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117048-59-6,MFCD03453309
Catalog No.:AA000DJW

117048-59-6 | Combretastatin A4

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1mg
98%
in stock  
$7.00   $5.00
- +
10mg
98%
in stock  
$19.00   $14.00
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25mg
98%
in stock  
$32.00   $22.00
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100mg
98%
in stock  
$87.00   $61.00
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250mg
98%
in stock  
$158.00   $110.00
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1g
98%
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$407.00   $285.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA000DJW
Chemical Name:
Combretastatin A4
CAS Number:
117048-59-6
Molecular Formula:
C18H20O5
Molecular Weight:
316.3484
MDL Number:
MFCD03453309
SMILES:
COc1cc(/C=C\c2ccc(c(c2)O)OC)cc(c1OC)OC
NSC Number:
613729
Properties
Computed Properties
 
Complexity:
358  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
6  
XLogP3:
3.7  

Downstream Synthesis Route

[1]JournalofMedicinalChemistry,1995,vol.38,p.1666-1672

[2]ChineseChemicalLetters,2015,vol.26,p.993-999

[3]JournalofChemicalResearch,2008,p.354-356

[4]ChemMedChem,2011,vol.6,p.488-497

[1]Fuerstner,Alois;Nikolakis,Katharina[LiebigsAnnalen,1996,#12,p.2107-2113]

[2]Huang,Xiaochao;Huang,Rizhen;Gou,Shaohua;Wang,Zhimei;Liao,Zhixin;Wang,Hengshan[BioconjugateChemistry,2016,vol.27,#9,p.2132-2148]

[3]Pettit,GeorgeR.;Singh,SheoBux;Boyd,MichaelR.;Hamel,Ernest;Pettit,RobinK.;etal.[JournalofMedicinalChemistry,1995,vol.38,#10,p.1666-1672]

[4]Huang,Xiaochao;Wang,Meng;Wang,Chungu;Hu,Weiwei;You,Qinghong;Yang,Yong;Yu,Chunhao;Liao,Zhixin;Gou,Shaohua;Wang,Hengshan[BioorganicChemistry,2019,vol.92]

[5]Li,Lingxue;Huang,Xiaochao;Huang,Rizhen;Gou,Shaohua;Wang,Zhimei;Wang,Hengshan[EuropeanJournalofMedicinalChemistry,2018,vol.156,p.666-679]

[6]Kamal,Ahmed;Mallareddy,Adla;JanakiRamaiah;Pushpavalli;Suresh,Paidakula;Kishor,Chandan;Murty;Rao,N.Sankara;Ghosh,Sowjanya;Addlagatta,Anthony;Pal-Bhadra,Manika[EuropeanJournalofMedicinalChemistry,2012,vol.56,p.166-178]

[7]Brown,DavidP.;Chen,Zhe-Sheng;Narayanan,Silpa;Wong,Thomas[JournalofNaturalProducts,2020]

[8]Huang,Xiaochao;Chen,Yuanhang;Zhong,Wentian;Liu,Zhikun;Zhang,Haijiang;Zhang,Bin;Wang,Hengshan[EuropeanJournalofMedicinalChemistry,2022,vol.244]

[9]Huang,Xiaochao;Chen,Yuanhang;Zhong,Wentian;Liu,Zhikun;Zhang,Haijiang;Zhang,Bin;Wang,Hengshan[EuropeanJournalofMedicinalChemistry,2022,vol.244]

[10]Orsini,Fulvia;Pelizzoni,Francesca;Bellini,Barbara;Miglierini,Giuliana[CarbohydrateResearch,1997,vol.301,#3-4,p.95-109]

[11]Locationinpatent:schemeortableFalciani,Chiara;Brunetti,Jlenia;Pagliuca,Chiara;Menichetti,Stefano;Vitellozzi,Lucia;Lelli,Barbara;Pini,Alessandro;Bracci,Luisa[ChemMedChem,2010,vol.5,#4,p.567-574]

[12]Locationinpatent:bodytextShen,Cheng-Huang;Shee,Jia-Jen;Wu,Jin-Yi;Lin,Yi-Wen;Wu,Jiann-Der;Liu,Yi-Wen[BritishJournalofPharmacology,2010,vol.160,#8,p.2008-2027]

[13]CurrentPatentAssignee:COUNCILOFSCIENTIFICANDINDUSTRIALRESEARCH(IN)-US2013/317231,2013,A1Locationinpatent:Sheet1

[14]Mahesh,Rasala;Nayak,VaditheLakshma;Babu,KorrapatiSuresh;Riyaz,Syed;Shaik,ThokhirBasha;Kumar,GajjelaBharth;Mallipeddi,PremaLatha;Reddy,ChallaRatna;Shekar,KuntaChandra;Jose,Jedy;Nagesh,Narayana;Kamal,Ahmed[ChemMedChem,2017,vol.12,#9,p.678-700]

[15]Hua,Shixian;Chen,Feihong;Gou,Shaohua[EuropeanJournalofMedicinalChemistry,2020,vol.187]

[16]Chen,Feihong;Gou,Shaohua;Hua,Shixian;Wang,Xinyi[EuropeanJournalofMedicinalChemistry,2020,vol.189]

[1]Zou,Yong;Huang,Qi;Huang,Tong-Kun;Ni,Qing-Chun;Zhang,En-Sheng;Xu,Tian-Long;Yuan,Mu;Li,Jun[OrganicandBiomolecularChemistry,2013,vol.11,#40,p.6967-6974]

[2]Gaukroger,Keira;Hadfield,JohnA.;Hepworth,LucyA.;Lawrence,NicholasJ.;McGown,AlanT.[JournalofOrganicChemistry,2001,vol.66,#24,p.8135-8138]

[3]Locationinpatent:experimentalpartXiao,Chun-Fen;Zou,Yong;Du,Jian-Li;Sun,Hong-Yi;Liu,Xian-Ke[SyntheticCommunications,2012,vol.42,#9,p.1243-1258]

[4]Ojike,FredrickO.;Lavignac,Nathalie;Casely-Hayford,MaxwellA.[JournalofNaturalProducts,2018,vol.81,#9,p.2101-2105]

[5]Liu,Ying-Qian;Li,Xiao-Jing;Zhao,Chun-Yan;Lu,Yan;Li,Wen-Qun;Liu,Zhen-Ling;Feng,Gang;Yang,Liu[MedicinalChemistryResearch,2013,vol.22,#5,p.2196-2206]

[6]Stefański,Tomasz;Mikstacka,Renata;Kurczab,Rafał;Dutkiewicz,Zbigniew;Kucińska,Małgorzata;Murias,Marek;Zielińska-Przyjemska,Małgorzata;Cichocki,Michał;Teubert,Anna;Kaczmarek,Mariusz;Hogendorf,Adam;Sobiak,Stanisław[EuropeanJournalofMedicinalChemistry,2018,vol.144,p.797-816]

[7]Tang,Yan;Tu,Zhewei;Sun,Jing;Zhu,Xiong;Liu,Kun;He,Shuying;Xu,Yungen[Lettersindrugdesignanddiscovery,2013,vol.10,#10,p.935-941]

[1]Huang,Rong;Sheng,Yao;Xu,Zili;Wei,Ding;Song,Xiaoling;Jiang,Biao;Chen,Hongli[EuropeanJournalofMedicinalChemistry,2021,vol.216]

[2]Keppel,Patrick;Sohr,Barbara;Kuba,Walter;Goldeck,Marion;Skrinjar,Philipp;Carlson,JonathanC.T.;Mikula,Hannes[ChemBioChem,2022,vol.23,#20]

[3]Huang,Zhiyong;Li,Shen-Huan;Long,Cheng-Yu;Tan,Weihong;Wang,Dan;Wang,Xue-Qiang[JournaloftheAmericanChemicalSociety,2021,vol.143,#23,p.8559-8564]

[4]Ragozin;Hesin;Bazylevich;Tuchinsky;Bovina;ShekhterZahavi;Oron-Herman;Kostenich;Firer;Rubinek;Wolf;Luboshits;Sherman;Gellerman[BioorganicandMedicinalChemistry,2018,vol.26,#13,p.3825-3836]

[5]Toki,BrianE.;Cerveny,CharlesG.;Wahl,AlanF.;Senter,PeterD.[JournalofOrganicChemistry,2002,vol.67,#6,p.1866-1872]

[1]Pettit,GeorgeR.;Rhodes,MonteR.;Herald,DelbertL.;Hamel,Ernest;Schmidt,JeanM.;Pettit,RobinK.[JournalofMedicinalChemistry,2005,vol.48,#12,p.4087-4099]

[2]Huang,Xiaochao;Chen,Yuanhang;Zhong,Wentian;Liu,Zhikun;Zhang,Haijiang;Zhang,Bin;Wang,Hengshan[EuropeanJournalofMedicinalChemistry,2022,vol.244]

[3]Huang,Xiaochao;Chen,Yuanhang;Zhong,Wentian;Liu,Zhikun;Zhang,Haijiang;Zhang,Bin;Wang,Hengshan[EuropeanJournalofMedicinalChemistry,2022,vol.244]

Literature

Title: 3-(3-Hydroxy-4-methoxyphenyl)-4-(3,4,5-trimethoxyphenyl)-1,2,5-selenadiazole (G-1103), a novel combretastatin A-4 analog, induces G2/M arrest and apoptosis by disrupting tubulin polymerization in human cervical HeLa cells and fibrosarcoma HT-1080 cells.

Journal: Chemico-biological interactions 20150205

Title: Autophagy blockade sensitizes the anticancer activity of CA-4 via JNK-Bcl-2 pathway.

