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112885-41-3,MFCD00867430
Catalog No.:AA007RM6
112885-41-3 | Mosapride
Pack Size
Purity
Availability
Price(USD)
Quantity
  
1g
98+%
in stock  
$19.00
- +
5g
98+%
in stock  
$61.00
- +
10g
98%
in stock  
$110.00
- +
25g
95%
in stock  
$225.00
- +
  • Technical Information
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Technical Information
Catalog Number:
AA007RM6
Chemical Name:
Mosapride
CAS Number:
112885-41-3
Molecular Formula:
C21H25ClFN3O3
Molecular Weight:
421.8929
MDL Number:
MFCD00867430
IUPAC Name:
4-amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methyl]benzamide
InChI:
InChI=1S/C21H25ClFN3O3/c1-2-28-20-10-19(24)18(22)9-17(20)21(27)25-11-16-13-26(7-8-29-16)12-14-3-5-15(23)6-4-14/h3-6,9-10,16H,2,7-8,11-13,24H2,1H3,(H,25,27)
InChI Key:
YPELFRMCRYSPKZ-UHFFFAOYSA-N
SMILES:
CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl
EC Number:
601-210-0
Properties
Computed Properties
 
Complexity:
521  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
421.157g/mol
Formal Charge:
0
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
421.897g/mol
Monoisotopic Mass:
421.157g/mol
Rotatable Bond Count:
7  
Topological Polar Surface Area:
76.8A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0
XLogP3:
2.8  

Synonyms
 
4-amino-5-chloro-2-ethoxy-N-((4-(4-fluorobenzyl)-2-morpholinyl)methyl)benzamide 
AS 4370 
CHEMBL60889 
Mosapride citrate dihydrate 
D06PZN 
MLS001401439 
ACN-S005338 
C21-H25-Cl-F-N3-O3 
CID119584 
AS 4370 
AS-4370 
CS-O-31167 
NCGC00160527-01 
Mosapride (INN) 
SMR000469200 
1665B 
A1334 
112885-42-4 
(+-)-4-amino-5-chloro-2-ethoxy-n-[[4-(4-fluorobenzyl)-2-morpholinyl]methyl]benzamide 
1246820-66-5 
4-amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]benzamide 
AK-41276 
4-amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methyl]benzamide 
Q-201413 
(+-)-4-Amino-5-chloro-2-ethoxy-N-((4-(p-fluorobenzyl)-2-morpholinyl)methyl)benzamide 
4-amino-5-chloro-2-ethoxy-N-({4-[(4-fluorophenyl)methyl]morpholin-2-yl}methyl)benzamide 
C21H25ClFN3O3 
Moza 
AS-4370 
4-amino-5-chloro-2-ethoxy-N-((4-(4-fluorobenzyl)morpholin-2-yl)methyl)benzamide 
4-amino-5-chloro-2-ethoxy-N-[[4-(4-fluorobenzyl)-2-morpholinyl]methyl]benzamide 
4-amino-5-chloro-2-ethoxy-N-{[4-(4-fluorobenzyl)morpholin-2-yl]methyl}benzamide 
4-azanyl-5-chloranyl-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methyl]benzamide 
Mosart (TN) 
AC1L3P2Q 
SCHEMBL16417 
GTPL242 
MLS004774042 
Mosapride citrate salt hydrate 
mosapride 
cid_119583 
DTXSID2048408 
BDBM94630 
CHEBI:94373 
CTK8B3325 
KS-00000IOE 
YPELFRMCRYSPKZ-UHFFFAOYSA-N 
BCP06695 
HY-B0189 
ANW-42285 
mosapride citrate 
BBL010131 
MFCD00867430 
PDSP1_001757 
PDSP2_001740 
STK711184 
AKOS005530698 
AC-4523 
AN-6321 
API0025932 
CS-2080 
Mosapride UI05MSP015CT 
DB11675 
DS-1071 
MCULE-1051026269 
RL00525 
RL00526 
RTR-002492 
4 CAmino-5-chloro-2-ethoxy-N-((4-(4-fluorobenzyl)-2-morpholinyl)methyl)benzamide 
NCGC00160527-02 
NCGC00160527-05 
BC679722 
Mosapride 
BR-41276 
LS-25426 
M687 
SMR003500712 
SY102307 
AB0015343 
AX8017587 
TR-002492 
4CH-009466 
FT-0631065 
112885-41-3 
ST24028880 
MFCD00867430 (95%) 
D08236 
S-4208 
AB00698266-07 
AB00698266_11 
885M413 
A802684 
A802685 
L000932 
4-amino-5-chloro-2-ethoxy-N-((4-(4-fluorobenzyl)-2-morpholinyl)methyl)benzamide 
SR-01000763405 
W-60401 
I06-1799 
J-002859 
J-514393 
SR-01000763405-4 
(- )-4-Amino-5-chloro-2-ethoxy-N-((4-(p-fluorobenzyl)-2-morpholinyl)methyl)-benzamide 
(- )-4-Amino-5-chloro-2-ethoxy-N-((4-(p-fluorobenzyl)-2-morpholinyl)methyl)-benzamide. 
Mosapride; 4-Amino-5-chloro-2-ethoxy-N-((4-(4-fluorobenzyl)-2-morpholinyl)methyl)benzamide 
4-amino-5-chloro-2-ethoxy-N-[[4-(4-fluorobenzyl)morpholin-2-yl]methyl]benzamide;citric acid 
Mosapride [INN] 
4-amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]benzamide;2-hydroxypropane-1,2,3-tricarboxylic acid 
4-amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methyl]benzamide;2-hydroxypropane-1,2,3-tricarboxylic acid 
4-Amino-5-chloro-2-ethoxy-N-[4-(4-fluoro-benzyl)-morpholin-2-ylmethyl]-benzamide; citrate(AS-4370) 
4-azanyl-5-chloranyl-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methyl]benzamide;2-oxidanylpropane-1,2,3-tricarboxylic acid 
Mosapride citrate 
Gasmotin 
Mosapride-d5 
UNII-I8MFJ1C0BY 
Mosapride citrate hydrate 
I8MFJ1C0BY 
Literature

