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117704-25-3,MFCD00894747
Catalog No.:AA00388H

117704-25-3 | 25-Cyclohexyl-5-O-demethyl-25-de(1-methylpropyl)avermectin A1a

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1g
95%
in stock  
$24.00   $17.00
- +
5g
95%
in stock  
$64.00   $45.00
- +
25g
95%
in stock  
$239.00   $167.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00388H
Chemical Name:
25-Cyclohexyl-5-O-demethyl-25-de(1-methylpropyl)avermectin A1a
CAS Number:
117704-25-3
Molecular Formula:
C50H74O14
Molecular Weight:
899.1142
MDL Number:
MFCD00894747
SMILES:
CO[C@H]1C[C@@H](O[C@H]([C@@H]1O[C@H]1C[C@H](OC)[C@H]([C@@H](O1)C)O)C)O[C@H]1[C@@H](C)/C=C/C=C/2\CO[C@H]3[C@]2(O)[C@@H](C=C([C@H]3O)C)C(=O)O[C@H]2C[C@@H](C/C=C/1\C)O[C@]1(C2)C=C[C@@H]([C@H](O1)C1CCCCC1)C
Properties
Computed Properties
 
Complexity:
1790  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
19  
Defined Bond Stereocenter Count:
3  
Heavy Atom Count:
64  
Hydrogen Bond Acceptor Count:
14  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
7  
XLogP3:
4.5  

Literature

Title: Differential modulation of FXR activity by chlorophacinone and ivermectin analogs.

Journal: Toxicology and applied pharmacology 20161215

Title: Identification of potential biomarkers of P-glycoprotein substrate neurotoxicity in transgenic mice expressing the mutated canine ABCB1 gene.

Journal: American journal of veterinary research 20141201

Title: Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor.

Journal: Scientific reports 20140101

Title: Moxidectin has a lower neurotoxic potential but comparable brain penetration in P-glycoprotein-deficient CF-1 mice compared to ivermectin.

Journal: Journal of veterinary pharmacology and therapeutics 20130601

Title: P-gp substrate-induced neurotoxicity in an Abcb1a knock-in/Abcb1b knock-out mouse model with a mutated canine ABCB1 targeted insertion.

Journal: Research in veterinary science 20130601

Title: Efficacy of two avermectins, doramectin and ivermectin against Argulus siamensis infestation in Indian major carp, Labeo rohita.

Journal: Veterinary parasitology 20121123

Title: Successful resolution of oesophageal spirocercosis in 20 dogs following daily treatment with oral doramectin.

Journal: Veterinary journal (London, England : 1997) 20120701

Title: Doramectin resistance in Haemonchus contortus on an alpaca farm in Belgium.

Journal: Veterinary parasitology 20120430

Title: Comparative in vitro characterization of moxidectin and doramectin percutaneous absorption through bovine skin.

Journal: Journal of veterinary pharmacology and therapeutics 20120401

Title: Analysis of doramectin in the serum of repeatedly treated pastured cattle used to predict the probability of cattle fever ticks (Acari: Ixodidae) feeding to repletion.

Journal: Experimental & applied acarology 20120401

Title: Lethal and sublethal effects of avermectin/milbemycin parasiticides on the African malaria vector, Anopheles arabiensis.

Journal: Journal of medical entomology 20120301

Title: Cooperia punctata: effect on cattle productivity?

Journal: Veterinary parasitology 20120210

Title: Four new doramectin congeners with acaricidal and insecticidal activity from Streptomyces avermitilis NEAU1069.

Journal: Chemistry & biodiversity 20111101

Title: Potential diffusion of doramectin into a soil amended with female pig manure. A field experiment.

Journal: Journal of agricultural and food chemistry 20111012

Title: A comparison of the efficacy of subcutaneously administered ivermectin, doramectin, and moxidectin against naturally infected Toxocara vitulorum in calves.

Journal: Tropical animal health and production 20110801

Title: Two new doramectin analogs from Streptomyces avermitilis NEAU1069: fermentation, isolation and structure elucidation.

Journal: The Journal of antibiotics 20110801

Title: Influence of P-glycoprotein inhibition on secretion of ivermectin and doramectin by milk in lactating sheep.

Journal: Veterinary parasitology 20110630

Title: Production of doramectin by rational engineering of the avermectin biosynthetic pathway.

Journal: Bioorganic & medicinal chemistry letters 20110601

Title: Therapeutic efficacy of Dormectin, Ivermectin and Levamisole against different stages of Trichinella spiralis in rats.

Journal: Turkiye parazitolojii dergisi 20110101

Title: The influence of gastrointestinal parasitism on fecal elimination of doramectin, in lambs.

Journal: Ecotoxicology and environmental safety 20101101

Title: Generalized demodecosis in three sibling, juvenile rock hyraxes (Procavia capensis).

Journal: Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20100901

Title: Resistance of gastrointestinal nematodes of sheep to some anthelmintics.

Journal: Journal of the Egyptian Society of Parasitology 20100801

Title: Efficacy of weekly oral doramectin treatment in canine demodicosis.

Journal: The Veterinary record 20100710

Title: Plasma disposition and fecal elimination of doramectin after oral or intramuscular administration in horses.

Journal: Veterinary parasitology 20100528

Title: Plasma dispositions of ivermectin, doramectin and moxidectin following subcutaneous administration in rabbits.

Journal: Laboratory animals 20100401

Title: Reversal of P-glycoprotein-mediated multidrug resistance in vitro by doramectin and nemadectin.

Journal: The Journal of pharmacy and pharmacology 20100301

Title: Effects of avermectins on neurite outgrowth in differentiating mouse neuroblastoma N2a cells.

Journal: Toxicology letters 20100201

Title: Factors influencing dissipation of avermectins in sheep faeces.

Journal: Ecotoxicology and environmental safety 20100101

Title: Comparison of efficacy of ivermectin and doramectin against mange mite (Sarcoptes scabiei) in naturally infested rabbits in Turkey.

Journal: Veterinaria italiana 20100101

Title: Construction of a doramectin producer mutant from an avermectin-overproducing industrial strain of Streptomyces avermitilis.

Journal: Canadian journal of microbiology 20091201

Title: Comparative therapeutic effect of moxidectin, doramectin and ivermectin on psoroptes mites infestation in buffalo (Bubalus bubalis).

Journal: Tropical animal health and production 20091001

Title: Residue depletion of doramectin in rabbit tissues after subcutaneous administration.

Journal: Journal of food protection 20091001

Title: Pharmacokinetics of doramectin in rabbits after subcutaneous administration.

Journal: Journal of veterinary pharmacology and therapeutics 20090801

Title: Effects of faecal residues of moxidectin and doramectin on the activity of arthropods in cattle dung.

Journal: Ecotoxicology and environmental safety 20090701

Title: The acute effects of single-dose orally administered doramectin, eprinomectin and selamectin on natural infections of Syphacia muris in rats.

Journal: Experimental parasitology 20090701

Title: The efficiency of avermectins (abamectin, doramectin and ivermectin) in the control of Boophilus microplus, in artificially infested bovines kept in field conditions.

Journal: Veterinary parasitology 20090526

Title: Relative inefficacy of pour-on macrocyclic lactone anthelmintic treatments against Cooperia species in Highland calves.

Journal: The Veterinary record 20090509

Title: Rapid method for multi-residue determination of avermectins in bovine liver using high-performance liquid chromatography with fluorescence detection.

Journal: Bulletin of environmental contamination and toxicology 20090401

Title: A sustained release gel formulation of doramectin for control of lone star ticks (Acari: Ixodidae) and horn flies (Diptera: Muscidae) on cattle.

Journal: Journal of economic entomology 20090401

Title: Efficacy of eprinomectin and doramectin against Amblyomma americanum (Acari: Ixodidae) on cattle.

