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1154-25-2,MFCD00151710
Catalog No.:AA000FV3

1154-25-2 | 5-(N-Ethyl-n-isopropyl)amiloride

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5mg
≥98%
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$82.00   $57.00
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10mg
≥98%
in stock  
$153.00   $107.00
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25mg
≥98%
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100mg
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA000FV3
Chemical Name:
5-(N-Ethyl-n-isopropyl)amiloride
CAS Number:
1154-25-2
Molecular Formula:
C11H18ClN7O
Molecular Weight:
299.7599
MDL Number:
MFCD00151710
SMILES:
NN=CNC(=O)c1nc(Cl)c(nc1N)N(C(C)C)CC
Properties
Computed Properties
 
Complexity:
372  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
4  
XLogP3:
1.3  

Downstream Synthesis Route
Literature

Title: Functional analysis and in vitro correction of splicing FAH mutations causing tyrosinemia type I.

Journal: Clinical genetics 20140801

Title: Blockade of peripheral and spinal Na+/H+ exchanger increases formalin-induced long-lasting mechanical allodynia and hyperalgesia in rats.

Journal: Brain research 20120926

Title: Anti-proliferative effect of atrial natriuretic peptide on colorectal cancer cells: evidence for an Akt-mediated cross-talk between NHE-1 activity and Wnt/β-catenin signaling.

Journal: Biochimica et biophysica acta 20120601

Title: Performance of cell-penetrating peptide-linked polymers physically mixed with poorly membrane-permeable molecules on cell membranes.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20120501

Title: The Na+/H+ exchanger NHE1, but not the Na+, HCO3(-) cotransporter NBCn1, regulates motility of MCF7 breast cancer cells expressing constitutively active ErbB2.

Journal: Cancer letters 20120428

Title: Intracellular pH regulation in unstimulated Calliphora salivary glands is Na+ dependent and requires V-ATPase activity.

Journal: The Journal of experimental biology 20120415

Title: Comparative characterization of Na+ transport in Cyprinodon variegatus variegatus and Cyprinodon variegatus hubbsi: a model species complex for studying teleost invasion of freshwater.

Journal: The Journal of experimental biology 20120401

Title: Flow cytometry analysis reveals a decrease in intracellular sodium during sperm capacitation.

Journal: Journal of cell science 20120115

Title: Uptake of ricinB-quantum dot nanoparticles by a macropinocytosis-like mechanism.

Journal: Journal of nanobiotechnology 20120101

Title: Ammonia excretion via Rhcg1 facilitates Na⁺ uptake in larval zebrafish, Danio rerio, in acidic water.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20111101

Title: Ebola virus enters host cells by macropinocytosis and clathrin-mediated endocytosis.

Journal: The Journal of infectious diseases 20111101

Title: The Ebola virus glycoprotein mediates entry via a non-classical dynamin-dependent macropinocytic pathway.

Journal: Virology 20111025

Title: Mechanism of ribonuclease A endocytosis: analogies to cell-penetrating peptides.

Journal: Biochemistry 20111004

Title: Presynaptic regulation of quantal size: K+/H+ exchange stimulates vesicular glutamate transport.

Journal: Nature neuroscience 20111001

Title: Bicarbonate, NBCe1, NHE, and carbonic anhydrase activity enhance lactate-H+ transport in bovine corneal endothelium.

Journal: Investigative ophthalmology & visual science 20111001

Title: Discovery, synthesis, and biological evaluation of novel SMN protein modulators.

Journal: Journal of medicinal chemistry 20110922

Title: Effect of aldosterone on the amplification of oncolytic vaccinia virus in human cancer lines.

Journal: The Korean journal of hepatology 20110901

Title: Role of the spinal Na+/H+ exchanger in formalin-induced nociception.

Journal: Neuroscience letters 20110821

Title: Plasma-accessible carbonic anhydrase at the tissue of a teleost fish may greatly enhance oxygen delivery: in vitro evidence in rainbow trout, Oncorhynchus mykiss.

Journal: The Journal of experimental biology 20110715

Title: Decoupling of the catalytic and transport activities of complex I from Rhodothermus marinus by sodium/proton antiporter inhibitor.

Journal: ACS chemical biology 20110520

Title: Dissection of the influenza A virus endocytic routes reveals macropinocytosis as an alternative entry pathway.

