[1]Tang,Xiaobo;Gu,Xiaoke;Ren,Zhiguang;Ma,Yuanfang;Lai,Yisheng;Peng,Hui;Peng,Sixun;Zhang,Yihua[BioorganicandMedicinalChemistryLetters,2012,vol.22,#8,p.2675-2680]
[2]Gu,Xiaoke;Ren,Zhiguang;Tang,Xiaobo;Peng,Hui;Ma,Yuanfang;Lai,Yisheng;Peng,Sixun;Zhang,Yihua[BioorganicandMedicinalChemistry,2012,vol.20,#8,p.2540-2548]
[3]CurrentPatentAssignee:BEIJINGYUANYANMEDICINETECH-CN107141278,2017,A
[4]CurrentPatentAssignee:XUZHOUMEDICALUNIVERSITY-CN108586425,2018,A
[5]CurrentPatentAssignee:CHONGQINGSHENGHUAXIPHARMACEUTICALCOLTD;CHONGQINGCHANGJIEPHARMACEUTICALCOLTD-CN116283886,2023,A
[1]Tang,Xiaobo;Gu,Xiaoke;Ren,Zhiguang;Ma,Yuanfang;Lai,Yisheng;Peng,Hui;Peng,Sixun;Zhang,Yihua[BioorganicandMedicinalChemistryLetters,2012,vol.22,#8,p.2675-2680]
[2]Gu,Xiaoke;Ren,Zhiguang;Tang,Xiaobo;Peng,Hui;Ma,Yuanfang;Lai,Yisheng;Peng,Sixun;Zhang,Yihua[BioorganicandMedicinalChemistry,2012,vol.20,#8,p.2540-2548]
[3]CurrentPatentAssignee:ZHEJIANGAUSUNPHARMACEUTICAL-CN106243079,2016,A
[4]CurrentPatentAssignee:XUZHOUMEDICALUNIVERSITY-CN108586426,2018,A
[5]CurrentPatentAssignee:XUZHOUMEDICALUNIVERSITY-CN108586425,2018,A
[1]Tang,Xiaobo;Gu,Xiaoke;Ren,Zhiguang;Ma,Yuanfang;Lai,Yisheng;Peng,Hui;Peng,Sixun;Zhang,Yihua[BioorganicandMedicinalChemistryLetters,2012,vol.22,#8,p.2675-2680]
[1]Tang,Xiaobo;Gu,Xiaoke;Ren,Zhiguang;Ma,Yuanfang;Lai,Yisheng;Peng,Hui;Peng,Sixun;Zhang,Yihua[BioorganicandMedicinalChemistryLetters,2012,vol.22,#8,p.2675-2680]
Title: Preparation and evaluation of bicyclol microemulsions for enhanced oral bioavailability.
Journal: Drug development and industrial pharmacy 20121101
Title: Alkaloids from the root of Isatis indigotica.
Journal: Journal of natural products 20120622
Title: A novel antihepatitis drug, bicyclol, prevents liver carcinogenesis in diethylnitrosamine-initiated and phenobarbital-promoted mice tumor model.
Journal: Journal of biomedicine & biotechnology 20120101
Title: [The clinical efficacy and safety of adefovir dipivoxil in combination with bicyclol for the treatment of senior patients with chronic hepatitis B].
Journal: Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology 20111201
Title: [Efficacy comparison between bicyclol and polyene phosphatidylcholine treatments for the patients with nonalcoholic fatty liver disease].
Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20110701
Title: Bioactive neolignans and lignans from the bark of Machilus robusta.
Journal: Journal of natural products 20110624
Title: [Effects of bicyclol on renal PAI-1 expression in rats with uniliteral ureteral obstruction].
Journal: Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20110601
Title: Effects of bicyclol on the activity and expression of CYP450 enzymes of rats after partial hepatectomy.
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20110601
Title: [Efficacy comparison between bicyclol and polyene phosphatidylcholine treatments for alcoholic liver disease].
Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20110601
Title: Protective effect of bicyclol on lipopolysaccharide-induced acute lung injury in mice.
