Home Amines 117354-64-0
117354-64-0,MFCD00069282
Catalog No.:AA000E2M

117354-64-0 | Benzeneethanesulfonic acid, β-(aminomethyl)-4-chloro-β-hydroxy-

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2.5mg
2 weeks  
$495.00   $347.00
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA000E2M
Chemical Name:
Benzeneethanesulfonic acid, β-(aminomethyl)-4-chloro-β-hydroxy-
CAS Number:
117354-64-0
Molecular Formula:
C9H12ClNO4S
Molecular Weight:
265.7139
MDL Number:
MFCD00069282
SMILES:
NCC(c1ccc(cc1)Cl)(CS(=O)(=O)O)O
Properties
Computed Properties
 
Complexity:
321  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
4  
Undefined Atom Stereocenter Count:
1  
XLogP3:
-2.8  

Literature

Title: GABA(B) receptors involvement in the effects induced by nicotine on anxiety-related behaviour in mice.

Journal: Pharmacological research 20120501

Title: Effects of GABAB receptor agonists and antagonists on glycemia regulation in mice.

Journal: European journal of pharmacology 20120227

Title: Involvement of hypothalamic periventricular GABAergic nerves in the central pressor response to clonidine in freely-moving conscious rats.

Journal: Journal of pharmacological sciences 20120101

Title: The GABA-B antagonist 2-hydroxysaclofen reverses the effects of baclofen on the discriminative stimulus effects of D-amphetamine in the conditioned taste aversion procedure.

Journal: Pharmacology, biochemistry, and behavior 20090701

Title: Changes in the properties of allosteric and orthosteric GABAB receptor ligands after a continuous, desensitizing agonist pretreatment.

Journal: European journal of pharmacology 20090128

Title: Role of GABA B receptors in the endomorphin-1-, but not endomorphin-2-, induced dopamine efflux in the nucleus accumbens of freely moving rats.

Journal: European journal of pharmacology 20080310

Title: Contribution of ventral tegmental GABA receptors to cocaine self-administration in rats.

Journal: Neurochemical research 20080301

Title: The metabotropic glutamate receptor 7 (mGluR7) allosteric agonist AMN082 modulates nucleus accumbens GABA and glutamate, but not dopamine, in rats.

Journal: Neuropharmacology 20080301

Title: Posterior hypothalamic GABAergic mediation of hippocampal theta in the cat.

Journal: Brain research bulletin 20070712

Title: Gamma-aminobutyric acid (GABA) receptor mediates suanzaorentang, a traditional Chinese herb remedy, -induced sleep alteration.

Journal: Journal of biomedical science 20070301

Title: Orexin A in the rostrolateral hypothalamic area induces feeding by modulating GABAergic transmission.

Journal: Brain research 20061213

Title: The supramammillary nucleus mediates primary reinforcement via GABA(A) receptors.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20050601

Title: GABAB receptors in the medial septum/diagonal band slice from 16-25 day rat.

Journal: Neuroscience 20050101

Title: Contribution of Ih and GABAB to synaptically induced afterhyperpolarizations in CA1: a brake on the NMDA response.

Journal: Journal of neurophysiology 20041001

Title: Peripheral GABAB agonists stimulate gastric acid secretion in mice.

Journal: British journal of pharmacology 20040701

Title: Activaton of GABAB receptor inhibits the excitability of rat small diameter trigeminal root ganglion neurons.

Journal: Neuroscience 20040101

Title: Gamma-aminobutyric acid neuropharmacological investigations on narcosis produced by nitrogen, argon, or nitrous oxide.

Journal: Anesthesia and analgesia 20030301

Title: Baclofen analgesia: involvement of the GABAergic system.

Journal: Pharmacological research 20020901

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Synaptic mechanisms regulating the activation of a Ca(2+)-mediated plateau potential in developing relay cells of the LGN.

Journal: Journal of neurophysiology 20020301

Title: GABA receptors modulate trigeminovascular nociceptive neurotransmission in the trigeminocervical complex.

Journal: British journal of pharmacology 20011001

Title: [Current responses mediated by endogenous GABA(B) and GABA(C) receptors in Xenopus oocytes].

Journal: Sheng li xue bao : [Acta physiologica Sinica] 20010801

Title: Sequence dependence of post-tetanic potentiation after sequential heterosynaptic stimulation in the rat auditory cortex.

Journal: The Journal of physiology 20010601

Title: Involvement of pallidothalamic circuitry in working memory.

Journal: Neuroscience 20010101

Title: Pretreatment of rat brain synaptosomes with GABA increases subsequent GABA uptake via GABA(B) receptor activation.

Journal: Neurochemical research 20010101

Title: Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.

Journal: Nature 19970320

Title: Hypotensive and hypertensive effects of catecholamines intrathecally injected in anesthetized rats.

Journal: Journal of the autonomic nervous system 19960610

Title: Involvement of cholinergic systems in the deficit of place learning in Morris water maze task induced by baclofen in rats.

Journal: Brain research 19950619

Title: 2-Hydroxy-saclofen: an improved antagonist at central and peripheral GABAB receptors.

Journal: Neuroscience letters 19880923

Title: Varani AP, et al. Baclofen and 2-hydroxysaclofen modify acute hypolocomotive and antinociceptive effects of nicotine. Eur J Pharmacol. 2014 Sep 5;738:200-5.

Title: Miranda F, et al. The GABA-B antagonist 2-hydroxysaclofen reverses the effects of baclofen on the discriminative stimulus effects of D-amphetamine in the conditioned taste aversion procedure. Pharmacol Biochem Behav. 2009 Jul;93(1):25-30.

Title: Akema T, et al. 2-Hydroxysaclofen, a potent GABAB receptor antagonist, stimulates luteinizing hormone secretion in female rats. Brain Res. 1991 Apr 12;546(1):143-5.

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Tags:117354-64-0 Molecular Formula|117354-64-0 MDL|117354-64-0 SMILES|117354-64-0 Benzeneethanesulfonic acid, β-(aminomethyl)-4-chloro-β-hydroxy-