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Home Other Building Blocks 104746-04-5
104746-04-5,MFCD08460933
Catalog No.:AA0037YY

104746-04-5 | (S)-10-Hydroxy-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥95%
in stock  
$52.00   $36.00
- +
5mg
98% by HPLC
in stock  
$148.00   $104.00
- +
10mg
98% by HPLC
in stock  
$206.00   $144.00
- +
25mg
98% by HPLC
in stock  
$364.00   $255.00
- +
50mg
98% by HPLC
in stock  
$575.00   $403.00
- +
100mg
98% by HPLC
in stock  
$949.00   $664.00
- +
500mg
98% by HPLC
in stock  
$2,920.00   $2,044.00
- +
1000mg
98% by HPLC
in stock  
$4,634.00   $3,244.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0037YY
Chemical Name:
(S)-10-Hydroxy-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide
CAS Number:
104746-04-5
Molecular Formula:
C15H14N2O2
Molecular Weight:
254.2839
MDL Number:
MFCD08460933
SMILES:
O[C@H]1Cc2ccccc2N(c2c1cccc2)C(=O)N
Properties
Computed Properties
 
Complexity:
347  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
XLogP3:
1.4  

Downstream Synthesis Route

[1]AngewandteChemie-InternationalEdition,2019,vol.58,p.4973-4977    Angew.Chem.,2019,vol.131,p.5027-5031,5

[2]Patent:WO2007/12793,2007,A1.Locationinpatent:Page/Pagecolumn16-17

[3]Patent:WO2007/12793,2007,A1.Locationinpatent:Page/Pagecolumn15-16;24

[4]Patent:WO2016/142164,2016,A1.Locationinpatent:Paragraph00181-00182

[5]Patent:WO2011/131315,2011,A1.Locationinpatent:Page/Pagecolumn10

[6]Patent:EP2383261,2011,A1.Locationinpatent:Page/Pagecolumn6

[7]Patent:WO2012/120356,2012,A2.Locationinpatent:Page/Pagecolumn23

[8]Patent:US2013/345198,2013,A1.Locationinpatent:Paragraph0151

[9]JournalofMedicinalChemistry,1999,vol.42,p.2582-2587

[10]Patent:WO2004/31155,2004,A1.Locationinpatent:Page21,22

[11]Patent:WO2004/31155,2004,A1.Locationinpatent:Page22

[12]Patent:WO2005/92290,2005,A1.Locationinpatent:Page/Pagecolumn13-14

[13]Patent:WO2005/92290,2005,A1.Locationinpatent:Page/Pagecolumn14

[14]Patent:WO2005/92294,2005,A1.Locationinpatent:Page/Pagecolumn16

[15]Patent:WO2005/92294,2005,A1.Locationinpatent:Page/Pagecolumn16

[16]Patent:US2006/194791,2006,A1.Locationinpatent:Page/Pagecolumn3

[17]Patent:US2006/194791,2006,A1.Locationinpatent:Page/Pagecolumn2-3

[18]Patent:WO2007/12793,2007,A1.Locationinpatent:Page/Pagecolumn21-22

[19]Patent:WO2007/12793,2007,A1.Locationinpatent:Page/Pagecolumn22-23

[20]Patent:WO2011/138795,2011,A2.Locationinpatent:Page/Pagecolumn24

[21]Patent:WO2011/138795,2011,A2

[22]JournalofMolecularCatalysisB:Enzymatic,2011,vol.72,p.294-297

[23]Patent:WO2012/121701,2012,A1

[24]Patent:WO2012/121701,2012,A1

[25]Patent:WO2013/8194,2013,A2

[26]OrganicProcessResearchandDevelopment,2014,vol.18,p.810-815

[27]Patent:US2015/65704,2015,A1

[28]Patent:CN106588773,2017,A

[29]Patent:US2016/122332,2016,A1

[1]CurrentPatentAssignee:VIATRISINC-WO2011/45648,2011,A2Locationinpatent:Page/Pagecolumn26;27

[2]Benes,Jan;Parada,António;Figueiredo,AnabelaA.;Alves,PaulaC.;Freitas,AnaP.;Learmonth,DavidA.;Cunha,RodrigoA.;Garrett,José;Soares-Da-Silva,Patrício[JournalofMedicinalChemistry,1999,vol.42,#14,p.2582-2587]

[3]CurrentPatentAssignee:SUNPHARMACEUTICALINDUSTRIESLIMITED-US2015/65704,2015,A1Locationinpatent:Paragraph00770084

[4]CurrentPatentAssignee:GLENMARKPHARMACEUTICALSLTD-WO2010/113179,2010,A2Locationinpatent:Page/Pagecolumn14-15

[5]CurrentPatentAssignee:MSNLABORATORIESPRIVATELIMITED-WO2011/138795,2011,A2Locationinpatent:Page/Pagecolumn24

[6]CurrentPatentAssignee:TEVAPHARMACEUTICALINDUSTRIESLTD.-WO2012/121701,2012,A1Locationinpatent:Page/Pagecolumn15

[7]CurrentPatentAssignee:SUNPHARMACEUTICALINDUSTRIESLIMITED-WO2013/8194,2013,A2Locationinpatent:Page/Pagecolumn15

[8]CurrentPatentAssignee:JUBILANTPHARMOVALTD-US2013/345198,2013,A1Locationinpatent:Paragraph0173

[1]Patent:WO2011/45648,2011,A2

[2]Patent:WO2011/117885,2011,A1

[3]Patent:WO2011/138795,2011,A2

[4]Patent:WO2012/121701,2012,A1

[5]Patent:WO2012/121701,2012,A1

[6]Patent:WO2013/8194,2013,A2

[7]Patent:WO2013/167985,2013,A1

[8]Patent:US2015/65704,2015,A1

[9]Patent:US2016/122332,2016,A1

[1]Kumar,N.Uday;Reddy,B.Sudhakar;Reddy,V.Prabhakar;Bandichhor,Rakeshwar[TetrahedronLetters,2014,vol.55,#4,p.910-912]

[2]UdayKumar;SudhakarReddy;PrabhakarReddy;Bandichhor,Rakeshwar[TetrahedronLetters,2014,vol.55,#4,p.910-912]

[3]CurrentPatentAssignee:HOLDINGF.I.S.S.P.A.-WO2016/142164,2016,A1Locationinpatent:Paragraph00166;00167;00168;00169-00172

[4]CurrentPatentAssignee:JUBILANTPHARMOVALTD-WO2012/120356,2012,A2Locationinpatent:Page/Pagecolumn23

[5]CurrentPatentAssignee:JUBILANTPHARMOVALTD-US2013/345198,2013,A1Locationinpatent:Paragraph0154

[6]CurrentPatentAssignee:SUNPHARMACEUTICALINDUSTRIESLIMITED-WO2013/8194,2013,A2Locationinpatent:Page/Pagecolumn20

[7]CurrentPatentAssignee:SUNPHARMACEUTICALINDUSTRIESLIMITED-US2015/65704,2015,A1Locationinpatent:Paragraph0099;0100

[8]CurrentPatentAssignee:DRREDDY'SLABORATORIESLIMITED-WO2011/91131,2011,A2Locationinpatent:Page/Pagecolumn40-41

[9]CurrentPatentAssignee:MSNLABORATORIESPRIVATELIMITED-WO2011/138795,2011,A2Locationinpatent:Page/Pagecolumn23

[10]CurrentPatentAssignee:CURIAINC-WO2011/131315,2011,A1Locationinpatent:Page/Pagecolumn11

[11]CurrentPatentAssignee:CURIAINC-EP2383261,2011,A1Locationinpatent:Page/Pagecolumn6

[12]CurrentPatentAssignee:LUPINLIMITED-US2018/127376,2018,A1Locationinpatent:Paragraph0026

[13]CurrentPatentAssignee:SHANGYAOKONYCHANGZHOUPHARMACEUTICALCOLTD-CN116063231,2023,ALocationinpatent:Paragraph0036;0042;0058-0060;0080-0082

[1]Patent:WO2011/91131,2011,A2.Locationinpatent:Page/Pagecolumn39

[2]Patent:WO2012/120356,2012,A2.Locationinpatent:Page/Pagecolumn23

[3]Patent:WO2013/8194,2013,A2

[4]RSCAdvances,2016,vol.6,p.98730-98736

[5]RSCAdvances,2016,vol.6,p.98730-98736

[6]RSCAdvances,2016,vol.6,p.98730-98736

[7]RSCAdvances,2016,vol.6,p.98730-98736

Literature

Title: Clinical utility of eslicarbazepine: current evidence.

Journal: Drug design, development and therapy 20150101

Title: The effects of eslicarbazepine on persistent Na⁺ current and the role of the Na⁺ channel β subunits.

Journal: Epilepsy research 20140201

Title: A chiral liquid chromatography method for the simultaneous determination of oxcarbazepine, eslicarbazepine, R-licarbazepine and other new chemical derivatives BIA 2-024, BIA 2-059 and BIA 2-265, in mouse plasma and brain.

Journal: Biomedical chromatography : BMC 20120301

Title: Pharmacokinetics of the monohydroxy derivative of oxcarbazepine and its enantiomers after a single intravenous dose given as racemate compared with a single oral dose of oxcarbazepine.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20110601

Title: [New drugs in the treatment of adult patients with refractery epilepsy].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20110101

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Tags:104746-04-5 Molecular Formula|104746-04-5 MDL|104746-04-5 SMILES|104746-04-5 (S)-10-Hydroxy-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide