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1033769-28-6,MFCD24386809
Catalog No.:AA008TDS

1033769-28-6 | Gnf 5837

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Purity
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Price(USD)
Quantity
  
1mg
98+%
in stock  
$23.00   $16.00
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5mg
98+%
in stock  
$53.00   $37.00
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50mg
98+%
in stock  
$174.00   $122.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA008TDS
Chemical Name:
Gnf 5837
CAS Number:
1033769-28-6
Molecular Formula:
C28H21F4N5O2
Molecular Weight:
535.4923
MDL Number:
MFCD24386809
SMILES:
O=C(Nc1cc(ccc1F)C(F)(F)F)Nc1ccc(c(c1)Nc1ccc2c(c1)NC(=O)/C/2=C\c1ccc[nH]1)C
Properties
Computed Properties
 
Complexity:
930  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
39  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
5  
XLogP3:
5.2  

Downstream Synthesis Route

[1]Albaugh,Pam;Fan,Yi;Mi,Yuan;Sun,Fangxian;Adrian,Francisco;Li,Nanxin;Jia,Yong;Sarkisova,Yelena;Kreusch,Andreas;Hood,Tami;Lu,Min;Liu,Guoxun;Huang,Shenlin;Liu,Zuosheng;Loren,Jon;Tuntland,Tove;Karanewsky,DonaldS.;Seidel,H.Martin;Molteni,Valentina[ACSMedicinalChemistryLetters,2012,vol.3,#2,p.140-145]

dimethyl2-(4-bromo-2-nitrophenyl)malonate 
  1033769-28-6 

[1]Albaugh,Pam;Fan,Yi;Mi,Yuan;Sun,Fangxian;Adrian,Francisco;Li,Nanxin;Jia,Yong;Sarkisova,Yelena;Kreusch,Andreas;Hood,Tami;Lu,Min;Liu,Guoxun;Huang,Shenlin;Liu,Zuosheng;Loren,Jon;Tuntland,Tove;Karanewsky,DonaldS.;Seidel,H.Martin;Molteni,Valentina[ACSMedicinalChemistryLetters,2012,vol.3,#2,p.140-145]

[1]ACSMedicinalChemistryLetters,2012,vol.3,p.140-145

C17H17N3O6 
  1033769-28-6 

[1]Albaugh,Pam;Fan,Yi;Mi,Yuan;Sun,Fangxian;Adrian,Francisco;Li,Nanxin;Jia,Yong;Sarkisova,Yelena;Kreusch,Andreas;Hood,Tami;Lu,Min;Liu,Guoxun;Huang,Shenlin;Liu,Zuosheng;Loren,Jon;Tuntland,Tove;Karanewsky,DonaldS.;Seidel,H.Martin;Molteni,Valentina[ACSMedicinalChemistryLetters,2012,vol.3,#2,p.140-145]

[1]ACSMedicinalChemistryLetters,2012,vol.3,p.140-145

Literature

Title: Discovery of GNF-5837, a Selective TRK Inhibitor with Efficacy in Rodent Cancer Tumor Models.

Journal: ACS medicinal chemistry letters 20120209

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