: Nature 20080131

Title: Sex determination: some like it hot (and some don't).

Journal: Nature 20080131

Title: Fadrozole reverses cardiac fibrosis in spontaneously hypertensive heart failure rats: discordant enantioselectivity versus reduction of plasma aldosterone.

Journal: Endocrinology 20080101

Title: Inhibition of injury-induced glial aromatase reveals a wave of secondary degeneration in the songbird brain.

Journal: Glia 20080101

Title: Aromatase inhibitors: past, present and future in breast cancer therapy.

Journal: Medical oncology (Northwood, London, England) 20080101

Title: Combined effects of DHEA and fadrozole on aggression and neural VIP immunoreactivity in the non-breeding male song sparrow.

Journal: Hormones and behavior 20080101

Title: Transmission of relaxin and estrogens to suckling canine pups via milk and possible association with hip joint laxity.

Journal: American journal of veterinary research 20080101

Title: Cloning and expression of R-Spondin1 in different vertebrates suggests a conserved role in ovarian development.

Journal: BMC developmental biology 20080101

Title: Gonadal expression of Sf1 and aromatase during sex determination in the red-eared slider turtle (Trachemys scripta), a reptile with temperature-dependent sex determination.

Journal: Differentiation; research in biological diversity 20071201

Title: Aromatase expression and cell proliferation following injury of the adult zebra finch hippocampus.

Journal: Developmental neurobiology 20071201

Title: Estrogen mediation of injury-induced cell birth in neuroproliferative regions of the adult zebra finch brain.

Journal: Developmental neurobiology 20070701

Title: Molecular cloning of doublesex and mab-3-related transcription factor 1, forkhead transcription factor gene 2, and two types of cytochrome P450 aromatase in Southern catfish and their possible roles in sex differentiation.

Journal: The Journal of endocrinology 20070701

Title: Windows of embryonic sexual lability in two lizard species with environmental sex determination.

Journal: Ecology 20070701

Title: Elevated plasma tissue inhibitor of metalloproteinase-1 level predicts decreased response and survival in metastatic breast cancer.

Journal: Cancer 20070515

Title: Establishment of the need for oestrogen during implantation in non-human primates.

Journal: Reproductive biomedicine online 20070501

Title: A graphical systems model to facilitate hypothesis-driven ecotoxicogenomics research on the teleost brain-pituitary-gonadal axis.

Journal: Environmental science & technology 20070101

Title: Fugu (Takifugu rubripes) sexual differentiation: CYP19 regulation and aromatase inhibitor induced testicular development.

Journal: Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation 20070101

Title: Human adrenocarcinoma (H295R) cells for rapid in vitro determination of effects on steroidogenesis: hormone production.

Journal: Toxicology and applied pharmacology 20061115

Title: Effects of aromatase inhibitors on in vitro steroidogenesis by Atlantic salmon (Salmo salar) gonadal and brain tissue.

Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20061001

Title: Survival with aromatase inhibitors and inactivators versus standard hormonal therapy in advanced breast cancer: meta-analysis.

Journal: Journal of the National Cancer Institute 20060920

Title: Individual differences in estrogen receptor alpha in select brain nuclei are associated with individual differences in aggression.

Journal: Hormones and behavior 20060801

Title: Masculinization of female golden rabbitfish Siganus guttatus using an aromatase inhibitor treatment during sex differentiation.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20060801

Title: Lead optimization providing a series of flavone derivatives as potent nonsteroidal inhibitors of the cytochrome P450 aromatase enzyme.

Journal: Journal of medicinal chemistry 20060727

Title: In vitro exposure of porcine prepubertal follicles to 4-chlorobiphenyl (PCB3) and its hydroxylated metabolites: effects on sex hormone levels and aromatase activity.

Journal: Toxicology letters 20060701

Title: Inhibition of cytochrome p450 brain aromatase reduces two male specific sexual behaviours in the male Endler guppy (Poecilia reticulata).

Journal: General and comparative endocrinology 20060701

Title: Evaluation of a commercial kit for measuring vitellogenin in the fathead minnow (Pimephales promelas).

