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Title: Determination of the phosphorylated metabolites of gemcitabine and of difluorodeoxyuridine by LCMSMS.
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Journal: Cancer chemotherapy and pharmacology 20111101
Title: The deaminated metabolite of gemcitabine, 2',2'-difluorodeoxyuridine, modulates the rate of gemcitabine transport and intracellular phosphorylation via deoxycytidine kinase.
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Title: Phase I study of Oral gemcitabine prodrug (LY2334737) alone and in combination with erlotinib in patients with advanced solid tumors.
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Title: Difluorodeoxyuridine plasma concentrations after low-dose gemcitabine during chemoradiation in head and neck cancer patients.
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Title: Effect of its deaminated metabolite, 2',2'-difluorodeoxyuridine, on the transport and toxicity of gemcitabine in HeLa cells.
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Title: Combinatorial pharmacologic effects of gemcitabine and its metabolite dFdU.
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Title: Ecotoxicity and genotoxicity assessment of cytotoxic antineoplastic drugs and their metabolites.
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Title: Population pharmacokinetics of gemcitabine and its metabolite in Japanese cancer patients: impact of genetic polymorphisms.
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Title: Gemcitabine-loaded PEGylated unilamellar liposomes vs GEMZAR: biodistribution, pharmacokinetic features and in vivo antitumor activity.
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Title: Pharmacokinetics of gemcitabine in non-small-cell lung cancer patients: impact of the 79A>C cytidine deaminase polymorphism.
Journal: European journal of clinical pharmacology 20100601
Title: Gemcitabine and epirubicin plasma concentration-related excretion in saliva in patients with non-small cell lung cancer.
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Title: Systemic absorption and pharmacokinetics of single-dose intravesical gemcitabine after transurethral resection of the bladder in non-muscle-invasive bladder cancer.
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Title: Development of a sensitive and selective LC-MS/MS method for simultaneous determination of gemcitabine and 2,2-difluoro-2-deoxyuridine in human plasma.
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Title: Mass flows of X-ray contrast media and cytostatics in hospital wastewater.
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Title: Pharmacokinetics of gemcitabine at fixed-dose rate infusion in patients with normal and impaired hepatic function.
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Title: Does saturable formation of gemcitabine triphosphate occur in patients?
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Title: Extensive metabolism and hepatic accumulation of gemcitabine after multiple oral and intravenous administration in mice.
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Title: New insights into the pharmacology and cytotoxicity of gemcitabine and 2',2'-difluorodeoxyuridine.
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Title: Phase I clinical trial of intrathecal gemcitabine in patients with neoplastic meningitis.
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Title: A pharmacodynamic model for the time course of tumor shrinkage by gemcitabine + carboplatin in non-small cell lung cancer patients.
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Title: Oral administration of gemcitabine in patients with refractory tumors: a clinical and pharmacologic study.
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Title: Measurement of plasma concentration of gemcitabine and its metabolite dFdU in hemodialysis patients with advanced urothelial cancer.
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Title: Prolonged versus standard gemcitabine infusion: translation of molecular pharmacology to new treatment strategy.
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Title: Simultaneous determination of gemcitabine and its main metabolite, dFdU, in plasma of patients with advanced non-small-cell lung cancer by high-performance liquid chromatography-tandem mass spectrometry.
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Title: Phase II study with the combination of gemcitabine and DTIC in patients with advanced soft tissue sarcomas.
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Title: Pharmacokinetics of gemcitabine in Japanese cancer patients: the impact of a cytidine deaminase polymorphism.
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Title: Pharmacokinetics and toxicity of an early single intravesical instillation of gemcitabine after endoscopic resection of superficial bladder cancer.
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Title: Validated assay for the simultaneous determination of the anti-cancer agent gemcitabine and its metabolite 2',2'-difluorodeoxyuridine in human plasma by high-performance liquid chromatography with tandem mass spectrometry.
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Title: Quantitative analysis of gemcitabine triphosphate in human peripheral blood mononuclear cells using weak anion-exchange liquid chromatography coupled with tandem mass spectrometry.
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Title: The radiosensitising effect of difluorodeoxyuridine, a metabolite of gemcitabine, in vitro.
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Title: Phase I/II trial of doxorubicin and fixed dose-rate infusion gemcitabine in advanced soft tissue sarcomas: a GEIS study.
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Title: High-performance liquid chromatographic method for the determination of gemcitabine and 2',2'-difluorodeoxyuridine in plasma and tissue culture media.
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Title: Pharmacokinetics of gemcitabine and its primary metabolite in dogs after intravenous bolus dosing and its in vitro pharmacodynamics.
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Title: Gemcitabine and atrial fibrillation: a rare manifestation of chemotherapy toxicity.
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Title: Micro-array analysis of resistance for gemcitabine results in increased expression of ribonucleotide reductase subunits.
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Title: Characterization of lipophilic gemcitabine prodrug-liposomal membrane interaction by differential scanning calorimetry.
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Title: Phase I clinical and pharmacologic study of a 2-weekly administration of cisplatin and gemcitabine in patients with advanced non-small cell lung cancer.
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Title: Severe drug toxicity associated with a single-nucleotide polymorphism of the cytidine deaminase gene in a Japanese cancer patient treated with gemcitabine plus cisplatin.
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Title: Intravesical gemcitabine in superficial bladder cancer: a phase II safety, efficacy and pharmacokinetic study.
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Title: Preparation, characterization, cytotoxicity and pharmacokinetics of liposomes containing lipophilic gemcitabine prodrugs.
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Title: Determination of gemcitabine and its metabolite in human plasma using high-pressure liquid chromatography coupled with a diode array detector.
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Title: Phase I clinical trial of fixed-dose rate infusional gemcitabine and dacarbazine in the treatment of advanced soft tissue sarcoma, with assessment of gemcitabine triphosphate accumulation.
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Title: Investigation of the pharmacokinetics of gemcitabine and 2',2'-difluorodeoxyuridine in human plasma by liquid chromatography.
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Title: Phase I trial and pharmacokinetics of gemcitabine in children with advanced solid tumors.
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Title: Intravesical administration of gemcitabine in superficial bladder cancer: a phase I study with pharmacodynamic evaluation.
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Title: Validated procedure for simultaneous trace level determination of the anti-cancer agent gemcitabine and its metabolite in human urine by high-performance liquid chromatography with tandem mass spectrometry.
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Title: An expedient assay for determination of gemcitabine and its metabolite in human plasma using isocratic ion-pair reversed-phase high-performance liquid chromatography.
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Title: Pharmacokinetics of gemcitabine in a patient with end-stage renal disease: effective clearance of its main metabolite by standard hemodialysis treatment.
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Title: Measurement of the anti-cancer agent gemcitabine in human plasma by high-performance liquid chromatography.
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Title: Intravesical gemcitabine therapy for superficial transitional cell carcinoma of the bladder: a phase I and pharmacokinetic study.
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Title: In vitro studies on the immunosuppressive effect of 2',2'-difluorodeoxycytidine (dFdC) and its metabolite 2',2'-difluorodeoxyuridine (dFdU).
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Title: Phase I-II and pharmacokinetic study of gemcitabine combined with oxaliplatin in patients with advanced non-small-cell lung cancer and ovarian carcinoma.
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Title: Pharmacokinetics of intrathecal gemcitabine in nonhuman primates.
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Title: Gemcitabine, epirubicin and paclitaxel: pharmacokinetic and pharmacodynamic interactions in advanced breast cancer.
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Title: Drug distribution and pharmacokinetic/pharmacodynamic relationship of paclitaxel and gemcitabine in patients with non-small-cell lung cancer.
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