Journal: Toxicology and applied pharmacology 20140115

Title: Structure-activity relationship and in vitro and in vivo evaluation of the potent cytotoxic anti-microtubule agent N-(4-methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride and its analogues as antitumor agents.

Journal: Journal of medicinal chemistry 20130912

Title: Synthesis and biological evaluation of novel heterocyclic derivatives of combretastatin A-4.

Journal: Bioorganic & medicinal chemistry letters 20121201

Title: The vascular-disrupting agent, combretastatin-A4-phosphate, enhances neurogenic vasoconstriction in rat small arteries.

Journal: European journal of pharmacology 20121115

Title: Novel cyanocombretastatins as potent tubulin polymerisation inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20121101

Title: Spatiotemporally controlled co-delivery of anti-vasculature agent and cytotoxic drug by octreotide-modified stealth liposomes.

Journal: Pharmaceutical research 20121001

Title: The vascular targeting agent Combretastatin-A4 directly induces autophagy in adenocarcinoma-derived colon cancer cells.

Journal: Biochemical pharmacology 20120901

Title: Antihyperuricemic and nephroprotective effects of resveratrol and its analogues in hyperuricemic mice.

Journal: Molecular nutrition & food research 20120901

Title: Fluorescence lifetime imaging of E-combretastatin uptake and distribution in live mammalian cells.

Journal: European journal of cancer (Oxford, England : 1990) 20120801

Title: In vitro and in vivo biological evaluation of new 4,5-disubstituted 1,2,3-triazoles as cis-constrained analogs of combretastatin A4.

Journal: European journal of medicinal chemistry 20120801

Title: Colon tumor growth and antivascular treatment in mice: complementary assessment with MR elastography and diffusion-weighted MR imaging.

Journal: Radiology 20120801

Title: Synthesis and structure-activity relationships of benzophenone-bearing diketopiperazine-type anti-microtubule agents.

Journal: Bioorganic & medicinal chemistry 20120715

Title: Synthesis, biological evaluation, and structure-activity relationships of novel substituted N-phenyl ureidobenzenesulfonate derivatives blocking cell cycle progression in S-phase and inducing DNA double-strand breaks.

Journal: Journal of medicinal chemistry 20120712

Title: High-sensitivity in vivo imaging for tumors using a spectral up-conversion nanoparticle NaYF4: Yb3+, Er3+ in cooperation with a microtubulin inhibitor.

Journal: Nanoscale 20120707

Title: Synthesis and biological evaluation of 1-benzylidene-3,4-dihydronaphthalen-2-one as a new class of microtubule-targeting agents.

Journal: Journal of medicinal chemistry 20120628

Title: Phase I trial of combretastatin A4 phosphate (CA4P) in combination with bevacizumab in patients with advanced cancer.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20120615

Title: Discovery and optimization of a series of 2-aryl-4-amino-5-(3',4',5'-trimethoxybenzoyl)thiazoles as novel anticancer agents.

Journal: Journal of medicinal chemistry 20120614

Title: Conformationnally restricted naphthalene derivatives type isocombretastatin A-4 and isoerianin analogues: synthesis, cytotoxicity and antitubulin activity.

Journal: European journal of medicinal chemistry 20120601

Title: Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents.

Journal: Bioorganic & medicinal chemistry 20120601

Title: Pharmacokinetics, excretion, and distribution of combretastatin A4 phosphate in rats.

Journal: Die Pharmazie 20120601

Title: Design, synthesis and biological evaluation of novel chalcone derivatives as antitubulin agents.

Journal: Bioorganic & medicinal chemistry 20120515

Title: Synthesis, biological evaluation, and molecular docking studies of 2,6-dinitro-4-(trifluoromethyl)phenoxysalicylaldoxime derivatives as novel antitubulin agents.

Journal: Bioorganic & medicinal chemistry 20120515

Title: Cholesterol superlattice modulates CA4P release from liposomes and CA4P cytotoxicity on mammary cancer cells.

Journal: Biophysical journal 20120502

Title: Discovery of small molecule inhibitors that interact with γ-tubulin.

Journal: Chemical biology & drug design 20120501

Title: Antineoplastic agents. 548. Synthesis of iodo- and diiodocombstatin phosphate prodrugs.

Journal: Journal of natural products 20120323

Title: Dehydrative fragmentation of 5-hydroxyalkyl-1H-tetrazoles: a mild route to alkylidenecarbenes.

Journal: Organic letters 20120316

Title: Substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones and analogues: synthesis, cytotoxic activity, and study of the mechanism of action.

Journal: Journal of medicinal chemistry 20120308

Title: Synthesis and biological evaluation of 1,4-diaryl-2-azetidinones as specific anticancer agents: activation of adenosine monophosphate activated protein kinase and induction of apoptosis.

Journal: Journal of medicinal chemistry 20120308

Title: Diffusion-weighted MR imaging allows monitoring the effect of combretastatin A4 phosphate on rabbit implanted VX2 tumor model: 12-day dynamic results.

Journal: European journal of radiology 20120301

Title: Increased endothelial cell selectivity of triazole-bridged dihalogenated A-ring analogues of combretastatin A-1.

Journal: Bioorganic & medicinal chemistry 20120301

Title: Synthesis and structure-activity relationship study of antimicrotubule agents phenylahistin derivatives with a didehydropiperazine-2,5-dione structure.

Journal: Journal of medicinal chemistry 20120209

Title: Synthesis, biological evaluation, and molecular docking studies of cinnamic acyl 1,3,4-thiadiazole amide derivatives as novel antitubulin agents.

Journal: Bioorganic & medicinal chemistry 20120201

Title: Design, synthesis, biological evaluation and molecular modeling of 1,3,4-oxadiazoline analogs of combretastatin-A4 as novel antitubulin agents.

Journal: Bioorganic & medicinal chemistry 20120115

Title: Synthesis and evaluation of 1,5-disubstituted tetrazoles as rigid analogues of combretastatin A-4 with potent antiproliferative and antitumor activity.

Journal: Journal of medicinal chemistry 20120112

Title: Targeted delivery of a combination therapy consisting of combretastatin A4 and low-dose doxorubicin against tumor neovasculature.

Journal: Nanomedicine : nanotechnology, biology, and medicine 20120101

Title: Phase Ib trial of radiotherapy in combination with combretastatin-A4-phosphate in patients with non-small-cell lung cancer, prostate adenocarcinoma, and squamous cell carcinoma of the head and neck.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20120101

Title: Comparison of two vascular-disrupting agents at a clinically relevant dose in rodent liver tumors with multiparametric magnetic resonance imaging biomarkers.

Journal: Anti-cancer drugs 20120101

Title: c-Jun N-terminal kinase mediates microtubule-depolymerizing agent-induced microtubule depolymerization and G2/M arrest in MCF-7 breast cancer cells.

Journal: Anti-cancer drugs 20120101

Title: Synthesis, biological evaluation and molecular modeling of 1,2,3-triazole analogs of combretastatin A-1.

Journal: Bioorganic & medicinal chemistry 20120101

Title: Vascular disrupting agent drug classes differ in effects on the cytoskeleton.

Journal: PloS one 20120101

Title: [Liposome formulations of combretastatin A4 and 4-arylcoumarin analog prodrugs: antitumor effect in the mouse model of breast cancer].

Journal: Biomeditsinskaia khimiia 20120101

Title: Design and synthesis of 2-heterocyclyl-3-arylthio-1H-indoles as potent tubulin polymerization and cell growth inhibitors with improved metabolic stability.

Journal: Journal of medicinal chemistry 20111222

Title: 5-Amino-2-aroylquinolines as highly potent tubulin polymerization inhibitors. Part 2. The impact of bridging groups at position C-2.

Journal: Journal of medicinal chemistry 20111222

Title: Patterning cells and shear flow conditions: convenient observation of endothelial cell remoulding, enhanced production of angiogenesis factors and drug response.

Journal: Lab on a chip 20111221

Title: Endostar enhances the antineoplastic effects of combretastatin A4 phosphate in an osteosarcoma xenograft.

Journal: Cancer letters 20111215

Title: One-pot synthesis and biological evaluation of 2-pyrrolidinyl-4-amino-5-(3',4',5'-trimethoxybenzoyl)thiazole: a unique, highly active antimicrotubule agent.

Journal: European journal of medicinal chemistry 20111201

Title: Substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonamides as antimitotics. Antiproliferative, antiangiogenic and antitumoral activity, and quantitative structure-activity relationships.

Journal: European journal of medicinal chemistry 20111101

Title: 1,1-Diarylalkenes as anticancer agents: dual inhibitors of tubulin polymerization and phosphodiesterase 4.

Journal: Bioorganic & medicinal chemistry 20111101

Title: Vascular effects dominate solid tumor response to treatment with combretastatin A-4-phosphate.

Journal: International journal of cancer 20111015

Title: The metabolic fate of isocombretastatin A-4 in human liver microsomes: identification, synthesis and biological evaluation of metabolites.

Journal: ChemMedChem 20111004

Title: Design, synthesis, and cytotoxicity of novel 3-arylidenones derived from alicyclic ketones.

Journal: Chemical biology & drug design 20111001

Title: Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.

Journal: Journal of medicinal chemistry 20110908

Title: Synthesis and biological activities of (R)- and (S)-N-(4-Methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride as potent cytotoxic antitubulin agents.

Journal: Journal of medicinal chemistry 20110908

Title: Synthesis and structure-activity relationships of constrained heterocyclic analogues of combretastatin A4.

Journal: ChemMedChem 20110905

Title: Microflow of fluorescently labelled red blood cells in tumours expressing single isoforms of VEGF and their response to vascular targeting agents.

Journal: Medical engineering & physics 20110901

Title: Phase II trial of combretastatin A4 phosphate, carboplatin, and paclitaxel in patients with platinum-resistant ovarian cancer.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20110901

Title: Design, synthesis and antiproliferative activities of biarylolefins based on polyhydroxylated and carbohydrate scaffolds.

Journal: European journal of medicinal chemistry 20110901

Title: Synthesis and biological evaluation of 1-(4'-Indolyl and 6'-Quinolinyl) indoles as a new class of potent anticancer agents.

Journal: European journal of medicinal chemistry 20110901

Title: Synthesis, biochemical and molecular modelling studies of antiproliferative azetidinones causing microtubule disruption and mitotic catastrophe.

Journal: European journal of medicinal chemistry 20110901

Title: Investigation of protein induction in tumour vascular targeted strategies by MALDI MSI.

Journal: Methods (San Diego, Calif.) 20110801

Title: Synthesis and biological evaluation of 4β-acrylamidopodophyllotoxin congeners as DNA damaging agents.

Journal: Bioorganic & medicinal chemistry 20110801

Title: Convergent synthesis and biological evaluation of 2-amino-4-(3',4',5'-trimethoxyphenyl)-5-aryl thiazoles as microtubule targeting agents.

Journal: Journal of medicinal chemistry 20110728

Title: Regioselective Suzuki coupling of dihaloheteroaromatic compounds as a rapid strategy to synthesize potent rigid combretastatin analogues.

Journal: Journal of medicinal chemistry 20110728

Title: Regioselective synthesis of water-soluble monophosphate derivatives of combretastatin A-1.

Journal: Journal of natural products 20110722

Title: Design, synthesis, biological evaluation, and structure-activity relationships of substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates as new tubulin inhibitors mimicking combretastatin A-4.

Journal: Journal of medicinal chemistry 20110714

Title: A novel class of trans-methylpyrazoline analogs of combretastatins: synthesis and in-vitro biological testing.

Journal: European journal of medicinal chemistry 20110701

Title: A pharmacokinetic and safety study of single dose intravenous combretastatin A4 phosphate in Chinese patients with refractory solid tumours.

Journal: British journal of clinical pharmacology 20110601

Title: In vivo near-infrared spectroscopy and magnetic resonance imaging monitoring of tumor response to combretastatin A-4-phosphate correlated with therapeutic outcome.

Journal: International journal of radiation oncology, biology, physics 20110601

Title: Imidazolone-amide bridges and their effects on tubulin polymerization in cis-locked vinylogous combretastatin-A4 analogues: synthesis and biological evaluation.

Journal: Bioorganic & medicinal chemistry 20110601

Title: Synthesis and biological evaluation of 4-arylcoumarin analogues of combretastatins. Part 2.

Journal: Journal of medicinal chemistry 20110512

Title: TIE2-expressing macrophages limit the therapeutic efficacy of the vascular-disrupting agent combretastatin A4 phosphate in mice.

Journal: The Journal of clinical investigation 20110502

Title: Synthesis of novel antimitotic agents based on 2-amino-3-aroyl-5-(hetero)arylethynyl thiophene derivatives.

Journal: Bioorganic & medicinal chemistry letters 20110501

Title: 4,5-Diaryl-3-aminopyrazole derivatives as analogs of Combretastatin A-4: synthesis and biological evaluation.

Journal: Archiv der Pharmazie 20110501

Title: BubR1 is required for the mitotic block induced by combretastatin-A4 and a novel cis-restricted ß-lactam analogue in human cancer cells.

Journal: International journal of molecular medicine 20110501

Title: Synthesis, biological evaluation, and molecular docking studies of resveratrol derivatives possessing chalcone moiety as potential antitubulin agents.

Journal: Bioorganic & medicinal chemistry 20110415

Title: Design, synthesis, and biological evaluation of novel γ-carboline ketones as anticancer agents.

Journal: European journal of medicinal chemistry 20110401

Title: Design and synthesis of novel enhanced water soluble hydroxyethyl analogs of combretastatin A-4.

Journal: Bioorganic & medicinal chemistry letters 20110401

Title: Acetyl analogs of combretastatin A-4: synthesis and biological studies.

Journal: Bioorganic & medicinal chemistry 20110401

Title: Synthesis and cytotoxic evaluation of N-(4-methoxy-1H-benzo[d]imidazol-7-yl)-arylsulfonamide and N-aryl-(4-methoxy-1H-benzo[d]imidazol)-7-sulfonamide analogs of combretastatin A-4.

Journal: Journal of Asian natural products research 20110401

Title: Application of plant allylpolyalkoxybenzenes in synthesis of antimitotic phenstatin analogues.

Journal: Bioorganic & medicinal chemistry letters 20110315

Title: Antitumor agents. 284. New desmosdumotin B analogues with bicyclic B-ring as cytotoxic and antitubulin agents.

Journal: Journal of medicinal chemistry 20110310

Title: Enhanced anti-tumor activity by the combination of TRAIL/Apo-2L and combretastatin A-4 against human colon cancer cells via induction of apoptosis in vitro and in vivo.

Journal: Cancer letters 20110301

Title: Materializing sequential killing of tumor vasculature and tumor cells via targeted polymeric micelle system.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20110210

Title: Synthesis and biological evaluation of 3,5-diaryl isoxazoline/isoxazole linked 2,3-dihydroquinazolinone hybrids as anticancer agents.

Journal: European journal of medicinal chemistry 20110201

Title: Support of a free radical mechanism for enhanced antitumor efficacy of the microtubule disruptor OXi4503.

Journal: Microvascular research 20110101

Title: Combretastatin-induced hypertension and the consequences for its combination with other therapies.

Journal: Vascular pharmacology 20110101

Title: Domino approach to 2-aroyltrimethoxyindoles as novel heterocyclic combretastatin A4 analogues.

Journal: European journal of medicinal chemistry 20110101

Title: Developments of combretastatin A-4 derivatives as anticancer agents.

Journal: Current medicinal chemistry 20110101

Title: Synthesis of antiproliferative flavones from calycopterin, major flavonoid of Calycopteris floribunda Lamk.

Journal: Bioorganic & medicinal chemistry 20110101

Title: Stable combretastatin A-4 analogues with sub-nanomolar efficacy against chemoresistant HT-29 cells.

Journal: International journal of clinical pharmacology and therapeutics 20110101

Title: Computational modeling of tumor response to vascular-targeting therapies--part I: validation.

Journal: Computational and mathematical methods in medicine 20110101

Title: Biological potential and structure-activity relationships of most recently developed vascular disrupting agents: an overview of new derivatives of natural combretastatin a-4.

Journal: Current medicinal chemistry 20110101

Title: Combretastatin A4 phosphate induces programmed cell death in vascular endothelial cells.

Journal: Oncology research 20110101

Title: Multifunctional dendrimer/combretastatin A4 inclusion complexes enable in vitro targeted cancer therapy.

Journal: International journal of nanomedicine 20110101

Title: Synthesis and evaluation of azetidinone analogues of combretastatin A-4 as tubulin targeting agents.

Journal: Journal of medicinal chemistry 20101223

Title: Lead identification of conformationally restricted β-lactam type combretastatin analogues: synthesis, antiproliferative activity and tubulin targeting effects.

Journal: European journal of medicinal chemistry 20101201

Title: Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-aryl/arylaminobenzo[b]thiophene derivatives as a novel class of antiproliferative agents.

Journal: European journal of medicinal chemistry 20101201

Title: Synthesis, molecular modeling and biological evaluation of guanidine derivatives as novel antitubulin agents.

Journal: Bioorganic & medicinal chemistry 20101201

Title: Detection of tumor response to a vascular disrupting agent by hyperpolarized 13C magnetic resonance spectroscopy.

Journal: Molecular cancer therapeutics 20101201

Title: Synthesis of antimitotic polyalkoxyphenyl derivatives of combretastatin using plant allylpolyalkoxybenzenes.

Journal: Journal of natural products 20101129

Title: Synthesis and discovery of water-soluble microtubule targeting agents that bind to the colchicine site on tubulin and circumvent Pgp mediated resistance.

Journal: Journal of medicinal chemistry 20101125

Title: Self-assembled core-shell vascular-targeted nanocapsules for temporal antivasculature and anticancer activities.

Journal: Small (Weinheim an der Bergstrasse, Germany) 20101122

Title: Effects of a combretastatin A4 analogous chalcone and its Pt-complex on cancer cells: A comparative study of uptake, cell cycle and damage to cellular compartments.

Journal: Biochemical pharmacology 20101115

Title: The vascular targeting agent combretastatin-A4 and a novel cis-Restricted {beta}-Lactam Analogue, CA-432, induce apoptosis in human chronic myeloid leukemia cells and ex vivo patient samples including those displaying multidrug resistance.

Journal: The Journal of pharmacology and experimental therapeutics 20101101

Title: Discovery of novel 2-aryl-4-benzoyl-imidazoles targeting the colchicines binding site in tubulin as potential anticancer agents.

Journal: Journal of medicinal chemistry 20101028

Title: Non-invasive imaging of combretastatin activity in two tumor models: Association with invasive estimates.

Journal: Acta oncologica (Stockholm, Sweden) 20101001

Title: 4-(3-Halo/amino-4,5-dimethoxyphenyl)-5-aryloxazoles and -N-methylimidazoles that are cytotoxic against combretastatin A resistant tumor cells and vascular disrupting in a cisplatin resistant germ cell tumor model.