Journal: Ecotoxicology and environmental safety 20060601

Title: Can the dextroenantiomer of the aromatase inhibitor fadrozole be useful for clinical investigation of aldosterone-synthase inhibition?

Journal: Journal of hypertension 20060601

Title: Investigation of aldosterone-synthase inhibition in rats.

Journal: Journal of hypertension 20060601

Title: Relationship between brain and ovary aromatase activity and isoform-specific aromatase mRNA expression in the fathead minnow (Pimephales promelas).

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20060310

Title: Effects of estrogen in the male rat medial amygdala: infusion of an aromatase inhibitor lowers mating and bovine serum albumin-conjugated estradiol implants do not promote mating.

Journal: Neuroendocrinology 20060101

Title: The effect of aromatase inhibitor, fadrozole, on sGnRHa stimulated LH secretion in goldfish (Carassius auratus) and common carp (Cyprinus carpio).

Journal: Reproductive biology 20060101

Title: Three-dimensional model of cytochrome P450 human aromatase.

Journal: Journal of enzyme inhibition and medicinal chemistry 20051201

Title: New aromatase inhibitors as second-line endocrine therapy in postmenopausal patients with metastatic breast carcinoma: a pooled analysis of the randomized trials.

Journal: Cancer 20051001

Title: Extragonadal synthesis of estradiol is protective against kainic acid excitotoxic damage to the hippocampus.

Journal: Neuroreport 20050928

Title: Estrogen provision by reactive glia decreases apoptosis in the zebra finch (Taeniopygia guttata).

Journal: Journal of neurobiology 20050801

Title: The adrenocortical tumor cell line NCI-H295R as an in vitro screening system for the evaluation of CYP11B2 (aldosterone synthase) and CYP11B1 (steroid-11beta-hydroxylase) inhibitors.

Journal: The Journal of steroid biochemistry and molecular biology 20050801

Title: Aromatase inhibition abolishes courtship behaviours in the ring dove (Streptopelia risoria) and reduces androgen and progesterone receptors in the hypothalamus and anterior pituitary gland.

Journal: Molecular and cellular biochemistry 20050801

Title: Evidence that estrogen regulates the sex change of honeycomb grouper (Epinephelus merra), a protogynous hermaphrodite fish.

Journal: Journal of experimental zoology. Part A, Comparative experimental biology 20050601

Title: Co-culture of primary human mammary fibroblasts and MCF-7 cells as an in vitro breast cancer model.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20050201

Title: Effects of sex steroids and their inhibitors on endocrine parameters and gender growth differences in Eurasian perch (Perca fluviatilis) juveniles.

Journal: Steroids 20050201

Title: Dehydroepiandrosterone regulates astroglia reaction to denervation of olfactory glomeruli.

Journal: Glia 20041115

Title: Successful detection of (anti-)androgenic and aromatase inhibitors in pre-spawning adult fathead minnows (Pimephales promelas) using easily measured endpoints of sexual development.

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20041018

Title: Effects of estrogens during embryonal development on crowing in the domestic fowl.

Journal: Physiology & behavior 20040930

Title: Combined effect of testosterone and apocynin on nitric oxide and superoxide production in PMA-differentiated THP-1 cells.

Journal: Biochimica et biophysica acta 20040917

Title: Glial aromatization decreases neural injury in the zebra finch (Taeniopygia guttata): influence on apoptosis.

Journal: Journal of neuroendocrinology 20040801

Title: Differential expression pattern and steroid hormone sensitivity of SNAP-25 and synaptoporin mRNA in the telencephalic song control nucleus HVC of the zebra finch.

Journal: The Journal of comparative neurology 20040712

Title: Effects of follicle stimulating hormone on estradiol-17 beta production and P-450 aromatase (CYP19) activity and mRNA expression in brown trout vitellogenic ovarian follicles in vitro.

Journal: General and comparative endocrinology 20040601

Title: Modulation by steroid hormones of a 'sexy' acoustic signal in an Oscine species, the Common Canary Serinus canaria.

Journal: Anais da Academia Brasileira de Ciencias 20040601

Title: Aromatase modulation alters gonadal differentiation in developing zebrafish (Danio rerio).

