Home Amines 1134156-31-2
1134156-31-2,MFCD18086892
Catalog No.:AA0008ET

1134156-31-2 | 5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine

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Purity
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Price(USD)
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5mg
≥95%
in stock  
$133.00   $93.00
- +
10mg
≥95%
in stock  
$252.00   $176.00
- +
25mg
98% by HPLC
in stock  
$473.00   $331.00
- +
50mg
98% by HPLC
in stock  
$761.00   $533.00
- +
100mg
98% by HPLC
in stock  
$1,270.00   $889.00
- +
500mg
98% by HPLC
in stock  
$3,958.00   $2,771.00
- +
1000mg
98% by HPLC
in stock  
$6,295.00   $4,407.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0008ET
Chemical Name:
5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine
CAS Number:
1134156-31-2
Molecular Formula:
C25H23Cl2N7O4
Molecular Weight:
556.4006
MDL Number:
MFCD18086892
SMILES:
N#Cc1ccc(cc1)COC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1c(NCc2ccc(c(c2)Cl)Cl)nc2c1ncnc2N
Properties
Computed Properties
 
Complexity:
831  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
38  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
8  
XLogP3:
2.4  

Literature

Title: Osteoblasts activate the Nrf2 signalling pathway in response to arsenic trioxide treatment.

Journal: The international journal of biochemistry & cell biology 20161001

Title: The nuclear factor erythroid 2-like 2 activator, tert-butylhydroquinone, improves cognitive performance in mice after mild traumatic brain injury.

Journal: Neuroscience 20121025

Title: Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity.

Journal: Journal of medicinal chemistry 20110623

Title: ATPases as drug targets: insights from heat shock proteins 70 and 90.

Journal: Journal of medicinal chemistry 20101028

Title: A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells.

Journal: Cancer chemotherapy and pharmacology 20100801

Title: Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design.

Journal: Journal of medicinal chemistry 20090326

Title: Massey AJ, et al. A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells. Cancer Chemother Pharmacol. 2010 Aug;66(3):535-45.

Title: Yang X, et al. Heat Shock Cognate 70 Inhibitor, VER-155008, Reduces Memory Deficits and Axonal Degeneration in a Mouse Model of Alzheimer's Disease. Front Pharmacol. 2018 Jan 30;9:48.

Title: Kita K, et al. Heat shock protein 70 inhibitors suppress androgen receptor expression in LNCaP95 prostate cancer cells. Cancer Sci. 2017 Sep;108(9):1820-1827.

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Tags:1134156-31-2 Molecular Formula|1134156-31-2 MDL|1134156-31-2 SMILES|1134156-31-2 5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine