Home Bromides 108179-91-5
108179-91-5,MFCD04039787
Catalog No.:AA003U75

108179-91-5 | SKF 83566 hydrobromide

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5mg
≥98%
in stock  
$89.00   $62.00
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10mg
≥98%
in stock  
$138.00   $96.00
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25mg
≥98%
in stock  
$278.00   $194.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003U75
Chemical Name:
SKF 83566 hydrobromide
CAS Number:
108179-91-5
Molecular Formula:
C17H19Br2NO
Molecular Weight:
413.1469
MDL Number:
MFCD04039787
SMILES:
CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O.Br
Properties
Properties
 
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
318  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
1  
Undefined Atom Stereocenter Count:
1  

Literature

Title: SKF 83566 attenuates the effects of ghrelin on performance in the object location memory task.

Journal: Neuroscience letters 20111031

Title: SKF-83566, a D1-dopamine receptor antagonist, inhibits the dopamine transporter.

Journal: Journal of neurochemistry 20110901

Title: Identification and evolutionary implications of neurotransmitter-ciliary interactions underlying the behavioral response to hypoxia in Lymnaea stagnalis embryos.

Journal: The Journal of experimental biology 20110815

Title: D1 receptor antagonist-induced long-term depression in the medial prefrontal cortex of rat, in vivo: an animal model of psychiatric hypofrontality.

Journal: Journal of psychopharmacology (Oxford, England) 20090801

Title: Ethanol facilitates glutamatergic transmission to dopamine neurons in the ventral tegmental area.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090101

Title: Methamphetamine enhances HIV infection of macrophages.

Journal: The American journal of pathology 20080601

Title: Evidence for the sensitivity of operant timing behaviour to stimulation of D1 dopamine receptors.

Journal: Psychopharmacology 20071201

Title: Dopamine reduction of GABA currents in striatal medium-sized spiny neurons is mediated principally by the D(1) receptor subtype.

Journal: Neurochemical research 20070201

Title: The serial reaction time task in the rat: effects of D1 and D2 dopamine-receptor antagonists.

Journal: Behavioural brain research 20061215

Title: Effects of d-amphetamine and DOI (2,5-dimethoxy-4-iodoamphetamine) on timing behavior: interaction between D1 and 5-HT2A receptors.

Journal: Psychopharmacology 20061201

Title: Evidence for a role of D1 dopamine receptors in d-amphetamine's effect on timing behaviour in the free-operant psychophysical procedure.

Journal: Psychopharmacology 20060401

Title: The signal transduction pathway for the dopamine D1 receptor in the guinea-pig cochlea.

Journal: Neuroscience 20060201

Title: Dopamine D1-like receptor-mediated inhibition of Cl/HCO3- exchanger activity in rat intestinal epithelial IEC-6 cells is regulated by G protein-coupled receptor kinase 6 (GRK 6).

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20060101

Title: Stepholidine protects against H2O2 neurotoxicity in rat cortical neurons by activation of Akt.

Journal: Neuroscience letters 20050805

Title: Involvement of G protein-coupled receptor kinase 4 and 6 in rapid desensitization of dopamine D1 receptor in rat IEC-6 intestinal epithelial cells.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20041001

Title: Dopamine D3 receptor-mediated inhibition of Na+/H+ exchanger activity in normotensive and spontaneously hypertensive rat proximal tubular epithelial cells.

Journal: British journal of pharmacology 20040801

Title: Dopamine stimulates snail albumen gland glycoprotein secretion through the activation of a D1-like receptor.

Journal: The Journal of experimental biology 20040601

Title: Age-related modifications of the morphological organization of pituicytes are associated with alteration of the GABAergic and dopaminergic innervation afferent to the neurohypophysial lobe.

Journal: The European journal of neuroscience 20031001

Title: Dopamine effect on the stimulus pattern related changes in response characteristics of R/G horizontal cells in carp retina.

Journal: Brain research 20030530

Title: Dopamine modulation of activity of cat sensorimotor cortex neurons during conditioned reflexes.

Journal: Neuroscience letters 20020920

Title: D2-like receptor-mediated inhibition of Na+-K+-ATPase activity is dependent on the opening of K+ channels.

Journal: American journal of physiology. Renal physiology 20020701

Title: Dopamine antagonists alter response allocation but do not suppress appetite for food in rats: contrast between the effects of SKF 83566, raclopride, and fenfluramine on a concurrent choice task.

Journal: Psychopharmacology 20020401

Title: Deafferentation-induced abnormal neurofilament phosphorylation in red nucleus neurones.

Journal: Neuropathology and applied neurobiology 20011201

Title: Ouabain-insensitive acidification by dopamine in renal OK cells: primary control of the Na(+)/H(+) exchanger.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20010701

Title: Stimulus properties of 7-OH-DPAT versus auto- and postsynaptic receptor-specific doses of quinpirole.

Journal: Pharmacology, biochemistry, and behavior 20010301

Title: Role of dopamine D1 receptors in the lethal effects of cocaine and a quaternary methiodide analog.

Journal: The Journal of pharmacology and experimental therapeutics 19931001

Title: Yan-You Huang, et al.D1/D5 Receptors and Histone Deacetylation Mediate the Gateway Effect of LTP in Hippocampal Dentate Gyrus.

Title: Melissa A Stouffer, et al. SKF-83566, a D1-dopamine Receptor Antagonist, Inhibits the Dopamine Transporter. J Neurochem. 2011 Sep;118(5):714-20.

Title: E H Ohlstein, et al. SCH 23390 and SK&F 83566 are antagonists at vascular dopamine and serotonin receptors. Eur J Pharmacol. 1985 Jan 22;108(2):205-8.

Title: Jason M Conley, et al. Development of a high-throughput screening paradigm for the discovery of small-molecule modulators of adenylyl cyclase: identification of an adenylyl cyclase 2 inhibitor. J Pharmacol Exp Ther. 2013 Nov;347(2):276-87

Title: Yan-You Huang, et al. D1/D5 receptors and histone deacetylation mediate the Gateway Effect of LTP in hippocampal dentate gyrus. Learn Mem. 2014 Feb 18;21(3):153-60. doi: 10.1101/lm.032292.113.

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