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1108743-60-7,MFCD28129099
Catalog No.:AA0039QC

1108743-60-7 | Entrectinib

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$52.00   $36.00
- +
5mg
98%
in stock  
$116.00   $82.00
- +
25mg
98%
in stock  
$212.00   $148.00
- +
250mg
98%
in stock  
$377.00   $264.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0039QC
Chemical Name:
Entrectinib
CAS Number:
1108743-60-7
Molecular Formula:
C31H34F2N6O2
Molecular Weight:
560.6375
MDL Number:
MFCD28129099
SMILES:
CN1CCN(CC1)c1ccc(c(c1)NC1CCOCC1)C(=O)Nc1n[nH]c2c1cc(cc2)Cc1cc(F)cc(c1)F
Properties
Computed Properties
 
Complexity:
847  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
41  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
7  
XLogP3:
5.7  

Literature

Title: Durable Clinical Response to Entrectinib in NTRK1-Rearranged Non-Small Cell Lung Cancer.

Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20151201

Title: Activity of second-generation ALK inhibitors against crizotinib-resistant mutants in an NPM-ALK model compared to EML4-ALK.

Journal: Cancer medicine 20150701

Title: Entrectinib: a potent new TRK, ROS1, and ALK inhibitor.

Journal: Expert opinion on investigational drugs 20150101

Title: ALK inhibitors in non-small cell lung cancer: crizotinib and beyond.

Journal: Clinical advances in hematology & oncology : H&O 20140701

Title: Ardini E, et al. Entrectinib, a Pan-TRK, ROS1, and ALK Inhibitor with Activity in Multiple Molecularly Defined Cancer Indications. Mol Cancer Ther. 2016 Apr;15(4):628-39.

Title: Iyer R, et al. Entrectinib is a potent inhibitor of Trk-driven neuroblastomas in a xenograft mouse model. Cancer Lett. 2016 Mar 28;372(2):179-86.

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