Name: Name:5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine
Brand: AABLOCKS
SKU: AA0008ET
Rating: 90 (10 reviews)

Catalog No.:AA0008ET

1134156-31-2 | 5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine

Pack Size

Purity

Availability

Price(USD)

Quantity

1mg

98%

in stock

$12.00 $9.00

- +

5mg

98%

in stock

$30.00 $21.00

- +

10mg

98%

in stock

$55.00 $38.00

- +

50mg

98%

in stock

$197.00 $138.00

- +

Technical Information
Properties
Literature
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Technical Information
Properties
Literature

Technical Information

Catalog Number:

AA0008ET

Chemical Name:

5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine

CAS Number:

1134156-31-2

Molecular Formula:

C25H23Cl2N7O4

Molecular Weight:

556.4006

MDL Number:

MFCD18086892

IUPAC Name:

4-[[(2R,3S,4R,5R)-5-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methoxymethyl]benzonitrile

InChI:

InChI=1S/C25H23Cl2N7O4/c26-16-6-5-15(7-17(16)27)9-30-25-33-19-22(29)31-12-32-23(19)34(25)24-21(36)20(35)18(38-24)11-37-10-14-3-1-13(8-28)2-4-14/h1-7,12,18,20-21,24,35-36H,9-11H2,(H,30,33)(H2,29,31,32)/t18-,20-,21-,24-/m1/s1

InChI Key:

ZXGGCBQORXDVTE-UMCMBGNQSA-N

SMILES:

N#Cc1ccc(cc1)COC[[email protected]]1O[[email protected]]([[email protected]@H]([[email protected]@H]1O)O)n1c(NCc2ccc(c(c2)Cl)Cl)nc2c1ncnc2N

Properties

Computed Properties

Complexity:

831

Compound Is Canonicalized:

Yes

Covalently-Bonded Unit Count:

Defined Atom Stereocenter Count:

Defined Bond Stereocenter Count:

Exact Mass:

555.119g/mol

Formal Charge:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Isotope Atom Count:

Molecular Weight:

556.404g/mol

Monoisotopic Mass:

555.119g/mol

Rotatable Bond Count:

Topological Polar Surface Area:

164A^2

Undefined Atom Stereocenter Count:

Undefined Bond Stereocenter Count:

XLogP3:

2.4

Synonyms

VER 155008

VER-155008

4-((((2R,3S,4R,5R)-5-(6-amino-8-(3,4-dichlorobenzylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)methyl)benzonitrile

4-[[(2r,3s,4r,5r)-5-[6-Amino-8-[(3,4-Dichlorophenyl)methylamino]purin-9-Yl]-3,4-Dihydroxy-Oxolan-2-Yl]methoxymethyl]benzonitrile

3FD

AK101867

4io8

MLS006010638

C25H23Cl2N7O4

CHEMBL470334

adenosine-derived inhibitor, 12

SCHEMBL16046542

VER155008

BDBM32378

CHEBI:95010

CTK8B9488

DTXSID00649014

BCP11966

EX-A2275

2290AA

ANW-62597

MFCD18086892

s7751

1134156-31-2

ZINC43208321

AKOS016003983

CS-3823

QC-9937

NCGC00263143-04

BC600787

HY-10941

SMR004701641

adenosine-derived inhibitor (Grp78), 13

AX8233406

VER-155008

TC-151342

ST24044025

A13351

VER-155008, >=98% (HPLC)

J-002962

BRD-K32330832-001-01-0

8-(3,4-Dichlorobenzyl)amino-5-O-(4-cyano-benzyl)adenosine

5'-O-(4-cyanobenzyl)-8-[(3,4-dichlorobenzyl)amino]adenosine

5'-O-[(4-Cyanophenyl)methyl]-8-{[(3,4-dichlorophenyl)methyl]amino}adenosine

Adenosine, 5'-O-[(4-cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-

VER155008

4-({[(2R,3S,4R,5R)-5-(6-amino-8-{[(3,4-dichlorophenyl)methyl]amino}-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}methyl)benzonitrile

D0H0AU

ZXGGCBQORXDVTE-UMCMBGNQSA-N

Hsp 70 inhibitor (cancer), Vernalis

A4387

C550733

Heat shock protein 70 inhibitor (cancer), Vernalis

C07

VER 155008

5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine

5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)-methyl]amino]-adenosine

4-((((2R,3S,4R,5R)-5-(6-Amino-8-((3,4-dichlorobenzyl)amino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)methyl)benzonitrile

Literature

Title: Osteoblasts activate the Nrf2 signalling pathway in response to arsenic trioxide treatment.

Journal: The international journal of biochemistry & cell biology 20161001

Title: The nuclear factor erythroid 2-like 2 activator, tert-butylhydroquinone, improves cognitive performance in mice after mild traumatic brain injury.

Journal: Neuroscience 20121025

Title: Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity.

Journal: Journal of medicinal chemistry 20110623

Title: ATPases as drug targets: insights from heat shock proteins 70 and 90.

Journal: Journal of medicinal chemistry 20101028

Title: A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells.

Journal: Cancer chemotherapy and pharmacology 20100801

Title: Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design.

Journal: Journal of medicinal chemistry 20090326

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