Home Bromides 108179-91-5
108179-91-5,MFCD04039787
Catalog No.:AA003U75
108179-91-5 | SKF 83566 hydrobromide
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10mg
99%
2 weeks  
$209.00   $147.00
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100mg
95%
2 weeks  
$375.00   $262.00
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250mg
95%
2 weeks  
$481.00   $337.00
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  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003U75
Chemical Name:
SKF 83566 hydrobromide
CAS Number:
108179-91-5
Molecular Formula:
C17H19Br2NO
Molecular Weight:
413.1469
MDL Number:
MFCD04039787
IUPAC Name:
8-bromo-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol;hydrobromide
InChI:
InChI=1S/C17H18BrNO.BrH/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12;/h2-6,9-10,15,20H,7-8,11H2,1H3;1H
InChI Key:
SDQJYYGODYRPBR-UHFFFAOYSA-N
SMILES:
CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O.Br
Properties
Computed Properties
 
Complexity:
318  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
412.981g/mol
Formal Charge:
0
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
413.153g/mol
Monoisotopic Mass:
410.983g/mol
Rotatable Bond Count:
1  
Topological Polar Surface Area:
23.5A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0

Synonyms
 
1H-3-benzazepin-7-ol, 8-bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl- 
1H-3-benzazepin-7-ol, 8-bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-, (S-isomer) 
SKF83566HG 
CPD000449276 
8-bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-olhydrobromide 
8-BROMO-2,3,4,5-TETRAHYDRO-3-METHYL-5-PHENYL-1H-3-BENZAZEPIN-7-OL HYDROBROMIDE 
C17H19Br2NO 
99295-33-7 
SMR000449276 
SKF83566 
MLS000758232 
MLS001423981 
7-bromo-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine 
CHEMBL1489369 
DTXSID6042606 
SCHEMBL16241879 
NOCAS_42606 
EX-A2523 
BN0486 
MFCD04039787 
AKOS024257988 
CCG-100754 
NC00004 
8-bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrobromide 
TRA0072364 
KS-0000010W 
AK270444 
SAM001247068 
Z3071 
SR-01000597811 
J-002067 
SR-01000597811-1 
8-bromo-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol;hydrobromide 
8-bromo-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-ol hydrobromide 
SK and F 83566 
Skf 83566 
SK and F-83566 
SKF 83566 
SKF 83566 hydrobromide 
108179-91-5 
8-Bromo-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol hydrobromide 
Literature

Title: SKF 83566 attenuates the effects of ghrelin on performance in the object location memory task.

Journal: Neuroscience letters 20111031

Title: SKF-83566, a D1-dopamine receptor antagonist, inhibits the dopamine transporter.

Journal: Journal of neurochemistry 20110901

Title: Identification and evolutionary implications of neurotransmitter-ciliary interactions underlying the behavioral response to hypoxia in Lymnaea stagnalis embryos.

Journal: The Journal of experimental biology 20110815

Title: D1 receptor antagonist-induced long-term depression in the medial prefrontal cortex of rat, in vivo: an animal model of psychiatric hypofrontality.

Journal: Journal of psychopharmacology (Oxford, England) 20090801

Title: Ethanol facilitates glutamatergic transmission to dopamine neurons in the ventral tegmental area.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090101

Title: Methamphetamine enhances HIV infection of macrophages.

Journal: The American journal of pathology 20080601

Title: Evidence for the sensitivity of operant timing behaviour to stimulation of D1 dopamine receptors.

Journal: Psychopharmacology 20071201

Title: Dopamine reduction of GABA currents in striatal medium-sized spiny neurons is mediated principally by the D(1) receptor subtype.

Journal: Neurochemical research 20070201

Title: The serial reaction time task in the rat: effects of D1 and D2 dopamine-receptor antagonists.

Journal: Behavioural brain research 20061215

Title: Effects of d-amphetamine and DOI (2,5-dimethoxy-4-iodoamphetamine) on timing behavior: interaction between D1 and 5-HT2A receptors.

Journal: Psychopharmacology 20061201

Title: Evidence for a role of D1 dopamine receptors in d-amphetamine's effect on timing behaviour in the free-operant psychophysical procedure.

Journal: Psychopharmacology 20060401

Title: The signal transduction pathway for the dopamine D1 receptor in the guinea-pig cochlea.

Journal: Neuroscience 20060201

Title: Dopamine D1-like receptor-mediated inhibition of Cl/HCO3- exchanger activity in rat intestinal epithelial IEC-6 cells is regulated by G protein-coupled receptor kinase 6 (GRK 6).

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20060101

Title: Stepholidine protects against H2O2 neurotoxicity in rat cortical neurons by activation of Akt.

Journal: Neuroscience letters 20050805

Title: Involvement of G protein-coupled receptor kinase 4 and 6 in rapid desensitization of dopamine D1 receptor in rat IEC-6 intestinal epithelial cells.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20041001

Title: Dopamine D3 receptor-mediated inhibition of Na+/H+ exchanger activity in normotensive and spontaneously hypertensive rat proximal tubular epithelial cells.

Journal: British journal of pharmacology 20040801

Title: Dopamine stimulates snail albumen gland glycoprotein secretion through the activation of a D1-like receptor.

Journal: The Journal of experimental biology 20040601

Title: Age-related modifications of the morphological organization of pituicytes are associated with alteration of the GABAergic and dopaminergic innervation afferent to the neurohypophysial lobe.

Journal: The European journal of neuroscience 20031001

Title: Dopamine effect on the stimulus pattern related changes in response characteristics of R/G horizontal cells in carp retina.

Journal: Brain research 20030530

Title: Dopamine modulation of activity of cat sensorimotor cortex neurons during conditioned reflexes.

Journal: Neuroscience letters 20020920

Title: D2-like receptor-mediated inhibition of Na+-K+-ATPase activity is dependent on the opening of K+ channels.

Journal: American journal of physiology. Renal physiology 20020701

Title: Dopamine antagonists alter response allocation but do not suppress appetite for food in rats: contrast between the effects of SKF 83566, raclopride, and fenfluramine on a concurrent choice task.

Journal: Psychopharmacology 20020401

Title: Deafferentation-induced abnormal neurofilament phosphorylation in red nucleus neurones.

Journal: Neuropathology and applied neurobiology 20011201

Title: Ouabain-insensitive acidification by dopamine in renal OK cells: primary control of the Na(+)/H(+) exchanger.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20010701

Title: Stimulus properties of 7-OH-DPAT versus auto- and postsynaptic receptor-specific doses of quinpirole.

Journal: Pharmacology, biochemistry, and behavior 20010301

Title: Role of dopamine D1 receptors in the lethal effects of cocaine and a quaternary methiodide analog.

Journal: The Journal of pharmacology and experimental therapeutics 19931001

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