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118159-48-1,MFCD00889471
Catalog No.:AA007QEJ

118159-48-1 | Bicyclol

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1mg
≥98%
in stock  
$53.00   $37.00
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5mg
≥98%
in stock  
$116.00   $81.00
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10mg
≥98%
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$203.00   $142.00
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50mg
98% by HPLC
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$854.00   $598.00
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100mg
98% by HPLC
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$1,431.00   $1,002.00
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500mg
98% by HPLC
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$4,477.00   $3,134.00
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1000mg
98% by HPLC
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA007QEJ
Chemical Name:
Bicyclol
CAS Number:
118159-48-1
Molecular Formula:
C19H18O9
Molecular Weight:
390.3408
MDL Number:
MFCD00889471
SMILES:
COC(=O)c1cc(OC)c2c(c1c1c(CO)cc(c3c1OCO3)OC)OCO2
Properties
Computed Properties
 
Complexity:
558  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
6  
XLogP3:
2.1  

Downstream Synthesis Route

[1]Tang,Xiaobo;Gu,Xiaoke;Ren,Zhiguang;Ma,Yuanfang;Lai,Yisheng;Peng,Hui;Peng,Sixun;Zhang,Yihua[BioorganicandMedicinalChemistryLetters,2012,vol.22,#8,p.2675-2680]

[2]Gu,Xiaoke;Ren,Zhiguang;Tang,Xiaobo;Peng,Hui;Ma,Yuanfang;Lai,Yisheng;Peng,Sixun;Zhang,Yihua[BioorganicandMedicinalChemistry,2012,vol.20,#8,p.2540-2548]

[3]CurrentPatentAssignee:BEIJINGYUANYANMEDICINETECH-CN107141278,2017,A

[4]CurrentPatentAssignee:XUZHOUMEDICALUNIVERSITY-CN108586425,2018,A

[5]CurrentPatentAssignee:CHONGQINGSHENGHUAXIPHARMACEUTICALCOLTD;CHONGQINGCHANGJIEPHARMACEUTICALCOLTD-CN116283886,2023,A

[1]Tang,Xiaobo;Gu,Xiaoke;Ren,Zhiguang;Ma,Yuanfang;Lai,Yisheng;Peng,Hui;Peng,Sixun;Zhang,Yihua[BioorganicandMedicinalChemistryLetters,2012,vol.22,#8,p.2675-2680]

[2]Gu,Xiaoke;Ren,Zhiguang;Tang,Xiaobo;Peng,Hui;Ma,Yuanfang;Lai,Yisheng;Peng,Sixun;Zhang,Yihua[BioorganicandMedicinalChemistry,2012,vol.20,#8,p.2540-2548]

[3]CurrentPatentAssignee:ZHEJIANGAUSUNPHARMACEUTICAL-CN106243079,2016,A

[4]CurrentPatentAssignee:XUZHOUMEDICALUNIVERSITY-CN108586426,2018,A

[5]CurrentPatentAssignee:XUZHOUMEDICALUNIVERSITY-CN108586425,2018,A

118159-48-1   
CASUnavailable 

[1]Tang,Xiaobo;Gu,Xiaoke;Ren,Zhiguang;Ma,Yuanfang;Lai,Yisheng;Peng,Hui;Peng,Sixun;Zhang,Yihua[BioorganicandMedicinalChemistryLetters,2012,vol.22,#8,p.2675-2680]

118159-48-1   
CASUnavailable 

[1]Tang,Xiaobo;Gu,Xiaoke;Ren,Zhiguang;Ma,Yuanfang;Lai,Yisheng;Peng,Hui;Peng,Sixun;Zhang,Yihua[BioorganicandMedicinalChemistryLetters,2012,vol.22,#8,p.2675-2680]

Literature

Title: Preparation and evaluation of bicyclol microemulsions for enhanced oral bioavailability.

Journal: Drug development and industrial pharmacy 20121101

Title: Alkaloids from the root of Isatis indigotica.

Journal: Journal of natural products 20120622

Title: A novel antihepatitis drug, bicyclol, prevents liver carcinogenesis in diethylnitrosamine-initiated and phenobarbital-promoted mice tumor model.

Journal: Journal of biomedicine & biotechnology 20120101

Title: [The clinical efficacy and safety of adefovir dipivoxil in combination with bicyclol for the treatment of senior patients with chronic hepatitis B].

Journal: Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology 20111201

Title: [Efficacy comparison between bicyclol and polyene phosphatidylcholine treatments for the patients with nonalcoholic fatty liver disease].

Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20110701

Title: Bioactive neolignans and lignans from the bark of Machilus robusta.

Journal: Journal of natural products 20110624

Title: [Effects of bicyclol on renal PAI-1 expression in rats with uniliteral ureteral obstruction].

Journal: Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20110601

Title: Effects of bicyclol on the activity and expression of CYP450 enzymes of rats after partial hepatectomy.

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20110601

Title: [Efficacy comparison between bicyclol and polyene phosphatidylcholine treatments for alcoholic liver disease].

Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20110601

Title: Protective effect of bicyclol on lipopolysaccharide-induced acute lung injury in mice.

Journal: Pulmonary pharmacology & therapeutics 20110401

Title: [Bicyclol protects rat thoracic aorta from superoxide anion-induced inhibition of vascular relaxation].

Journal: Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20110201

Title: Determination of bicyclol in dog plasma using liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100801

Title: Effects of bicyclol on immunological liver fibrosis in rats.

Journal: Journal of Asian natural products research 20100501

Title: Involvement of HSP70 in the protection of bicyclol on apoptosis of HepG2 cells intoxicated by d-galactosamine.

Journal: Journal of Asian natural products research 20100401

Title: Bicyclol attenuates pro-inflammatory cytokine and chemokine productions in CpG-DNA-stimulated L02 hepatocytes by inhibiting p65-NF-kappaB and p38-MAPK activation.

Journal: Die Pharmazie 20100301

Title: Hepatoprotective constituents from the roots and stems of Erycibe hainanesis.

Journal: Journal of natural products 20100226

Title: Bicyclol protects HepG2 cells against D-galactosamine-induced apoptosis through inducing heat shock protein 27 and mitochondria associated pathway.

Journal: Acta pharmacologica Sinica 20100201

Title: Chemical constituents of the bark of Machilus wangchiana and their biological activities.

Journal: Journal of natural products 20091201

Title: Establishment of liquid chromatography/mass spectrometry for determination of bicyclol in rat single-pass intestinal perfusion.

Journal: Biomedical chromatography : BMC 20091001

Title: Bicyclol attenuates oxidative stress and neuronal damage following transient forebrain ischemia in mouse cortex and hippocampus.

Journal: Neuroscience letters 20090807

Title: [The analyse of effectiveness in HBeAg-positive chronic viral hepatitis B treated by adefovir dipivoxil combined with bicyclol].

Journal: Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology 20090801

Title: Protective effect of bicyclol on tetracycline-induced fatty liver in mice.

Journal: Toxicology 20090710

Title: Inhibitory effect of anti-hepatitis drug bicyclol on invasion of human hepatocellular carcinoma MHCC97-H cells with high metastasis potential and its relative mechanisms.

Journal: Journal of Asian natural products research 20090601

Title: Induction of overexpression of the 27- and 70-kDa heat shock proteins by bicyclol attenuates concanavalin A-Induced liver injury through suppression of nuclear factor-kappaB in mice.

Journal: Molecular pharmacology 20090501

Title: Protect effect of bicyclol on cisplatin-induced nephrotoxicity in mice.

Journal: Archives of toxicology 20090401

Title: Effect of bicyclol on cisplatin-induced hepatotoxicity in the hepatocarcinoma 22 tumour-bearing mice.

Journal: Basic & clinical pharmacology & toxicology 20090401

Title: Effects of bicyclol on liver regeneration after partial hepatectomy in rats.

Journal: Digestive diseases and sciences 20090401

Title: Bicyclol: a novel drug for treating chronic viral hepatitis B and C.

Journal: Medicinal chemistry (Shariqah (United Arab Emirates)) 20090101

Title: Protection by bicyclol derivatives against acetaminophen-induced acute liver failure in mice and its active mechanism.

Journal: Liver international : official journal of the International Association for the Study of the Liver 20081101

Title: Pharmacokinetics of bicyclol in rats with acute hepatic failure.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20081101

Title: Bicyclol: a novel antihepatitis drug with hepatic heat shock protein 27/70-inducing activity and cytoprotective effects in mice.

Journal: Cell stress & chaperones 20080901

Title: [Effect of bicyclol on gene expression profiles in mice with liver injury induced by concanavalin A].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20080601

Title: Protective effect of bicyclol on acute alcohol-induced liver injury in mice.

Journal: European journal of pharmacology 20080531

Title: [Relationship between the genetic polymorphism of CYP3A5 gene and the clinical response to bicyclol in chronic hepatitis B].

