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115-46-8,MFCD00066980
Catalog No.:AA000FGV

115-46-8 | Alpha,alpha-diphenyl-4-piperidinomethanol

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5g
99%
in stock  
$12.00   $8.00
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25g
98%
in stock  
$56.00   $39.00
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100g
98%
in stock  
$175.00   $123.00
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  • Technical Information
  • Properties
  • Literature
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  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA000FGV
Chemical Name:
Alpha,alpha-diphenyl-4-piperidinomethanol
CAS Number:
115-46-8
Molecular Formula:
C18H21NO
Molecular Weight:
267.3654
MDL Number:
MFCD00066980
SMILES:
OC(c1ccccc1)(c1ccccc1)C1CCNCC1
Properties
Properties
 
BP:
445.5 °C at 760 mmHg  
Form:
Solid  
MP:
160-163 °C  
Refractive Index:
1.5100 (estimate)  
Storage:
Room Temperature;  

Computed Properties
 
Complexity:
268  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  
XLogP3:
2.9  

Literature

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Structural determinants for histamine H(1) affinity, hERG affinity and QTc prolongation in a series of terfenadine analogs.

Journal: Bioorganic & medicinal chemistry letters 20090901

Title: Hepatobiliary disposition of a drug/metabolite pair: Comprehensive pharmacokinetic modeling in sandwich-cultured rat hepatocytes.

Journal: The Journal of pharmacology and experimental therapeutics 20060801

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: The effect of short- and long-term administration of verapamil on the disposition of cytochrome P450 3A and P-glycoprotein substrates.

Journal: Clinical pharmacology and therapeutics 20060301

Title: The effect of rifampin administration on the disposition of fexofenadine.

Journal: Clinical pharmacology and therapeutics 20010301

Title: Interplay between CYP3A-mediated metabolism and polarized efflux of terfenadine and its metabolites in intestinal epithelial Caco-2 (TC7) cell monolayers.

Journal: Pharmaceutical research 19990501

Title: Brown DA, et, al. The effects of some centrally acting drugs on ganglionic transmission in the cat.

Title: Jurima-Romet M, et, al. Induction of CYP3A and associated terfenadine N-dealkylation in rat hepatocytes cocultured with 3T3 cells. Cell Biol Toxicol. 1995 Dec;11(6):313-27.

Title: BRAUN DL, et, al. The pharmacologic activity of alpha-(4-piperidyl)-benzhydrol hydrochloride (azacyclonol hydrochloride); an ataractive agent. J Pharmacol Exp Ther. 1956 Oct;118(2):153-61.

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Tags:115-46-8 Molecular Formula|115-46-8 MDL|115-46-8 SMILES|115-46-8 Alpha,alpha-diphenyl-4-piperidinomethanol |Organic_Building_Blocks