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1140909-48-3,MFCD20923480
Catalog No.:AA000AGG

1140909-48-3 | Cabozantinib s-malate

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5mg
99+%
in stock  
$7.00   $5.00
- +
10mg
99+%
in stock  
$9.00   $7.00
- +
250mg
99+%
in stock  
$39.00   $28.00
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1g
99+%
in stock  
$101.00   $71.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA000AGG
Chemical Name:
Cabozantinib s-malate
CAS Number:
1140909-48-3
Molecular Formula:
C32H30FN3O10
Molecular Weight:
635.5931
MDL Number:
MFCD20923480
SMILES:
OC(=O)C[C@@H](C(=O)O)O.COc1cc2nccc(c2cc1OC)Oc1ccc(cc1)NC(=O)C1(CC1)C(=O)Nc1ccc(cc1)F
Properties
Computed Properties
 
Complexity:
924  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
46  
Hydrogen Bond Acceptor Count:
12  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
11  

Literature

Title: Cabozantinib for the treatment of progressive metastatic medullary thyroid cancer.

Journal: Expert review of clinical pharmacology 20160101

Title: Cabozantinib versus Everolimus in Advanced Renal-Cell Carcinoma.

Journal: The New England journal of medicine 20151105

Title: Cabozantinib: a MET, RET, and VEGFR2 tyrosine kinase inhibitor.

Journal: Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer 20140101

Title: Novel molecular targeted therapies for refractory thyroid cancer.

Journal: Head & neck 20120501

Title: Novel molecular targets for the therapy of castration-resistant prostate cancer.

Journal: European urology 20120501

Title: Suppression of tumor invasion and metastasis by concurrent inhibition of c-Met and VEGF signaling in pancreatic neuroendocrine tumors.

Journal: Cancer discovery 20120301

Title: c-Met is a marker of pancreatic cancer stem cells and therapeutic target.

Journal: Gastroenterology 20111201

Title: Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth.

Journal: Molecular cancer therapeutics 20111201

Title: Novel therapies for metastatic castrate-resistant prostate cancer.

Journal: Journal of the National Cancer Institute 20111116

Title: Multi-targeted tyrosine kinase inhibitors in clinical development: focus on XL-184 (cabozantinib).

Journal: Drugs of today (Barcelona, Spain : 1998) 20111101

Title: VEGF and c-Met blockade amplify angiogenesis inhibition in pancreatic islet cancer.

Journal: Cancer research 20110715

Title: Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110701

Title: Activated MET is a molecular prognosticator and potential therapeutic target for malignant peripheral nerve sheath tumors.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20110615

Title: The effects of four different tyrosine kinase inhibitors on medullary and papillary thyroid cancer cells.

Journal: The Journal of clinical endocrinology and metabolism 20110601

Title: XL184 (cabozantinib) for medullary thyroid carcinoma.

Journal: Expert opinion on investigational drugs 20110301

Title: Current status of molecularly targeted drugs for the treatment of advanced thyroid cancer.

Journal: Endocrine journal 20110101

Title: Novel treatment of medullary thyroid cancer.

Journal: Current opinion in endocrinology, diabetes, and obesity 20091001

Title: You WK, et al. VEGF and c-Met blockade amplify angiogenesis inhibition in pancreatic islet cancer. Cancer Res, 2011, 71(14), 4758-4768.

Title: Torres KE, et al. Activated MET is a molecular prognosticator and potential therapeutic target for malignant peripheral nerve sheath tumors. Clin Cancer Res, 2011, 17(12), 3943-3955.

Title: Yakes FM, et al. Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth. Mol Cancer Ther, 2011, 10(12), 2298-2308.

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