Title: Effect of mosapride on prednisolone-induced gastric mucosal injury and gastric-emptying disorder in dog.

Journal: The Journal of veterinary medical science 20120901

Title: Dual role of serotonin in the pathogenesis of indomethacin-induced small intestinal ulceration: pro-ulcerogenic action via 5-HT3 receptors and anti-ulcerogenic action via 5-HT4 receptors.

Journal: Pharmacological research 20120901

Title: Pharmacokinetic and bioavailability studies of 5 mg mosapride tablets in healthy Korean volunteers.

Journal: International journal of clinical pharmacology and therapeutics 20120701

Title: A placebo-controlled trial of acotiamide for meal-related symptoms of functional dyspepsia.

Journal: Gut 20120601

Title: Effect of mosapride citrate on gastric emptying in interferon-induced gastroparesis.

Journal: Digestive diseases and sciences 20120601

Title: The effects of 5-HT4 receptor agonist, mosapride citrate, on visceral hypersensitivity in a rat model.

Journal: Digestive diseases and sciences 20120601

Title: Acotiamide, a new orally active acetylcholinesterase inhibitor, stimulates gastrointestinal motor activity in conscious dogs.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20120601

Title: [Clinical efficacy of electroacupuncture combined with dalitong granule for gastroesophageal reflux disease and its mechanism].

Journal: Zhongguo zhen jiu = Chinese acupuncture & moxibustion 20120601

Title: Efficacy of mosapride citrate with polyethylene glycol solution for colonoscopy preparation.

Journal: World journal of gastroenterology 20120528

Title: A prospective randomized trial of mosapride vs. placebo in constipation-predominant irritable bowel syndrome.

Journal: The American journal of gastroenterology 20120501

Title: Comparison of PPIs and H2-receptor antagonists plus prokinetics for dysmotility-like dyspepsia.

Journal: World journal of gastroenterology 20120407

Title: Systematic review: cardiovascular safety profile of 5-HT(4) agonists developed for gastrointestinal disorders.

Journal: Alimentary pharmacology & therapeutics 20120401

Title: Asian consensus report on functional dyspepsia.

Journal: Journal of neurogastroenterology and motility 20120401

Title: Effects of Rikkunshito (TJ-43) on Esophageal Motor Function and Gastroesophageal Reflux.

Journal: Journal of neurogastroenterology and motility 20120401

Title: Influence of Full-body Water Immersion on Esophageal Motor Function and Intragastric Pressure.

Journal: Journal of neurogastroenterology and motility 20120401

Title: Occurrence of Intestinal Pseudo-obstruction in a Brainstem Hemorrhage Patient.

Journal: Annals of rehabilitation medicine 20120401

Title: Comparison of effects of a selective 5-HT reuptake inhibitor versus a 5-HT4 receptor agonist on in vivo neurogenesis at the rectal anastomosis in rats.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20120315

Title: Amino acid and vitamin supplementation improved health conditions in elderly participants.

Journal: Journal of clinical biochemistry and nutrition 20120301

Title: Stability-indicating methods for the determination of mosapride citrate in the presence of its degradation products according to ICH guidelines.

Journal: Drug testing and analysis 20120201

Title: Influence of gastric acid on gastric emptying and gastric distension-induced pain response in rats--effects of famotidine and mosapride.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20120201

Title: Cyclic vomiting syndrome developed after stroke.

Journal: Annals of rehabilitation medicine 20120201

Title: Large-scale randomized clinical study on functional dyspepsia treatment with mosapride or teprenone: Japan Mosapride Mega-Study (JMMS).

Journal: Journal of gastroenterology and hepatology 20120101

Title: Oral hypertonic electrolyte-glucose/mosapride complex solution for resuscitation of burn shock in dogs.

Journal: Journal of burn care & research : official publication of the American Burn Association 20120101

Title: Improved oral bioavailability of poorly water-soluble indirubin by a supersaturatable self-microemulsifying drug delivery system.

Journal: International journal of nanomedicine 20120101

Title: Early effect of oral administration of omeprazole with mosapride as compared with those of omeprazole alone on the intragastric pH.

