+1 858-523-8231
Login | Register
AA Blocks, Building Blocks, Catalysts, Inhibitors
Login | Register
Home Other Building Blocks 1047644-62-1
1047644-62-1,MFCD26961098
Catalog No.:AA008TAI

1047644-62-1 | GSK-2110183C

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
99%
in stock  
$37.00   $26.00
- +
2mg
99%
in stock  
$47.00   $33.00
- +
5mg
99%
in stock  
$77.00   $54.00
- +
100mg
99%
in stock  
$1,152.00   $807.00
- +
1g
99%
in stock  
$1,345.00   $942.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA008TAI
Chemical Name:
GSK-2110183C
CAS Number:
1047644-62-1
Molecular Formula:
C18H17Cl2FN4OS
Molecular Weight:
427.3232
MDL Number:
MFCD26961098
SMILES:
NCC(NC(=O)c1sc(c(c1)c1c(Cl)cnn1C)Cl)Cc1cccc(c1)F
Properties
Computed Properties
 
Complexity:
520  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
6  
XLogP3:
4  

Upstream Synthesis Route

[1]Patent:WO2008/98104,2008,A1,.Locationinpatent:Page/Pagecolumn191-192

[2]DrugsoftheFuture,2014,vol.39,#8,p.541-546

[1]DrugsoftheFuture,2014,vol.39,#8,p.541-546

[2]DrugsoftheFuture,2014,vol.39,#8,p.541-546

[1]DrugsoftheFuture,2014,vol.39,#8,p.541-546

[2]DrugsoftheFuture,2014,vol.39,#8,p.541-546

[1]DrugsoftheFuture,2014,vol.39,#8,p.541-546

[1]DrugsoftheFuture,2014,vol.39,#8,p.541-546

Downstream Synthesis Route

[1]DrugsoftheFuture,2014,vol.39,p.541-546

[2]Patent:WO2008/98104,2008,A1.Locationinpatent:Page/Pagecolumn191-192

[1]Patent:US2010/197754,2010,A1.Locationinpatent:Page/Pagecolumn8-9

[2]Patent:WO2008/98104,2008,A1.Locationinpatent:Page/Pagecolumn191-192

[1]DrugsoftheFuture,2014,vol.39,p.541-546

[2]Patent:WO2008/98104,2008,A1

[1]DrugsoftheFuture,2014,vol.39,p.541-546

[2]Patent:WO2008/98104,2008,A1

C10H8Cl2N2O2S 
  1047644-62-1 

[1]DrugsoftheFuture,2014,vol.39,p.541-546

Literature

Title: The novel AKT inhibitor afuresertib shows favorable safety, pharmacokinetics, and clinical activity in multiple myeloma.

Journal: Blood 20141002

Title: Discovery of novel AKT inhibitors with enhanced anti-tumor effects in combination with the MEK inhibitor.

Journal: PloS one 20140101

Title: Yamaji M, et al. Novel ATP-competitive Akt inhibitor Afuresertib suppresses the proliferation of malignant pleural mesothelioma cells. Cancer Med. 2017 Nov;6(11):2646-2659.

Title: Dumble M, et al. Discovery of novel AKT inhibitors with enhanced anti-tumor effects in combination with the MEK inhibitor. PLoS One. 2014 Jun 30;9(6):e100880

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 1047644-62-1
2070009-64-0

2070009-64-0

 1047634-63-8

1047634-63-8
Building Blocks
More >
Tags:1047644-62-1 Molecular Formula|1047644-62-1 MDL|1047644-62-1 SMILES|1047644-62-1 GSK-2110183C