Journal: PLoS pathogens 20110301

Title: Expression and modulation of Na(+) /H(+) exchanger 1 gene in hepatocellular carcinoma: A potential therapeutic target.

Journal: Journal of gastroenterology and hepatology 20110201

Title: Sodium hydrogen exchanger as a mediator of hydrostatic edema-induced intestinal contractile dysfunction.

Journal: Surgery 20110101

Title: The cardioprotective effect of brief acidic reperfusion after ischemia in perfused rat hearts is not mimicked by inhibition of the Na(+)/H(+) exchanger NHE1.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20110101

Title: Contribution of the amiloride-sensitive component and the Na+/H+ exchanger to renal responsiveness to vasoconstrictors.

Journal: Pharmacology 20110101

Title: Ammonia uptake in Manduca sexta midgut is mediated by an amiloride sensitive cation/proton exchanger: Transport studies and mRNA expression analysis of NHE7, 9, NHE8, and V-ATPase (subunit D).

Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20101201

Title: Effect of metabolic acidosis on neonatal proximal tubule acidification.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20101101

Title: Inhibition of Na(+)/H(+) exchanger 1 by 5-(N-ethyl-N-isopropyl) amiloride reduces hypoxia-induced hepatocellular carcinoma invasion and motility.

Journal: Cancer letters 20100928

Title: Discovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assay.

Journal: Antimicrobial agents and chemotherapy 20100901

Title: Larvae of the midge Chironomus riparius possess two distinct mechanisms for ionoregulation in response to ion-poor conditions.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20100901

Title: Cellular entry of ebola virus involves uptake by a macropinocytosis-like mechanism and subsequent trafficking through early and late endosomes.

Journal: PLoS pathogens 20100901

Title: [Comparison of mechanisms and cellular uptake of cell-penetrating peptide on different cell lines].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20100901

Title: Ouabain stimulates Na-K-ATPase through a sodium/hydrogen exchanger-1 (NHE-1)-dependent mechanism in human kidney proximal tubule cells.

Journal: American journal of physiology. Renal physiology 20100701

Title: A role for Na+/H+ exchangers and intracellular pH in regulating vitamin C-driven electron transport across the plasma membrane.

Journal: The Biochemical journal 20100513

Title: AE2 Cl-/HCO3- exchanger is required for normal cAMP-stimulated anion secretion in murine proximal colon.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20100401

Title: Ammonium-dependent sodium uptake in mitochondrion-rich cells of medaka (Oryzias latipes) larvae.

Journal: American journal of physiology. Cell physiology 20100201

Title: A clathrin independent macropinocytosis-like entry mechanism used by bluetongue virus-1 during infection of BHK cells.

Journal: PloS one 20100101

Title: pH regulating transporters in neurons from various chemosensitive brainstem regions in neonatal rats.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20091101

Title: Bicarbonate transport by the human pancreatic ductal cell line HPAF.

Journal: Pancreas 20091101

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Protein transport in human cells mediated by covalently and noncovalently conjugated arginine-rich intracellular delivery peptides.

Journal: Peptides 20090901

Title: Blockade of epithelial sodium channels improves sperm motility in asthenospermia patients.

Journal: International journal of andrology 20090801

Title: Role of the sodium hydrogen exchanger in maitotoxin-induced cell death in cultured rat cortical neurons.

Journal: Toxicon : official journal of the International Society on Toxinology 20090801

Title: Nhe1 is a luminal Na+/H+ exchanger in mouse choroid plexus and is targeted to the basolateral membrane in Ncbe/Nbcn2-null mice.

Journal: American journal of physiology. Cell physiology 20090601

Title: Identification of the Na+/H+ exchanger 1 in dorsal root ganglion and spinal cord: its possible role in inflammatory nociception.

Journal: Neuroscience 20090421

Title: Amiloride derivatives induce apoptosis by depleting ER Ca(2+) stores in vascular endothelial cells.

Journal: British journal of pharmacology 20090401

Title: The Na+/H+ exchanger modulates long-term potentiation in rat hippocampal slices.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20090301

Title: Activation of Na+/H+ and K+/H+ exchange by calyculin A in Amphiuma tridactylum red blood cells: implications for the control of volume-induced ion flux activity.

Journal: American journal of physiology. Cell physiology 20081101

Title: Luminal hydrochloric acid stimulates rapid transepithelial ion fluxes in rodent esophageal stratified squamous epithelium.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20080901

Title: Transport activities involved in intracellular pH recovery following acid and alkali challenges in rat brain microvascular endothelial cells.

Journal: Pflugers Archiv : European journal of physiology 20080801

Title: Late expression of Na+/H+ exchanger 1 (NHE1) and neuroprotective effects of NHE inhibitor in the gerbil hippocampal CA1 region induced by transient ischemia.

Journal: Experimental neurology 20080801

Title: Increased colonic sodium absorption in rats with chronic renal failure is partially mediated by AT1 receptor agonism.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20080801

Title: Lidocaine increases intracellular sodium concentration through a Na+-H+ exchanger in an identified Lymnaea neuron.

Journal: Anesthesia and analgesia 20080501

Title: Cellular uptake of cell-penetrating peptides pVEC and transportan in plants.

Journal: Journal of peptide science : an official publication of the European Peptide Society 20080401

Title: Impaired acid secretion in cortical collecting duct intercalated cells from H-K-ATPase-deficient mice: role of HKalpha isoforms.

Journal: American journal of physiology. Renal physiology 20080301

Title: Oxidative stress and the genomic regulation of aldosterone-stimulated NHE1 activity in SHR renal proximal tubular cells.

Journal: Molecular and cellular biochemistry 20080301

Title: 5-(N-ethyl-N-isopropyl)-amiloride enhances SMN2 exon 7 inclusion and protein expression in spinal muscular atrophy cells.

Journal: Annals of neurology 20080101

Title: Targeting splicing in spinal muscular atrophy.

Journal: Annals of neurology 20080101

Title: Mitochondrial Complex I superoxide production is attenuated by uncoupling.

Journal: The international journal of biochemistry & cell biology 20080101

Title: Troglitazone induced cytosolic acidification via extracellular signal-response kinase activation and mitochondrial depolarization: complex I proton pumping regulates ammoniagenesis in proximal tubule-like LLC-PK1 cells.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20080101

Title: Enhanced Na+/H+ exchange activity contributes to the pathogenesis of muscular dystrophy via involvement of P2 receptors.

Journal: The American journal of pathology 20071101

Title: The alpha2-adrenergic receptor agonist UK 14,304 inhibits secretin-stimulated ductal secretion by downregulation of the cAMP system in bile duct-ligated rats.

Journal: American journal of physiology. Cell physiology 20071001

Title: Bicarbonate-dependent pH(i) regulation by chondrocytes within the superficial zone of bovine articular cartilage.

Journal: Journal of cellular physiology 20070901

Title: Lysophosphatidylserine increases membrane potentials in rat C6 glioma cells.

Journal: Archives of pharmacal research 20070901

Title: NHE1 inhibition by amiloride- and benzoylguanidine-type compounds. Inhibitor binding loci deduced from chimeras of NHE1 homologues with endogenous differences in inhibitor sensitivity.

Journal: The Journal of biological chemistry 20070706

Title: Loss of calcineurin homologous protein-1 in chicken B lymphoma DT40 cells destabilizes Na+/H+ exchanger isoform-1 protein.

Journal: American journal of physiology. Cell physiology 20070701

Title: Apoptosis induction is associated with decreased NHE1 expression in neonatal unilateral ureteric obstruction.

Journal: BJU international 20070701

Title: pH-dependent toxicity of sulphur mustard in vitro.

Journal: Toxicology and applied pharmacology 20070615

Title: Delay of acute intracellular pH recovery after acidosis decreases endothelial cell activation.

Journal: Journal of cellular physiology 20070501

Title: The role played by endocytosis in albumin-induced secretion of TGF-beta1 by proximal tubular epithelial cells.

Journal: American journal of physiology. Renal physiology 20070501

Title: Reduction of intracellular pH inhibits the expression of VEGF in K562 cells after targeted inhibition of the Na+/H+ exchanger.

Journal: Leukemia research 20070401

Title: Inhibition of lipopolysaccharide-induced prostaglandin E2 production and inflammation by the Na+/H+ exchanger inhibitors.

Journal: The Journal of pharmacology and experimental therapeutics 20070401

Title: An improved in vitro model of human intestinal follicle-associated epithelium to study nanoparticle transport by M cells.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20070401

Title: A vacuolar-type H+-ATPase and a Na+/H+ exchanger contribute to intracellular pH regulation in cockroach salivary ducts.