Journal: Journal of economic entomology 20090401

Title: A comparative kinetic study of doramectin and moxidectin in zebu Gobra cattle (Bos indicus).

Journal: Parasitology research 20081101

Title: The curative and antioxidative efficiency of doramectin and doramectin+vitamin AD3E treatment on Psoroptes cuniculi infestation in rabbits.

Journal: Research in veterinary science 20081001

Title: Efficacy of doramectin against natural and experimental infections of Lernaea cyprinacea in carps.

Journal: Veterinary parasitology 20081001

Title: Endectocide activity of a new long-action formulation containing 2.25% ivermectin+1.25% abamectin in cattle.

Journal: Veterinary parasitology 20080817

Title: Spirocerca lupi infection in the dog: a review.

Journal: Veterinary journal (London, England : 1997) 20080601

Title: A comparison of the efficacy of doramectin, closantel and levamisole in the treatment of the 'oriental eye fluke', Philophthalmus gralli, in commercially reared ostriches (Struthio camelus).

Journal: Journal of the South African Veterinary Association 20080601

Title: Patterns of doramectin tissue residue depletion in parasitized vs nonparasitized lambs.

Journal: Parasitology research 20080401

Title: Pattern of ivermectin (sheep) and doramectin (cattle) residues in muscular tissue from various anatomical locations.

Journal: Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20080401

Title: [Parafilariasis, are we seeing it again in 2008?].

Journal: Tijdschrift voor diergeneeskunde 20080301

Title: Toxicity of abamectin and doramectin to soil invertebrates.

Journal: Environmental pollution (Barking, Essex : 1987) 20080101

Title: Endectocide residues affect insect attraction to dung from treated cattle: implications for toxicity tests.

Journal: Medical and veterinary entomology 20071201

Title: Detection of the nt230(del4) MDR1 mutation in White Swiss Shepherd dogs: case reports of doramectin toxicosis, breed predisposition, and microsatellite analysis.

Journal: Journal of veterinary pharmacology and therapeutics 20071001

Title: Comparative study of doramectin and fipronil in the treatment of equine chorioptic mange.

Journal: The Veterinary record 20070908

Title: Comparative efficacy of different anthelmintics against fenbendazole-resistant nematodes of pashmina goats.

Journal: Veterinary research communications 20070801

Title: Aberrant extradural spinal migration of Spirocerca lupi: four dogs.

Journal: The Journal of small animal practice 20070501

Title: A screening level index for assessing the impacts of veterinary medicines on dung flies.

Journal: Environmental science & technology 20070401

Title: Doramectin and albendazole resistance in sheep in The Netherlands.

Journal: Veterinary parasitology 20070315

Title: Efficacy of a single doramectin injection against adult female Boophilus microplus (Acari: Ixodidae) in the final stages of engorgement before detachment.

Journal: Journal of medical entomology 20070301

Title: The derivatisation of avermectins and milbemycins in milk: new insights and improvement of the procedure.

Journal: Analytica chimica acta 20070227

Title: A field study on the efficacy of doramectin against strongyles and its egg reappearance period in horses.

Journal: DTW. Deutsche tierarztliche Wochenschrift 20070201

Title: Gastrointestinal parasitism reduces the plasma availability of doramectin in lambs.

Journal: Veterinary journal (London, England : 1997) 20070101

Title: Interaction of macrocyclic lactones with P-glycoprotein: structure-affinity relationship.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20070101

Title: Fecal egg count reductions and performance effect of Dectomax, Cydectin, and Cydectin plus Synanthic as used in feedlot steers.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20070101

Title: A 3-year field evaluation of pasture rotation and supplementary feeding to control parasite infection in first-season grazing cattle--effects on animal performance.

Journal: Veterinary parasitology 20061220

Title: Survey of parasite control on beef farms in south-west England.

Journal: The Veterinary record 20061111

Title: Time profile of abamectin and doramectin excretion and degradation in sheep faeces.