Journal: Journal of medicinal chemistry 20100923

Title: 1,2,3-triazole analogs of combretastatin A-4 as potential microtubule-binding agents.

Journal: Bioorganic & medicinal chemistry 20100915

Title: Identification of CKD-516: a potent tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors.

Journal: Journal of medicinal chemistry 20100909

Title: Structure-activity relationships of indole compounds derived from combretastatin A4: synthesis and biological screening of 5-phenylpyrrolo[3,4-a]carbazole-1,3-diones as potential antivascular agents.

Journal: European journal of medicinal chemistry 20100901

Title: Design, synthesis and biological evaluation of 3,5-diaryl-isoxazoline/isoxazole-pyrrolobenzodiazepine conjugates as potential anticancer agents.

Journal: European journal of medicinal chemistry 20100901

Title: Targeted polymeric micelle system for delivery of combretastatin A4 to tumor vasculature in vitro.

Journal: Pharmaceutical research 20100901

Title: A nanocapsular combinatorial sequential drug delivery system for antiangiogenesis and anticancer activities.

Journal: Biomaterials 20100901

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Title: Synthesis and in vitro antitumor activity of new 4,5-dihydropyrazole derivatives.

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Title: [Progress in the study of tubulin inhibitors].

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Title: Novel combretastatin A-4 derivative XN0502 induces cell cycle arrest and apoptosis in A549 cells.

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Title: Combretastatin A-4 inhibits cell growth and metastasis in bladder cancer cells and retards tumour growth in a murine orthotopic bladder tumour model.

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Title: Combretastatin A4 phosphate: a novel vascular disrupting agent.

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Title: Identification of the human UDP-glucuronosyltransferases involved in the glucuronidation of combretastatin A-4.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20100701

Title: Structural determinants of resveratrol for cell proliferation inhibition potency: experimental and docking studies of new analogs.

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Journal: Journal of enzyme inhibition and medicinal chemistry 20100601

Title: [New strategies for NSCLC: is inhibition of tumour vasculature useful].

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Title: Synthesis and antitumor activity of 1,5-disubstituted 1,2,4-triazoles as cis-restricted combretastatin analogues.

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Title: Highly chemo- and stereoselective palladium-catalyzed transfer semihydrogenation of internal alkynes affording cis-alkenes.

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Title: Synthesis and biological evaluation of combretastatin analogs as cell cycle inhibitors of the G1 to S transition in Saccharomyces cerevisiae.

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Title: A Phase Ib trial of CA4P (combretastatin A-4 phosphate), carboplatin, and paclitaxel in patients with advanced cancer.

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Title: Synthesis, antitubulin, and antiproliferative SAR of analogues of 2-methoxyestradiol-3,17-O,O-bis-sulfamate.

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Title: Design and in vitro evaluation of branched peptide conjugates: turning nonspecific cytotoxic drugs into tumor-selective agents.

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Journal: Journal of enzyme inhibition and medicinal chemistry 20100401

Title: Pyrazolone-fused combretastatins and their precursors: synthesis, cytotoxicity, antitubulin activity and molecular modeling studies.

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Title: An efficient synthetic strategy for obtaining 4-methoxy carbon isotope labeled combretastatin A-4 phosphate and other Z-combretastatins.

Journal: Journal of natural products 20100326

Title: Targeted delivery of RGD-modified liposomes encapsulating both combretastatin A-4 and doxorubicin for tumor therapy: in vitro and in vivo studies.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20100301

Title: Oxazole-bridged combretastatin A analogues with improved anticancer properties.

Journal: ChemMedChem 20100301

Title: Exploring the effect of 2,3,4-trimethoxy-phenyl moiety as a component of indolephenstatins.

Journal: European journal of medicinal chemistry 20100201

Title: A boronic acid chalcone analog of combretastatin A-4 as a potent anti-proliferation agent.

Journal: Bioorganic & medicinal chemistry 20100115

Title: Design, synthesis, and biological evaluations of 2,5-diaryl-2,3-dihydro-1,3,4-oxadiazoline analogs of combretastatin-A4.

Journal: Journal of medicinal chemistry 20100114

Title: Novel hybrids from lamellarin D and combretastatin A 4 as cytotoxic agents.

Journal: European journal of medicinal chemistry 20100101

Title: Synthesis and antitumor-evaluation of cyclopropyl-containing combretastatin analogs.

Journal: Bioorganic & medicinal chemistry letters 20091215

Title: Vascular disrupting activity of tubulin-binding 1,5-diaryl-1H-imidazoles.

Journal: Journal of medicinal chemistry 20091210

Title: Development of a rapid and sensitive LC-MS/MS assay for the determination of combretastatin A4 phosphate, combretastatin A4 and combretastatin A4 glucuronide in beagle dog plasma and its application to a pharmacokinetic study.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20091115

Title: Combretastatin-like chalcones as inhibitors of microtubule polymerization. Part 1: synthesis and biological evaluation of antivascular activity.

Journal: Bioorganic & medicinal chemistry 20091115

Title: Combretastatin-like chalcones as inhibitors of microtubule polymerisation. Part 2: Structure-based discovery of alpha-aryl chalcones.

Journal: Bioorganic & medicinal chemistry 20091115

Title: Reproducibility and changes in the apparent diffusion coefficients of solid tumours treated with combretastatin A4 phosphate and bevacizumab in a two-centre phase I clinical trial.

Journal: European radiology 20091101

Title: Synthesis, biological evaluation of 1,1-diarylethylenes as a novel class of antimitotic agents.

Journal: ChemMedChem 20091101

Title: Application of the McMurry coupling reaction in the synthesis of tri- and tetra-arylethylene analogues as potential cancer chemotherapeutic agents.

Journal: Bioorganic & medicinal chemistry 20091001

Title: Design, synthesis and structure-activity relationship of 2-(3',4',5'-trimethoxybenzoyl)-benzo[b]furan derivatives as a novel class of inhibitors of tubulin polymerization.

Journal: Bioorganic & medicinal chemistry 20091001

Title: Contribution of granulocyte colony-stimulating factor to the acute mobilization of endothelial precursor cells by vascular disrupting agents.

Journal: Cancer research 20091001

Title: AVE8062: a new combretastatin derivative vascular disrupting agent.

Journal: Expert opinion on investigational drugs 20091001

Title: E-Combretastatin and E-resveratrol structural modifications: antimicrobial and cancer cell growth inhibitory beta-E-nitrostyrenes.

Journal: Bioorganic & medicinal chemistry 20090915

Title: 2-Arylamino-4-amino-5-aroylthiazoles. 'One-pot' synthesis and biological evaluation of a new class of inhibitors of tubulin polymerization.

Journal: Journal of medicinal chemistry 20090910

Title: Isocombretastatins A: 1,1-diarylethenes as potent inhibitors of tubulin polymerization and cytotoxic compounds.

Journal: Bioorganic & medicinal chemistry 20090901

Title: Antineoplastic agents. 579. Synthesis and cancer cell growth evaluation of E-stilstatin 3: a resveratrol structural modification.

Journal: Journal of natural products 20090901

Title: Design and synthesis of 2-(3-benzo[b]thienyl)-6,7-methylenedioxyquinolin-4-one analogues as potent antitumor agents that inhibit tubulin assembly.

Journal: Journal of medicinal chemistry 20090813

Title: Isocombretastatins a versus combretastatins a: the forgotten isoCA-4 isomer as a highly promising cytotoxic and antitubulin agent.

Journal: Journal of medicinal chemistry 20090723

Title: 1,4-Diamino-2,3-dicyano-1,4-bis(methylthio)butadiene (U0126) enhances the cytotoxicity of combretastatin A4 independently of mitogen-activated protein kinase kinase.

Journal: The Journal of pharmacology and experimental therapeutics 20090701

Title: Anticancer strategies involving the vasculature.

Journal: Nature reviews. Clinical oncology 20090701

Title: A phase I trial of radioimmunotherapy with 131I-A5B7 anti-CEA antibody in combination with combretastatin-A4-phosphate in advanced gastrointestinal carcinomas.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090701

Title: A diaryl sulfide, sulfoxide, and sulfone bearing structural similarities to combretastatin A-4.

Journal: European journal of medicinal chemistry 20090601

Title: Targeted treatment of choroidal neovascularization using integrin-mediated sterically stabilized liposomes loaded with combretastatin A4.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20090601

Title: Nitric oxide synthase inhibition enhances the tumor vascular-damaging effects of combretastatin a-4 3-o-phosphate at clinically relevant doses.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090601

Title: Vascular disrupting agents: a novel mechanism of action in the battle against non-small cell lung cancer.

Journal: The oncologist 20090601

Title: Antineoplastic agents. 578. Synthesis of stilstatins 1 and 2 and their water-soluble prodrugs.

Journal: Journal of natural products 20090327

Title: Antineoplastic agents. 565. Synthesis of combretastatin D-2 phosphate and dihydro-combretastatin D-2.

Journal: Journal of natural products 20090325

Title: Preclinical evaluation of vascular-disrupting agents in Ewing's sarcoma family of tumours.

Journal: European journal of cancer (Oxford, England : 1990) 20090301

Title: Synthesis and biological evaluation of cis-locked vinylogous combretastatin-A4 analogues: derivatives with a cyclopropyl-vinyl or a cyclopropyl-amide bridge.

Journal: Bioorganic & medicinal chemistry letters 20090301

Title: Diffusion-weighted MRI of hepatic tumor in rats: comparison between in vivo and postmortem imaging acquisitions.

Journal: Journal of magnetic resonance imaging : JMRI 20090301

Title: A phase II trial of fosbretabulin in advanced anaplastic thyroid carcinoma and correlation of baseline serum-soluble intracellular adhesion molecule-1 with outcome.

Journal: Thyroid : official journal of the American Thyroid Association 20090301

Title: Up-regulation of connective tissue growth factor in endothelial cells by the microtubule-destabilizing agent combretastatin A-4.

Journal: Molecular cancer research : MCR 20090201

Title: A review and update of the current status of the vasculature-disabling agent combretastatin-A4 phosphate (CA4P).

Journal: Expert opinion on investigational drugs 20090201

Title: In vitro and in vivo phase II metabolism of combretastatin A-4: evidence for the formation of a sulphate conjugate metabolite.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20090201

Title: Pt(II) complexes of a combretastatin A-4 analogous chalcone: effects of conjugation on cytotoxicity, tumor specificity, and long-term tumor growth suppression.

Journal: Journal of medicinal chemistry 20090122

Title: Design, synthesis and biological evaluation of novel stilbene-based antitumor agents.

Journal: Bioorganic & medicinal chemistry 20090115

Title: Treatment of rodent liver tumor with combretastatin a4 phosphate: noninvasive therapeutic evaluation using multiparametric magnetic resonance imaging in correlation with microangiography and histology.

Journal: Investigative radiology 20090101

Title: Combination of combretastatin A4 phosphate and doxorubicin-containing liposomes affects growth of B16-F10 tumors.

Journal: Acta biochimica Polonica 20090101

Title: Pharmacological inhibition of the hypertensive response to combretastatin A-4 phosphate in rats.

Journal: Vascular pharmacology 20090101

Title: Synthesis and structure-activity relationships of 2-amino-1-aroylnaphthalene and 2-hydroxy-1-aroylnaphthalenes as potent antitubulin agents.

Journal: Journal of medicinal chemistry 20081225

Title: Novel A-ring and B-ring modified combretastatin A-4 (CA-4) analogues endowed with interesting cytotoxic activity.

Journal: Journal of medicinal chemistry 20081009

Title: Vibrational spectra and ab initio molecular orbital calculations of the novel anti-cancer drug combretastatin A-4 prodrug.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20081001

Title: Naphthylphenstatins as tubulin ligands: synthesis and biological evaluation.

Journal: Bioorganic & medicinal chemistry 20081001

Title: Synthesis and biological evaluation of polymethoxylated 4-heteroarylcoumarins as tubulin assembly inhibitor.

Journal: Bioorganic & medicinal chemistry 20081001

Title: Tumour vascular disrupting agents: combating treatment resistance.

Journal: The British journal of radiology 20081001

Title: Design, synthesis, biochemical, and biological evaluation of nitrogen-containing trifluoro structural modifications of combretastatin A-4.

Journal: Bioorganic & medicinal chemistry letters 20080915

Title: Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-N,N-dimethylamino benzo[b]furan derivatives as inhibitors of tubulin polymerization.

Journal: Bioorganic & medicinal chemistry 20080915

Title: 1,2,3,4-tetrahydro-2-thioxopyrimidine analogs of combretastatin-A4.

Journal: European journal of medicinal chemistry 20080901

Title: Design, synthesis and biological evaluation of dihydronaphthalene and benzosuberene analogs of the combretastatins as inhibitors of tubulin polymerization in cancer chemotherapy.

Journal: Bioorganic & medicinal chemistry 20080901

Title: Antineoplastic agents. 552. Oxidation of combretastatin A-1: trapping the o-quinone intermediate considered the metabolic product of the corresponding phosphate prodrug.

Journal: Journal of natural products 20080901

Title: Asymmetric synthesis of 2,3-dihydro-2-arylquinazolin-4-ones: methodology and application to a potent fluorescent tubulin inhibitor with anticancer activity.

Journal: Journal of medicinal chemistry 20080814

Title: Synthesis and biological evaluation of new disubstituted analogues of 6-methoxy-3-(3',4',5'-trimethoxybenzoyl)-1H-indole (BPR0L075), as potential antivascular agents.

Journal: Bioorganic & medicinal chemistry 20080801

Title: Discovery of 4-amino and 4-hydroxy-1-aroylindoles as potent tubulin polymerization inhibitors.

Journal: Journal of medicinal chemistry 20080724

Title: Relationship between human tumour angiogenic profile and combretastatin-induced vascular shutdown: an exploratory study.

Journal: British journal of cancer 20080722

Title: Antivascular effects of combretastatin A4 phosphate in breast cancer xenograft assessed using dynamic bioluminescence imaging and confirmed by MRI.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080701

Title: Synthesis and antitumor activity of benzils related to combretastatin A-4.

Journal: Bioorganic & medicinal chemistry letters 20080601

Title: Diarylmethyloxime and hydrazone derivatives with 5-indolyl moieties as potent inhibitors of tubulin polymerization.

Journal: Bioorganic & medicinal chemistry 20080601

Title: Design, synthesis, and biological evaluation of thiophene analogues of chalcones.

Journal: Bioorganic & medicinal chemistry 20080515

Title: 2-(6-aryl-3(Z)-hexen-1,5-diynyl)anilines as a new class of potent antitubulin agents.

Journal: Journal of medicinal chemistry 20080508

Title: Synthesis and biological activity of fluorinated combretastatin analogues.

Journal: Journal of medicinal chemistry 20080508

Title: The tubulin-depolymerising agent combretastatin-4 induces ectopic aster assembly and mitotic catastrophe in lung cancer cells H460.

Journal: Apoptosis : an international journal on programmed cell death 20080501

Title: 1,5-Disubstituted 1,2,3-triazoles as cis-restricted analogues of combretastatin A-4: Synthesis, molecular modeling and evaluation as cytotoxic agents and inhibitors of tubulin.

Journal: Bioorganic & medicinal chemistry 20080501

Title: Tubulysin analogs incorporating desmethyl and dimethyl tubuphenylalanine derivatives.

Journal: Bioorganic & medicinal chemistry letters 20080501

Title: p38 MAPK, but not ERK1/2, is critically involved in the cytotoxicity of the novel vascular disrupting agent combretastatin A4.

Journal: International journal of cancer 20080415

Title: Blood vessel maturation and response to vascular-disrupting therapy in single vascular endothelial growth factor-A isoform-producing tumors.

Journal: Cancer research 20080401

Title: Combretastatin A-4 activates AMP-activated protein kinase and improves glucose metabolism in db/db mice.

Journal: Pharmacological research 20080401

Title: Synthesis and biological evaluation of 1-methyl-2-(3',4',5'-trimethoxybenzoyl)-3-aminoindoles as a new class of antimitotic agents and tubulin inhibitors.

Journal: Journal of medicinal chemistry 20080313

Title: Preclinical studies to predict efficacy of vascular changes induced by combretastatin a-4 disodium phosphate in patients.

Journal: International journal of radiation oncology, biology, physics 20080301

Title: Efficacy of selected natural products as therapeutic agents against cancer.

Journal: Journal of natural products 20080301

Title: Combretastatin dinitrogen-substituted stilbene analogues as tubulin-binding and vascular-disrupting agents.

Journal: Journal of natural products 20080301

Title: The microtubule-targeting agent CA4P regresses leukemic xenografts by disrupting interaction with vascular cells and mitochondrial-dependent cell death.

Journal: Blood 20080215

Title: Design, synthesis, and in vitro antitumor activity of new 1,4-diarylimidazole-2-ones and their 2-thione analogues.

Journal: Bioorganic & medicinal chemistry letters 20080201

Title: Segmentation of dynamic contrast enhanced magnetic resonance imaging data.

Journal: Acta oncologica (Stockholm, Sweden) 20080101

Title: Solution-phase parallel synthesis and biological evaluation of combretatriazoles.

Journal: Journal of combinatorial chemistry 20080101

Title: The effect of combretastatin A4 disodium phosphate and 5,6-dimethylxanthenone-4-acetic acid on water diffusion and blood perfusion in tumours.

Journal: Acta oncologica (Stockholm, Sweden) 20080101

Title: 3-(2'-Bromopropionylamino)-benzamides as novel S-phase arrest agents.

Journal: Bioorganic & medicinal chemistry letters 20071215

Title: In vitro metabolism study of combretastatin A-4 in rat and human liver microsomes.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20071201

Title: Mechanism of retinoblastoma tumor cell death after focal chemotherapy, radiation, and vascular targeting therapy in a mouse model.

Journal: Investigative ophthalmology & visual science 20071201

Title: Combretastatin a-4 analogs as anticancer agents.

Journal: Mini reviews in medicinal chemistry 20071201

Title: Conformationally restricted macrocyclic analogues of combretastatins.

Journal: Bioorganic & medicinal chemistry letters 20071115

Title: Assessment of tumor response to the vascular disrupting agents 5,6-dimethylxanthenone-4-acetic acid or combretastatin-A4-phosphate by intrinsic susceptibility magnetic resonance imaging.

Journal: International journal of radiation oncology, biology, physics 20071115

Title: Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry.

Journal: Bioorganic & medicinal chemistry 20071101

Title: Design, synthesis, and biological testing of pyrazoline derivatives of combretastatin-A4.

Journal: Bioorganic & medicinal chemistry letters 20071101

Title: Tumour targeting by microtubule-depolymerizing vascular disrupting agents.

Journal: Expert opinion on therapeutic targets 20071101

Title: Combretastatin A4-induced differential cytotoxicity and reduced metastatic ability by inhibition of AKT function in human gastric cancer cells.

