Home Quinolines 1144-20-3
1144-20-3,MFCD00160565
Catalog No.:AA000B5Z

1144-20-3 | 2-Phenylquinolin-4-ol

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250mg
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500mg
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1g
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$306.00   $214.00
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2.5g
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5g
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10g
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA000B5Z
Chemical Name:
2-Phenylquinolin-4-ol
CAS Number:
1144-20-3
Molecular Formula:
C15H11NO
Molecular Weight:
221.2539
MDL Number:
MFCD00160565
SMILES:
Oc1cc(nc2c1cccc2)c1ccccc1
NSC Number:
28866
Properties
Computed Properties
 
Complexity:
328  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
1  
XLogP3:
3.2  

Downstream Synthesis Route

[1]JournaloftheAmericanChemicalSociety,1950,vol.72,p.1723

[1]Just[ChemischeBerichte,1886,vol.19,p.1464,1466]Niementowski[ChemischeBerichte,1905,vol.38,p.2045][ChemischeBerichte,1907,vol.40,p.4285]

[1]Gabriel;Gerhard[ChemischeBerichte,1921,vol.54,p.1617]

[1]JournaloftheAmericanChemicalSociety,1950,vol.72,p.1723

[1]TetrahedronLetters,2004,vol.45,p.7903-7906

Literature

Title: CWF-145, a novel synthetic quinolone derivative exerts potent antimitotic activity against human prostate cancer: Rapamycin enhances antimitotic drug-induced apoptosis through the inhibition of Akt/mTOR pathway.

Journal: Chemico-biological interactions 20161225

Title: Evaluation of synthetic acridones and 4-quinolinones as potent inhibitors of cathepsins L and V.

Journal: European journal of medicinal chemistry 20120801

Title: Antioxidant properties of 4-quinolones and structurally related flavones.

Journal: Bioorganic & medicinal chemistry 20120115

Title: KHC-4 anti-cancer effects on human PC3 prostate cancer cell line.

Journal: The American journal of Chinese medicine 20120101

Title: Evolution from a natural flavones nucleus to obtain 2-(4-Propoxyphenyl)quinoline derivatives as potent inhibitors of the S. aureus NorA efflux pump.

Journal: Journal of medicinal chemistry 20110825

Title: Non-covalent inhibitors of rhinovirus 3C protease.

Journal: Bioorganic & medicinal chemistry letters 20110115

Title: Specific microtubule-depolymerizing agents augment efficacy of dendritic cell-based cancer vaccines.

Journal: Journal of biomedical science 20110101

Title: Novel quinolone CHM-1 induces apoptosis and inhibits metastasis in a human osterogenic sarcoma cell line.

Journal: Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20091201

Title: Induction of mitotic arrest and apoptosis by a novel synthetic quinolone analogue, CWC-8, via intrinsic and extrinsic apoptotic pathways in human osteogenic sarcoma U-2 OS cells.

Journal: Anticancer research 20090801

Title: Selective targeting of tumorigenic cancer cell lines by microtubule inhibitors.

Journal: PloS one 20090101

Title: CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitro and in vivo.

Journal: Molecular cancer therapeutics 20080201

Title: CHM-1 inhibits hepatocyte growth factor-induced invasion of SK-Hep-1 human hepatocellular carcinoma cells by suppressing matrix metalloproteinase-9 expression.

Journal: Cancer letters 20071108

Title: Quinolone analogue inhibits tubulin polymerization and induces apoptosis via Cdk1-involved signaling pathways.

Journal: Biochemical pharmacology 20070630

Title: 2-(3-Fluorophenyl)-6-methoxyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (YJC-1) induces mitotic phase arrest in A549 cells.

Journal: European journal of pharmacology 20070315

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Cancer preventive agents, Part 2: Synthesis and evaluation of 2-phenyl-4-quinolone and 9-oxo-9,10-dihydroacridine derivatives as novel antitumor promoters.

Journal: Bioorganic & medicinal chemistry 20050715

Title: Synthesis and biological relationships of 3',6-substituted 2-phenyl-4-quinolone-3-carboxylic acid derivatives as antimitotic agents.

Journal: Bioorganic & medicinal chemistry 20050103

Title: Antitumor Agents. 211. Fluorinated 2-phenyl-4-quinolone derivatives as antimitotic antitumor agents.

Journal: Journal of medicinal chemistry 20011108

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Tags:1144-20-3 Molecular Formula|1144-20-3 MDL|1144-20-3 SMILES|1144-20-3 2-Phenylquinolin-4-ol