Journal: Environmental pollution (Barking, Essex : 1987) 20061101

Title: Effects of mid-season avermectin treatments on pyrethroid resistance in horn fly (Diptera: Muscidae) populations at three locations in Louisiana.

Journal: Veterinary parasitology 20061010

Title: Comparison of scratching behaviour of growing pigs with sarcoptic mange before and after treatment, employing two distinct approaches.

Journal: Veterinary parasitology 20060910

Title: A fenbendazole oral drench in addition to an ivermectin pour-on reduces parasite burden and improves feedlot and carcass performance of finishing heifers compared with endectocides alone.

Journal: Journal of animal science 20060801

Title: [A case of very serious Sarcoptes mange in alpacas (Lama pacos)].

Journal: Tijdschrift voor diergeneeskunde 20060415

Title: A method for sheep scab control by applying selective treatment based on flock serology.

Journal: Veterinary parasitology 20060331

Title: Comparative plasma dispositions of ivermectin and doramectin following subcutaneous and oral administration in dogs.

Journal: Veterinary parasitology 20060218

Title: Determination of abamectin, doramectin, emamectin, eprinomectin, ivermectin, and moxidectin in milk by liquid chromatography electrospray tandem mass specrometry.

Journal: Journal of AOAC International 20060101

Title: Multiresidue analysis of avermectins in cattle liver by liquid chromatography/tandem mass spectrometry.

Journal: Journal of AOAC International 20060101

Title: [Sarcoptes scabiei var. suis in a closed pig breeding and fattening herd and control possibilities after treatment].

Journal: Berliner und Munchener tierarztliche Wochenschrift 20060101

Title: Plasma pharmacokinetics and faecal excretion of ivermectin (Eqvalan paste) and doramectin (Dectomax, 1%) following oral administration in donkeys.

Journal: Research in veterinary science 20051201

Title: Tolerance of therapeutic doses of abamectin and doramectin in Istrian Pramenka sheep.

Journal: Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20051201

Title: Doramectin concentration profiles in the gastrointestinal tract of topically-treated calves: Influence of animal licking restriction.

Journal: Veterinary parasitology 20051010

Title: Use of doramectin for treatment of sarcoptic mange in five Angora rabbits.

Journal: Veterinary dermatology 20050801

Title: Degradation of abamectin and doramectin on sheep grazed pasture.

Journal: Ecotoxicology (London, England) 20050801

Title: Association of the kdr and superkdr sodium channel mutations with resistance to pyrethroids in Louisiana populations of the horn fly, Haematobia irritans irritans (L.).

Journal: Veterinary parasitology 20050420

Title: Persistent efficacy of doramectin against Haemonchus contortus in goats.

Journal: The Veterinary record 20050402

Title: Semi-synthetic DNA shuffling of aveC leads to improved industrial scale production of doramectin by Streptomyces avermitilis.

Journal: Metabolic engineering 20050101

Title: Multiresidue analysis of avermectins in bovine liver by immunoaffinity column cleanup procedure and liquid chromatography with fluorescence detector.

Journal: Journal of AOAC International 20050101

Title: [Post-embrionic development of Stomoxys calcitrans (Linnaeus,1758) (Diptera: Muscidae)feed in feces of treated bovines with different avermectins].

Journal: Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria 20050101

Title: Endectocide exchanges between grazing cattle after pour-on administration of doramectin, ivermectin and moxidectin.

Journal: International journal for parasitology 20041001

Title: Depletion rate of doramectin from blood serum of penned female white-tailed deer (Artiodactyla: Cervidae).

Journal: Journal of medical entomology 20040901

Title: The pharmacokinetics of topical doramectin in llamas (Lama glama) and alpacas (Lama pacos).

Journal: Journal of veterinary pharmacology and therapeutics 20040601

Title: Amphids: the neuronal ultrastructure of macrocyclic-lactone-resistant Haemonchus contortus.

