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Home Deuterated Building Blocks 1185053-50-2
1185053-50-2,MFCD09752113
Catalog No.:AA01CB5N

1185053-50-2 | Clozapine-d8

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
cp98%，98%D
in stock  
$516.00   $362.00
- +
5mg
cp98%，98%D
in stock  
$1,541.00   $1,079.00
- +
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA01CB5N
Chemical Name:
Clozapine-d8
CAS Number:
1185053-50-2
Molecular Formula:
C18H11ClD8N4
Molecular Weight:
334.8726
MDL Number:
MFCD09752113
SMILES:
CN1C([2H])([2H])C([2H])([2H])N(C(C1([2H])[2H])([2H])[2H])C1=Nc2cc(Cl)ccc2Nc2c1cccc2
Properties
Computed Properties
 
Complexity:
446  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
8  
Rotatable Bond Count:
1  
XLogP3:
3.1  

Literature

Title: Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

Title: Seeman P, et al. Clozapine, a fast-off-D2 antipsychotic. ACS Chem Neurosci. 2014 Jan 15;5(1):24-9.

Title: Zhukovskaya NL, et al. Clozapine downregulates 5-hydroxytryptamine6 (5-HT6) and upregulates 5-HT7 receptors in HeLa cells. Neurosci Lett. 2000 Jul 21;288(3):236-40.

Title: Moreno JL, et al. Persistent effects of chronic clozapine on the cellular and behavioral responses to LSD in mice. Psychopharmacology (Berl). 2013 Jan;225(1):217-26.

Title: Zorn SH, et al. Clozapine is a potent and selective muscarinic M4 receptor agonist. Eur J Pharmacol. 1994 Nov 15;269(3):R1-2.

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SDS
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Tags:1185053-50-2 Molecular Formula|1185053-50-2 MDL|1185053-50-2 SMILES|1185053-50-2 Clozapine-d8