Journal: BMC gastroenterology 20120101

Title: Comparison of a Chinese Herbal Medicine (CCH1) and Lactulose as First-Line Treatment of Constipation in Long-Term Care: A Randomized, Double-Blind, Double-Dummy, and Placebo-Controlled Trial.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Effect of a New Prokinetic Agent DA-9701 Formulated with Corydalis Tuber and Pharbitidis Semen on Cytochrome P450 and UDP-Glucuronosyltransferase Enzyme Activities in Human Liver Microsomes.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Efficacy of omeprazole, famotidine, mosapride and teprenone in patients with upper gastrointestinal symptoms: an omeprazole-controlled randomized study (J-FOCUS).

Journal: BMC gastroenterology 20120101

Title: Prokinetic effect of the 5-HT4R agonist mosapride on canine gastric motility.

Journal: The Journal of veterinary medical science 20111201

Title: Characterization and optimization of orodispersible mosapride film formulations.

Journal: AAPS PharmSciTech 20111201

Title: Itopride in the treatment of functional dyspepsia in Chinese patients: a prospective, multicentre, post-marketing observational study.

Journal: Clinical drug investigation 20111201

Title: Practice pattern of gastroenterologists for the management of GERD under the minimal influence of the insurance reimbursement guideline: a multicenter prospective observational study.

Journal: Journal of Korean medical science 20111201

Title: Failure of a Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy of H. pylori Eradication in H. pylori-Infected Patients with Functional Dyspepsia.

Journal: Gut and liver 20111201

Title: [Long-term efficacy and safety research on functional dyspepsia treated with electroacupuncture and Zhizhu Kuanzhong capsule].

Journal: Zhongguo zhen jiu = Chinese acupuncture & moxibustion 20111201

Title: Relative bioavailability of a 5 mg mosapride/10 mg rabeprazole fixed dose combination tablet versus separate single tablets in healthy volunteers: a single-dose randomized open-label crossover study.

Journal: Current medical research and opinion 20111101

Title: Characteristics of 5-hydroxytryptamine receptors involved in contraction of feline ileal longitudinal smooth muscle.

Journal: The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 20111001

Title: Mosapride accelerates the delayed gastric emptying of high-viscosity liquids: a crossover study using continuous real-time C breath test (BreathID System).

Journal: Journal of neurogastroenterology and motility 20111001

Title: Acotiamide hydrochloride (Z-338) enhances gastric motility and emptying by inhibiting acetylcholinesterase activity in rats.

Journal: European journal of pharmacology 20110901

Title: Pharmacologic and complementary and alternative medicine therapies for irritable bowel syndrome.

Journal: Gut and liver 20110901

Title: Formulation optimization of solid dispersion of mosapride hydrochloride.

Journal: Archives of pharmacal research 20110901

Title: Mosapride citrate improves postoperative ileus of patients with colectomy.

Journal: Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20110801

Title: Effect of 5-HT4 receptor agonist mosapride citrate on rectosigmoid sensorimotor function in patients with irritable bowel syndrome.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20110801

Title: Effects of mosapride on esophageal secondary peristalsis in humans.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20110701

Title: Health related quality of life in functional gastrointestinal disorders in Asia.

Journal: Journal of neurogastroenterology and motility 20110701

Title: Neuronal stimulation with 5-hydroxytryptamine 4 receptor induces anti-inflammatory actions via α7nACh receptors on muscularis macrophages associated with postoperative ileus.

Journal: Gut 20110501

Title: Physiological evaluation of residual stomach motility after local resection in conscious dogs.

Journal: Surgery today 20110501

Title: Addition of prokinetic therapy to a PPI in reflux diseases.

Journal: Alimentary pharmacology & therapeutics 20110401

Title: Simotang enhances gastrointestinal motility, motilin and cholecystokinin expression in chronically stressed mice.

Journal: World journal of gastroenterology 20110328

Title: In vitro enhanced differentiation of neural networks in ES gut-like organ from mouse ES cells by a 5-HT4-receptor activation.

Journal: Biochemical and biophysical research communications 20110325

Title: Acotiamide hydrochloride (Z-338), a new selective acetylcholinesterase inhibitor, enhances gastric motility without prolonging QT interval in dogs: comparison with cisapride, itopride, and mosapride.

Journal: The Journal of pharmacology and experimental therapeutics 20110301

Title: Effect of chronic pain on morphine-induced respiratory depression in mice.

Journal: Neuroscience 20110203

Title: Proton pump inhibitor versus prokinetic therapy in patients with functional dyspepsia: is therapeutic response predicted by Rome III subgroups?

Journal: Journal of gastroenterology 20110201

Title: Randomised clinical trial: efficacy of the addition of a prokinetic, mosapride citrate, to omeprazole in the treatment of patients with non-erosive reflux disease - a double-blind, placebo-controlled study.

Journal: Alimentary pharmacology & therapeutics 20110201

Title: The Traditional Japanese Medicine Rikkunshito Promotes Gastric Emptying via the Antagonistic Action of the 5-HT(3) Receptor Pathway in Rats.

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: Effects of mosapride citrate, a 5-HT4-receptor agonist, on gastric distension-induced visceromotor response in conscious rats.