Journal: Parassitologia 20040601

Title: Therapeutic and persistent efficacy of a single application of doramectin applied either as a pour-on or injection to cattle infested with Boophilus microplus (Acari: Ixodidae).

Journal: Journal of medical entomology 20040501

Title: Dectomax injectable solution for cattle and sheep.

Journal: The Veterinary record 20040313

Title: Determination of abamectin and doramectin in sheep faeces using HPLC with fluorescence detection.

Journal: Biomedical chromatography : BMC 20040301

Title: [Outbreak of sheep scab on two adjacent common alpine pastures in the canton of Schwyz (Switzerland)].

Journal: Schweizer Archiv fur Tierheilkunde 20040201

Title: Pharmacokinetic evaluation of four ivermectin generic formulations in calves.

Journal: Veterinary parasitology 20040130

Title: Doramectin toxicity in a collie.

Journal: The Veterinary record 20031206

Title: Spirocerca lupi in dogs: prophylactic effect of doramectin.

Journal: Research in veterinary science 20031201

Title: Assessment of cypermethrin and doramectin for controlling wohlfahrtiosis in Crete.

Journal: Veterinary parasitology 20031030

Title: The comparative serum disposition kinetics of subcutaneous administration of doramectin, ivermectin and moxidectin in the Australian Merino sheep.

Journal: Journal of veterinary pharmacology and therapeutics 20031001

Title: Fly larvicidal activity in the faeces of cattle and pigs treated with endectocide products.

Journal: Medical and veterinary entomology 20030901

Title: Anthelmintic treatment in horses: the extra-label use of products and the danger of under-dosing.

Journal: Journal of the South African Veterinary Association 20030601

Title: Detection of antibodies in sera of weaned pigs after contact infection with Sarcoptes scabiei var. suis and after treatment with an antiparasitic agent by three different indirect ELISAs.

Journal: Veterinary parasitology 20030515

Title: Disposition of doramectin milk residues in lactating dairy sheep.

Journal: Journal of agricultural and food chemistry 20030507

Title: Engineering the aveC gene to enhance the ratio of doramectin to its CHC-B2 analogue produced in Streptomyces avermitilis.

Journal: Biotechnology and bioengineering 20030505

Title: Simultaneous determination of residual antiparasitic lactones in bovine muscle and liver by liquid chromatography with fluorescence detection.

Journal: Journal of AOAC International 20030101

Title: Efficacy of a new long-acting formulation of ivermectin and other injectable avermectins against induced Psoroptes ovis infestations in cattle.

Journal: Parasitology research 20021201

Title: Reductions of non-pest insects in dung of cattle treated with endectocides: a comparison of four products.

Journal: Bulletin of entomological research 20021201

Title: Evaluation of doramectin for the treatment of experimental canine spirocercosis.

Journal: Veterinary parasitology 20021016

Title: Possible anxiolytic effects of ivermectin in rats.

Journal: Veterinary research communications 20020601

Title: Dirofilaria repens infection in a dog: diagnosis and treatment with melarsomine and doramectin.

Journal: Veterinary parasitology 20020430

Title: Benefit of the control of gastrointestinal nematode infection in goats in the dry zone of Sri Lanka.

Journal: Journal of veterinary medicine. B, Infectious diseases and veterinary public health 20020401

Title: Pharmacokinetics of doramectin and ivermectin after oral administration in horses.

Journal: Veterinary journal (London, England : 1997) 20020301

Title: Validation of a simple liquid chromatographic method for determination and quantitation of residual ivermectin and doramectin in pig liver.

Journal: Journal of AOAC International 20020101

Title: Elimination of mange mites Sarcoptes scabiei var. suis from two naturally infested Danish sow herds using a single injection regime with doramectin.

Journal: Acta veterinaria Scandinavica 20020101

Title: Persistent efficacy of doramectin topical solution against induced infestations of Bovicola bovis and Solenopotes capillatus.

