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116-38-1,MFCD00055064
Catalog No.:AA000BA0

116-38-1 | Edrophonium chloride

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25mg
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100mg
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250mg
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$86.00   $60.00
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500mg
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1g
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA000BA0
Chemical Name:
Edrophonium chloride
CAS Number:
116-38-1
Molecular Formula:
C10H16ClNO
Molecular Weight:
201.6931
MDL Number:
MFCD00055064
SMILES:
CC[N+](c1cccc(c1)O)(C)C.[Cl-]
NSC Number:
759577
Properties
Properties
 
Form:
Solid  
Refractive Index:
1.6000 (estimate)  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
145  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
13  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  

Literature

Title: Hopeahainol A binds reversibly at the acetylcholinesterase (AChE) peripheral site and inhibits enzyme activity with a novel higher order concentration dependence.

Journal: Chemico-biological interactions 20161125

Title: Targeted oxidation of Torpedo californica acetylcholinesterase by singlet oxygen: identification of N-formylkynurenine tryptophan derivatives within the active-site gorge of its complex with the photosensitizer methylene blue.

Journal: The Biochemical journal 20121115

Title: Congenital myasthenic syndromes: current diagnostic and therapeutic approaches.

Journal: Neuropediatrics 20120801

Title: Myasthenia gravis can cause camptocormia.

Journal: Journal of neurology, neurosurgery, and psychiatry 20120401

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: Discordant thymectomy in identical twins concordant for myasthenia gravis.

Journal: Annals of internal medicine 20111004

Title: Multiple inhibitory actions of lidocaine on Torpedo nicotinic acetylcholine receptors transplanted to Xenopus oocytes.

Journal: Journal of neurochemistry 20110601

Title: Preparation, in vitro screening and molecular modelling of symmetrical bis-quinolinium cholinesterase inhibitors--implications for early myasthenia gravis treatment.

Journal: Bioorganic & medicinal chemistry letters 20110415

Title: Preparation and in vitro screening of symmetrical bis-isoquinolinium cholinesterase inhibitors bearing various connecting linkage--implications for early Myasthenia gravis treatment.

Journal: European journal of medicinal chemistry 20110201

Title: Failure to reverse prolonged vecuronium-induced neuromuscular blockade with edrophonium in an anesthetized dog.

Journal: Journal of the American Animal Hospital Association 20110101

Title: A predictive ligand-based Bayesian model for human drug-induced liver injury.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20101201

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Design, synthesis, and biological evaluation of coumarin derivatives tethered to an edrophonium-like fragment as highly potent and selective dual binding site acetylcholinesterase inhibitors.

Journal: ChemMedChem 20100903

Title: Rapid and label-free screening of enzyme inhibitors using segmented flow electrospray ionization mass spectrometry.

Journal: Journal of the American Society for Mass Spectrometry 20100701

Title: Rapid chemical antagonism of neuromuscular blockade by L-cysteine adduction to and inactivation of the olefinic (double-bonded) isoquinolinium diester compounds gantacurium (AV430A), CW 002, and CW 011.

Journal: Anesthesiology 20100701

Title: Myasthenia gravis in an adolescent patient presenting to the pediatric emergency department.

Journal: Pediatric emergency care 20100501

Title: [Neuromuscular disease--myasthenia gravis].

Journal: MMW Fortschritte der Medizin 20100114

Title: Pseudo-internuclear ophthalmoplegia as a sign of overlapping myasthenia gravis in a patient with 'intractable' hypothyroidism.

Journal: Internal medicine (Tokyo, Japan) 20100101

Title: A case of diplopia and arm weakness.

Journal: BMJ (Clinical research ed.) 20091125

Title: Dysfunction of the longitudinal muscles of the oesophagus in eosinophilic oesophagitis.

Journal: Gut 20090801

Title: Racial differences in myasthenia gravis in Alabama.

Journal: Muscle & nerve 20090301

Title: Clinical implications of new neuromuscular concepts and agents: so long, neostigmine! So long, sux!

Journal: Journal of critical care 20090301

Title: Generalized and neurotransmitter-selective noradrenergic denervation in Parkinson's disease with orthostatic hypotension.