Journal: The Journal of experimental biology 20070401

Title: Vitamin C transport and SVCT1 transporter expression in chick renal proximal tubule cells in culture.

Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20070301

Title: Role of Na+/H+ exchanger in the pathogenesis of ischemic acute renal failure in mice.

Journal: Journal of cardiovascular pharmacology 20070301

Title: Colony-stimulating factor-1 increases osteoclast intracellular pH and promotes survival via the electroneutral Na/HCO3 cotransporter NBCn1.

Journal: Endocrinology 20070201

Title: Apical electrolyte concentration modulates barrier function and tight junction protein localization in bovine mammary epithelium.

Journal: American journal of physiology. Cell physiology 20070101

Title: Positive inotropic effects of carbon monoxide-releasing molecules (CO-RMs) in the isolated perfused rat heart.

Journal: British journal of pharmacology 20061201

Title: Effects of Na+/H+ exchanger inhibitors on subcellular localisation of endocytic organelles and intracellular dynamics of protein transduction domains HIV-TAT peptide and octaarginine.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20061128

Title: Transporters involved in regulation of intracellular pH in primary cultured rat brain endothelial cells.

Journal: The Journal of physiology 20061101

Title: NHE2 is the main apical NHE in mouse colonic crypts but an alternative Na+-dependent acid extrusion mechanism is upregulated in NHE2-null mice.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20061001

Title: Relative contribution of V-H+ATPase and NA+/H+ exchanger to bicarbonate reabsorption in proximal convoluted tubules of old rats.

Journal: Aging cell 20061001

Title: Molecular characterization of sodium/proton exchanger 3 (NHE3) from the yellow fever vector, Aedes aegypti.

Journal: The Journal of experimental biology 20060901

Title: Cytotoxic mechanisms of Zn2+ and Cd2+ involve Na+/H+ exchanger (NHE) activation by ROS.

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20060720

Title: Chronic high glucose inhibits albumin reabsorption by lysosomal alkalinization in cultured porcine proximal tubular epithelial cells (LLC-PK1).

Journal: Diabetes research and clinical practice 20060601

Title: Effects of bafilomycin A1, a vacuolar type H+ ATPase inhibitor, on the thermosensitivity of a human pancreatic cancer cell line.

Journal: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20060601

Title: Involvement of Na+/H+ exchanger in the calcium signaling in epimastigotes of Trypanosoma cruzi.

Journal: FEBS letters 20060515

Title: Control of intracellular trafficking of ICAM-1-targeted nanocarriers by endothelial Na+/H+ exchanger proteins.

Journal: American journal of physiology. Lung cellular and molecular physiology 20060501

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: The effect of acidosis on adenosine release from cultured rat forebrain neurons.

Journal: Brain research 20060412

Title: Axial flow modulates proximal tubule NHE3 and H-ATPase activities by changing microvillus bending moments.

Journal: American journal of physiology. Renal physiology 20060201

Title: Involvement of the Na+/H+ exchanger in membrane phosphatidylserine exposure during human platelet activation.

Journal: Biochimica et biophysica acta 20060201

Title: PGE2-induced apoptotic cell death in K562 human leukaemia cells.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20060101

Title: Vectorial bicarbonate transport by Capan-1 cells: a model for human pancreatic ductal secretion.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20060101

Title: Differential contribution of troponin I phosphorylation sites to the endothelin-modulated contractile response.

Journal: The Journal of biological chemistry 20051216

Title: Mechanisms for nongenomic and genomic effects of aldosterone on Na+/H+ exchange in vascular smooth muscle cells.

Journal: Journal of hypertension 20051201

Title: Properties of motility in Bacillus subtilis powered by the H+-coupled MotAB flagellar stator, Na+-coupled MotPS or hybrid stators MotAS or MotPB.

Journal: Journal of molecular biology 20050916

Title: Na+/H+ exchanger activity is increased in doxorubicin-resistant human colon cancer cells and its modulation modifies the sensitivity of the cells to doxorubicin.

Journal: International journal of cancer 20050720

Title: Dual modes of 5-(N-ethyl-N-isopropyl)amiloride modulation of apical dipeptide uptake in the human small intestinal epithelial cell line Caco-2.

Journal: Cellular and molecular life sciences : CMLS 20050701

Title: Zinc and 17beta-estradiol induce modifications in Na+/H+ exchanger and pyruvate kinase activity through protein kinase C in isolated mantle/gonad cells of Mytilus galloprovincialis.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20050701

Title: An IkappaB-beta COOH terminal region protein is essential for the proliferation of CHO cells under acidic stress.

