Home Other Building Blocks 1173699-31-4
1173699-31-4,MFCD29472283
Catalog No.:AA000E3A

1173699-31-4 | Amg-337

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
in stock  
$35.00   $25.00
- +
5mg
98+%
in stock  
$85.00   $60.00
- +
10mg
98+%
in stock  
$126.00   $89.00
- +
1g
98+%
in stock  
$7,957.00   $5,570.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA000E3A
Chemical Name:
Amg-337
CAS Number:
1173699-31-4
Molecular Formula:
C23H22FN7O3
Molecular Weight:
463.4643
MDL Number:
MFCD29472283
SMILES:
COCCOc1cnc2c(c1)c(=O)n(cc2)[C@@H](c1nnc2n1cc(cc2F)c1cnn(c1)C)C
Properties
Computed Properties
 
Complexity:
760  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
8  
Rotatable Bond Count:
7  
XLogP3:
1.5  

Downstream Synthesis Route

[1]CurrentPatentAssignee:AMGENINC-WO2014/210042,2014,A2Locationinpatent:Paragraph00273-00278

[1]CurrentPatentAssignee:AMGENINC-WO2014/210042,2014,A2Locationinpatent:Paragraph00279-00284

[1]CurrentPatentAssignee:AMGENINC-WO2014/210042,2014,A2

[1]CurrentPatentAssignee:AMGENINC-WO2014/210042,2014,A2

[1]CurrentPatentAssignee:AMGENINC-WO2014/210042,2014,A2

Literature

Title: Paul E. Hughes, et al. AMG 337, a novel, potent and selective MET kinase inhibitor, has robust growth inhibitory activity in MET-dependent cancer models. Cancer Res October 1, 2014 74; 728

Title: Cecchi F, et al. Targeting the HGF/Met signaling pathway in cancer therapy. Expert Opin Ther Targets. 2012 Jun;16(6):553-572.

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SDS
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Tags:1173699-31-4 Molecular Formula|1173699-31-4 MDL|1173699-31-4 SMILES|1173699-31-4 Amg-337