Journal: The Journal of pharmacology and experimental therapeutics 20071001

Title: Combination chemotherapy including combretastatin A4 phosphate and paclitaxel is effective against anaplastic thyroid cancer in a nude mouse xenograft model.

Journal: The Journal of clinical endocrinology and metabolism 20070801

Title: Novel potent antimitotic heterocyclic ketones: synthesis, antiproliferative activity, and structure-activity relationships.

Journal: Bioorganic & medicinal chemistry letters 20070701

Title: Synthesis and biological activity of naphthalene analogues of phenstatins: naphthylphenstatins.

Journal: Bioorganic & medicinal chemistry letters 20070615

Title: Arylthioindole inhibitors of tubulin polymerization. 3. Biological evaluation, structure-activity relationships and molecular modeling studies.

Journal: Journal of medicinal chemistry 20070614

Title: Synthesis and biological evaluation of 2- and 3-aminobenzo[b]thiophene derivatives as antimitotic agents and inhibitors of tubulin polymerization.

Journal: Journal of medicinal chemistry 20070503

Title: The concise synthesis of chalcone, indanone and indenone analogues of combretastatin A4.

Journal: Bioorganic & medicinal chemistry 20070501

Title: Characterizing the tumor response to treatment with combretastatin A4 phosphate.

Journal: International journal of radiation oncology, biology, physics 20070501

Title: A Ramberg-Bäcklund route to the stilbenoid anti-cancer agents combretastatin A-4 and DMU-212.

Journal: Chemical communications (Cambridge, England) 20070428

Title: Vascular disrupting agents in clinical development.

Journal: British journal of cancer 20070423

Title: Synthesis and evaluation of 4/5-hydroxy-2,3-diaryl(substituted)-cyclopent-2-en-1-ones as cis-restricted analogues of combretastatin A-4 as novel anticancer agents.

Journal: Journal of medicinal chemistry 20070419

Title: Tumor antivascular effects of radiotherapy combined with combretastatin a4 phosphate in human non-small-cell lung cancer.

Journal: International journal of radiation oncology, biology, physics 20070401

Title: N-Phenyl-N'-(2-chloroethyl)urea analogues of combretastatin A-4: Is the N-phenyl-N'-(2-chloroethyl)urea pharmacophore mimicking the trimethoxy phenyl moiety?

Journal: Bioorganic & medicinal chemistry letters 20070401

Title: Evaluation of the vascular targeting agent combretastatin a-4 prodrug on retinal neovascularization in the galactose-fed dog.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20070401

Title: Potent antitubulin tumor cell cytotoxins based on 3-aroyl indazoles.

Journal: Journal of medicinal chemistry 20070308

Title: Novel pyridinyl and pyrimidinylcarbazole sulfonamides as antiproliferative agents.

Journal: Bioorganic & medicinal chemistry letters 20070301

Title: Highly potent triazole-based tubulin polymerization inhibitors.

Journal: Journal of medicinal chemistry 20070222

Title: Synthesis and cytotoxic activities of 4,5-diarylisoxazoles.

Journal: Bioorganic & medicinal chemistry letters 20070215

Title: Synthesis and activity of Combretastatin A-4 analogues: 1,2,3-thiadiazoles as potent antitumor agents.

Journal: Bioorganic & medicinal chemistry letters 20070215

Title: MZ3 induces apoptosis in human leukemia cells.

Journal: Cancer chemotherapy and pharmacology 20070201

Title: Early effects of combretastatin-A4 disodium phosphate on tumor perfusion and interstitial fluid pressure.

Journal: Neoplasia (New York, N.Y.) 20070201

Title: Combretastatin CA-4 and combretastatin derivative induce mitotic catastrophe dependent on spindle checkpoint and caspase-3 activation in non-small cell lung cancer cells.

Journal: Apoptosis : an international journal on programmed cell death 20070101

Title: Dose-response relationship of ultrasound contrast agent in an in vivo murine melanoma model.

Journal: Cancer imaging : the official publication of the International Cancer Imaging Society 20070101

Title: Thrombospondins deployed by thrombopoietic cells determine angiogenic switch and extent of revascularization.

Journal: The Journal of clinical investigation 20061201

Title: Synthesis and biological properties of bioreductively targeted nitrothienyl prodrugs of combretastatin A-4.

Journal: Molecular cancer therapeutics 20061101

Title: Synthesis and structure-activity relationships of carbazole sulfonamides as a novel class of antimitotic agents against solid tumors.

Journal: Journal of medicinal chemistry 20061019

Title: 2-amino and 2'-aminocombretastatin derivatives as potent antimitotic agents.

Journal: Journal of medicinal chemistry 20061019

Title: Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-amino 5-aryl thiophenes as a new class of tubulin inhibitors.

Journal: Journal of medicinal chemistry 20061019

Title: Structure-activity-relationship studies of conformationally restricted analogs of combretastatin A-4 derived from SU5416.

Journal: Bioorganic & medicinal chemistry 20061001

Title: Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors.

Journal: Science (New York, N.Y.) 20060922

Title: Synthesis and cytotoxic evaluation of combretafurans, potential scaffolds for dual-action antitumoral agents.

Journal: Journal of medicinal chemistry 20060824

Title: Interaction of 4-arylcoumarin analogues of combretastatins with microtubule network of HBL100 cells and binding to tubulin.

Journal: Biochemistry 20060801

Title: Low-dose combretastatin A4 phosphate enhances the immune response of tumor hosts to experimental colon carcinoma.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20060801

Title: 4,5-Diaryl-1H-pyrrole-2-carboxylates as combretastatin A-4/lamellarin T hybrids: synthesis and evaluation as anti-mitotic and cytotoxic agents.

Journal: Bioorganic & medicinal chemistry 20060701

Title: Synthesis and biological evaluation of (3,4,5-trimethoxyphenyl)indol-3-ylmethane derivatives as potential antivascular agents.

Journal: Bioorganic & medicinal chemistry 20060701

Title: Promising new treatments for neovascular age-related macular degeneration.

Journal: Expert opinion on investigational drugs 20060701

Title: Effect of the second-generation vascular disrupting agent OXi4503 on tumor vascularity.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20060701

Title: Early effects of combretastatin A4 phosphate assessed by anatomic and carbogen-based functional magnetic resonance imaging on rat bladder tumors implanted in nude mice.

Journal: Neoplasia (New York, N.Y.) 20060701

Title: Synthesis and biological evaluation of 2-amino-3-(3',4',5'-trimethoxybenzoyl)-5-aryl thiophenes as a new class of potent antitubulin agents.

Journal: Journal of medicinal chemistry 20060629

Title: Isoxazole-type derivatives related to combretastatin A-4, synthesis and biological evaluation.

Journal: Bioorganic & medicinal chemistry 20060615

Title: Medicinal chemistry of combretastatin A4: present and future directions.

Journal: Journal of medicinal chemistry 20060601

Title: Novel combretastatin analogues endowed with antitumor activity.

Journal: Journal of medicinal chemistry 20060601

Title: Current development status of small-molecule vascular disrupting agents.

Journal: Current opinion in investigational drugs (London, England : 2000) 20060601

Title: A tumor vasculature targeted liposome delivery system for combretastatin A4: design, characterization, and in vitro evaluation.

Journal: AAPS PharmSciTech 20060407

Title: Benzoylphenylurea sulfur analogues with potent antitumor activity.

Journal: Journal of medicinal chemistry 20060406

Title: Oxadiazole derivatives as a novel class of antimitotic agents: Synthesis, inhibition of tubulin polymerization, and activity in tumor cell lines.

Journal: Bioorganic & medicinal chemistry letters 20060301

Title: C8c-C15 monoseco-analogues of the phenanthroquinolizidine alkaloids julandine and cryptopleurine exhibiting potent anti-angiogenic properties.

Journal: Bioorganic & medicinal chemistry letters 20060101

Title: NPI-2358 is a tubulin-depolymerizing agent: in-vitro evidence for activity as a tumor vascular-disrupting agent.

Journal: Anti-cancer drugs 20060101

Title: In vivo antitumour effect of combretastatin A-4 phosphate added to fractionated irradiation.

Journal: Anticancer research 20060101

Title: The effects of the vascular disrupting agents combretastatin A-4 disodium phosphate, 5,6-dimethylxanthenone-4-acetic acid and ZD6126 in a murine tumour: a comparative assessment using MRI and MRS.

Journal: Acta oncologica (Stockholm, Sweden) 20060101

Title: Macular degeneration: the latest in current medical management.

Journal: Retina (Philadelphia, Pa.) 20060101

Title: Combretastatin A-1 phosphate potentiates the antitumor activity of carboplatin and paclitaxel in a severe combined immunodeficiency disease (SCID) mouse model of human ovarian carcinoma.

Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20060101

Title: A targeted liposome delivery system for combretastatin A4: formulation optimization through drug loading and in vitro release studies.

Journal: PDA journal of pharmaceutical science and technology 20060101

Title: Anti-vascular agent Combretastatin A-4-P modulates hypoxia inducible factor-1 and gene expression.

Journal: BMC cancer 20060101

Title: Conformationally restricted analogs of Combretastatin A-4 derived from SU5416.

Journal: Bioorganic & medicinal chemistry letters 20051215

Title: Synthesis and structure-activity relationships of 1,2,4-triazoles as a novel class of potent tubulin polymerization inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20051201

Title: Plant-based anticancer molecules: a chemical and biological profile of some important leads.

Journal: Bioorganic & medicinal chemistry 20051101

Title: Effect of vascular targeting agent in rat tumor model: dynamic contrast-enhanced versus diffusion-weighted MR imaging.