Journal: Journal of pharmacological sciences 20110101

Title: Pharmacokinetics and bioequivalence study of two mosapride citrate formulations after single-dose administration in healthy Chinese male volunteers.

Journal: Arzneimittel-Forschung 20110101

Title: Post-traumatic intra-cocoon mesenteric tear: a case report.

Journal: Case reports in gastroenterology 20110101

Title: Are symptomatic changes in irritable bowel syndrome correlated with the capsule endoscopy transit time? A pilot study using the 5-HT4 receptor agonist mosapride.

Journal: Hepato-gastroenterology 20110101

Title: The Pharmacology of TD-8954, a Potent and Selective 5-HT(4) Receptor Agonist with Gastrointestinal Prokinetic Properties.

Journal: Frontiers in pharmacology 20110101

Title: Determination of cetirizine in human plasma using high performance liquid chromatography coupled with tandem mass spectrometric detection: application to a bioequivalence study.

Journal: Arzneimittel-Forschung 20110101

Title: Bladder, bowel, and sexual dysfunction in Parkinson's disease.

Journal: Parkinson's disease 20110101

Title: Usefulness of a slow nutrient drinking test for evaluating gastric perception and accommodation.

Journal: Digestion 20110101

Title: Ultrasonographic evaluation of vincristine-induced gastric hypomotility and the prokinetic effect of mosapride in dogs.

Journal: Journal of veterinary internal medicine 20110101

Title: Identification of Forced Degradation Products of Itopride by LC-PDA and LC-MS.

Journal: Indian journal of pharmaceutical sciences 20110101

Title: Efficacy of mosapride citrate in proximal gastric accommodation and gastrointestinal motility in healthy volunteers: a double-blind placebo-controlled ultrasonographic study.

Journal: Journal of gastroenterology 20101201

Title: Effect of probiotic Lactobacillus (Lacidofil® cap) for the prevention of antibiotic-associated diarrhea: a prospective, randomized, double-blind, multicenter study.

Journal: Journal of Korean medical science 20101201

Title: Development of a novel combination tablet containing trimebutine maleate and mosapride citrate for the treatment of functional dyspepsia.

Journal: International journal of pharmaceutics 20101115

Title: Pharmacotherapy for gastroparesis: an attempt to evaluate a safer alternative.

Journal: Journal of neurogastroenterology and motility 20101001

Title: Pharmacokinetics of the gastroprokinetic agent mosapride citrate after single oral administration in horses.

Journal: The Journal of veterinary medical science 20100801

Title: Mosapride as an adjunct to lansoprazole for symptom relief of reflux oesophagitis.

Journal: British journal of clinical pharmacology 20100801

Title: Clinical study on the treatment of gastroesophageal reflux by acupuncture.

Journal: Chinese journal of integrative medicine 20100801

Title: A 5-HT(4)-receptor activation-induced neural plasticity enhances in vivo reconstructs of enteric nerve circuit insult.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20100701

Title: Arrhythmic risk biomarkers for the assessment of drug cardiotoxicity: from experiments to computer simulations.

Journal: Philosophical transactions. Series A, Mathematical, physical, and engineering sciences 20100628

Title: Evolving drugs in gastroesophageal reflux disease: pharmacologic treatment beyond proton pump inhibitors.

Journal: Expert opinion on pharmacotherapy 20100601

Title: Neuropathy, retinopathy, and glucose-lowering treatments.

Journal: Diabetes care 20100601

Title: Effects of mosapride on esophageal functions and gastroesophageal reflux.

Journal: Journal of gastroenterology and hepatology 20100601

Title: Antiangiogenic effect of a selective 5-HT4 receptor agonist.

Journal: The Journal of surgical research 20100401

Title: The prokinetic effect of mosapride citrate combined with omeprazole therapy improves clinical symptoms and gastric emptying in PPI-resistant NERD patients with delayed gastric emptying.

Journal: Journal of gastroenterology 20100401

Title: Idiopathic proximal hemimegacolon in an adult woman.

Journal: Journal of neurogastroenterology and motility 20100401

Title: HPLC-fluorescence assay for measuring mosapride in small volumes of rat plasma.

Journal: Biomedical chromatography : BMC 20100301

Title: The effect of mosapride (5HT-4 receptor agonist) on insulin sensitivity and GLUT4 translocation.

Journal: Diabetes research and clinical practice 20100301

Title: The 5-HT4 receptor agonist mosapride attenuates NSAID-induced gastric mucosal damage.

Journal: Journal of gastroenterology 20100201

Title: The effect of mosapride citrate on constipation in patients with diabetes.

Journal: Diabetes research and clinical practice 20100101

Title: Endoscopic evaluation of gastric emptying and effect of mosapride citrate on gastric emptying.

Journal: Yonsei medical journal 20100101

Title: Protracted cisplatin-induced vomiting responding to mosapride.

Journal: Indian journal of cancer 20100101

Title: A case of cyclic vomiting syndrome responding to gonadotropin-releasing hormone analogue.

Journal: Journal of neurogastroenterology and motility 20100101

Title: Update on the management of constipation in the elderly: new treatment options.