Journal: Movement disorders : official journal of the Movement Disorder Society 20080915

Title: Reversal of asynchrony between circular and longitudinal muscle contraction in nutcracker esophagus by atropine.

Journal: Gastroenterology 20080901

Title: Evaluation and diagnosis of noncardiac chest pain.

Journal: Disease-a-month : DM 20080901

Title: Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors.

Journal: Bioorganic & medicinal chemistry 20080801

Title: [Surprising etiology of chronic deglutition disorder. Diagnosis at a glance in dysphagia].

Journal: MMW Fortschritte der Medizin 20080605

Title: Cardiovascular and autonomic nervous effects of edrophonium and atropine combinations during neuromuscular blockade antagonism in sheep.

Journal: Veterinary anaesthesia and analgesia 20080501

Title: Electrophysiological signs and the prevalence of adverse effects of acetylcholinesterase inhibitors in patients with myasthenia gravis.

Journal: Muscle & nerve 20080301

Title: Cholinergic stimulation induces asynchrony between the circular and longitudinal muscle contraction during esophageal peristalsis.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20080301

Title: Fiberoptic endoscopic evaluation of swallowing with simultaneous Tensilon application in diagnosis and therapy of myasthenia gravis.

Journal: Journal of neurology 20080201

Title: Myasthenia gravis-like syndrome in a Hereford heifer.

Journal: Journal of veterinary internal medicine 20080101

Title: Relevance of mild ineffective oesophageal motility (IOM) and potential pharmacological reversibility of severe IOM in patients with gastro-oesophageal reflux disease.

Journal: Alimentary pharmacology & therapeutics 20071115

Title: [Videofluorographic evaluation of dysphagia in a patient with myasthenia gravis].

Journal: Rinsho shinkeigaku = Clinical neurology 20071001

Title: A case report of myasthenia gravis localized to the larynx.

Journal: Auris, nasus, larynx 20070901

Title: Diverse inhibitory actions of quaternary ammonium cholinesterase inhibitors on Torpedo nicotinic ACh receptors transplanted to Xenopus oocytes.

Journal: British journal of pharmacology 20070801

Title: Sugammadex reversal of rocuronium-induced neuromuscular blockade: a comparison with neostigmine-glycopyrrolate and edrophonium-atropine.

Journal: Anesthesia and analgesia 20070301

Title: Is there still a role for edrophonium in diagnosing ocular myasthenia.

Journal: European journal of neurology 20070301

Title: [Thoracic pain caused by esophageal dysfunction in patients with ischemic cardiopathy].

Journal: Medicina clinica 20070120

Title: Dropped head sign as the only symptom of myasthenia gravis.

Journal: Internal medicine (Tokyo, Japan) 20070101

Title: Pseudomyasthenia in a patient with pontine glioma.

Journal: Clinical neurology and neurosurgery 20061201

Title: LC/MS/MS analysis of quaternary ammonium drugs and herbicides in whole blood.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20061002

Title: Edrophonium provocative testing for the evaluation of upper gastrointestinal hypersensitivity in patients with nonulcer dyspepsia.

Journal: Digestive diseases and sciences 20060801

Title: A systematic review of diagnostic studies in myasthenia gravis.

Journal: Neuromuscular disorders : NMD 20060701

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Automated method, based on micro-sequential injection, for the study of enzyme kinetics and inhibition.

Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20060101

Title: Is pancreatic polypeptide response to food ingestion a reliable index of vagal function in type 1 diabetes?

Journal: Scandinavian journal of clinical and laboratory investigation 20060101

Title: Is NMDA receptor activation essential for the production of locomotor-like activity in the neonatal rat spinal cord?

Journal: Journal of neurophysiology 20051201

Title: Bread-and-butter in diagnosis of myasthenia gravis.

Journal: Archives of neurology 20051201

Title: Nonresponsiveness to anticholinesterase agents in patients with MuSK-antibody-positive MG.

Journal: Neurology 20051108

Title: Advances in the diagnosis of neuromuscular junction disorders.

Journal: American journal of physical medicine & rehabilitation 20050801

Title: Clinical utility of videofluorography with concomitant Tensilon administration in the diagnosis of bulbar myasthenia gravis.

Journal: Digestive diseases and sciences 20050501

Title: Edrophonium-induced right ventricular outflow tract tachycardia.

Journal: Pacing and clinical electrophysiology : PACE 20050101

Title: [Role of esophageal provocative tests in the investigation of patients with chest pain of undetermined origin].

Journal: Arquivos de gastroenterologia 20050101

Title: Congenital myasthenia gravis in Smooth-Haired Miniature Dachshund dogs.

Journal: Journal of veterinary internal medicine 20050101

Title: Sensory testing of the esophagus.

Journal: Journal of clinical gastroenterology 20040901

Title: 'Dropped head sign' in myasthenia gravis.

Journal: Neuromuscular disorders : NMD 20040901

Title: Does acetylcholinesterase inhibition affect catecholamine secretion by adrenomedullary cells?

Journal: The Israel Medical Association journal : IMAJ 20040701

Title: Nitric oxide and cardiac muscarinic control in humans.

Journal: Hypertension (Dallas, Tex. : 1979) 20040501

Title: Mutation in the AChR ion channel gate underlies a fast channel congenital myasthenic syndrome.

Journal: Neurology 20040413

Title: Response of thymectomy: clinical and pathological characteristics among seronegative and seropositive myasthenia gravis patients.

Journal: Acta neurologica Scandinavica 20040301

Title: Myasthenia gravis in childhood.

Journal: Binocular vision & strabismus quarterly 20040101

Title: Prevalence of esophageal disorders in patients with recurrent chest pain.

Journal: Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus 20040101

Title: [Biochemical characteristics of cholinesterase from taenia Hymenolepis diminuta].

Journal: Wiadomosci parazytologiczne 20040101

Title: Natural monomeric form of fetal bovine serum acetylcholinesterase lacks the C-terminal tetramerization domain.

Journal: Biochemistry 20031230

Title: Edrophonium effectively antagonizes neuromuscular block at the laryngeal adductors induced by rapacuronium, rocuronium and cisatracurium, but not mivacurium.

Journal: Canadian journal of anaesthesia = Journal canadien d'anesthesie 20031101

Title: Interactions of edrophonium with neostigmine in the rat trachea.

Journal: Anesthesia and analgesia 20031001

Title: Cage amines as the stopper inhibitors of cholinesterases.

Journal: Bioorganic & medicinal chemistry letters 20030901

Title: Positive tensilon test and intracranial tumor: a case report.

Journal: European journal of ophthalmology 20030701

Title: Facile synthesis of [11C]edrophonium and its analogues as new potential PET imaging agents for heart acetylcholinesterase.

Journal: Bioorganic & medicinal chemistry letters 20030519

Title: The edrophonium test.

Journal: Seminars in neurology 20030301

Title: Development of generalized disease at 2 years in patients with ocular myasthenia gravis.

Journal: Archives of neurology 20030201

Title: Simplified tilt table test protocol with continuous upright position during medication administration and no hydration.

Journal: Pacing and clinical electrophysiology : PACE 20030101

Title: [Premonitory depression].

Journal: Ryoikibetsu shokogun shirizu 20030101

Title: Potencies and selectivities of inhibitors of acetylcholinesterase and its molecular forms in normal and Alzheimer's disease brain.

Journal: Acta biologica Hungarica 20030101

Title: Autosomal recessive limb girdle myasthenia in two sisters.

Journal: Neurology India 20021201

Title: A comparison of the chronotropic and dromotropic actions between adenosine triphosphate and edrophonium in patients undergoing coronary artery bypass graft surgery.

Journal: Journal of cardiothoracic and vascular anesthesia 20021001

Title: A safe and noninvasive test for vagal integrity revisited.

Journal: Archives of surgery (Chicago, Ill. : 1960) 20020801

Title: [Ocular myasthenic syndrome and systemic lupus erythematosus].

Journal: Klinische Monatsblatter fur Augenheilkunde 20020701

Title: The effect of edrophonium on autonomic outflow.

Journal: Anesthesiology 20020301

Title: [What to do in case of acquired ptosis].

Journal: Journal francais d'ophtalmologie 20020301

Title: Oxyaniliniums as acetylcholinesterase inhibitors for the reversal of neuromuscular block.

Journal: Bioorganic & medicinal chemistry letters 20020121

Title: Effects of the anticholinesterase edrophonium on spectral analysis of heart rate and blood pressure variability in humans.

Journal: The Journal of pharmacology and experimental therapeutics 20020101

Title: [Myasthenia gravis].

Journal: La Revue du praticien 20020101

Title: [Technical consideration for repetitive nerve stimulation].

Journal: Rinsho shinkeigaku = Clinical neurology 20020101

Title: Reversal of mivacurium chloride: edrophonium of spontaneous recovery in microscopic laryngeal surgery.

Journal: Acta anaesthesiologica Sinica 20011201

Title: Asystole induced by edrophonium following beta blockade.

Journal: Neurology 20010828

Title: Edrophonium antagonism of cisatracurium-induced neuromuscular block: dose requirements in children and adults.

Journal: Anaesthesia and intensive care 20010801

Title: [Voice disorders caused by neurological diseases].

Journal: Revista de neurologia 20010701

Title: Thioflavin T is a fluorescent probe of the acetylcholinesterase peripheral site that reveals conformational interactions between the peripheral and acylation sites.

Journal: The Journal of biological chemistry 20010629

Title: Does 'butyrylization' of acetylcholinesterase through substitution of the six divergent aromatic amino acids in the active center gorge generate an enzyme mimic of butyrylcholinesterase?

Journal: Biochemistry 20010626

Title: The effect of cholinergic enhancement during filling cystometry: can edrophonium chloride be used as a provocative test for overactive bladder?

Journal: The Journal of urology 20010501

Title: Myasthenia gravis: an elusive diagnosis in older people.

Journal: Journal of the American Geriatrics Society 20010501

Title: Interaction of edrophonium with muscarinic acetylcholine M2 and M3 receptors.

Journal: Anesthesiology 20010501

Title: Reversal of rocuronium with edrophonium during propofol versus sevoflurane anesthesia.

Journal: Acta anaesthesiologica Scandinavica 20010201

Title: A dose-response study of anticholinesterase drugs on contractile and phosphatidylinositol responses of rat trachea.

Journal: Anesthesia and analgesia 20010101

Title: Sustained esophageal contraction: a marker of esophageal chest pain identified by intraluminal ultrasonography.

Journal: Gastroenterology 19990101

Title: Catecholamine facilitated reentrant ventricular tachycardia: uncoupling of adenosine's antiadrenergic effects.

Journal: Journal of cardiovascular electrophysiology 19990101

Title: Synthesis and study of thiocarbonate derivatives of choline as potential inhibitors of acetylcholinesterase.

Journal: Journal of medicinal chemistry 19970912

Title: The effect of edrophonium chloride-induced chest pain on esophageal blood flow and motility.

Journal: Scandinavian journal of gastroenterology 19970201

Title: Fresh frozen plasma and edrophonium in a patient with a plasma cholinesterase deficiency.

Journal: Anaesthesia 19930601

Title: Persisting chloroquine-induced myasthenia?

Journal: Acta clinica Belgica 19910101

Title: Oculogyric crisis after the Tensilon test.

Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 19900101

Title: Prospective evaluation of high-dose bethanechol in investigation of esophageal chest pain.

Journal: Digestive diseases and sciences 19891101

Title: Glycopyrronium requirements for antagonism of the muscarinic side effects of edrophonium.

Journal: British journal of anaesthesia 19890101

Title: Positive response to edrophonium in death adder (Acanthophis antarcticus) envenomation.

Journal: Australian and New Zealand journal of medicine 19881001

Title: Edrophonium-hyoscine butylbromide mixture for reversal of neuromuscular blockade: heart rate changes in infants and children.

Journal: Anaesthesia 19880701

Title: Augmented anti-acetylcholine receptor response following long-term penicillamine administration.

Journal: Annals of neurology 19840701

Title: Cardiac arrest following treatment of paroxysmal atrial tachycardia with edrophonium.

Journal: Anesthesiology 19790301

Title: Ventricular asystole after edrophonium chloride administration.

Journal: JAMA 19760308

Title: Cardiac arrest during edrophonium administration.

Journal: American heart journal 19710301

Title: Recurarization--fact or fiction.

Journal: Anesthesia and analgesia 19710101

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Tags:116-38-1 Molecular Formula|116-38-1 MDL|116-38-1 SMILES|116-38-1 Edrophonium chloride