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113158-34-2,MFCD00069374
Catalog No.:AA01DZKW

113158-34-2 | NorbinaltorphimineDihydrochlorideSalt

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1mg
98
1 week  
$96.00   $68.00
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5mg
98%
1 week  
$201.00   $141.00
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10mg
98%
1 week  
$289.00   $202.00
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50mg
98%
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$876.00   $613.00
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100mg
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01DZKW
Chemical Name:
NorbinaltorphimineDihydrochlorideSalt
CAS Number:
113158-34-2
Molecular Formula:
C40H45Cl2N3O6
Molecular Weight:
734.7078
MDL Number:
MFCD00069374
SMILES:
Oc1ccc2c3c1O[C@@H]1[C@@]43CCN([C@H](C2)[C@]4(O)Cc2c1[nH]c1c2C[C@@]2([C@@]34[C@H]1Oc1c4c(C[C@H]2N(CC3)CC2CC2)ccc1O)O)CC1CC1.Cl.Cl
Properties
Computed Properties
 
Complexity:
1340  
Covalently-Bonded Unit Count:
3  
Defined Atom Stereocenter Count:
8  
Heavy Atom Count:
51  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
7  
Rotatable Bond Count:
4  

Literature

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Title: Selective κ opioid antagonists nor-BNI, GNTI and JDTic have low affinities for non-opioid receptors and transporters.

Journal: PloS one 20130101

Title: Analgesic properties of chimeric peptide based on morphiceptin and PFRTic-amide.

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Title: Dysregulation of kappa-opioid receptor systems by chronic nicotine modulate the nicotine withdrawal syndrome in an age-dependent manner.

Journal: Psychopharmacology 20121101

Title: κ opioid regulation of anxiety-like behavior during acute ethanol withdrawal.

Journal: Pharmacology, biochemistry, and behavior 20120701

Title: Central kappa opioid receptors modulate salt appetite in rats.

Journal: Physiology & behavior 20120625

Title: Salvinorin A has antiinflammatory and antinociceptive effects in experimental models of colitis in mice mediated by KOR and CB1 receptors.

Journal: Inflammatory bowel diseases 20120601

Title: Agonist-selective effects of opioid receptor ligands on cytosolic calcium concentration in rat striatal neurons.

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Title: Structure of the human κ-opioid receptor in complex with JDTic.

Journal: Nature 20120517

Title: κ-Opioid receptors within the nucleus accumbens shell mediate pair bond maintenance.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20120516

Title: Ontogenetic differences in ethanol's motivational properties during infancy.

Journal: Alcohol (Fayetteville, N.Y.) 20120501

Title: Regulation of GABA and glutamate release from proopiomelanocortin neuron terminals in intact hypothalamic networks.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20120321

Title: Early role of the κ opioid receptor in ethanol-induced reinforcement.

Journal: Physiology & behavior 20120320

Title: Effect of κ-opioid receptor agonist on the growth of non-small cell lung cancer (NSCLC) cells.

Journal: British journal of cancer 20120313

Title: Local kappa opioid receptor activation decreases temporomandibular joint inflammation.

Journal: Inflammation 20120201

Title: Opioidergic modulation of ethanol self-administration in the ventral pallidum.

Journal: Alcoholism, clinical and experimental research 20120201

Title: The role of endogenous dynorphin in ethanol-induced state-dependent CPP.

Journal: Behavioural brain research 20120201

Title: Blockade of kappa opioid receptors attenuates the development of depressive-like behaviors induced by cocaine withdrawal in rats.

Journal: Neuropharmacology 20120101

Title: Kisspeptin signaling is indispensable for neurokinin B, but not glutamate, stimulation of gonadotropin secretion in mice.

Journal: Endocrinology 20120101

Title: Early maternal separation affects ethanol-induced conditioning in a nor-BNI insensitive manner, but does not alter ethanol-induced locomotor activity.

Journal: Pharmacology, biochemistry, and behavior 20120101

Title: Long-acting κ opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity.

Journal: BMC pharmacology 20120101

Title: Antinociceptive action of isolated mitragynine from Mitragyna Speciosa through activation of opioid receptor system.

Journal: International journal of molecular sciences 20120101

Title: Learning and memory impairment induced by salvinorin A, the principal ingredient of Salvia divinorum, in wistar rats.

Journal: International journal of toxicology 20111201

Title: Sex difference in κ-opioid receptor (KOPR)-mediated behaviors, brain region KOPR level and KOPR-mediated guanosine 5'-O-(3-[35S]thiotriphosphate) binding in the guinea pig.

Journal: The Journal of pharmacology and experimental therapeutics 20111101

Title: YFa and analogs: investigation of opioid receptors in smooth muscle contraction.

Journal: World journal of gastroenterology 20111028

Title: The effects of opioid receptor antagonists on electroacupuncture-produced anti-allodynia/hyperalgesia in rats with paclitaxel-evoked peripheral neuropathy.

Journal: Brain research 20110926

Title: Central administration of neuronostatin induces antinociception in mice.

Journal: Peptides 20110901

Title: The action of a synthetic derivative of Met5-enkephalin-Arg6-Phe7 on behavioral and endocrine responses.

Journal: Peptides 20110801

Title: Activation of κ opioid receptors increases intrinsic excitability of dentate gyrus granule cells.

Journal: The Journal of physiology 20110715

Title: Ketanserin potentiates morphine-induced antinociception mediated by kappa-receptor activation.

Journal: Pharmacological research 20110701

Title: Kappa opioid receptor localization and coupling to nitric oxide production in cells of the anterior chamber.

Journal: Investigative ophthalmology & visual science 20110701

Title: Inhibitory effects of processed Aconiti tuber on morphine-induced conditioned place preference in rats.

Journal: Journal of ethnopharmacology 20110614

Title: Delayed postoperative latent pain sensitization revealed by the systemic administration of opioid antagonists in mice.

Journal: European journal of pharmacology 20110425

Title: Exposure to cocaine alters dynorphin-mediated regulation of excitatory synaptic transmission in nucleus accumbens neurons.

Journal: Biological psychiatry 20110201

Title: Morphine postconditioning attenuates ICAM-1 expression on endothelial cells.

Journal: Journal of Korean medical science 20110201

Title: μ-Opioid receptors in the nucleus accumbens shell region mediate the effects of amphetamine on inhibitory control but not impulsive choice.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110105

Title: Differential expression and sensitivity of presynaptic and postsynaptic opioid receptors regulating hypothalamic proopiomelanocortin neurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110105

Title: U50,488H postconditioning reduces apoptosis after myocardial ischemia and reperfusion.

Journal: Life sciences 20110103

Title: Systemic κ-opioid receptor antagonism by nor-binaltorphimine reduces dependence-induced excessive alcohol self-administration in rats.

Journal: Addiction biology 20110101

Title: Synergism between dexketoprofen and meloxicam in an orofacial formalin test was not modified by opioid antagonists.

Journal: Pharmacological reports : PR 20110101

Title: Sex-specificity and estrogen-dependence of kappa opioid receptor-mediated antinociception and antihyperalgesia.

Journal: Pain 20101201

Title: Attenuation of cannabinoid-induced inhibition of medullary dorsal horn neurons by a kappa-opioid receptor antagonist.

Journal: Brain research 20101104

Title: Effect of acute topical application of +-pentazocine on the mechanical allodynia in diabetic mice.

Journal: European journal of pharmacology 20100901

Title: Evidence of central and peripheral sensitization in a rat model of narcotic bowel-like syndrome.

Journal: Gastroenterology 20100801

Title: Behavioral stress may increase the rewarding valence of cocaine-associated cues through a dynorphin/kappa-opioid receptor-mediated mechanism without affecting associative learning or memory retrieval mechanisms.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20100801

Title: [The study of effects and mechanism of U50, 488H on electrical coupling during ischemia in the perfused isolated rat heart].

Journal: Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20100801

Title: Attenuation of cocaine-induced reinstatement of drug seeking in squirrel monkeys: kappa opioid and serotonergic mechanisms.

Journal: Psychopharmacology 20100601

Title: Effects of kappa opioids in an assay of pain-depressed intracranial self-stimulation in rats.

Journal: Psychopharmacology 20100601

Title: The effects of kappa-opioid receptor ligands on prepulse inhibition and CRF-induced prepulse inhibition deficits in the rat.

Journal: Psychopharmacology 20100601

Title: Consequences of opioid receptor mutation on actions of univalent and bivalent kappa and delta ligands.

Journal: Psychopharmacology 20100601

Title: Effectiveness of analogs of the kappa opioid receptor antagonist (3R)-7-hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic) to reduce U50,488-induced diuresis and stress-induced cocaine reinstatement in rats.

Journal: Psychopharmacology 20100601

Title: Evidence for a role of opioids in epoxyeicosatrienoic acid-induced cardioprotection in rat hearts.

Journal: American journal of physiology. Heart and circulatory physiology 20100601

Title: Endogenous kappa-opioid mediation of stress-induced potentiation of ethanol-conditioned place preference and self-administration.

Journal: Psychopharmacology 20100601

Title: The effects of acute restraint stress on nociceptive responses evoked by the injection of formalin into the temporomandibular joint of female rats.

Journal: Stress (Amsterdam, Netherlands) 20100501

Title: Remifentanil post-conditioning attenuates cardiac ischemia-reperfusion injury via kappa or delta opioid receptor activation.

Journal: Acta anaesthesiologica Scandinavica 20100401

Title: Involvement of the kappa-opioid receptor in nitrous oxide-induced analgesia in mice.

Journal: Journal of anesthesia 20100401

Title: Pretreatment time with norbinaltorphimine.

Journal: Anesthesia and analgesia 20100401

Title: Mu and kappa opioid receptor expression in the mediobasal hypothalamus and effectiveness of selective antagonists on prolactin release during lactation.

Journal: Neuroscience 20100317

Title: Antinociceptive effects of galanin in the central nucleus of amygdala of rats, an involvement of opioid receptors.

Journal: Brain research 20100312

Title: A prolonged protein kinase C-mediated, opioid-related antinociceptive effect of st John's Wort in mice.

Journal: The journal of pain : official journal of the American Pain Society 20100201

Title: Forebrain PENK and PDYN gene expression levels in three inbred strains of mice and their relationship to genotype-dependent morphine reward sensitivity.

Journal: Psychopharmacology 20100201

Title: Characteristics and comparative severity of respiratory response to toxic doses of fentanyl, methadone, morphine, and buprenorphine in rats.

Journal: Toxicology letters 20091215

Title: The unconditioned fear produced by morphine withdrawal is regulated by mu- and kappa-opioid receptors in the midbrain tectum.

Journal: Behavioural brain research 20091201

Title: The antinociceptive properties of reboxetine in acute pain.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20091001

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Inhibition of kappa opioid receptors attenuated increased cocaine intake in rats with extended access to cocaine.

Journal: Psychopharmacology 20090901

Title: Selective mu- and kappa-opioid receptor antagonists administered into the nucleus accumbens interfere with rapid tolerance to ethanol in rats.

Journal: Psychopharmacology 20090901

Title: Central adiponectin functions to inhibit arginine vasopressin release in conscious rats.

Journal: Journal of neuroendocrinology 20090901

Title: Prodynorphin gene deficiency potentiates nalbuphine-induced behavioral sensitization and withdrawal syndrome in mice.

Journal: Drug and alcohol dependence 20090901

Title: Potential anxiolytic- and antidepressant-like effects of salvinorin A, the main active ingredient of Salvia divinorum, in rodents.

Journal: British journal of pharmacology 20090701

Title: Opioid, cannabinoid CB1 and NOP receptors do not mediate APAP-induced hypothermia in rats.

Journal: Pharmacology, biochemistry, and behavior 20090501

Title: Central administration of somatostatin stimulates feeding behavior in chicks.

Journal: General and comparative endocrinology 20090501

Title: Myocardial apoptosis and infarction after ischemia/reperfusion are attenuated by kappa-opioid receptor agonist.

Journal: Archives of medical research 20090501

Title: Association of increased pain threshold by noise with central opioid neurons.

Journal: The Chinese journal of physiology 20090430

Title: Kappa-opioid system regulates the long-lasting behavioral adaptations induced by early-life exposure to methylphenidate.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090401

Title: Endogenous kappa opioid activation mediates stress-induced deficits in learning and memory.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20090401

Title: Effects of TRK-820, a selective kappa opioid receptor agonist, on rat schizophrenia models.

Journal: European journal of pharmacology 20090315

Title: Protection conferred by Corticotropin-releasing hormone in rat primary cortical neurons against chemical ischemia involves opioid receptor activation.

Journal: Brain research 20090227

Title: Activation of kappa opioid receptors decreases synaptic transmission and inhibits long-term potentiation in the basolateral amygdala of the mouse.

Journal: European journal of pain (London, England) 20090201

Title: Prodynorphin-derived peptides are critical modulators of anxiety and regulate neurochemistry and corticosterone.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090201

Title: Inhibitory effect of low-dose pentazocine on the development of antinociceptive tolerance to morphine.

Journal: Journal of anesthesia 20090101

Title: Crucial role of peripheral kappa-opioid receptors in a model of periodontal disease in rats.

Journal: Journal of periodontal research 20081201

Title: Dynorphin inhibits NEP activity in R1.1 mouse thymoma cells.

Journal: Cell biochemistry and function 20081201

Title: Genetic and early environmental contributions to alcohol's aversive and physiological effects.

Journal: Pharmacology, biochemistry, and behavior 20081101

Title: C2 spinal cord stimulation induces dynorphin release from rat T4 spinal cord: potential modulation of myocardial ischemia-sensitive neurons.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20081101

Title: kappa-Opioid receptor stimulation inhibits augmentation of Ca(2+) transient and hypertrophy induced by isoprenaline in neonatal rat ventricular myocytes - Role of CaMKIIdelta(B).

Journal: European journal of pharmacology 20081024

Title: In vivo characterization of (-)(-)MCL-144 and (+)(-)MCL-193: isomeric, bivalent ligands with mu/kappa agonist properties.

Journal: Neurochemical research 20081001

Title: Possible involvement of dynorphin A release via mu1-opioid receptor on supraspinal antinociception of endomorphin-2.

Journal: Peptides 20080901

Title: The analgesic effect of paeoniflorin on neonatal maternal separation-induced visceral hyperalgesia in rats.

Journal: The journal of pain : official journal of the American Pain Society 20080601

Title: The spinal antinociceptive effects of endomorphins in rats: behavioral and G protein functional studies.

Journal: Anesthesia and analgesia 20080601

Title: Role of opioid system in modulation of pain sensitivity under conditons of low and high environmental temperature.

Journal: Bulletin of experimental biology and medicine 20080601

Title: YFa, a chimeric opioid peptide, induces kappa-specific antinociception with no tolerance development during 6 days of chronic treatment.

Journal: Journal of neuroscience research 20080515

Title: The comparison of effects of processed Aconiti tuber, U50488H and MK-801 on the antinociceptive tolerance to morphine.

Journal: Journal of ethnopharmacology 20080417

Title: Intramuscular administration of morphine reduces mustard-oil-induced craniofacial-muscle pain behavior in lightly anesthetized rats.

Journal: European journal of pain (London, England) 20080401

Title: Morphine postconditioning protects against reperfusion injury in the isolated rat hearts.

Journal: The Journal of surgical research 20080401

Title: Methionine-enkephalin modulation of hydrogen peroxide (H2O2) release by rat peritoneal macrophages involves different types of opioid receptors.

Journal: Neuropeptides 20080401

Title: Evidence that cardioprotection by postconditioning involves preservation of myocardial opioid content and selective opioid receptor activation.

Journal: American journal of physiology. Heart and circulatory physiology 20080301

Title: Opioid receptors are involved in the sedative and antinociceptive effects of hesperidin as well as in its potentiation with benzodiazepines.

Journal: European journal of pharmacology 20080212

Title: The kappa-opioid receptor antagonist nor-BNI inhibits cocaine and amphetamine, but not cannabinoid (WIN 52212-2), abstinence-induced withdrawal in planarians: an instance of 'pharmacologic congruence'.

Journal: Brain research 20080208

Title: Pharmacological evidence for a motivational role of kappa-opioid systems in ethanol dependence.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20080201

Title: Involvement of kappa-opioid and endocannabinoid system on Salvinorin A-induced reward.

Journal: Biological psychiatry 20080201

Title: The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20080109

Title: Pharmacological selectivity of CTAP in a warm water tail-withdrawal antinociception assay in rats.

Journal: Psychopharmacology 20080101

Title: Expression of a Gi-coupled receptor in the heart causes impaired Ca2+ handling, myofilament injury, and dilated cardiomyopathy.

Journal: American journal of physiology. Heart and circulatory physiology 20080101

Title: Kappa agonist-induced reinstatement of cocaine seeking in squirrel monkeys: a role for opioid and stress-related mechanisms.

Journal: The Journal of pharmacology and experimental therapeutics 20071101

Title: Catalytic aerobic oxidation of nor-binaltorphimine (nor-BNI) analogs without 4,5-epoxy bridge affords a more selective ligand for kappa opioid receptor than the representative kappa antagonist nor-BNI.

Journal: Chemical & pharmaceutical bulletin 20071001

Title: Ethanol alters the effect of kappa receptor ligands on dopamine release in the nucleus accumbens.

Journal: Physiology & behavior 20070910

Title: Naloxone rapidly evokes endogenous kappa opioid receptor-mediated hyperalgesia in naïve mice pretreated briefly with GM1 ganglioside or in chronic morphine-dependent mice.

Journal: Brain research 20070905

Title: Central inhibition of opioid receptor subtypes and its effect on haemorrhagic hypotension in conscious sheep.

