Home Fluorides 1173022-16-6
1173022-16-6,MFCD08703093
Catalog No.:AA000E0S

1173022-16-6 | Spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one, 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-, hydrochloride (1:1)

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1mg
≥98%
in stock  
$49.00   $34.00
- +
5mg
≥98%
in stock  
$122.00   $85.00
- +
10mg
≥98%
in stock  
$190.00   $133.00
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25mg
≥98%
in stock  
$412.00   $288.00
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50mg
in stock  
$700.00   $490.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA000E0S
Chemical Name:
Spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one, 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-, hydrochloride (1:1)
CAS Number:
1173022-16-6
Molecular Formula:
C21H22ClF3N2O2
Molecular Weight:
426.8598
MDL Number:
MFCD08703093
SMILES:
O=C1Nc2ccccc2C2(O1)CCN(CC2)CCc1ccc(cc1)C(F)(F)F.Cl
Properties
Computed Properties
 
Complexity:
552  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  

Literature

Title: Role of human pulmonary fibroblast-derived MCP-1 in cell activation and migration in experimental silicosis.

Journal: Toxicology and applied pharmacology 20151015

Title: Involvement of CCR-2 chemokine receptor activation in ischemic preconditioning and postconditioning of brain in mice.

Journal: Cytokine 20121001

Title: Monocyte chemoattractant protein-1 mediates angiotensin II-induced vascular smooth muscle cell proliferation via SAPK/JNK and ERK1/2.

Journal: Molecular and cellular biochemistry 20120701

Title: Ammonium pyrrolidine dithiocarbamate and RS 102895 attenuate opioid withdrawal in vivo and in vitro.

Journal: Psychopharmacology 20120301

Title: Mirzadegan T, et al. Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundle. J Biol Chem. 2000 Aug 18;275(33):25562-71.

Title: Park J, et al. MCP-1/CCR2 system is involved in high glucose-induced fibronectin and type IV collagen expression in cultured mesangial cells. Am J Physiol Renal Physiol. 2008 Sep;295(3):F749-57.

Title: Ren F, et al. Analgesic Effect of Intrathecal Administration of Chemokine Receptor CCR2 Antagonist is Related to Change in Spinal NR2B, nNOS, and SIGIRR Expression in Rat with Bone Cancer Pain. Cell Biochem Biophys. 2015 Jun;72(2):611-6.

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SDS
Tags:1173022-16-6 Molecular Formula|1173022-16-6 MDL|1173022-16-6 SMILES|1173022-16-6 Spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one, 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-, hydrochloride (1:1)