Journal: Journal of cellular physiology 20050401

Title: Muscarinic activation of Na+-dependent ion transporters and modulation by bicarbonate in rat submandibular gland acinus.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20050401

Title: Heat-induced changes in intracellular Na+, pH and bioenergetic status in superfused RIF-1 tumour cells determined by 23Na and 31P magnetic resonance spectroscopy.

Journal: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20050301

Title: Impaired regulation of pH homeostasis by oxidative stress in rat brain capillary endothelial cells.

Journal: Cellular and molecular neurobiology 20050201

Title: Different contributions of endothelin-A and endothelin-B receptors in postischemic cardiac dysfunction and norepinephrine overflow in rat hearts.

Journal: Circulation 20050125

Title: Catecholamine clearance from alveolar spaces of rat and human lungs.

Journal: Respiration; international review of thoracic diseases 20050101

Title: Novel antiinflammatory vascular benefits of systemic and stent-based delivery of ethylisopropylamiloride.

Journal: Circulation 20041214

Title: Acidification reduces mitochondrial calcium uptake in rat cardiac mitochondria.

Journal: American journal of physiology. Heart and circulatory physiology 20041201

Title: Rapid nongenomic effects of 3,5,3'-triiodo-L-thyronine on the intracellular pH of L-6 myoblasts are mediated by intracellular calcium mobilization and kinase pathways.

Journal: Endocrinology 20041201

Title: Inhibition of bicarbonate reabsorption in the rat proximal tubule by activation of luminal P2Y1 receptors.

Journal: American journal of physiology. Renal physiology 20041001

Title: Endocardial endothelium modulates subendocardial pH(i) of rabbit papillary muscles: role of transendothelial HCO(3)(-) transport.

Journal: Cardiovascular research 20040901

Title: Differential regulation of Na+/H+ exchange isoform activities by enteropathogenic E. coli in human intestinal epithelial cells.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20040801

Title: Activation of the apical Na+/H+ exchanger NHE3 by formate: a basis of enhanced fluid and electrolyte reabsorption by formate in the kidney.

Journal: American journal of physiology. Renal physiology 20040801

Title: Intracellular acidification by inhibition of the Na+/H+-exchanger leads to caspase-independent death of cerebellar granule neurons resembling paraptosis.

Journal: Cell death and differentiation 20040701

Title: CD44 interaction with Na+-H+ exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion.

Journal: The Journal of biological chemistry 20040625

Title: Inhibition of carcinogen-bioactivating cytochrome P450 1 isoforms by amiloride derivatives.

Journal: Biochemical pharmacology 20040501

Title: Cadmium induces both pyruvate kinase and Na+/H+ exchanger activity through protein kinase C mediated signal transduction, in isolated digestive gland cells of Mytilus galloprovincialis (L.).

Journal: The Journal of experimental biology 20040401

Title: Stimulation of NHE3 in OKP cells by an autocrine mechanism.

Journal: Nephron. Experimental nephrology 20040101

Title: Bidirectional regulation of renal cortical Na+,K+-ATPase by protein kinase C.

Journal: Acta biochimica Polonica 20040101

Title: Involvement of Na+/H+ exchanger in desmopressin-induced platelet procoagulant response.

Journal: Acta biochimica Polonica 20040101

Title: Sodium and chloride transport in soft water and hard water acclimated zebrafish (Danio rerio).

Journal: Biochimica et biophysica acta 20031230

Title: Demonstration of a functional apical sodium hydrogen exchanger in isolated rat gastric glands.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20031201

Title: The Na+/H+ exchange inhibitor: a new therapeutic approach for hepatic ischemia injury in rats.

Journal: Transplantation proceedings 20031201

Title: Critical role for NHE1 in intracellular pH regulation in pancreatic acinar cells.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20031101

Title: Na+ overload during ischemia and reperfusion in rat hearts: comparison of the Na+/H+ exchange blockers EIPA, cariporide and eniporide.

Journal: Molecular and cellular biochemistry 20030801

Title: [3H]-DA release evoked by low pH medium and internal H+ accumulation in rat hypothalamic synaptosomes: involvement of calcium ions.