Journal: Acta physiologica (Oxford, England) 20070901

Title: Sexually dimorphic recruitment of spinal opioid analgesic pathways by the spinal application of morphine.

Journal: The Journal of pharmacology and experimental therapeutics 20070801

Title: Effects of selective opioid receptor antagonists on alcohol-induced and nicotine-induced antinociception.

Journal: Alcoholism, clinical and experimental research 20070801

Title: Involvement of kappa opioid receptors in formalin-induced inhibition of analgesic tolerance to morphine in mice.

Journal: The Journal of pharmacy and pharmacology 20070801

Title: Transient activation of the CA3 Kappa opioid system in the dorsal hippocampus modulates complex memory processing in mice.

Journal: Neurobiology of learning and memory 20070701

Title: Selectivity of delta- and kappa-opioid ligands depends on the route of central administration in mice.

Journal: The Journal of pharmacology and experimental therapeutics 20070701

Title: Nociceptin/orphanin FQ decreases serotonin efflux in the rat brain but in contrast to a kappa-opioid has no antagonistic effect on mu-opioid-induced increases in serotonin efflux.

Journal: Neuroscience 20070615

Title: Different effects of opioid antagonists on mu-, delta-, and kappa-opioid receptors with and without agonist pretreatment.

Journal: The Journal of pharmacology and experimental therapeutics 20070501

Title: Oxycodone's mechanism of action and potency differences after spinal and systemic routes of administration.

Journal: Anesthesiology 20070501

Title: Inhibition of tolerance to spinal morphine antinociception by low doses of opioid receptor antagonists.

Journal: European journal of pharmacology 20070410

Title: Sciatic nerve ligation-induced proliferation of spinal cord astrocytes is mediated by kappa opioid activation of p38 mitogen-activated protein kinase.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20070307

Title: Involvement of delta-and mu-opioid receptors in the delayed cerebral ischemic tolerance induced by repeated electroacupuncture preconditioning in rats.

Journal: Chinese medical journal 20070305

Title: Pharmacological and genetic manipulation of kappa opioid receptors: effects on cocaine- and pentylenetetrazol-induced convulsions and seizure kindling.

Journal: Neuropharmacology 20070301

Title: Hallucinatory and rewarding effect of salvinorin A in zebrafish: kappa-opioid and CB1-cannabinoid receptor involvement.

Journal: Psychopharmacology 20070301

Title: Activation of kappa-opioid receptor as a method for prevention of ischemic and reperfusion arrhythmias: role of protein kinase C and K(ATP) channels.

Journal: Bulletin of experimental biology and medicine 20070201

Title: Paradoxical hyperalgesia induced by mu-opioid receptor agonist endomorphin-2, but not endomorphin-1, microinjected into the centromedial amygdala of the rat.

Journal: European journal of pharmacology 20070112

Title: Involvement of opioid receptors in oxytocin-induced antinociception in the nucleus accumbens of rats.

Journal: The journal of pain : official journal of the American Pain Society 20070101

Title: Expression and localization of delta-, kappa-, and mu-opioid receptors in human spermatozoa and implications for sperm motility.

Journal: The Journal of clinical endocrinology and metabolism 20061201

Title: [Role of kappa-opioid receptors in the regulation of cardiac resistance to arrhythmogenic effects of ischemia and reperfusion].

Journal: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20061201

Title: Beta-endorphin differentially affects inflammation in two inbred rat strains.

Journal: European journal of pharmacology 20061107

Title: Kappa-opioid receptor antagonism improves recovery from myocardial stunning in chronically instrumented dogs.

Journal: Anesthesia and analgesia 20061001

Title: Quantitative no-net-flux microdialysis permits detection of increases and decreases in dopamine uptake in mouse nucleus accumbens.

Journal: Journal of neuroscience methods 20060915

Title: Big dynorphin, a prodynorphin-derived peptide produces NMDA receptor-mediated effects on memory, anxiolytic-like and locomotor behavior in mice.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20060901

Title: Downstream regulatory element antagonistic modulator regulates islet prodynorphin expression.

Journal: American journal of physiology. Endocrinology and metabolism 20060901

Title: Kappa-opioid receptor modulation of accumbal dopamine concentration during operant ethanol self-administration.

Journal: Neuropharmacology 20060901

Title: Atypical anxiolytic-like response to naloxone in benzodiazepine-resistant 129S2/SvHsd mice: role of opioid receptor subtypes.

Journal: Psychopharmacology 20060801

Title: Anticonvulsive effects of kappa-opioid receptor modulation in an animal model of ethanol withdrawal.

Journal: Genes, brain, and behavior 20060801

Title: Involvement of mu- and delta-opioid receptors in the antinociceptive effects induced by AMPA receptor antagonist in the spinal cord of rats.

Journal: Neuroscience letters 20060710

Title: Schild (apparent pA2) analysis of a kappa-opioid antagonist in Planaria.

Journal: European journal of pharmacology 20060701

Title: Inhibition of morphine tolerance by processed Aconiti tuber is mediated by kappa-opioid receptors.

Journal: Journal of ethnopharmacology 20060630

Title: Kappa opioid receptor activation of p38 MAPK is GRK3- and arrestin-dependent in neurons and astrocytes.

Journal: The Journal of biological chemistry 20060630

Title: Social defeat stress-induced behavioral responses are mediated by the endogenous kappa opioid system.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20060601

Title: Reduction of lipopolysaccharide-induced interleukin-6 production by the kappa opioid U50,488 in a mouse monocyte-like cell line.

Journal: International immunopharmacology 20060601

Title: Involvements of mu- and kappa-opioid receptors in morphine-induced antinociception in the nucleus accumbens of rats.

Journal: Neuroscience letters 20060515

Title: Vagotonic effects of enkephalin are not mediated by sympatholytic mechanisms.

Journal: Experimental biology and medicine (Maywood, N.J.) 20060401

Title: Endogenous kappa opioid receptor systems modulate the responsiveness of mesoaccumbal dopamine neurons to ethanol.