Journal: Radiology 20051101

Title: Combretastatin A4 phosphate induces rapid regression of tumor neovessels and growth through interference with vascular endothelial-cadherin signaling.

Journal: The Journal of clinical investigation 20051101

Title: Antineoplastic strategy: irreversible tumor blood flow stasis induced by the combretastatin A-4 derivative AVE8062 (AC7700).

Journal: Chemotherapy 20051001

Title: Antineoplastic agents. 509: synthesis of fluorcombstatin phosphate and related 3-halostilbenes(1).

Journal: Journal of natural products 20051001

Title: A common pharmacophore for a diverse set of colchicine site inhibitors using a structure-based approach.

Journal: Journal of medicinal chemistry 20050922

Title: Synthesis and preliminary biological evaluation of new anti-tubulin agents containing different benzoheterocycles.

Journal: Bioorganic & medicinal chemistry letters 20050915

Title: Taking down tumors: vascular disrupting agents entering clinical trials.

Journal: Journal of the National Cancer Institute 20050907

Title: Structure-based discovery of a boronic acid bioisostere of combretastatin A-4.

Journal: Chemistry & biology 20050901

Title: Stilbenophane analogues of deoxycombretastatin A-4.

Journal: The Journal of organic chemistry 20050805

Title: Synthesis and biological activity of mustard derivatives of combretastatins.

Journal: Bioorganic & medicinal chemistry letters 20050801

Title: Antineoplastic agents. 515. Synthesis of human cancer cell growth inhibitors derived from 3,4-methylenedioxy-5,4'-dimethoxy-3'-amino-Z-stilbene.

Journal: Journal of natural products 20050801

Title: Diffusion-weighted magnetic resonance imaging allows noninvasive in vivo monitoring of the effects of combretastatin a-4 phosphate after repeated administration.

Journal: Neoplasia (New York, N.Y.) 20050801

Title: Synthesis and biological evaluation of vinylogous combretastatin A-4 derivatives.

Journal: Organic & biomolecular chemistry 20050721

Title: Tumor physiologic response to combretastatin A4 phosphate assessed by MRI.

Journal: International journal of radiation oncology, biology, physics 20050701

Title: Vascular targeting and antiangiogenesis agents induce drug resistance effector GRP78 within the tumor microenvironment.

Journal: Cancer research 20050701

Title: Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A-41.

Journal: Journal of medicinal chemistry 20050616

Title: New antitubulin derivatives in the combretastatin A4 series: synthesis and biological evaluation.

Journal: Bioorganic & medicinal chemistry 20050601

Title: Synthesis and cytotoxic evaluation of combretafurazans.

Journal: Journal of medicinal chemistry 20050505

Title: Novel vascular targeting/disrupting agents: combretastatin A4 phosphate and related compounds.

Journal: Current oncology reports 20050301

Title: Tumour parameters affected by combretastatin A-4 phosphate therapy in a human colorectal xenograft model in nude mice.

Journal: European journal of cancer (Oxford, England : 1990) 20050301

Title: Antimitotic activity and reversal of breast cancer resistance protein-mediated drug resistance by stilbenoids from Bletilla striata.

Journal: Bioorganic & medicinal chemistry letters 20050215

Title: Phase I trial of combretastatin a-4 phosphate with carboplatin.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050215

Title: Heterocyclic and phenyl double-bond-locked combretastatin analogues possessing potent apoptosis-inducing activity in HL60 and in MDR cell lines.

Journal: Journal of medicinal chemistry 20050210

Title: Quantitative structure-activity relationship (5D-QSAR) study of combretastatin-like analogues as inhibitors of tubulin assembly.

Journal: Journal of medicinal chemistry 20050127

Title: Further naphthylcombretastatins. An investigation on the role of the naphthalene moiety.

Journal: Journal of medicinal chemistry 20050127

Title: Combretastatin A-4 prodrug in the treatment of a murine model of retinoblastoma.

Journal: Investigative ophthalmology & visual science 20050101

Title: Evaluation of anti-vascular therapy with texture analysis.

Journal: Anticancer research 20050101

Title: Combretastatin A-4 resistance in H460 human lung carcinoma demonstrates distinctive alterations in beta-tubulin isotype expression.

Journal: Anticancer research 20050101

Title: Arylthioindoles, potent inhibitors of tubulin polymerization.

Journal: Journal of medicinal chemistry 20041202

Title: The tubulin-binding agent combretastatin A-4-phosphate arrests endothelial cells in mitosis and induces mitotic cell death.

Journal: The American journal of pathology 20041001

Title: Combretastatin A4 phosphate: background and current clinical status.

Journal: Expert opinion on investigational drugs 20040901

Title: Consideration of QT/QTc interval data in a phase I study in patients with advanced cancer.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040901

Title: Concise synthesis and structure-activity relationships of combretastatin A-4 analogues, 1-aroylindoles and 3-aroylindoles, as novel classes of potent antitubulin agents.

Journal: Journal of medicinal chemistry 20040812

Title: A new family of quinoline and quinoxaline analogues of combretastatins.

Journal: Bioorganic & medicinal chemistry letters 20040716

Title: Vascular-targeting therapies for treatment of malignant disease.

Journal: Cancer 20040615

Title: Synthesis and structure-activity relationships of 3-aminobenzophenones as antimitotic agents.

Journal: Journal of medicinal chemistry 20040520

Title: Examination of the 1,4-disubstituted azetidinone ring system as a template for combretastatin A-4 conformationally restricted analogue design.

Journal: Bioorganic & medicinal chemistry letters 20040503

Title: Combretastatin A4 phosphate.

Journal: Anti-cancer drugs 20040301

Title: Comparative preclinical pharmacokinetic and metabolic studies of the combretastatin prodrugs combretastatin A4 phosphate and A1 phosphate.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040215

Title: Induction of tumour blood flow stasis and necrosis: a new function for epinephrine similar to that of combretastatin A-4 derivative AVE8062 (AC7700).

Journal: British journal of cancer 20040126

Title: Vascular targeting agents as cancer therapeutics.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040115

Title: Combretastatin A-4 phosphate enhances CPT-11 activity independently of the administration sequence.

Journal: European journal of cancer (Oxford, England : 1990) 20040101

Title: Cardiovascular safety profile of combretastatin a4 phosphate in a single-dose phase I study in patients with advanced cancer.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040101

Title: Abilities of 3,4-diarylfuran-2-one analogs of combretastatin A-4 to inhibit both proliferation of tumor cell lines and growth of relevant tumors in nude mice.

Journal: Anticancer research 20040101

Title: Synthesis and biological evaluation of 4-arylcoumarin analogues of combretastatins.

Journal: Journal of medicinal chemistry 20031204

Title: Phase I trial of the antivascular agent combretastatin A4 phosphate on a 5-day schedule to patients with cancer: magnetic resonance imaging evidence for altered tumor blood flow.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20031201

Title: Thrombosis and Hemostasis Issues in Cancer - Second International Conference. 19-21 September, 2003, Bergamo, Italy.

Journal: IDrugs : the investigational drugs journal 20031101

Title: Combretastatin A-4 analogues as antimitotic antitumor agents.

Journal: Current medicinal chemistry 20030901

Title: Antitumor activity of TZT-1027 (Soblidotin) against vascular endothelial growth factor-secreting human lung cancer in vivo.

Journal: Cancer science 20030901

Title: Assessment of pharmacodynamic vascular response in a phase I trial of combretastatin A4 phosphate.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030801

Title: Combretastatin A4 phosphate has tumor antivascular activity in rat and man as demonstrated by dynamic magnetic resonance imaging.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030801

Title: Combretastatin A-4 phosphate suppresses development and induces regression of choroidal neovascularization.

Journal: Investigative ophthalmology & visual science 20030801

Title: Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.

Journal: Journal of medicinal chemistry 20030717

Title: (E)-1-(2-Hydroxy-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene.

Journal: Acta crystallographica. Section C, Crystal structure communications 20030701

Title: Vascular targeting effect of combretastatin A-4 phosphate dominates the inherent angiogenesis inhibitory activity.

Journal: International journal of cancer 20030520

Title: Novel 6,7-diphenyl-2,3,8,8a-tetrahydro-1H-indolizin-5-one analogues as cytotoxic agents.

Journal: Bioorganic & medicinal chemistry letters 20030519

Title: Synthesis, in vitro, and in vivo evaluation of phosphate ester derivatives of combretastatin A-4.

Journal: Bioorganic & medicinal chemistry letters 20030505

Title: Synthesis, anticancer activity, and inhibition of tubulin polymerization by conformationally restricted analogues of lavendustin A.

Journal: Journal of medicinal chemistry 20030424

Title: Antineoplastic agents. 487. Synthesis and biological evaluation of the antineoplastic agent 3,4-methylenedioxy-5,4'-dimethoxy-3'-amino-Z-stilbene and derived amino acid amides.

Journal: Journal of medicinal chemistry 20030213

Title: Structure-activity and crystallographic analysis of benzophenone derivatives-the potential anticancer agents.

Journal: Bioorganic & medicinal chemistry letters 20030106

Title: Evaluation of antimitotic agents by quantitative comparisons of their effects on the polymerization of purified tubulin.

Journal: Cell biochemistry and biophysics 20030101

Title: Vascular targeting: a potential additional anti-cancer treatment.

Journal: Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie 20030101

Title: Oxi4503, a novel vascular targeting agent: effects on blood flow and antitumor activity in comparison to combretastatin A-4 phosphate.

Journal: Anticancer research 20030101

Title: The vascular targeting agent combretastatin A-4-phosphate induces neutrophil recruitment to endothelial cells in vitro.