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20040414

Title: Characterization of stable human aromatase expressed in E. coli.

Journal: Steroids 20040401

Title: Expression of aromatase mRNA and effects of aromatase inhibitor during ovarian development in the medaka, Oryzias latipes.

Journal: Journal of experimental zoology. Part A, Comparative experimental biology 20040301

Title: Sex inversion of sexually immature honeycomb grouper (Epinephelus merra) by aromatase inhibitor.

Journal: Zoological science 20040301

Title: Presynaptic N-methyl-D-aspartate receptor expression is increased by estrogen in an aromatase-rich area of the songbird hippocampus.

Journal: The Journal of comparative neurology 20040216

Title: Expression of androgen receptor mRNA in zebra finch song system: developmental regulation by estrogen.

Journal: The Journal of comparative neurology 20040216

Title: The effects of the aromatase inhibitor fadrozole hydrochloride on fetuses and uteri in late pregnant rats.

Journal: The Journal of endocrinology 20040201

Title: An aromatase inhibitor or high water temperature induce oocyte apoptosis and depletion of P450 aromatase activity in the gonads of genetic female zebrafish during sex-reversal.

Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20040101

Title: Lack of efficacy of fadrozole in treating precocious puberty in girls with the McCune-Albright syndrome.

Journal: The Journal of clinical endocrinology and metabolism 20031201

Title: Does alligator testis produce estradiol? A comparison of ovarian and testicular aromatase.

Journal: Biology of reproduction 20031001

Title: Effect of non-steroidal aromatase inhibitor on blood plasma ovarian steroid and thyroid hormones in laying hen (Gallus domesticus).

Journal: Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20030901

Title: Degree of sex reversal as related to plasma steroid levels in genetic female chickens (Gallus domesticus) treated with Fadrozole.

Journal: Molecular reproduction and development 20030801

Title: Role of aromatization in anticipatory and consummatory aspects of sexual behavior in male rats.

Journal: Hormones and behavior 20030801

Title: Estradiol in the male rat amygdala facilitates mounting but not ejaculation.

Journal: Physiology & behavior 20030701

Title: Delayed implantation induced by fadrozole hydrochloride in rats.

Journal: Contraception 20030701

Title: Endogenous estrogen formation is neuroprotective in model of cerebellar ataxia.

Journal: Endocrine 20030601

Title: Estrogen regulates tyrosine hydroxylase expression in the neonate mouse midbrain.

Journal: Journal of neurobiology 20030301

Title: Successful treatment of a symptomatic uterine leiomyoma in a perimenopausal woman with a nonsteroidal aromatase inhibitor.

Journal: Fertility and sterility 20030301

Title: Aromatase inhibition affects testosterone-induced masculinization of song and the neural song system in female canaries.

Journal: Journal of neurobiology 20030205

Title: DMRT1 is upregulated in the gonads during female-to-male sex reversal in ZW chicken embryos.

Journal: Biology of reproduction 20030201

Title: Double-blind randomised trial comparing the non-steroidal aromatase inhibitors letrozole and fadrozole in postmenopausal women with advanced breast cancer.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20030101

Title: Induction of XY sex reversal by estrogen involves altered gene expression in a teleost, tilapia.

Journal: Cytogenetic and genome research 20030101

Title: Inhibition of p-450 aromatase prevents feminisation and induces protection during cysticercosis.

Journal: International journal for parasitology 20021001

Title: Effects of the aromatase inhibitor fadrozole on plasma sex steroid secretion, spermatogenesis and epididymis morphology in the lizard, Podarcis sicula.

Journal: Molecular reproduction and development 20020901

Title: Relationship of serum HER-2/neu and serum CA 15-3 in patients with metastatic breast cancer.

Journal: Clinical chemistry 20020801

Title: Morphological sex reversal upon short-term exposure to endocrine modulators in juvenile fathead minnow (Pimephales promelas).

Journal: Toxicology letters 20020510

Title: Evaluation of the aromatase inhibitor fadrozole in a short-term reproduction assay with the fathead minnow (Pimephales promelas).

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20020501

Title: Testosterone promotes paternal behaviour in a monogamous mammal via conversion to oestrogen.