Journal: Alcoholism, clinical and experimental research 20060401

Title: Reinforcing properties of ethanol in neonatal rats: involvement of the opioid system.

Journal: Behavioral neuroscience 20060401

Title: Characterization of the antinociceptive effects of oxycodone in diabetic mice.

Journal: European journal of pharmacology 20060327

Title: Dynorphin A (2-13) improves mecamylamine-induced learning impairment accompanied by reversal of reductions in acetylcholine release in rats.

Journal: Neuropeptides 20060201

Title: [Delayed electrical uncoupling is involved in kappa-opioid receptor activation -induced cardioprotective effect in the isolated rat heart].

Journal: Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20060201

Title: Paradoxical effects of prodynorphin gene deletion on basal and cocaine-evoked dopaminergic neurotransmission in the nucleus accumbens.

Journal: The European journal of neuroscience 20060101

Title: Antinociceptive profile of salvinorin A, a structurally unique kappa opioid receptor agonist.

Journal: Pharmacology, biochemistry, and behavior 20060101

Title: Kappa-opioid receptor-mediated effects of the plant-derived hallucinogen, salvinorin A, on inverted screen performance in the mouse.

Journal: Behavioural pharmacology 20051201

Title: Localization of opioid receptor antagonist [3H]-LY255582 binding sites in mouse brain: comparison with the distribution of mu, delta and kappa binding sites.

Journal: Neuropeptides 20051201

Title: Antinociceptive effect of shakuyakukanzoto, a Kampo medicine, in diabetic mice.

Journal: Journal of pharmacological sciences 20051201

Title: Antinociception, tolerance and withdrawal symptoms induced by 7-hydroxymitragynine, an alkaloid from the Thai medicinal herb Mitragyna speciosa.

Journal: Life sciences 20051119

Title: Antinociceptive effect of oxycodone in diabetic mice.

Journal: European journal of pharmacology 20051107

Title: A single injection of the kappa opioid antagonist norbinaltorphimine increases ethanol consumption in rats.

Journal: Psychopharmacology 20051101

Title: Subclass opioid receptors associated with the cardiovascular depression after traumatic shock and the antishock effects of its specific receptor antagonists.

Journal: Shock (Augusta, Ga.) 20051101

Title: Coordinated and spatial upregulation of arc in striatonigral neurons correlates with L-dopa-induced behavioral sensitization in dyskinetic rats.

Journal: Journal of neuropathology and experimental neurology 20051101

Title: Effects of the local administration of selective mu-, delta-and kappa-opioid receptor agonists on osteosarcoma-induced hyperalgesia.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20051101

Title: Inhibitory control of the acute mu-withdrawal response by indirectly activated adenosine A1 and kappa-opioid systems in the Guinea-pig ileum; reversal by cholecystokinin.

Journal: Neurotoxicology 20051001

Title: Pharmacological study on the novel antinociceptive agent, a novel monoterpene alkaloid from Incarvillea sinensis.

Journal: Biological & pharmaceutical bulletin 20051001

Title: Improvement of memory impairment by (+)- and (-)-pentazocine via sigma, but not kappa opioid receptors.

Journal: Brain research 20050928

Title: The kappa-opioid receptor is involved in the stimulating effect of nicotine on adrenocortical activity but not in nicotine induced anxiety.

Journal: Behavioural brain research 20050908

Title: Involvement of the opioid system in the effects induced by nicotine on anxiety-like behaviour in mice.

Journal: Psychopharmacology 20050901

Title: Kinin and opioid receptors in the paratrigeminal nucleus modulate the somatosensory reflex to rat sciatic nerve stimulation.

Journal: Peptides 20050801

Title: In vitro electrophysiologic effects of morphine in rabbit ventricular myocytes.

Journal: Anesthesiology 20050801

Title: Kappa opioid receptor activation disrupts prepulse inhibition of the acoustic startle in rats.

Journal: Biological psychiatry 20050615

Title: Involvement of mu-, delta- and kappa-opioid receptor subtypes in the discriminative-stimulus effects of delta-9-tetrahydrocannabinol (THC) in rats.

Journal: Psychopharmacology 20050601

Title: Major effect of pyrrolic N-benzylation in norbinaltorphimine, the selective kappa-opioid receptor antagonist.

Journal: Journal of medicinal chemistry 20050310

Title: A Tyr-W-MIF-1 analog containing D-Pro2 acts as a selective mu2-opioid receptor antagonist in the mouse.

Journal: The Journal of pharmacology and experimental therapeutics 20050301

Title: Characterisation of opioid receptors involved in modulating circular and longitudinal muscle contraction in the rat ileum.

Journal: British journal of pharmacology 20050301

Title: Direct evidence for the involvement of the mesolimbic kappa-opioid system in the morphine-induced rewarding effect under an inflammatory pain-like state.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20050101

Title: [The antiarrhythmic effect of (-)-U-50,488 in rats with acute ischemia and reperfusion of heart is mediated by kappa1-opioid receptor activation].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20050101

Title: Sexual dimorphism in the antinociception mediated by kappa opioid receptors in the rat temporomandibular joint.

Journal: Neuroscience letters 20041206

Title: Effects of the kappa opioid agonist U50,488 and the kappa opioid antagonist nor-binaltorphimine on choice between cocaine and food in rhesus monkeys.

Journal: Psychopharmacology 20041101

Title: Opioid receptors and acetaminophen (paracetamol).

Journal: European journal of pharmacology 20041025

Title: Involvement of opioid receptors in the oxytocin-induced antinociception in the central nervous system of rats.

Journal: Regulatory peptides 20040815

Title: Nonopioidergic mechanism mediating morphine-induced antianalgesia in the mouse spinal cord.

Journal: The Journal of pharmacology and experimental therapeutics 20040701

Title: Instrumental learning within the spinal cord: III. Prior exposure to noncontingent shock induces a behavioral deficit that is blocked by an opioid antagonist.