Journal: Clinical interventions in aging 20100101

Title: Anesthesia management of a morbidly obese patient in prone position for lumbar spine surgery.

Journal: Journal of craniovertebral junction & spine 20100101

Title: Translating 5-HT receptor pharmacology.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20091201

Title: [Effect of electro-acupuncture in treating morphine sulfate caused constipation in tumor patients].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20091001

Title: Gastroparesis: current concepts and management.

Journal: Gut and liver 20090901

Title: Characterization of metabolic profile of mosapride citrate in rat and identification of two new metabolites: Mosapride N-oxide and morpholine ring-opened mosapride by UPLC-ESI-MS/MS.

Journal: Journal of pharmaceutical and biomedical analysis 20090815

Title: Effect of mosapride citrate hydrate on the colon cleansing action of polyethylene glycol electrolyte lavage solution (PEG-ELS) in guinea pigs.

Journal: Journal of pharmacological sciences 20090801

Title: Assessment of gastric motor function by cine magnetic resonance imaging.

Journal: Journal of gastroenterology and hepatology 20090801

Title: Iatrogenic QT Abnormalities and Fatal Arrhythmias: Mechanisms and Clinical Significance.

Journal: Current cardiology reviews 20090801

Title: Rebamipide and mosapride enhance pilocarpine-induced salivation.

Journal: North American journal of medical sciences 20090801

Title: [Effect of prokinetic agents on the electrical activity of stomach and duodenum in rats].

Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20090701

Title: Effects of mosapride on motility of the small intestine and caecum in normal horses after jejunocaecostomy.

Journal: Journal of veterinary science 20090601

Title: [Clinical observation on transcutaneous electrical acupoint stimulation for treatment of functional dyspepsia].

Journal: Zhongguo zhen jiu = Chinese acupuncture & moxibustion 20090601

Title: [Study on colonic motility and efficacy analysis in patients with slow-transit constipation treated with self-formulated Xingchang Decoction].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20090501

Title: Effects of mosapride citrate, metoclopramide hydrochloride, lidocaine hydrochloride, and cisapride citrate on equine gastric emptying, small intestinal and caecal motility.

Journal: Research in veterinary science 20090401

Title: Effectiveness of prokinetic agents against diseases external to the gastrointestinal tract.

Journal: Journal of gastroenterology and hepatology 20090401

Title: Mosapride and postoperative ileus.

Journal: Diseases of the colon and rectum 20090401

Title: Docking model of drug binding to the human ether-à-go-go potassium channel guided by tandem dimer mutant patch-clamp data: a synergic approach.

Journal: Journal of medicinal chemistry 20090326

Title: The plasticity of the defecation reflex pathway in the enteric nervous system of guinea pigs.

Journal: Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20090201

Title: Rapid effect of mosapride citrate, 5-HT4 receptor agonist, on fasting blood glucose in Type 2 diabetes patients.

Journal: Journal of diabetes and its complications 20090101

Title: Impaired gastric motility and its relationship to reflux symptoms in patients with nonerosive gastroesophageal reflux disease.

Journal: Journal of gastroenterology 20090101

Title: Early effects of oral administration of lafutidine with mosapride compared with lafutidine alone on intragastric pH values.

Journal: BMC gastroenterology 20090101

Title: Indirect spectrofluorimetric determination of mosapride citrate in pharmaceutical formulations.

Journal: Acta poloniae pharmaceutica 20090101

Title: 3-[(4-Amino-5-chloro-2-ethoxy-benz-amido)meth-yl]pyrrolo[2,1-c][1,4]oxazin-5-ium chloride monohydrate.

Journal: Acta crystallographica. Section E, Structure reports online 20090101

Title: Effect of mosapride on recovery of intestinal motility after hand-assisted laparoscopic colectomy for carcinoma.

Journal: Diseases of the colon and rectum 20081101

Title: Choledochoscope manometry about different drugs on the Sphincter of Oddi.

Journal: World journal of gastroenterology 20081014

Title: Validation of 13C-acetic acid breath test by measuring effects of loperamide, morphine, mosapride, and itopride on gastric emptying in mice.

Journal: Biological & pharmaceutical bulletin 20081001

Title: Acotiamide hydrochloride (Z-338), a novel prokinetic agent, restores delayed gastric emptying and feeding inhibition induced by restraint stress in rats.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20080901

Title: Frequency scale symptoms for gastroesophageal reflux disease (Frequency Scale for Symptoms of GERD) predicts need for addition of prokinetics to proton pump inhibitor therapy.

Journal: Journal of gastroenterology and hepatology 20080801

Title: Multiple system atrophy and impaired gallbladder emptying.

Journal: Movement disorders : official journal of the Movement Disorder Society 20080715

Title: The in vivo gastrointestinal activity of TD-5108, a selective 5-HT(4) receptor agonist with high intrinsic activity.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20080701

Title: The in vitro pharmacological profile of TD-5108, a selective 5-HT(4) receptor agonist with high intrinsic activity.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20080701

Title: Effect of itopride hydrochloride on the ileal and colonic motility in guinea pig in vitro.

