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1175-06-0,MFCD00003572
Catalog No.:AA000EAS

1175-06-0 | Cholestan-6-one, 3-hydroxy-, (3β,5α)-

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5mg
98%
1 week  
$304.00   $213.00
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10mg
98%
1 week  
$447.00   $313.00
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA000EAS
Chemical Name:
Cholestan-6-one, 3-hydroxy-, (3β,5α)-
CAS Number:
1175-06-0
Molecular Formula:
C27H46O2
Molecular Weight:
402.6529
MDL Number:
MFCD00003572
SMILES:
CC(CCC[C@H]([C@H]1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CC(=O)[C@@H]2[C@]1(C)CC[C@@H](C2)O)C)C
Properties
Computed Properties
 
Complexity:
612  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
9  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
7.7  

Literature

Title: Probing amphotericin B single channel activity by membrane dipole modifiers.

Journal: PloS one 20120101

Title: The local electric field within phospholipid membranes modulates the charge transfer reactions in reaction centres.

Journal: Biochimica et biophysica acta 20090801

Title: Effect of agents modifying the membrane dipole potential on properties of syringomycin E channels.

Journal: Langmuir : the ACS journal of surfaces and colloids 20070619

Title: Comparison of excitation and emission ratiometric fluorescence methods for quantifying the membrane dipole potential.

Journal: Biochimica et biophysica acta 20070101

Title: Effect of cholesterol on the interaction of the HIV GP41 fusion peptide with model membranes. Importance of the membrane dipole potential.

Journal: Biochemistry 20061226

Title: Effect of the mitochondrial transition pore inhibitor, S-15176, on rat liver mitochondria: ATP synthase modulation and mitochondrial uncoupling induction.

Journal: Biochemical pharmacology 20060928

Title: Phlorizin- and 6-ketocholestanol-mediated antagonistic modulation of alamethicin activity in phospholipid planar membranes.

Journal: Langmuir : the ACS journal of surfaces and colloids 20060926

Title: Agaric acid induces mitochondrial permeability transition through its interaction with the adenine nucleotide translocase. Its dependence on membrane fluidity.

Journal: Mitochondrion 20050801

Title: Two-color fluorescent probes for imaging the dipole potential of cell plasma membranes.

Journal: Biochimica et biophysica acta 20050630

Title: Interaction of phloretin and 6-ketocholestanol with DPPC-liposomes as phospholipid model membranes.

Journal: International journal of pharmaceutics 20050427

Title: Influence of 6-ketocholestanol on skin permeation of 5-aminolevulinic acid and evaluation of chemical stability.

Journal: Journal of pharmaceutical sciences 20041101

Title: Phloretin and 6-ketocholestanol: membrane interactions studied by a phospholipid/polydiacetylene colorimetric assay and differential scanning calorimetry.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20040301

Title: Sterol structure and sphingomyelin acyl chain length modulate lateral packing elasticity and detergent solubility in model membranes.

Journal: Biophysical journal 20031201

Title: Influence of molecular dipoles on human skin permeability: Use of 6-ketocholestanol to enhance the transdermal delivery of bacitracin.

Journal: Journal of pharmaceutical sciences 20030501

Title: Influence of phloretin and 6-ketocholestanol on the skin permeation of sodium-fluorescein.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20030429

Title: Influence of lipophilic counter-ions in combination with phloretin and 6-ketocholestanol on the skin permeation of 5-aminolevulinic acid.

Journal: International journal of pharmaceutics 20030414

Title: Pore formation by 6-ketocholestanol in phospholipid monolayers and its interpretation by a general nucleation-and-growth model accounting for the sigmoidal shape of voltage-clamp curves of ion channels.

Journal: Journal of the American Chemical Society 20030402

Title: Effects of the membrane dipole potential on the interaction of saquinavir with phospholipid membranes and plasma membrane receptors of Caco-2 cells.

Journal: The Journal of biological chemistry 20011019

Title: Effects of oxygenated sterol on phospholipid bilayer properties: a molecular dynamics simulation.

Journal: Chemistry and physics of lipids 20010701

Title: Influence of phloretin and 6-ketocholestanol on the permeation of progesterone through porcine skin.

Journal: International journal of pharmaceutics 20010417

Title: Effect of phloretin on ionophore mediated electroneutral transmembrane translocations of H(+), K(+) and Na(+) in phospholipid vesicles.

Journal: Biochimica et biophysica acta 20010209

Title: Control of a redox reaction on lipid bilayer surfaces by membrane dipole potential.

Journal: Biophysical journal 20010101

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Tags:1175-06-0 Molecular Formula|1175-06-0 MDL|1175-06-0 SMILES|1175-06-0 Cholestan-6-one, 3-hydroxy-, (3β,5α)-