Journal: Neurobiology of learning and memory 20040701

Title: Study of the involvement of K+ channels in the peripheral antinociception of the kappa-opioid receptor agonist bremazocine.

Journal: European journal of pharmacology 20040628

Title: The antinociceptive effect of Delta9-tetrahydrocannabinol in the arthritic rat.

Journal: European journal of pharmacology 20040616

Title: Relative contribution of endogenous opioids to myocardial ischemic tolerance.

Journal: The Journal of surgical research 20040501

Title: Effect of the kappa opioid agonist R-84760 on cocaine-induced increases in striatal dopamine levels and cocaine-induced place preference in C57BL/6J mice.

Journal: Psychopharmacology 20040401

Title: Opioid-mediated modulation of calcium currents in striatal and pallidal neurons following reserpine treatment: focus on kappa response.

Journal: Synapse (New York, N.Y.) 20040301

Title: Opioid receptor antagonists increase [Ca2+]i in rat arterial smooth muscle cells in hemorrhagic shock.

Journal: Acta pharmacologica Sinica 20040301

Title: Supraspinal and spinal cord opioid receptors are responsible for antinociception following intrathecal morphine injections.

Journal: European journal of anaesthesiology 20040301

Title: Region-dependent G-protein activation by kappa-opioid receptor agonists in the mouse brain.

Journal: Neuroscience letters 20040212

Title: Importance of phenolic address groups in opioid kappa receptor selective antagonists.

Journal: Journal of medicinal chemistry 20040212

Title: Reassessment of buprenorphine in conditioned place preference: temporal and pharmacological considerations.

Journal: Psychopharmacology 20040201

Title: Prolonged kappa opioid receptor phosphorylation mediated by G-protein receptor kinase underlies sustained analgesic tolerance.

Journal: The Journal of biological chemistry 20040116

Title: Mu opioid modulation of oxytocin secretion in late pregnant and parturient rats. Involvement of noradrenergic neurotransmission.

Journal: Neuroendocrinology 20040101

Title: Neuroanatomical and neuropharmacological study of opioid pathways in the mesencephalic tectum: effect of mu(1)- and kappa-opioid receptor blockade on escape behavior induced by electrical stimulation of the inferior colliculus.

Journal: Brain research 20031205

Title: Nonopioid receptor-mediated effects of U-50,488H on [Ca(2+)]i and extracellular dopamine in PC12 cells.

Journal: Journal of neuroscience research 20031115

Title: Kappa-opioid agonists directly inhibit midbrain dopaminergic neurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20031105

Title: kappa-Opioid withdrawal in Planaria.

Journal: Neuroscience letters 20031009

Title: Roles of KATP channels in delayed cardioprotection and intracellular Ca(2+) in the rat heart as revealed by kappa-opioid receptor stimulation with U50488H.

Journal: British journal of pharmacology 20031001

Title: Involvement of oxytocin in spinal antinociception in rats with inflammation.

Journal: Brain research 20030905

Title: Involvement of central mu-opioid system in the scratching behavior in mice, and the suppression of it by the activation of kappa-opioid system.

Journal: European journal of pharmacology 20030905

Title: Ultra-long antagonism of kappa opioid agonist-induced diuresis by intracisternal nor-binaltorphimine in monkeys.

Journal: Brain research 20030822

Title: Interleukin-2 increases activity of sarcoplasmic reticulum Ca2+-ATPase, but decreases its sensitivity to calcium in rat cardiomyocytes.

Journal: The Journal of pharmacology and experimental therapeutics 20030801

Title: Effects of U50,488H on transient outward and ultra-rapid delayed rectifier K+ currents in young human atrial myocytes.

Journal: European journal of pharmacology 20030725

Title: Antinociceptive properties of oxymorphazole in the mouse.

Journal: European journal of pharmacology 20030725

Title: Kappa opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20030702

Title: Enhanced binding of nor-binaltorphimine to kappa-opioid receptors in rats dependent on butorphanol.

Journal: Journal of neuroscience research 20030615

Title: Role of kappa-opioid receptor activation in pharmacological preconditioning of swine.

Journal: American journal of physiology. Heart and circulatory physiology 20030601

Title: Morphine withdrawal precipitated by specific mu, delta or kappa opioid receptor antagonists: a c-Fos protein study in the rat central nervous system.

Journal: The European journal of neuroscience 20030601

Title: Endogenous opioid peptides contribute to antinociceptive potency of intrathecal [Dmt1]DALDA.

Journal: The Journal of pharmacology and experimental therapeutics 20030501

Title: Effect of opioid receptor antagonists on hypothalamic-pituitary-adrenal activity in rhesus monkeys.

Journal: Psychoneuroendocrinology 20030501

Title: The antitussive effects of endomorphin-1 and endomorphin-2 in mice.

Journal: European journal of pharmacology 20030425

Title: Identity of the putative delta1-opioid receptor as a delta-kappa heteromer in the mouse spinal cord.

Journal: European journal of pharmacology 20030425

Title: Activation of kappa-opioid receptors inhibits pruritus evoked by subcutaneous or intrathecal administration of morphine in monkeys.

Journal: The Journal of pharmacology and experimental therapeutics 20030401

Title: Agonist/antagonist properties of nalbuphine, butorphanol and (-)-pentazocine in male vs. female rats.

Journal: Pharmacology, biochemistry, and behavior 20030401

Title: Opioid receptor subtypes involved in the regulation of prolactin secretion during pregnancy and lactation.

Journal: Journal of neuroendocrinology 20030301

Title: Modulation of myofilament Ca2+ densitivity by delta- and kappa-opioid agonists in intact guinea pig hearts.

Journal: Anesthesia and analgesia 20030301

Title: Blockade of mu-opioid receptor-mediated G-protein activation and antinociception by TRK-820 in mice.

Journal: European journal of pharmacology 20030207

Title: Behavioral and neuroendocrine actions of the Met-enkephalin-related peptide MERF.

Journal: Hormones and behavior 20030201

Title: U50,488 inhibits HIV-1 Tat-induced monocyte chemoattractant protein-1 (CCL2) production by human astrocytes.