Journal: Pulmonary pharmacology & therapeutics 20110401
Title: [Bicyclol protects rat thoracic aorta from superoxide anion-induced inhibition of vascular relaxation].
Journal: Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20110201
Title: Determination of bicyclol in dog plasma using liquid chromatography-tandem mass spectrometry.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100801
Title: Effects of bicyclol on immunological liver fibrosis in rats.
Journal: Journal of Asian natural products research 20100501
Title: Involvement of HSP70 in the protection of bicyclol on apoptosis of HepG2 cells intoxicated by d-galactosamine.
Journal: Journal of Asian natural products research 20100401
Title: Bicyclol attenuates pro-inflammatory cytokine and chemokine productions in CpG-DNA-stimulated L02 hepatocytes by inhibiting p65-NF-kappaB and p38-MAPK activation.
Journal: Die Pharmazie 20100301
Title: Hepatoprotective constituents from the roots and stems of Erycibe hainanesis.
Journal: Journal of natural products 20100226
Title: Bicyclol protects HepG2 cells against D-galactosamine-induced apoptosis through inducing heat shock protein 27 and mitochondria associated pathway.
Journal: Acta pharmacologica Sinica 20100201
Title: Chemical constituents of the bark of Machilus wangchiana and their biological activities.
Journal: Journal of natural products 20091201
Title: Establishment of liquid chromatography/mass spectrometry for determination of bicyclol in rat single-pass intestinal perfusion.
Journal: Biomedical chromatography : BMC 20091001
Title: Bicyclol attenuates oxidative stress and neuronal damage following transient forebrain ischemia in mouse cortex and hippocampus.
Journal: Neuroscience letters 20090807
Title: [The analyse of effectiveness in HBeAg-positive chronic viral hepatitis B treated by adefovir dipivoxil combined with bicyclol].
Journal: Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology 20090801
Title: Protective effect of bicyclol on tetracycline-induced fatty liver in mice.
Journal: Toxicology 20090710
Title: Inhibitory effect of anti-hepatitis drug bicyclol on invasion of human hepatocellular carcinoma MHCC97-H cells with high metastasis potential and its relative mechanisms.
Journal: Journal of Asian natural products research 20090601
Title: Induction of overexpression of the 27- and 70-kDa heat shock proteins by bicyclol attenuates concanavalin A-Induced liver injury through suppression of nuclear factor-kappaB in mice.
Journal: Molecular pharmacology 20090501
Title: Protect effect of bicyclol on cisplatin-induced nephrotoxicity in mice.
Journal: Archives of toxicology 20090401
Title: Effect of bicyclol on cisplatin-induced hepatotoxicity in the hepatocarcinoma 22 tumour-bearing mice.
Journal: Basic & clinical pharmacology & toxicology 20090401
Title: Effects of bicyclol on liver regeneration after partial hepatectomy in rats.
Journal: Digestive diseases and sciences 20090401
Title: Bicyclol: a novel drug for treating chronic viral hepatitis B and C.
Journal: Medicinal chemistry (Shariqah (United Arab Emirates)) 20090101
Title: Protection by bicyclol derivatives against acetaminophen-induced acute liver failure in mice and its active mechanism.
Journal: Liver international : official journal of the International Association for the Study of the Liver 20081101
Title: Pharmacokinetics of bicyclol in rats with acute hepatic failure.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20081101
Title: Bicyclol: a novel antihepatitis drug with hepatic heat shock protein 27/70-inducing activity and cytoprotective effects in mice.
Journal: Cell stress & chaperones 20080901
Title: [Effect of bicyclol on gene expression profiles in mice with liver injury induced by concanavalin A].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20080601
Title: Protective effect of bicyclol on acute alcohol-induced liver injury in mice.
Journal: European journal of pharmacology 20080531
Title: [Relationship between the genetic polymorphism of CYP3A5 gene and the clinical response to bicyclol in chronic hepatitis B].
Journal: Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology 20080201
Title: [Protective effect of bicyclol against acute fatty liver induced by tetracycline in mice].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20080101
Title: A study of intestinal absorption of bicyclol in rats: active efflux transport and metabolism as causes of its poor bioavailability.