Journal: Veterinary parasitology 20011213

Title: Genetic approaches for controlling ratios of related polyketide products in fermentation processes.

Journal: Journal of industrial microbiology & biotechnology 20011201

Title: Evaluation of the persistent activity of injectable endectocides against Psoroptes ovis.

Journal: The Veterinary record 20011027

Title: Effects of treatments with endectocide on the weight gain of grazing cattle in a warm temperate climate.

Journal: The Veterinary record 20010901

Title: Plasma pharmacokinetics and faecal excretion of ivermectin, doramectin and moxidectin following oral administration in horses.

Journal: Equine veterinary journal 20010901

Title: Preventing transmission of Sarcoptes scabiei var. suis from infested sows to nursing piglets by a prefarrowing treatment with doramectin injectable solution.

Journal: Veterinary parasitology 20010831

Title: Efficacy of a long-acting formulation of ivermectin against Psoroptes ovis (Hering, 1838) on cattle.

Journal: Veterinary parasitology 20010628

Title: Resistance of Cooperia to ivermectin treatments in grazing cattle of the Humid Pampa, Argentina.

Journal: Veterinary parasitology 20010612

Title: Comparison of ivermectin, doramectin, selamectin, and eleven intermediates in a nematode larval development assay.

Journal: The Journal of parasitology 20010601

Title: [Effect of a single injection of doramectin on gastrointestinal nematode infections of sheep grazing on alpine pastures].

Journal: Schweizer Archiv fur Tierheilkunde 20010601

Title: Milk kinetics of moxidectin and doramectin in goats.

Journal: Research in veterinary science 20010601

Title: Effects of parenteral administration of doramectin or a combination of ivermectin and clorsulon on control of gastrointestinal nematode and liver fluke infections and on growth performance in cattle.

Journal: Journal of the American Veterinary Medical Association 20010501

Title: Persistent efficacy of doramectin and moxidectin against Cooperia oncophora infections in cattle.

Journal: Veterinary parasitology 20010419

Title: Diagnosis of psoroptic sheep scab with an improved enzyme-linked immunosorbent assay.

Journal: Veterinary parasitology 20010402

Title: Impact of doramectin treatment at the time of feedlot entry on the productivity of yearling steers with natural nematode infections.

Journal: American journal of veterinary research 20010401

Title: Efficacy of doramectin injectable against Oestrus ovis and gastrointestinal nematodes in sheep in the southwestern region of France.

Journal: Veterinary parasitology 20010320

Title: Larvicidal activity of endectocides against pest flies in the dung of treated cattle.

Journal: Medical and veterinary entomology 20010301

Title: Efficacy of macrocyclic lactones for the control of larvae of the Old World screw-worm fly (Chrysomya bezziana).

Journal: Australian veterinary journal 20010201

Title: Davey RB, Pound JM, Klavons JA, Lohmeyer KH, Freeman JM, Olafson PU.Analysis of doramectin in the serum of repeatedly treated pastured cattle used to predict the probability of cattle fever ticks (Acari: Ixodidae) feeding to repletion.Exp Appl Acarol. 2012 Apr;56(4):365-74. doi: 10.1007/s10493-012-9525-1.

Title: Wang XJ, Zhang J, Wang JD, Huang SX, Chen YH, Liu CX, Xiang WS.Four new doramectin congeners with acaricidal and insecticidal activity from Streptomyces avermitilis NEAU1069.Chem Biodivers. 2011 Nov;8(11):2117-25. doi: 10.1002/cbdv.201000295.

Title: Gordana Panic, et al. Activity Profile of an FDA-Approved Compound Library against Schistosoma mansoni. PLoS Negl Trop Dis. 2015 Jul 31;9(7):e0003962.

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SDS
Tags:117704-25-3 Molecular Formula|117704-25-3 MDL|117704-25-3 SMILES|117704-25-3 25-Cyclohexyl-5-O-demethyl-25-de(1-methylpropyl)avermectin A1a