Journal: Biochemical pharmacology 20030101

Title: Functional interactions between delta- and mu-opioid receptors in rat thermoregulation.

Journal: European journal of pharmacology 20030101

Title: Opioid receptor antagonists modulate Ca2+-activated K+ channels in mesenteric arterial smooth muscle cells of rats in hemorrhagic shock.

Journal: Shock (Augusta, Ga.) 20030101

Title: [The opiatergic link between the antiarrhythmic effect of adaptation and hypoxia in the model of ischemia and reperfusion in vivo].

Journal: Patologicheskaia fiziologiia i eksperimental'naia terapiia 20030101

Title: Differential antinociceptive effects of L-arginine and 3-morpholinosydoimine.

Journal: Proceedings of the Western Pharmacology Society 20030101

Title: Focal kappa-opioid receptor-mediated dependence and withdrawal in the nucleus paragigantocellularis.

Journal: Pharmacology, biochemistry, and behavior 20021201

Title: Dynorphin-independent spinal cannabinoid antinociception.

Journal: Pain 20021201

Title: Intraventricular insulin decreases kappa opioid-mediated sucrose intake in rats.

Journal: Peptides 20021201

Title: Inhibition of urinary bladder motility by a spinal action of U-50488H in rats.

Journal: The Journal of pharmacy and pharmacology 20021201

Title: Expression of functional kappa-opioid receptors on murine dendritic cells.

Journal: Immunology letters 20021021

Title: Effects of opioid antagonists on unconditioned and conditioned hyperactivity to morphine.

Journal: Pharmacology, biochemistry, and behavior 20021001

Title: Pharmacology of opioid inhibition to noxious uterine cervical distension.

Journal: Anesthesiology 20021001

Title: Kappa opioid antagonist effects of the novel kappa antagonist 5'-guanidinonaltrindole (GNTI) in an assay of schedule-controlled behavior in rhesus monkeys.

Journal: Psychopharmacology 20021001

Title: Lack of the nociceptin receptor does not affect acute or chronic nociception in mice.

Journal: Peptides 20020901

Title: Different effects of methionine-enkephalin on paw edema in two inbred rat strains.

Journal: Peptides 20020901

Title: Involvement of the opioid system in the anxiolytic-like effects induced by Delta(9)-tetrahydrocannabinol.

Journal: Psychopharmacology 20020801

Title: Relationship between NOC/oFQ, dynorphin, and COX-2 activation in impaired NMDA cerebrovasodilation after brain injury.

Journal: Journal of neurotrauma 20020801

Title: Involvement of endogenous opioid systems in nociceptin-induced spinal antinociception in rats.

Journal: Brain research 20020726

Title: Anti-nociceptive effect of neuropeptide Y in the nucleus accumbens of rats: an involvement of opioid receptors in the effect.

Journal: Brain research 20020614

Title: Effect of prodynorphin-derived opioid peptides on the ovulatory luteinizing hormone surge in the proestrous rat.

Journal: Endocrine 20020601

Title: Delta opioid inhibition of light-induced phase advances in hamster circadian activity rhythms.

Journal: Brain research 20020524

Title: Motivational effects mu- and kappa-opioid agonists following acute and chronic restraint stress: involvement of dopamine D(1) and D(2) receptors.

Journal: Behavioural brain research 20020514

Title: Dynorphin A(1-17)-induced feeding: pharmacological characterization using selective opioid antagonists and antisense probes in rats.

Journal: The Journal of pharmacology and experimental therapeutics 20020501

Title: Inhibition of cAMP accumulation by kappa-receptor activation in isolated iris-ciliary bodies: role of phosphodiesterase and protein kinase C.

Journal: The Journal of pharmacology and experimental therapeutics 20020501

Title: The neuropeptide FF analogue, 1DMe, reduces in vivo dynorphin release from the rat spinal cord.

Journal: Journal of neurochemistry 20020501

Title: Possible involvement of mu1-opioid receptors in the fentanyl- or morphine-induced antinociception at supraspinal and spinal sites.

Journal: Life sciences 20020405

Title: Analysis of opioid receptor subtype antagonist effects upon mu opioid agonist-induced feeding elicited from the ventral tegmental area of rats.

Journal: Brain research 20020301

Title: Crystal structure of biphalin sulfate: a multireceptor opioid peptide.

Journal: The journal of peptide research : official journal of the American Peptide Society 20020301

Title: Comparison of the peripheral and central effects of the opioid agonists loperamide and morphine in the formalin test in rats.

Journal: Neuropharmacology 20020201

Title: Antipruritic activity of the kappa-opioid receptor agonist, TRK-820.

Journal: European journal of pharmacology 20020125

Title: Blockade of nigral and pallidal opioid receptors suppresses vacuous chewing movements in a rodent model of tardive dyskinesia.

Journal: Neuroscience 20020101

Title: The effect of the leucopyrokinin analogue: [2-8]-leucopyrokinin on central opioid receptors in rats.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20011101

Title: Administration of mu-, kappa- or delta2-receptor agonists via osmotic minipumps suppresses murine splenic antibody responses.

Journal: International immunopharmacology 20011001

Title: Differential antinociceptive effects induced by intrathecally administered endomorphin-1 and endomorphin-2 in the mouse.

Journal: European journal of pharmacology 20010921

Title: Biphasic alterations of cAMP levels and inhibition of norepinephrine release in iris-ciliary body by bremazocine.

Journal: The Journal of pharmacology and experimental therapeutics 20010901

Title: GR89,696: a potent kappa-opioid agonist with subtype selectivity in rhesus monkeys.

Journal: The Journal of pharmacology and experimental therapeutics 20010901

Title: Mu- and delta-opioid receptor antagonists reduce levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease.

Journal: Experimental neurology 20010901

Title: Kappa-opioid receptors on lymphocytes of a human lymphocytic cell line: morphine-induced up-regulation as evidenced by competitive RT-PCR and indirect immunofluorescence.

