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111-94-4,MFCD00001956
Catalog No.:AA0033F2

111-94-4 | 3,3'-Iminodipropionitrile

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1g
98%
in stock  
$24.00   $17.00
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5g
98%
in stock  
$34.00   $24.00
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25g
99%
in stock  
$86.00   $60.00
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100g
99%
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$265.00   $185.00
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500g
90%
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$1,208.00   $846.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0033F2
Chemical Name:
3,3'-Iminodipropionitrile
CAS Number:
111-94-4
Molecular Formula:
C6H9N3
Molecular Weight:
123.1558
MDL Number:
MFCD00001956
SMILES:
N#CCCNCCC#N
NSC Number:
7770
UN Number:
3334
Properties
Properties
 
BP:
205 °C25 mm Hg(lit.)  
Form:
Liquid  
MP:
-6 °C  
Refractive Index:
n20/D 1.47(lit.)  

Computed Properties
 
Complexity:
126  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
9  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  
XLogP3:
-0.8  

Literature

Title: Strain and Sex Differences in the Vestibular and Systemic Toxicity of 3,3'-Iminodipropionitrile in Mice.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20170301

Title: Maternal exposure to 3,3'-iminodipropionitrile targets late-stage differentiation of hippocampal granule cell lineages to affect brain-derived neurotrophic factor signaling and interneuron subpopulations in rat offspring.

Journal: Journal of applied toxicology : JAT 20150801

Title: Acute toxic effects of 3,3'-iminodipropionitrile on hypothalamic-pituitary-gonadal axis in male rats.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20140101

Title: Surface chemical conversion of 3-glycidoxypropyldimethylethoxysilane on hydroxylated silicon surface: FT-IR, contact angle and ellipsometry analysis.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20121201

Title: N-nitro-L-arginine, a nitric oxide synthase inhibitor, aggravates iminodipropionitrile-induced neurobehavioral and vestibular toxicities in rats.

Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20121101

Title: Vestibular toxicity of cis-2-pentenenitrile in the rat.

Journal: Toxicology letters 20120620

Title: The involvement of neurofilament heavy chain phosphorylation in the maturation and degeneration of rat oocytes.

Journal: Endocrinology 20120401

Title: Loss of neurofilaments in the neuromuscular junction in a rat model of proximal axonopathy.

Journal: Neuropathology and applied neurobiology 20120201

Title: Role of CYP2E1-mediated metabolism in the acute and vestibular toxicities of nineteen nitriles in the mouse.

Journal: Toxicology letters 20120125

Title: Acute reproductive toxicity of 3,3'-iminodipropionitrile in female rats.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20120101

Title: Domino alkylation/oxa-Michael of 1,3-cyclohexanediones: steering the C/O-chemoselectivity to reach tetrahydrobenzofuranones.

Journal: Organic & biomolecular chemistry 20111007

Title: Selective atonal gene delivery improves balance function in a mouse model of vestibular disease.

Journal: Gene therapy 20110901

Title: A new unifying hypothesis for lathyrism, konzo and tropical ataxic neuropathy: nitriles are the causative agents.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20110301

Title: Butenenitriles have low axonopathic potential in the rat.

Journal: Toxicology letters 20110205

Title: Clinical physiology and mechanism of dizocilpine (MK-801): electron transfer, radicals, redox metabolites and bioactivity.

Journal: Oxidative medicine and cellular longevity 20100101

Title: Nervous and vestibular toxicities of acrylonitrile and iminodipropionitrile.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20090701

Title: Pentoxifylline attenuates iminodipropionitrile-induced behavioral abnormalities in rats.

Journal: Behavioural pharmacology 20090701

Title: Neurovestibular toxicities of acrylonitrile and iminodipropionitrile in rats: a comparative evaluation of putative mechanisms and target sites.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20090501

Title: Phosphorylation and compactness of neurofilaments in multiple sclerosis: indicators of axonal pathology.

Journal: Experimental neurology 20081001

Title: [Curative effect and possible mechanisms of topiramate in treatment of Tourette syndrome in rats].

Journal: Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20080801

Title: Requirement of vimentin filament assembly for beta3-adrenergic receptor activation of ERK MAP kinase and lipolysis.

Journal: The Journal of biological chemistry 20070323

Title: Behavioral disturbances and hair cell loss in the inner ear following nitrile exposure in mice, guinea pigs, and frogs.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20070301

Title: Protective effect of hydrocortisone on iminodipropionitrile-induced neurotoxicity in rats.