Journal: Neurochemistry international 20030701

Title: Ethyl isopropyl amiloride inhibits smooth muscle cell proliferation and migration by inducing apoptosis and antagonizing urokinase plasminogen activator activity.

Journal: Canadian journal of physiology and pharmacology 20030701

Title: Non-genomic regulation of intermediate conductance potassium channels by aldosterone in human colonic crypt cells.

Journal: Gut 20030601

Title: PTH stimulates a Cl(-)-dependent and EIPA-sensitive current in chick proximal tubule cells in culture.

Journal: American journal of physiology. Renal physiology 20030501

Title: Mutations of Arg440 and Gly455/Gly456 oppositely change pH sensing of Na+/H+ exchanger 1.

Journal: The Journal of biological chemistry 20030404

Title: Differential sensitivity of human monocytes and macrophages to ANP: a role of intracellular pH on reactive oxygen species production through the phospholipase involvement.

Journal: Journal of leukocyte biology 20030401

Title: Inhibition of erythrocyte cation channels and apoptosis by ethylisopropylamiloride.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20030401

Title: Role of Na+/H+ exchanger in acetylcholine-mediated pulmonary artery contraction of spontaneously hypertensive rats.

Journal: European journal of pharmacology 20030319

Title: Antifibrogenic effects of canrenone, an antialdosteronic drug, on human hepatic stellate cells.

Journal: Gastroenterology 20030201

Title: Effect of protein kinase C activation on Na+-H+ exchange in erythrocytes of frog Rana temporaria.

Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20030101

Title: Intracellular pH regulation in U937 human monocytes: roles of V-ATPase and Na+/H+ exchange.

Journal: Immunobiology 20030101

Title: Endolymphatic sodium homeostasis by Reissner's membrane.

Journal: Neuroscience 20030101

Title: Electrophysiological properties of the Plasmodium Falciparum-induced cation conductance of human erythrocytes.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20030101

Title: [Activation of the Na/H exchange in erythrocytes of the frog Rana ridibunda].

Journal: Zhurnal evoliutsionnoi biokhimii i fiziologii 20030101

Title: Dependence of Plasmodium falciparum in vitro growth on the cation permeability of the human host erythrocyte.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20030101

Title: Sodium-proton exchange in crayfish.

Journal: Biochimica et biophysica acta 20021113

Title: Apical H(+)/base transporters mediating bicarbonate absorption and pH(i) regulation in the OMCD.

Journal: American journal of physiology. Renal physiology 20021101

Title: NHE blockade inhibits chemokine production and NF-kappaB activation in immunostimulated endothelial cells.

Journal: American journal of physiology. Cell physiology 20020801

Title: Loss of cell volume regulation during metabolic inhibition in renal epithelial cells (A6): role of intracellular pH.

Journal: American journal of physiology. Cell physiology 20020801

Title: Glucose stimulates O2 consumption, NOS, and Na/H exchange in diabetic rat proximal tubules.

Journal: American journal of physiology. Renal physiology 20020801

Title: Cytostatic potential of novel agents that inhibit the regulation of intracellular pH.

Journal: British journal of cancer 20020715

Title: Apical Na+/H+ exchange near the base of mouse colonic crypts.

Journal: American journal of physiology. Cell physiology 20020701

Title: Expression and function of sodium transporters in two opossum kidney cell clonal sublines.

Journal: American journal of physiology. Renal physiology 20020701

Title: Na+/H+ exchanger blockade inhibits enterocyte inflammatory response and protects against colitis.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20020701

Title: Mitochondrial damage during ischemia determines post-ischemic contractile dysfunction in perfused rat heart.

Journal: Journal of molecular and cellular cardiology 20020701

Title: Inhibitors of NHE-1 Na+/H+ exchange reduce mouse intraocular pressure.

Journal: Investigative ophthalmology & visual science 20020601

Title: Intestinal NaCl transport in NHE2 and NHE3 knockout mice.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20020501

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Basolateral membrane Cl(-)-, Na(+)-, and K(+)-coupled base transport mechanisms in rat MTALH.

Journal: American journal of physiology. Renal physiology 20020401

Title: Dehydroascorbic acid uptake by coronary artery smooth muscle: effect of intracellular acidification.

Journal: The Biochemical journal 20020301

Title: [Modification of damaging effect of ultraviolet radiation on peritoneal macrophage membranes in mice].