Journal: Proceedings. Biological sciences 20020422

Title: Development of sexual partner preference in the zebra finch: a socially monogamous, pair-bonding animal.

Journal: Archives of sexual behavior 20020201

Title: Sex reversal and aromatase in chicken.

Journal: The Journal of experimental zoology 20011201

Title: [An elderly woman with breast cancer and multiple liver metastasis that responded well to combination therapy of fadrozole and tamoxifen].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20011201

Title: A summary of second-line randomized studies of aromatase inhibitors.

Journal: The Journal of steroid biochemistry and molecular biology 20011201

Title: A comparative approach to structure-function studies of mammalian aromatases.

Journal: The Journal of steroid biochemistry and molecular biology 20011201

Title: [Hepatic infusion of docetaxel using PEIT for a patient with stage IV breast cancer].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20011101

Title: Enantioselectivity of some 1-[(benzofuran-2-yl) phenylmethyl] imidazoles as aromatase (P450AROM) inhibitors.

Journal: Journal of enzyme inhibition 20011101

Title: Estrogen stimulates brain-derived neurotrophic factor expression in embryonic mouse midbrain neurons through a membrane-mediated and calcium-dependent mechanism.

Journal: Journal of neuroscience research 20011015

Title: Expression of AMH, SF1, and SOX9 in gonads of genetic female chickens during sex reversal induced by an aromatase inhibitor.

Journal: Developmental dynamics : an official publication of the American Association of Anatomists 20011001

Title: Effect of the aromatase inhibitor CGS-16949A on pregnancy and secretion of progesterone, estradiol-17beta, prostaglandins E and F2alpha (PGE; PGF2alpha) and pregnancy specific protein B (PSPB) in 90-day ovariectomized pregnant ewes.

Journal: Prostaglandins & other lipid mediators 20010901

Title: Advances in aromatase inhibition: clinical efficacy and tolerability in the treatment of breast cancer.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20010901

Title: Sex reversal in Nile tilapia (Oreochromis niloticus) using a nonsteroidal aromatase inhibitor.

Journal: The Journal of experimental zoology 20010701

Title: [Endocrine therapy for advanced or recurrent breast cancer].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20010701

Title: Brain aromatase is neuroprotective.

Journal: Journal of neurobiology 20010615

Title: Regulation of plasma gonadotropin II secretion by sex steroids, aromatase inhibitors, and antiestrogens in the protandrous black porgy, Acanthopagrus schlegeli Bleeker.

Journal: Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20010601

Title: Evaluation of the male pubertal onset assay to detect testosterone and steroid biosynthesis inhibitors in CD rats.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20010401

Title: Aromatase inhibition reduces specifically one display of the ring dove courtship behavior.

Journal: General and comparative endocrinology 20010401

Title: [Endometriosis and aromatase inhibitor].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20010101

Title: Intracellular aromatase and its relevance to the pharmacological efficacy of aromatase inhibitors.

Journal: The Journal of steroid biochemistry and molecular biology 20010101

Title: Synergistic effect of CGS16949A and 5-fluorouracil on a human breast cancer cell line.

Journal: European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes 20010101

Title: Inhibitory effect of a novel non-steroidal aromatase inhibitor, YM511 on the proliferation of MCF-7 human breast cancer cell.

Journal: The Journal of steroid biochemistry and molecular biology 19960501

Title: A study of fadrozole, a new aromatase inhibitor, in postmenopausal women with advanced metastatic breast cancer.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 19920101

Title: The effect of the aromatase inhibitor, rogletimide (pyridoglutethimide), on guinea pig adrenal cell steroidogenesis and placental microsomal aromatase activity: comparison with aminoglutethimide and CGS 16949A.

Journal: The Journal of steroid biochemistry and molecular biology 19911101

Title: Fadrozole hydrochloride: a potent, selective, nonsteroidal inhibitor of aromatase for the treatment of estrogen-dependent disease.

Journal: Journal of medicinal chemistry 19910201

Title: Highly selective inhibition of estrogen biosynthesis by CGS 20267, a new non-steroidal aromatase inhibitor.

Journal: The Journal of steroid biochemistry and molecular biology 19901220

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