Journal: Anticancer research 20030101

Title: Drug based approaches for targeting tumor vasculature: development of combretastatin A4 phosphate.

Journal: Pathophysiology of haemostasis and thrombosis 20030101

Title: The development of combretastatin A4 phosphate as a vascular targeting agent.

Journal: International journal of radiation oncology, biology, physics 20021201

Title: Combination of vascular targeting agents with thermal or radiation therapy.

Journal: International journal of radiation oncology, biology, physics 20021201

Title: Enhancement of vascular targeting by inhibitors of nitric oxide synthase.

Journal: International journal of radiation oncology, biology, physics 20021201

Title: Combretastatin A4 phosphate has primary antineoplastic activity against human anaplastic thyroid carcinoma cell lines and xenograft tumors.

Journal: Thyroid : official journal of the American Thyroid Association 20021201

Title: Schedule dependence of combretastatin A4 phosphate in transplanted and spontaneous tumour models.

Journal: International journal of cancer 20021101

Title: The vascular response of tumor and normal tissues in the rat to the vascular targeting agent, combretastatin A-4-phosphate, at clinically relevant doses.

Journal: International journal of oncology 20021001

Title: Combretastatin-A4 prodrug induces mitotic catastrophe in chronic lymphocytic leukemia cell line independent of caspase activation and poly(ADP-ribose) polymerase cleavage.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20020801

Title: A phase I pharmacokinetic and translational study of the novel vascular targeting agent combretastatin a-4 phosphate on a single-dose intravenous schedule in patients with advanced cancer.

Journal: Cancer research 20020615

Title: Antineoplastic agents. 465. Structural modification of resveratrol: sodium resverastatin phosphate.

Journal: Journal of medicinal chemistry 20020606

Title: Synthesis and structure-activity relationship of 2-aminobenzophenone derivatives as antimitotic agents.

Journal: Journal of medicinal chemistry 20020606

Title: One-pot synthesis of benzo[b]furan and indole inhibitors of tubulin polymerization.

Journal: Journal of medicinal chemistry 20020606

Title: Vascular targeting agents enhance chemotherapeutic agent activities in solid tumor therapy.

Journal: International journal of cancer 20020501

Title: Acute effects of vascular modifying agents in solid tumors assessed by noninvasive laser Doppler flowmetry and near infrared spectroscopy.

Journal: Neoplasia (New York, N.Y.) 20020501

Title: The influence of combretastatin A-4 and vinblastine on interstitial fluid pressure in BT4An rat gliomas.

Journal: Cancer letters 20020425

Title: Potent, orally active heterocycle-based combretastatin A-4 analogues: synthesis, structure-activity relationship, pharmacokinetics, and in vivo antitumor activity evaluation.

Journal: Journal of medicinal chemistry 20020411

Title: Differential sensitivity of two adenocarcinoma xenografts to the anti-vascular drugs combretastatin A4 phosphate and 5,6-dimethylxanthenone-4-acetic acid, assessed using MRI and MRS.

Journal: NMR in biomedicine 20020401

Title: Inhibition of proliferative retinopathy by the anti-vascular agent combretastatin-A4.

Journal: The American journal of pathology 20020301

Title: Synthesis and biological evaluation of 2-indolyloxazolines as a new class of tubulin polymerization inhibitors. Discovery of A-289099 as an orally active antitumor agent.

Journal: Bioorganic & medicinal chemistry letters 20020211

Title: The biology of the combretastatins as tumour vascular targeting agents.

Journal: International journal of experimental pathology 20020201

Title: Preclinical evaluations of therapies combining the vascular targeting agent combretastatin A-4 disodium phosphate and conventional anticancer therapies in the treatment of Kaposi's sarcoma.

Journal: Acta oncologica (Stockholm, Sweden) 20020101

Title: Activity of the vascular targeting agent combretastatin A-4 disodium phosphate in a xenograft model of AIDS-associated Kaposi's sarcoma.

Journal: Acta oncologica (Stockholm, Sweden) 20020101

Title: Anti-tumor and anti-vascular effects of the novel tubulin-binding agent combretastatin A-1 phosphate.

Journal: Anticancer research 20020101

Title: Critical assessment of angiogenesis inhibitors in clinical trials.

Journal: I supplementi di Tumori : official journal of Societa italiana di cancerologia ... [et al.] 20020101

Title: Tumor vasculature is targeted by the combination of combretastatin A-4 and hyperthermia.

Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20011201

Title: Novel syntheses of cis and trans isomers of combretastatin A-4.

Journal: The Journal of organic chemistry 20011130

Title: Combretastatin A-4 disodium phosphate: a vascular targeting agent that improves that improves the anti-tumor effects of hyperthermia, radiation, and mild thermoradiotherapy.

Journal: International journal of radiation oncology, biology, physics 20011115

Title: Antitumor Agents. 211. Fluorinated 2-phenyl-4-quinolone derivatives as antimitotic antitumor agents.

Journal: Journal of medicinal chemistry 20011108

Title: Potent anti-metastatic activity of combretastatin-A4.

Journal: International journal of oncology 20011001

Title: The susceptibility of tumors to the antivascular drug combretastatin A4 phosphate correlates with vascular permeability.

Journal: Cancer research 20010915

Title: The synthesis and tubulin binding activity of thiophene-based analogues of combretastatin A-4.

Journal: Bioorganic & medicinal chemistry letters 20010903

Title: Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: intravital microscopy and measurement of vascular permeability.

Journal: Cancer research 20010901

Title: Combretastatin A-4 and hyperthermia;a potent combination for the treatment of solid tumors.

Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20010801

Title: Interaction between combretastatin A-4 disodium phosphate and radiation in murine tumors.

Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20010801

Title: Eradication of colorectal xenografts by combined radioimmunotherapy and combretastatin a-4 3-O-phosphate.

Journal: Cancer research 20010615

Title: Combretastatin A-4 prodrug inhibits growth of human non-small cell lung cancer in a murine xenotransplant model.

Journal: The Annals of thoracic surgery 20010501

Title: Novel sulfonate analogues of combretastatin A-4: potent antimitotic agents.

Journal: Bioorganic & medicinal chemistry letters 20010409

Title: Combretastatin A4 prodrug study of effect on the growth and the microvasculature of colorectal liver metastases in a murine model.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20010401

Title: Specific targeting of cytosine deaminase to solid tumors by engineered Clostridium acetobutylicum.

Journal: Cancer gene therapy 20010401

Title: Combretastatin-A4 disrupts neovascular development in non-neoplastic tissue.

Journal: British journal of cancer 20010301

Title: Improvement of Clostridium tumour targeting vectors evaluated in rat rhabdomyosarcomas.

Journal: FEMS immunology and medical microbiology 20010201

Title: In vivo antitumor effect of vascular targeting combined with either ionizing radiation or anti-angiogenesis treatment.

Journal: International journal of radiation oncology, biology, physics 20010201

Title: Comparative effects of combretastatin A-4 disodium phosphate and 5,6-dimethylxanthenone-4-acetic acid on blood perfusion in a murine tumour and normal tissues.

Journal: International journal of radiation biology 20010201

Title: Design, synthesis, and biological evaluation of a series of lavendustin A analogues that inhibit EGFR and Syk tyrosine kinases, as well as tubulin polymerization.

Journal: Journal of medicinal chemistry 20010201

Title: Targeting tumour vasculature: the development of combretastatin A4.

Journal: The Lancet. Oncology 20010201

Title: Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers.

Journal: Bioorganic & medicinal chemistry letters 20010108

Title: Combretastatin A-4 and doxorubicin combination treatment is effective in a preclinical model of human medullary thyroid carcinoma.

Journal: Oncology reports 20010101

Title: Stoppage of blood flow in 3-methylcholanthrene-induced autochthonous primary tumor due to a novel combretastatin A-4 derivative, AC7700, and its antitumor effect.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20010101

Title: Evaluation of combretastatin A-4 prodrug in a non-Hodgkin's lymphoma xenograft model: preclinical efficacy.

Journal: Anti-cancer drugs 20010101

Title: Effects of combretastatin A4 phosphate on endothelial cell morphology in vitro and relationship to tumour vascular targeting activity in vivo.

Journal: Anticancer research 20010101

Title: 6-Alkylamino- and 2,3-dihydro-3'-methoxy-2-phenyl-4-quinazolinones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.

Journal: Journal of medicinal chemistry 20001116

Title: Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4.

Journal: Experientia 19890215

Title: Interactions of tubulin with potent natural and synthetic analogs of the antimitotic agent combretastatin: a structure-activity study.

Journal: Molecular pharmacology 19880801

Title: Tochinai R, et al. Combretastatin A4 disodium phosphate-induced myocardial injury. J Toxicol Pathol. 2016 Jul;29(3):163-71.

Title: Signoretto E, et al. Stimulation of Eryptosis by Combretastatin A4 Phosphate Disodium (CA4P). Cell Physiol Biochem. 2016;38(3):969-8

Title: Zhu J, et al. Co-Encapsulation of Combretastatin-A4 Phosphate and Doxorubicin in Polymersomes for Synergistic Therapy of Nasopharyngeal Epidermal Carcinoma. J Biomed Nanotechnol. 2015 Jun;11(6):997-1006.

Title: Yao N, et al. Combretastatin A4 phosphate treatment induces vasculogenic mimicry formation of W256 breast carcinoma tumor in vitro and in vivo. Tumour Biol. 2015 Nov;36(11):8499-510

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Tags:117048-59-6 Molecular Formula|117048-59-6 MDL|117048-59-6 SMILES|117048-59-6 Combretastatin A4