Journal: Basic & clinical pharmacology & toxicology 20070301

Title: Propagation of scrapie in peripheral nerves after footpad infection in normal and neurotoxin exposed hamsters.

Journal: Veterinary research 20070101

Title: Mechanism of neurotoxic 3,3'-iminodipropionitrile: relation to unsaturated nitriles, cocaine, and reactive oxygen species.

Journal: Medical hypotheses 20060101

Title: Behavioral and pathological effects in the rat define two groups of neurotoxic nitriles.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20051201

Title: Does copper ameliorate the vestibular toxicity of iminodipropionitrile (IDPN)?

Journal: Neurotoxicology 20050601

Title: Extruding auditory hair cells in rats exposed to subchronic 3,3'-iminodipropionitrile.

Journal: Environmental toxicology and pharmacology 20050501

Title: The neurotoxicity of iminodipropionitrile (IDPN) is ameliorated by copper.

Journal: Neurotoxicology 20050301

Title: Role of oxidative metabolites of cocaine in toxicity and addiction: oxidative stress and electron transfer.

Journal: Medical hypotheses 20050101

Title: On the similarity of cocaine and 3,3'-iminodipropionitrile.

Journal: Medical hypotheses 20050101

Title: Sodium benzoate attenuates iminodipropionitrile-induced behavioral syndrome in rats.

Journal: Behavioural pharmacology 20041201

Title: Metoclopramide attenuates iminodipropionitrile-induced oxidative stress and neurobehavioral toxicity in rats.

Journal: Pharmacology, biochemistry, and behavior 20041101

Title: Retinal microvascular patency in the diabetic rat.

Journal: International ophthalmology 20040701

Title: Inhibitory effect of free radical scavenger, MCI-186, in the increase of hydroxyl radical induced by iminodipropionitrile in rats.

Journal: Journal of the neurological sciences 20040415

Title: Distal effects in a model of proximal axonopathy: 3,3'-iminodipropionitrile causes specific loss of neurofilaments in rat vestibular afferent endings.

Journal: Acta neuropathologica 20031101

Title: Influence of age on iminodipropionitrile-induced vestibular and neurobehavioral toxicities in rats.

Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20030901

Title: Expression of neurotransmitter genes in motor regions of the dyskinetic rat after iminodipropionitrile.

Journal: Neuroscience letters 20030814

Title: A hypothetical mathematical construct explaining the mechanism of biological amplification in an experimental model utilizing picoTesla (PT) electromagnetic fields.

Journal: Medical hypotheses 20030601

Title: [Neurobehavioral toxicity of acrylamide and IDPN (3,3'-iminodipropionitrile) in rats by 28-day oral administration--problems encountered in collaborative study and a commentary on conducting neurobehavioral testing].

Journal: The Journal of toxicological sciences 20030501

Title: Comparison of cis- and trans-crotononitrile effects in the rat reveals specificity in the neurotoxic properties of nitrile isomers.

Journal: Toxicology and applied pharmacology 20030301

Title: Three-dimensional mapping of the lesions induced by beta-beta'-iminodiproprionitrile, methyl iodide and methyl methacrylate in the rat nasal cavity.

Journal: Toxicologic pathology 20030101

Title: Attenuation of iminodipropionitrile induced behavioral syndrome by sodium salicylate in rats.

Journal: Pharmacology, biochemistry, and behavior 20021001

Title: Masses of phosphorylated neurofilaments are associated with abnormal golgi apparatus of anterior horn neurons of beta, beta'-iminodipropionitrile-intoxicated rats.

Journal: Neuropathology : official journal of the Japanese Society of Neuropathology 20020601

Title: Relationship between insult intensity and mode of hair cell loss in the vestibular system of rats exposed to 3,3'-iminodipropionitrile.

Journal: The Journal of comparative neurology 20011029

Title: Pathology of the rat vestibular sensory epithelia during subchronic 3,3'-iminodipropionitrile exposure: hair cells may not be the primary target of toxicity.

Journal: Acta neuropathologica 20011001

Title: Behavioural disturbances and sensory pathology following allylnitrile exposure in rats.

Journal: Brain research 20010622

Title: Characterization of olfactory deficits in the rat following administration of 2,6-dichlorobenzonitrile (dichlobenil), 3,3'-iminodipropionitrile, or methimazole.

Journal: Fundamental and applied toxicology : official journal of the Society of Toxicology 19960101

Title: The ototoxicity of 3,3'-iminodipropionitrile: functional and morphological evidence of cochlear damage.

Journal: Hearing research 19941101

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