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113558-15-9,MFCD15071140
Catalog No.:AA0008W9

113558-15-9 | Baohuoside i

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1mg
98%
in stock  
$7.00   $5.00
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5mg
98%
in stock  
$11.00   $8.00
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100mg
98%
in stock  
$85.00   $60.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0008W9
Chemical Name:
Baohuoside i
CAS Number:
113558-15-9
Molecular Formula:
C27H30O10
Molecular Weight:
514.5211
MDL Number:
MFCD15071140
SMILES:
COc1ccc(cc1)c1oc2c(CC=C(C)C)c(O)cc(c2c(=O)c1O[C@@H]1O[C@@H](C)[C@@H]([C@H]([C@H]1O)O)O)O
Properties
Computed Properties
 
Complexity:
874  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
5  
Heavy Atom Count:
37  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
6  
XLogP3:
3.5  

Literature

Title: Blockade of epidermal growth factor receptor/mammalian target of rapamycin pathway by Icariside II results in reduced cell proliferation of osteosarcoma cells.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20141101

Title: Herba epimedii flavonoids suppress osteoclastic differentiation and bone resorption by inducing G2/M arrest and apoptosis.

Journal: Biochimie 20121201

Title: Icariside II potentiates paclitaxel-induced apoptosis in human melanoma A375 cells by inhibiting TLR4 signaling pathway.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120901

Title: Reactive oxygen species-mediated mitochondrial pathway is involved in Baohuoside I-induced apoptosis in human non-small cell lung cancer.

Journal: Chemico-biological interactions 20120730

Title: Icarisid II, a PDE5 inhibitor from Epimedium wanshanense, increases cellular cGMP by enhancing NOS in diabetic ED rats corpus cavernosum tissue.

Journal: Andrologia 20120501

Title: [Comparative study on chemical quality of main species of epimedium].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20120401

Title: Influence of vitamin E tocopherol polyethylene glycol succinate 1000 on intestinal absorption of icariside II.

Journal: Die Pharmazie 20120101

Title: Effects of icariside II on improving erectile function in rats with streptozotocin-induced diabetes.

Journal: Journal of andrology 20120101

Title: Icariside II induces apoptosis in U937 acute myeloid leukemia cells: role of inactivation of STAT3-related signaling.

Journal: PloS one 20120101

Title: Icariside II enhances Nrf2 nuclear translocation to upregulate phase II detoxifying enzyme expression coupled with the ERK, Akt and JNK signaling pathways.

Journal: Molecules (Basel, Switzerland) 20111103

Title: [Effects of icariin and icariside II on eNOS expression and NOS activity in porcine aorta endothelial cells].

Journal: Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20110818

Title: Janus activated kinase 2/signal transducer and activator of transcription 3 pathway mediates icariside II-induced apoptosis in U266 multiple myeloma cells.

Journal: European journal of pharmacology 20110301

Title: Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans.

Journal: PloS one 20110101

Title: [Comparative study on the osteogenic differentiation of rat bone marrow stromal cells effected by icariin and icariside II].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20101201

Title: Preparation of icariside II from icariin by enzymatic hydrolysis method.

Journal: Fitoterapia 20100701

Title: [Quality research on Epimedium cut crude drug processed with oil].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100601

Title: Synthesis and antimultidrug resistance evaluation of icariin and its derivatives.

Journal: Bioorganic & medicinal chemistry letters 20090801

Title: Cyclooxygenase-2/prostaglandin E2 pathway mediates icariside II induced apoptosis in human PC-3 prostate cancer cells.

Journal: Cancer letters 20090718

Title: [Sampling in quality control of medicinal materials-A case of Epimedium].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090401

Title: Intestinal absorption mechanisms of prenylated flavonoids present in the heat-processed Epimedium koreanum Nakai (Yin Yanghuo).

Journal: Pharmaceutical research 20080901

Title: Icariside II from Epimedium koreanum inhibits hypoxia-inducible factor-1alpha in human osteosarcoma cells.

Journal: European journal of pharmacology 20080128

Title: Statistically designed enzymatic hydrolysis for optimized production of icariside II as a novel melanogenesis inhibitor.

Journal: Journal of microbiology and biotechnology 20080101

Title: Simultaneous determination of icariin, icariside II and osthole in rat plasma after oral administration of the extract of Gushudan (a Chinese compound formulation) by LC-MS/MS.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071201

Title: LC-MS/MS method for the simultaneous determination of icariin and its major metabolites in rat plasma.

Journal: Journal of pharmaceutical and biomedical analysis 20071130

Title: Simultaneous determination of 15 flavonoids in Epimedium using pressurized liquid extraction and high-performance liquid chromatography.

Journal: Journal of chromatography. A 20070907

Title: Icaritin and its glycosides enhance osteoblastic, but suppress osteoclastic, differentiation and activity in vitro.

Journal: Life sciences 20070816

Title: Effect of Baohuoside-1 aglycone and tacrolimus monotherapy and combination therapy on prevention of acute heart allograft rejection in the rat.

Journal: Microsurgery 20070101

Title: Multiple conformations of phosphodiesterase-5: implications for enzyme function and drug development.

Journal: The Journal of biological chemistry 20060728

Title: Baohuoside-1 inhibits activated T cell proliferation at G(1)-S phase transition.

Journal: Transplant immunology 20051001

Title: Baohuoside-1, a novel immunosuppressive molecule, inhibits lymphocyte activation in vitro and in vivo.

Journal: Transplantation 20040927

Title: Kim B, et al. Baohuoside I suppresses invasion of cervical and breast cancer cells through the downregulation of CXCR4 chemokine receptor expression. Biochemistry. 2014 Dec 9;53(48):7562-9.

Title: Song J, et al. Reactive oxygen species-mediated mitochondrial pathway is involved in Baohuoside I-induced apoptosis in human non-small cell lung cancer. Chem Biol Interact. 2012 Jul 30;199(1):9-17.

Title: Wang L, et al. The flavonoid Baohuoside-I inhibits cell growth and downregulates survivin and cyclin D1 expression in esophageal carcinoma via β-catenin-dependent signaling. Oncol Rep. 2011 Nov;26(5):1149-56.

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