Journal: Yonsei medical journal 20080630

Title: The prokinetic effect of mosapride citrate on horse gastric emptying rates.

Journal: The Journal of veterinary medical science 20080601

Title: Frequency scale for symptoms of gastroesophageal reflux disease predicts the need for addition of prokinetics to proton pump inhibitor therapy.

Journal: Journal of gastroenterology and hepatology 20080501

Title: Quantitative determination of domperidone in human plasma by ultraperformance liquid chromatography with electrospray ionization tandem mass spectrometry.

Journal: Biomedical chromatography : BMC 20080401

Title: 5-Amino-6-chloro-N-[(1-isobutylpiperidin-4-yl)methyl]-2-methylimidazo[1,2-alpha]pyridine-8-carboxamide (CJ-033,466), a novel and selective 5-hydroxytryptamine4 receptor partial agonist: pharmacological profile in vitro and gastroprokinetic effect in conscious dogs.

Journal: The Journal of pharmacology and experimental therapeutics 20080401

Title: A new possibility for repairing the anal dysfunction by promoting regeneration of the reflex pathways in the enteric nervous system.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20080401

Title: Long-term Ultrasonographic Follow-up Study of Gastric Motility in Patients with Functional Dyspepsia.

Journal: Journal of clinical biochemistry and nutrition 20080301

Title: The effect of mosapride citrate on proximal and distal colonic motor function in the guinea-pig in vitro.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20080201

Title: Effects of milnacipran on binge eating - a pilot study.

Journal: Neuropsychiatric disease and treatment 20080201

Title: High-performance liquid chromatography and thin-layer chromatography for the simultaneous quantitation of rabeprazole and mosapride in pharmaceutical products.

Journal: Journal of chromatographic science 20080101

Title: Mosapride in gastrointestinal disorders.

Journal: Drugs 20080101

Title: Efficacy of prokinetic agents in improving bowel preparation for colonoscopy.

Journal: Digestion 20080101

Title: Effects of mosapride citrate on patients after vagal nerve, lower esophageal sphincter, and pyloric sphincter-preserving nearly total gastrectomy reconstructed by jejunal J pouch interposition, and postoperative quality of life.

Journal: Hepato-gastroenterology 20080101

Title: Role of ion channel modifiers in reversal of morphine-induced gastrointestinal inertia by prokinetic agents in mice.

Journal: Indian journal of experimental biology 20080101

Title: Prokinetics influence the pharmacokinetics of rabeprazole.

Journal: Digestion 20080101

Title: Liquid chromatography-tandem mass spectrometric method for determination of mosapride citrate in equine tissues.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071015

Title: Effect of mosapride on gastrointestinal transit time and diagnostic yield of capsule endoscopy.

Journal: Journal of gastroenterology and hepatology 20071001

Title: Treatment of functional dyspepsia with serotonin agonists: a meta-analysis of randomized controlled trials.

Journal: Journal of gastroenterology and hepatology 20071001

Title: The 5-HT(4) agonists cisapride, mosapride, and CJ-033466, a Novel potent compound, exhibit different human ether-a-go-go-related gene (hERG)-blocking activities.

Journal: Journal of pharmacological sciences 20071001

Title: Thermal care of functional dyspepsia based on bicarbonate-sulphate-calcium water: a sequential clinical trial.

Journal: Evidence-based complementary and alternative medicine : eCAM 20070901

Title: [Determination of mosapride in human plasma by high performance liquid chromatography tandem mass spectrometry].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20070801

Title: Quantification of pseudoephedrine in human plasma by LC-MS/MS using mosapride as internal standard.

Journal: Biomedical chromatography : BMC 20070301

Title: Meta-analysis of the effects of prokinetic agents in patients with functional dyspepsia.

Journal: Journal of gastroenterology and hepatology 20070301

Title: Quantification of fexofenadine in human plasma by liquid chromatography coupled to electrospray tandem mass spectrometry using mosapride as internal standard.

Journal: Biomedical chromatography : BMC 20070201

Title: Mosapride citrate prolongs survival in stroke patients with gastrostomy.

Journal: Journal of the American Geriatrics Society 20070101

Title: Prokinetic drug utility in the treatment of gastroesophageal reflux esophagitis: a systematic review of randomized controlled trials.

Journal: Open medicine : a peer-reviewed, independent, open-access journal 20070101

Title: Enhancement of the intrinsic defecation reflex by mosapride, a 5-HT4 agonist, in chronically lumbosacral denervated guinea pigs.

Journal: Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20061001

Title: [Effects of acute hypobaric hypoxia on gastric emptying and intestinal propulsion: experiment with rats].

Journal: Zhonghua yi xue za zhi 20060912

Title: [Serotonin 5- HT4 receptor agonist (mosapride citrate)].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20060801

Title: The effect of mosapride on esophageal motility and bolus transit in asymptomatic volunteers.

Journal: Journal of clinical gastroenterology 20060401

Title: Enantioselective determination of a gastroprokinetic drug using amylose tris-(3,5-dimethylphenylcarbamate) as a stationary phase by HPLC.

Journal: Journal of pharmaceutical and biomedical analysis 20060213

Title: Effects of mosapride citrate on patients after vagal nerve preserving distal gastrectomy reconstructed by interposition of a jejunal J pouch with a jejunal conduit for early gastric cancer.

Journal: World journal of surgery 20060201

Title: Simultaneous quantification of cilostazol and its primary metabolite 3,4-dehydrocilostazol in human plasma by rapid liquid chromatography/tandem mass spectrometry.

Journal: Analytical and bioanalytical chemistry 20060201

Title: Measurement of 5-HT4 receptor-mediated esophageal responses by digital sonomicrometry in the anesthetized rat.

Journal: Journal of pharmacological and toxicological methods 20060101

Title: Mosapride improves food intake, while not worsening glycemic control and obesity, in ob/ob obese mice with decreased gastric emptying.

Journal: Journal of diabetes and its complications 20060101

Title: Simultaneous quantification of fexofenadine and pseudoephedrine in human plasma by liquid chromatography/tandem mass spectrometry with electrospray ionization: method development, validation and application to a clinical study.

Journal: Rapid communications in mass spectrometry : RCM 20060101

Title: Acid regurgitation associated with persistent cough after pulmonary resection: an observational study.

Journal: Cough (London, England) 20060101

Title: Rapid, simple and highly sensitive LC-ESI-MS/MS method for the quantification of tamsulosin in human plasma.

Journal: Biomedical chromatography : BMC 20051201

Title: Increased gastric motility during 5-HT4 agonist therapy reduces response fluctuations in Parkinson's disease.

Journal: Parkinsonism & related disorders 20051201

Title: Validation and application of a high-performance liquid chromatography--tandem mass spectrometry assay for mosapride in human plasma.

Journal: Biomedical chromatography : BMC 20050901

Title: The 5-hydroxytryptamine 4 receptor agonist mosapride does not antagonize morphine-induced respiratory depression.

Journal: Clinical pharmacology and therapeutics 20050901

Title: A 5-HT4 agonist, mosapride, enhances intrinsic rectorectal and rectoanal reflexes after removal of extrinsic nerves in guinea pigs.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20050801

Title: Effects of mosapride, a 5-hydroxytryptamine 4 receptor agonist, on electrical activity of the small intestine and cecum in horses.

Journal: American journal of veterinary research 20050801

Title: Mosapride citrate, a novel 5-HT4 agonist and partial 5-HT3 antagonist, ameliorates constipation in parkinsonian patients.

Journal: Movement disorders : official journal of the Movement Disorder Society 20050601

Title: Usefulness of famotidine in functional dyspepsia patient treatment: comparison among prokinetic, acid suppression and antianxiety therapies.

Journal: Alimentary pharmacology & therapeutics 20050601

Title: Effects of famotidine, mosapride and tandospirone for treatment of functional dyspepsia.

Journal: Alimentary pharmacology & therapeutics 20050601

Title: New strategy of therapy for functional dyspepsia using famotidine, mosapride and amitriptyline.

Journal: Alimentary pharmacology & therapeutics 20050601

Title: [Comparative study on treatment of diabetic gastroparesis by acupuncture and Western medicine].

Journal: Zhongguo zhen jiu = Chinese acupuncture & moxibustion 20050401

Title: Clinical outcomes and management of mechanism-based inhibition of cytochrome P450 3A4.

Journal: Therapeutics and clinical risk management 20050301

Title: Persistent cough following pulmonary resection: observational and empiric study of possible causes.

Journal: The Annals of thoracic surgery 20050101

Title: Randomised, double-blind, comparative study to evaluate the efficacy and safety of ganaton (itopride hydrochloride) and mosapride citrate in the management of functional dyspepsia.

Journal: Journal of the Indian Medical Association 20041201

Title: Development and validation of a liquid chromatographic method for determination of related-substances of mosapride citrate in bulk drugs and pharmaceuticals.

Journal: Journal of pharmaceutical and biomedical analysis 20041119

Title: [The effect of mosapride on quality of life in functional dyspepsia].

Journal: The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 20040301

Title: [A randomized controlled Multi-center clinical trial on mosapride in the treatment of functional dyspepsia].

Journal: Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 20040201

Title: [New preparation method for barium enema: efficacy and administration of oral intestinal lavage solution with gastrointestinal prokinetic agent].

Journal: Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica 20040101

Title: Comparison of efficacy of pantoprazole alone versus pantoprazole plus mosapride in therapy of gastroesophageal reflux disease: a randomized trial.

Journal: Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus 20040101

Title: The effect of mosapride on oesophageal motor function and acid reflux in patients with gastro-oesophageal reflux disease.

Journal: European journal of gastroenterology & hepatology 20031001

Title: Effect of mosapride on glycemic control and gastric emptying in type 2 diabetes mellitus patients with gastropathy.

Journal: Diabetes research and clinical practice 20030901

Title: Investigation into the effects of mosapride on motility of Guinea pig stomach, ileum, and colon.

Journal: Yonsei medical journal 20030830

Title: A 5-HT4 agonist mosapride enhances rectorectal and rectoanal reflexes in guinea pigs.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20030801

Title: Stimulatory action of itopride hydrochloride on colonic motor activity in vitro and in vivo.