Journal: International immunopharmacology 20010901

Title: Kappa opioid agonist-induced changes in IOP: correlation with 3H-NE release and cAMP accumulation.

Journal: Experimental eye research 20010801

Title: Inducible HSP70 mediates delayed cardioprotection via U-50488H pretreatment in rat ventricular myocytes.

Journal: American journal of physiology. Heart and circulatory physiology 20010701

Title: Rostral ventrolateral medullary opioid receptor subtypes in the inhibitory effect of electroacupuncture on reflex autonomic response in cats.

Journal: Autonomic neuroscience : basic & clinical 20010620

Title: Endomorphins 1 and 2, endogenous mu-opioid receptor agonists, impair passive avoidance learning in mice.

Journal: European journal of pharmacology 20010608

Title: Pharmacological characterization of the dermorphin analog [Dmt(1)]DALDA, a highly potent and selective mu-opioid peptide.

Journal: European journal of pharmacology 20010504

Title: The selective kappa-opioid receptor agonist U50,488H attenuates voluntary ethanol intake in the rat.

Journal: Behavioural brain research 20010501

Title: Opioids suppress basal and nicotine-induced catecholamine secretion via a stabilizing effect on actin filaments.

Journal: Endocrinology 20010501

Title: Norbinaltorphimine, a selective kappa-opioid receptor antagonist, induces an itch-associated response in mice.

Journal: European journal of pharmacology 20010420

Title: The role of minoxidil on endogenous opioid peptides in the spinal cord: a putative co-agonist relationship between K-ATP openers and opioids.

Journal: European journal of pharmacology 20010406

Title: Characterization of opioid receptors modulating neurogenic contractions of circular muscle from porcine ileum and evidence that delta- and kappa-opioid receptors are coexpressed in myenteric neurons.

Journal: The Journal of pharmacology and experimental therapeutics 20010401

Title: Enadoline discrimination in squirrel monkeys: effects of opioid agonists and antagonists.

Journal: The Journal of pharmacology and experimental therapeutics 20010401

Title: The novel kappa-opioid receptor agonist TRK-820 suppresses the rewarding and locomotor-enhancing effects of morphine in mice.

Journal: Life sciences 20010302

Title: Ultrasonic vocalizations of preweanling rats: involvement of both alpha(2)-adrenoceptor and kappa-opioid receptor systems.

Journal: European journal of pharmacology 20010301

Title: TRK-820, a selective kappa-opioid agonist, produces potent antinociception in cynomolgus monkeys.

Journal: Japanese journal of pharmacology 20010301

Title: Antinociceptive effect produced by intracerebroventricularly administered dynorphin A is potentiated by p-hydroxymercuribenzoate or phosphoramidon in the mouse formalin test.

Journal: Brain research 20010209

Title: Morphine upregulates kappa-opioid receptors of human lymphocytes.

Journal: Advances in experimental medicine and biology 20010101

Title: Elevation of atrial natriuretic peptide levels in aqueous humor of the rabbit by kappa opioid receptor agonists.

Journal: Neuropeptides 20010101

Title: Interactions between kappa opioid agonists and cocaine. Preclinical studies.

Journal: Annals of the New York Academy of Sciences 20000101

Title: The adrenergic receptor agonist, clonidine, potentiates the anti-parkinsonian action of the selective kappa-opioid receptor agonist, enadoline, in the monoamine-depleted rat.

Journal: British journal of pharmacology 19991201

Title: Modulation of neurotransmitter release in the basal ganglia of the rat brain by dynorphin peptides.

Journal: The Journal of pharmacology and experimental therapeutics 19990901

Title: Activation of peripheral kappa opioid receptors inhibits capsaicin-induced thermal nociception in rhesus monkeys.

Journal: The Journal of pharmacology and experimental therapeutics 19990401

Title: Opioid efficacy in a C6 glioma cell line stably expressing the human kappa opioid receptor.

Journal: The Journal of pharmacology and experimental therapeutics 19990201

Title: Delta-opioid receptor antagonist inhibits immunomodulation by Met-enkephalin analogs.

Journal: Neuroimmunomodulation 19990101

Title: Endomorphin-1 and endomorphin-2 activate mu-opioid receptors in myenteric neurons of the guinea-pig small intestine.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 19981201

Title: Evidence that spinal endogenous opioidergic systems control the expression of chronic pain-related behaviors in spinally injured rats.

Journal: Experimental brain research 19980101

Title: A kappa opioid antagonist blocks sensitization in a rodent model of Parkinson's disease.

Journal: Neuroreport 19970210

Title: Extraordinary potency of a novel delta opioid receptor agonist is due in part to increased efficacy.

Journal: Life sciences 19970101

Title: Involvement of the opioid system in the anxiolytic effect of diazepam in mice.

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Title: Pronociceptive effects of the neuropeptide, nociceptin, in the land snail, Cepaea nemoralis.

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Title: Opioid effects on spinal [3H]5-hydroxytryptamine release are not related to their antinociceptive action.

Journal: European journal of pharmacology 19950105

Title: Kappa opioid receptor agonists inhibit the pilocarpine-induced seizures and toxicity in the mouse.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 19941201

Title: U50,488, a kappa opioid receptor agonist, attenuates cocaine-induced increases in extracellular dopamine in the nucleus accumbens of rats.

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Title: Flax SM, et al. Effect of norbinaltorphimine on ∆⁹-tetrahydrocannabinol (THC)-induced taste avoidance in adolescent and adult Sprague-Dawley rats. Psychopharmacology (Berl). 2015 Sep;232(17):3193-201.

Title: Jackson KJ, et al. Effects of the kappa opioid receptor antagonist, norbinaltorphimine, on stress and drug-induced reinstatement of nicotine-conditioned place preference in mice. Psychopharmacology (Berl). 2013 Apr;226(4):763-8.

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Tags:113158-34-2 Molecular Formula|113158-34-2 MDL|113158-34-2 SMILES|113158-34-2 NorbinaltorphimineDihydrochlorideSalt