Journal: Radiatsionnaia biologiia, radioecologiia 20020101

Title: Ion exchangers mediating NaCl transport in the renal proximal tubule.

Journal: Cell biochemistry and biophysics 20020101

Title: Role of NHE isoforms in mediating bicarbonate reabsorption along the nephron.

Journal: American journal of physiology. Renal physiology 20011201

Title: Propofol protection of sodium-hydrogen exchange activity sustains glutamate uptake during oxidative stress.

Journal: Anesthesia and analgesia 20011101

Title: Inhibition of Na superset+/H superset+ exchange decreases albumin-induced NF-kappaB activation in renal proximal tubular cell lines (OK and LLC-PK1 cells).

Journal: European journal of medical research 20011029

Title: Localization and functional characterization of Na+/H+ exchanger isoform NHE4 in rat thick ascending limbs.

Journal: American journal of physiology. Renal physiology 20011001

Title: Amiloride derivatives are potent blockers of KATP channels.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20011001

Title: Rapid acid extrusion response triggered by alpha(1) adrenoceptor in CHO cells.

Journal: The Journal of physiology 20010815

Title: Inhibition of the Na(+)/H(+) antiporter suppresses IL-12 p40 production by mouse macrophages.

Journal: Biochimica et biophysica acta 20010620

Title: Bafilomycin A(1) inhibits rhinovirus infection in human airway epithelium: effects on endosome and ICAM-1.

Journal: American journal of physiology. Lung cellular and molecular physiology 20010601

Title: Propofol increases myofilament Ca2+ sensitivity and intracellular pH via activation of Na+-H+ exchange in rat ventricular myocytes.

Journal: Anesthesiology 20010601

Title: pH regulation and buffering power in gastric smooth muscle.

Journal: Pflugers Archiv : European journal of physiology 20010601

Title: Roles of ATP and cytoskeleton in the regulation of Na+/H+ exchanger along the nephron luminal membrane.

Journal: Journal of cellular physiology 20010401

Title: HCO3- salvage mechanisms in the submandibular gland acinar and duct cells.

Journal: The Journal of biological chemistry 20010330

Title: Inhibition of Na+-H+ exchanger-3 interferes with apical receptor-mediated endocytosis via vesicle fusion.

Journal: The Journal of physiology 20010315

Title: Characterization of apical membrane Cl-dependent Na/H exchange in crypt cells of rat distal colon.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20010301

Title: Effects of SM-20550, a selective Na+-H+ exchange inhibitor, on the ion transport of myocardial mitochondria.

Journal: Molecular and cellular biochemistry 20010301

Title: Inhibition of the NA(+)/H(+) exchanger reduces rat hepatic stellate cell activity and liver fibrosis: an in vitro and in vivo study.

Journal: Gastroenterology 20010201

Title: Protective effect of SM-20550, a selective Na+ - H+ exchange inhibitor, on ischemia-reperfusion-injured hearts.

Journal: Journal of cardiovascular pharmacology 20010201

Title: Regulation of tubular cell MCP-1 production by intracellular ions: a role for sodium and calcium.

Journal: Experimental nephrology 20010101

Title: The Na(+)/H(+) exchanger SM-20220 attenuates ischemic injury in in vitro and in vivo models.

Journal: Pharmacology 20010101

Title: A method for measurement of muscarinic receptor-mediated responses in dissociated single colon longitudinal smooth muscle cells.

Journal: Journal of pharmacological and toxicological methods 20010101

Title: Effect of SMP-300, a new Na+/H+ exchange inhibitor, on myocardial ischemia and experimental angina models in rats.

Journal: Japanese journal of pharmacology 20001001

Title: Altered inotropic response of endothelin-1 in cardiomyocytes from rats with isoproterenol-induced cardiomyopathy.

Journal: Cardiovascular research 19980901

Title: Diamine oxidase is the amiloride-binding protein and is inhibited by amiloride analogues.

Journal: The Journal of biological chemistry 19940401

Title: Novel amiloride analog allosterically modulates the alpha 2-adrenergic receptor but does not inhibit Na+/H+ exchange.

Journal: Molecular pharmacology 19920801

Title: Human kidney amiloride-binding protein: cDNA structure and functional expression.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19901001

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Tags:1154-25-2 Molecular Formula|1154-25-2 MDL|1154-25-2 SMILES|1154-25-2 5-(N-Ethyl-n-isopropyl)amiloride