Journal: The Journal of pharmacology and experimental therapeutics 20030801

Title: Application of LC-MS/MS for the identification of a polar impurity in mosapride, a gastroprokinetic drug.

Journal: Journal of pharmaceutical and biomedical analysis 20030601

Title: A case of ACTH-independent macronodular adrenal hyperplasia: simultaneous expression of several aberrant hormone receptors in the adrenal gland.

Journal: Endocrine journal 20030601

Title: Relative efficacy of some prokinetic drugs in morphine-induced gastrointestinal transit delay in mice.

Journal: World journal of gastroenterology 20030415

Title: 5-HT4 receptors contribute to the motor stimulating effect of levosulpiride in the guinea-pig gastrointestinal tract.

Journal: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20030401

Title: Drug interaction between mosapride and erythromycin without electrocardiographic changes.

Journal: Japanese heart journal 20030301

Title: Synthesis and structure-affinity relationships of novel N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)pyridine-3-carboxamides with potent serotonin 5-HT3 and dopamine D2 receptor antagonistic activity.

Journal: Journal of medicinal chemistry 20030227

Title: 5-HT4 receptor ligands: applications and new prospects.

Journal: Journal of medicinal chemistry 20030130

Title: Effect of temperature on the reversal in the retention order of the enantiomers of mosapride on Chiral-AGP.

Journal: Journal of biochemical and biophysical methods 20021231

Title: Effects of mosapride citrate, a 5-HT4 receptor agonist, on colonic motility in conscious guinea pigs.

Journal: Japanese journal of pharmacology 20021201

Title: A validated RP-HPLC method for the determination of mosapride citrate in bulk drug samples and pharmaceutical formulations.

Journal: Die Pharmazie 20021201

Title: The determination of mosapride citrate in bulk drug samples and pharmaceutical dosage forms using HPLC.

Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20021101

Title: In vivo assessment of acceleration of motor activity associated with acetylcholine release via 5-hydroxytryptamine4 receptor in dog intestine.

Journal: Japanese journal of pharmacology 20020901

Title: [Reflux esophagitis].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20020801

Title: 5-HT4 receptor enhances the propulsive power of the peristaltic reflex in the rat distal colon.

Journal: Autonomic neuroscience : basic & clinical 20020731

Title: Mosapride, a 5HT-4 receptor agonist, improves insulin sensitivity and glycaemic control in patients with Type II diabetes mellitus.

Journal: Diabetologia 20020601

Title: Dose finding study of mosapride in functional dyspepsia: a placebo-controlled, randomized study.

Journal: Alimentary pharmacology & therapeutics 20020501

Title: Drug-induced ventricular tachyarrhythmia in isolated rabbit hearts with atrioventricular block.

Journal: Pharmacology & toxicology 20020501

Title: Novel N-[1-(1-substituted 4-piperidinylmethyl)-4-piperidinyl]benzamides as potent colonic prokinetic agents.

Journal: Bioorganic & medicinal chemistry letters 20020325

Title: [Prokinetics of gastrointestinal system; its newer aspects with regard to motillity stimulants].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20020201

Title: KDR-5169, a new gastrointestinal prokinetic agent, enhances gastric contractile and emptying activities in dogs and rats.

Journal: European journal of pharmacology 20020111

Title: 5-HT4 receptors in the hippocampus modulate rat locomotor activity.

Journal: Hippocampus 20020101

Title: Teratogenicity of the I(Kr)-blocker cisapride: relation to embryonic cardiac arrhythmia.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20020101

Title: Influence of mosapride citrate on gastric motility and autonomic nervous function: evaluation by spectral analyses of heart rate and blood pressure variabilities, and by electrogastrography.

Journal: Journal of gastroenterology 20020101

Title: Gastrointestinal prokinetic drugs have different affinity for the human cardiac human ether-à-gogo K(+) channel.

Journal: The Journal of pharmacology and experimental therapeutics 20011201

Title: Characteristics of fluvoxamine-induced nausea.

Journal: Psychiatry research 20011130

Title: Effects of mosapride citrate on human plasma levels of motilin, gastrin, somatostatin, and secretin.

Journal: Biological & pharmaceutical bulletin 20010901

Title: Effects of 5-HT(4) receptor agonists, cisapride and mosapride citrate on electrocardiogram in anaesthetized rats and guinea-pigs and conscious cats.

Journal: Pharmacology & toxicology 20010801

Title: Pharmacological characterization of a novel 5-HT4 receptor agonist, TS-951, in vitro.

Journal: Pharmacology 20010701

Title: Torsades de pointes ventricular tachycardia induced by mosapride and flecainide in the presence of hypokalemia.

Journal: Pacing and clinical electrophysiology : PACE 20010101

Title: The involvement of flavin-containing monooxygenase but not CYP3A4 in metabolism of itopride hydrochloride, a gastroprokinetic agent: comparison with cisapride and mosapride citrate.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20001001

Title: Structure of the human serotonin 5-HT4 receptor gene and cloning of a novel 5-HT4 splice variant.

Journal: Journal of neurochemistry 20000201

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