Journal: Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20080101
Title: Bicyclol, a synthetic dibenzocyclooctadiene derivative, decreases hepatic lipids but increases serum triglyceride level in normal and hypercholesterolaemic mice.
Journal: The Journal of pharmacy and pharmacology 20071201
Title: [Effectiveness and safety of bicyclol combined with thymosin in treatment of chronic viral hepatitis B].
Journal: Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology 20071201
Title: [Comparison of bicyclol therapy for patients with genotype B and C of hepatitis B virus].
Journal: Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology 20071201
Title: [Synthesis of metabolites of bicyclol].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20071001
Title: [Use of bicyclol in treatment of chronic hepatitis B virus infection: a systematic review].
Journal: Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology 20070601
Title: Bicyclol for chronic hepatitis C.
Journal: The Cochrane database of systematic reviews 20070124
Title: Chemoprevention of bicyclol against hepatic preneoplastic lesions.
Journal: Cancer biology & therapy 20061201
Title: A useful agent for chemoprevention of hepatocellular carcinoma?
Journal: Cancer biology & therapy 20061201
Title: Bicyclol for chronic hepatitis B.
Journal: The Cochrane database of systematic reviews 20061018
Title: Effects of bicyclol on dimethylnitrosamine-induced liver fibrosis in mice and its mechanism of action.
Journal: Life sciences 20060704
Title: Chemopreventive effect of bicyclol on malignant transformation of WB-F344 rat liver epithelial cells and its effect on related signal transduction in vitro.
Journal: Cancer letters 20060518
Title: Chemosensitizing multiple drug resistance of human carcinoma by Bicyclol involves attenuated p-glycoprotein, GST-P and Bcl-2.
Journal: Cancer biology & therapy 20060501
Title: Hepatoprotective sesquiterpene glycosides from Sarcandra glabra.
Journal: Journal of natural products 20060401
Title: Protective effect of bicyclol on acute hepatic failure induced by lipopolysaccharide and D-galactosamine in mice.
Journal: European journal of pharmacology 20060318
Title: [Resolution of racemic anti-hepatitis drug ( +/- ) -bicyclol].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20060301
Title: [Advances in the research of anti-hepatic fibrosis drugs].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20060101
Title: [Protective effects of bicyclol on alcohol-induced liver damage in mice].
Journal: Zhonghua yi xue za zhi 20051221
Title: [Study on treatment effectiveness and safety in children with chronic hepatitis B or C using bicyclo tablets].
Journal: Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology 20051201
Title: [Histological study of livers from the patients with chronic hepatitis B treated with bicyclol].
Journal: Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology 20050901
Title: Mechanism of protective action of bicyclol against CCl-induced liver injury in mice.
Journal: Liver international : official journal of the International Association for the Study of the Liver 20050801
Title: [Effect of bicyclol tablets on cellular immune responses in patients with chronic hepatitis B].
Journal: Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20050601
Title: Toxicity of novel anti-hepatitis drug bicyclol: a preclinical study.
Journal: World journal of gastroenterology 20050207
Title: [Metabolism of bicyclol in rat and human liver microsomes in vitro].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20050201
Title: [Protective effects of bicyclol on liver fibrosis induced by carbon tetrachloride].
Journal: Zhonghua yi xue za zhi 20041217
Title: Inhibition of Fas/FasL mRNA expression and TNF-alpha release in concanavalin A-induced liver injury in mice by bicyclol.
Journal: World journal of gastroenterology 20040615
Title: Effects of bicyclol on aflatoxin B1 metabolism and hepatotoxicity in rats.
Journal: Acta pharmacologica Sinica 20021001
Title: [The protective effect of bicyclol on ischemia-reperfusion induced kidney injury in rats].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20020601
Title: [Effect of bicyclol on acetaminophen-induced hepatotoxicity: energetic metabolism and mitochondrial injury in acetaminophen-intoxicated mice].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20011001
Title: Walsh, S.W., Y. Wang, and A. Killian, AA-2414, an antioxidant and thromboxane receptor blocker, completely inhibits peroxide-induced vasoconstriction in the human placenta. J Pharmacol Exp Ther, 1999. 290(1): p. 220-6.