+1 858-523-8231
Login | Register
AA Blocks, Building Blocks, Catalysts, Inhibitors
Login | Register
Home Carboxes 1144035-53-9
1144035-53-9,MFCD20527274
Catalog No.:AA000B63

1144035-53-9 | 1-Piperazinecarboxylic acid, 4-[3-(2,3-dihydro-2-oxo-6-benzoxazolyl)-3-oxopropyl]-, (3,5-dichlorophenyl)methyl ester

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
in stock  
$15.00   $11.00
- +
5mg
98+%
in stock  
$37.00   $26.00
- +
10mg
98+%
in stock  
$54.00   $38.00
- +
25mg
98+%
in stock  
$91.00   $64.00
- +
100mg
95%
in stock  
$331.00   $232.00
- +
250mg
95%
in stock  
$522.00   $365.00
- +
1g
95%
in stock  
$1,316.00   $921.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA000B63
Chemical Name:
1-Piperazinecarboxylic acid, 4-[3-(2,3-dihydro-2-oxo-6-benzoxazolyl)-3-oxopropyl]-, (3,5-dichlorophenyl)methyl ester
CAS Number:
1144035-53-9
Molecular Formula:
C22H21Cl2N3O5
Molecular Weight:
478.3252
MDL Number:
MFCD20527274
SMILES:
Clc1cc(COC(=O)N2CCN(CC2)CCC(=O)c2ccc3c(c2)oc(=O)[nH]3)cc(c1)Cl
Properties
Computed Properties
 
Complexity:
693  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
7  
XLogP3:
3.2  

Literature

Title: A novel autotaxin inhibitor reduces lysophosphatidic acid levels in plasma and the site of inflammation.

Journal: The Journal of pharmacology and experimental therapeutics 20100701

Title: Gierse J, et al. A novel autotaxin inhibitor reduces lysophosphatidic acid levels in plasma and the site of inflammation. J Pharmacol Exp Ther. 2010 Jul;334(1):310-7.

Title: Bhave SR, et al. Autotaxin Inhibition with PF-8380 Enhances the Radiosensitivity of Human and Murine Glioblastoma Cell Lines. Front Oncol. 2013 Sep 17;3:236.

Title: Cao P, et al. Autocrine lysophosphatidic acid signaling activates β-catenin and promotes lung allograft fibrosis. J Clin Invest. 2017 Apr 3;127(4):1517-1530.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 1144035-53-9
2070015-01-7

2070015-01-7

 1144036-95-2

1144036-95-2

 1144035-43-7

1144035-43-7

 1144035-02-8

1144035-02-8

 1144035-27-7

1144035-27-7

 1144036-48-5

1144036-48-5
Building Blocks
More >
Tags:1144035-53-9 Molecular Formula|1144035-53-9 MDL|1144035-53-9 SMILES|1144035-53-9 1-Piperazinecarboxylic acid, 4-[3-(2,3-dihydro-2-oxo-6-benzoxazolyl)-3-oxopropyl]-, (3,5-dichlorophenyl)methyl ester