Title: A marine sponge alkaloid derivative 4-chloro fascaplysin inhibits tumor growth and VEGF mediated angiogenesis by disrupting PI3K/Akt/mTOR signaling cascade.
Journal: Chemico-biological interactions 20170925
Title: Chemistry and biology of fascaplysin, a potent marine-derived CDK-4 inhibitor.
Journal: Mini reviews in medicinal chemistry 20120601
Title: Fascaplysin as a specific inhibitor for CDK4: insights from molecular modelling.
Journal: PloS one 20120101
Title: 3-bromohomofascaplysin A, a fascaplysin analogue from a Fijian Didemnum sp. ascidian.
Journal: Bioorganic & medicinal chemistry 20111115
Title: Fascaplysin exert anti-tumor effects through apoptotic and anti-angiogenesis pathways in sarcoma mice model.
Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20110717
Title: Direct effects of fascaplysin on human umbilical vein endothelial cells attributing the anti-angiogenesis activity.
Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20101001
Title: Silver catalyzed cascade synthesis of alkaloid ring systems: concise total synthesis of fascaplysin, homofascaplysin C and analogues.
Journal: Chemical communications (Cambridge, England) 20100707
Title: Antimalarial and antitubercular nostocarboline and eudistomin derivatives: synthesis, in vitro and in vivo biological evaluation.
Journal: Bioorganic & medicinal chemistry 20100215
Title: [Anti-proliferation of human cervical cancer HeLa cell line by fascaplysin through apoptosis induction].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20090901
Title: Fascaplysin-inspired diindolyls as selective inhibitors of CDK4/cyclin D1.
Journal: Bioorganic & medicinal chemistry 20090815
Title: Recent research in selective cyclin-dependent kinase 4 inhibitors for anti-cancer treatment.
Journal: Current medicinal chemistry 20090101
Title: Design, synthesis and biological evaluation of new tryptamine and tetrahydro-beta-carboline-based selective inhibitors of CDK4.
Journal: Bioorganic & medicinal chemistry 20080815
Title: A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Journal: Proceedings of the National Academy of Sciences of the United States of America 20071218
Title: Fascaplysin, a selective CDK4 inhibitor, exhibit anti-angiogenic activity in vitro and in vivo.
Journal: Cancer chemotherapy and pharmacology 20070301
Title: Synthesis, crystal structure and biological activity of beta-carboline based selective CDK4-cyclin D1 inhibitors.
Journal: Organic & biomolecular chemistry 20061221
Title: Inhibition of cancer cell growth by cyclin dependent kinase 4 inhibitors synthesized based on the structure of fascaplysin.
Journal: Bioorganic chemistry 20061001
Title: Limited redundancy in phosphorylation of retinoblastoma tumor suppressor protein by cyclin-dependent kinases in acute lymphoblastic leukemia.
Journal: The American journal of pathology 20060901
Title: CA224, a non-planar analogue of fascaplysin, inhibits Cdk4 but not Cdk2 and arrests cells at G0/G1 inhibiting pRB phosphorylation.
Journal: Bioorganic & medicinal chemistry letters 20060815
Title: Design, synthesis and biological activity of new CDK4-specific inhibitors, based on fascaplysin.
Journal: Organic & biomolecular chemistry 20060307
Title: A common protein fold topology shared by flavonoid biosynthetic enzymes and therapeutic targets.
Journal: Journal of natural products 20060101
Title: New fascaplysin-based CDK4-specific inhibitors: design, synthesis and biological activity.
Journal: Chemical communications (Cambridge, England) 20040807
Title: Cytotoxic alkaloids from the marine sponge Thorectandra sp.
Journal: Natural product research 20040601
Title: Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources.
Journal: Journal of natural products 20040501
Title: Langerhans cell histiocytosis immunohistochemical expression of fascin, a dendritic cell marker.
Journal: American journal of clinical pathology 20020901
Title: DNA binding properties of the marine sponge pigment fascaplysin.
Journal: Bioorganic & medicinal chemistry 20010401
Title: Inhibition of cyclin-dependent kinase 4 (Cdk4) by fascaplysin, a marine natural product.
Journal: Biochemical and biophysical research communications 20000907
Title: A new bioactive sesterterpene and antiplasmodial alkaloids from the marine sponge hyrtios cf. erecta.
Journal: Journal of natural products 20000601