Journal: Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology 20080201

Title: [Protective effect of bicyclol against acute fatty liver induced by tetracycline in mice].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20080101

Title: A study of intestinal absorption of bicyclol in rats: active efflux transport and metabolism as causes of its poor bioavailability.

Journal: Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20080101

Title: Bicyclol, a synthetic dibenzocyclooctadiene derivative, decreases hepatic lipids but increases serum triglyceride level in normal and hypercholesterolaemic mice.

Journal: The Journal of pharmacy and pharmacology 20071201

Title: [Effectiveness and safety of bicyclol combined with thymosin in treatment of chronic viral hepatitis B].

Journal: Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology 20071201

Title: [Comparison of bicyclol therapy for patients with genotype B and C of hepatitis B virus].

Journal: Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology 20071201

Title: [Synthesis of metabolites of bicyclol].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20071001

Title: [Use of bicyclol in treatment of chronic hepatitis B virus infection: a systematic review].

Journal: Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology 20070601

Title: Bicyclol for chronic hepatitis C.

Journal: The Cochrane database of systematic reviews 20070124

Title: Chemoprevention of bicyclol against hepatic preneoplastic lesions.

Journal: Cancer biology & therapy 20061201

Title: A useful agent for chemoprevention of hepatocellular carcinoma?

Journal: Cancer biology & therapy 20061201

Title: Bicyclol for chronic hepatitis B.

Journal: The Cochrane database of systematic reviews 20061018

Title: Effects of bicyclol on dimethylnitrosamine-induced liver fibrosis in mice and its mechanism of action.

Journal: Life sciences 20060704

Title: Chemopreventive effect of bicyclol on malignant transformation of WB-F344 rat liver epithelial cells and its effect on related signal transduction in vitro.

Journal: Cancer letters 20060518

Title: Chemosensitizing multiple drug resistance of human carcinoma by Bicyclol involves attenuated p-glycoprotein, GST-P and Bcl-2.

Journal: Cancer biology & therapy 20060501

Title: Hepatoprotective sesquiterpene glycosides from Sarcandra glabra.

Journal: Journal of natural products 20060401

Title: Protective effect of bicyclol on acute hepatic failure induced by lipopolysaccharide and D-galactosamine in mice.

Journal: European journal of pharmacology 20060318

Title: [Resolution of racemic anti-hepatitis drug ( +/- ) -bicyclol].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20060301

Title: [Advances in the research of anti-hepatic fibrosis drugs].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20060101

Title: [Protective effects of bicyclol on alcohol-induced liver damage in mice].

Journal: Zhonghua yi xue za zhi 20051221

Title: [Study on treatment effectiveness and safety in children with chronic hepatitis B or C using bicyclo tablets].

Journal: Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology 20051201

Title: [Histological study of livers from the patients with chronic hepatitis B treated with bicyclol].

Journal: Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology 20050901

Title: Mechanism of protective action of bicyclol against CCl-induced liver injury in mice.

Journal: Liver international : official journal of the International Association for the Study of the Liver 20050801

Title: [Effect of bicyclol tablets on cellular immune responses in patients with chronic hepatitis B].

Journal: Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20050601

Title: Toxicity of novel anti-hepatitis drug bicyclol: a preclinical study.

Journal: World journal of gastroenterology 20050207

Title: [Metabolism of bicyclol in rat and human liver microsomes in vitro].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20050201

Title: [Protective effects of bicyclol on liver fibrosis induced by carbon tetrachloride].

Journal: Zhonghua yi xue za zhi 20041217

Title: Inhibition of Fas/FasL mRNA expression and TNF-alpha release in concanavalin A-induced liver injury in mice by bicyclol.

Journal: World journal of gastroenterology 20040615

Title: Effects of bicyclol on aflatoxin B1 metabolism and hepatotoxicity in rats.

Journal: Acta pharmacologica Sinica 20021001

Title: [The protective effect of bicyclol on ischemia-reperfusion induced kidney injury in rats].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20020601

Title: [Effect of bicyclol on acetaminophen-induced hepatotoxicity: energetic metabolism and mitochondrial injury in acetaminophen-intoxicated mice].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20011001

Title: Walsh, S.W., Y. Wang, and A. Killian, AA-2414, an antioxidant and thromboxane receptor blocker, completely inhibits peroxide-induced vasoconstriction in the human placenta. J Pharmacol Exp Ther, 1999. 290(1): p. 220-6.

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